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Case Report Open Access

Response to immunotherapy in a patient with advanced epithelioid sarcoma of adrenal gland: A case report

  • Authors:
    • Jingwen Wang
    • Chen Lu
    • Xi Tang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, P.R. China, Department of Pathology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 659
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    Published online on: September 7, 2022
       https://doi.org/10.3892/etm.2022.11595
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Abstract

Epithelioid sarcoma (ES) is a rare and highly invasive soft tissue malignant tumor with uncertain histogenesis. The localization of ES in the adrenal gland is rather unusual. The present study reported a case of stage IV ES in the adrenal gland of a 28‑year‑old male. The tissue biopsy of adrenal and lung lesions revealed epithelioid cells. Immunohistochemistry indicated that the tumor cells were strongly positive for cytokeratin (CK)8, CK, epithelial membrane antigen (EMA), CD34 and programmed cell death protein 1 ligand (PD‑L1) but negative for nuclear integrase interactor 1 expression. The next‑generation sequencing technology was applied using peripheral blood, indicating a low tumor mutation burden of 4.11 mutations (Muts)/Mb and somatic mutations in SMARCB1. After diagnosis, the patient underwent unsuccessful palliative chemotherapy and radiotherapy. However, application of immune checkpoint inhibitors (ICIs) achieved partial remission and the overall survival reached 25 months. ICI monotherapy may be a feasible treatment for patients with ES with a strong expression of PD‑L1.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Lu C and Tang X: Response to immunotherapy in a patient with advanced epithelioid sarcoma of adrenal gland: A case report. Exp Ther Med 24: 659, 2022.
APA
Wang, J., Lu, C., & Tang, X. (2022). Response to immunotherapy in a patient with advanced epithelioid sarcoma of adrenal gland: A case report. Experimental and Therapeutic Medicine, 24, 659. https://doi.org/10.3892/etm.2022.11595
MLA
Wang, J., Lu, C., Tang, X."Response to immunotherapy in a patient with advanced epithelioid sarcoma of adrenal gland: A case report". Experimental and Therapeutic Medicine 24.5 (2022): 659.
Chicago
Wang, J., Lu, C., Tang, X."Response to immunotherapy in a patient with advanced epithelioid sarcoma of adrenal gland: A case report". Experimental and Therapeutic Medicine 24, no. 5 (2022): 659. https://doi.org/10.3892/etm.2022.11595
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Lu C and Tang X: Response to immunotherapy in a patient with advanced epithelioid sarcoma of adrenal gland: A case report. Exp Ther Med 24: 659, 2022.
APA
Wang, J., Lu, C., & Tang, X. (2022). Response to immunotherapy in a patient with advanced epithelioid sarcoma of adrenal gland: A case report. Experimental and Therapeutic Medicine, 24, 659. https://doi.org/10.3892/etm.2022.11595
MLA
Wang, J., Lu, C., Tang, X."Response to immunotherapy in a patient with advanced epithelioid sarcoma of adrenal gland: A case report". Experimental and Therapeutic Medicine 24.5 (2022): 659.
Chicago
Wang, J., Lu, C., Tang, X."Response to immunotherapy in a patient with advanced epithelioid sarcoma of adrenal gland: A case report". Experimental and Therapeutic Medicine 24, no. 5 (2022): 659. https://doi.org/10.3892/etm.2022.11595
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