Metabolic alkalosis‑an adverse effect of baking soda misuse: A case report and literature review

Diaconu,Anca; Florea,Ioana; Vlad,Cristiana-Elena; Achiței,Răzvan; Florea,Laura

doi:10.3892/etm.2022.11594

Metabolic alkalosis‑an adverse effect of baking soda misuse: A case report and literature review

Authors:
- Anca Diaconu
- Ioana Florea
- Cristiana-Elena Vlad
- Răzvan Achiței
- Laura Florea
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Affiliations: Department of Cardiology, Cardiovascular Diseases Institute, Iasi 700503, Romania, Department of Endocrinology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, Iasi 700115, Romania, Department of Internal Medicine‑Nephrology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, Iasi 700115, Romania, Department of Anesthesiology and Intensive Care, Regional Institute of Oncology, Iasi 700483, Romania
Published online on: September 7, 2022 https://doi.org/10.3892/etm.2022.11594
Article Number: 658
Copyright: © Diaconu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

Baking soda overdose is rarely reported. However, several cases have been previously documented, as baking soda has gained popularity as an over‑the‑counter remedy. The present study reported the case of a 69‑year‑old male patient hospitalized with metabolic alkalosis (pH 7.61; bicarbonate levels, 53.2 mEq/l), hypokalemia (K⁺ 2.6 mEq/l), acute kidney injury (serum creatinine level 4.02 mg/dl) and hepatic toxicity (alanine transaminase, 955 U/l; aspartate transaminase, 1,091 U/l) in the context of baking soda misuse as an alternative treatment for gout. The patient's past medical history included chronic uric acid nephropathy, gout, arterial hypertension and permanent atrial fibrillation. Under corrective treatment for the hydro‑electrolyte and acid‑base imbalances, the hepatic injury and inflammation markers were within normal limits; uric acid and creatinine serum levels also decreased.

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