Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2022 Volume 24 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2022 Volume 24 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway

  • Authors:
    • Honghao Jiang
    • Xiaoyong Zhou
    • Liuqing Chen
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, Hubei 430030, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 667
    |
    Published online on: September 8, 2022
       https://doi.org/10.3892/etm.2022.11603
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Asiaticoside, isolated from Centella asiatica, shows great improvement on wound healing and anti‑oxidation function in vitro and in vivo. From previous research, asiaticoside possesses the potential capability to delay skin aging and reduce wrinkles clinically, but its underlying mechanism to regulate aging have not well‑investigated. The present study found that asiaticoside could improve the viability and maintains a normal morphology in ultraviolet (UV)‑exposure cells. In addition, β‑galactosidase release was inhibited by treatment of asiaticoside in UV damaged cells was observed. The present study confirmed that UV‑induced ROS generation and SOD reduction could be attenuated by incubation of asiaticoside. By using RNA sequencing technology, differential genes between UV and asiaticoside treatment were demonstrated and enriched genes suggested that asiaticoside is able to negatively regulate cell cycle and MAPK pathways. Western blotting was employed to clarify the variation of key proteins in TGF‑β1/Smad pathway and cell cycle and the result implied that asiaticoside is capable of attenuating upregulation of TGF‑β1, Smad2 and Smad3 to reverse cell senescence. The present study investigated regulation of asiaticoside to TGF‑β1/Smad pathway in UV‑induced HaCat cells, showing its potential to against photoaging.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Rabe JH, Mamelak AJ, McElgunn PJ, Morison WL and Sauder DN: Photoaging: Mechanisms and repair. J Am Acad Dermatol. 55:1–19. 2006.PubMed/NCBI View Article : Google Scholar

2 

Tobin DJ: Introduction to skin aging. J Tissue Viability. 26:37–46. 2017.PubMed/NCBI View Article : Google Scholar

3 

Watson RE, Gibbs NK, Griffiths CE and Sherratt MJ: Damage to skin extracellular matrix induced by UV exposure. Antioxid Redox Signal. 21:1063–1077. 2014.PubMed/NCBI View Article : Google Scholar

4 

Russo PA and Halliday GM: Inhibition of nitric oxide and reactive oxygen species production improves the ability of a sunscreen to protect from sunburn, immunosuppression and photocarcinogenesis. Br J Dermatol. 155:408–415. 2006.PubMed/NCBI View Article : Google Scholar

5 

Hasham R, Choi HK, Sarmidi MR and Park CS: Protective effects of a Ficus deltoidea (Mas cotek) extract against UVB-induced photoageing in skin cells. Biotechnology and Bioprocess Engineering. 18:185–193. 2013.

6 

Sun L, Xu C, Lin P, Quigg A, Chin WC and Santschi PH: . Photo-oxidation of proteins facilitates the preservation of high molecular weight dissolved organic nitrogen in the ocean. Marine Chemistry. 229(103907)2021.

7 

Liu S, Mizu H and Yamauchi H: Photoinflammatory responses to UV-irradiated ketoprofen mediated by the induction of ROS generation, enhancement of cyclooxygenase-2 expression and regulation of multiple signaling pathways. Free Radic Biol Med. 48:772–780. 2010.PubMed/NCBI View Article : Google Scholar

8 

Wondrak GT, Roberts MJ, Cervantes-Laurean D, Jacobson MK and Jacobson EL: Proteins of the extracellular matrix are sensitizers of photo-oxidative stress in human skin cells. J Invest Dermatol. 121:578–586. 2003.PubMed/NCBI View Article : Google Scholar

9 

Severino J, Allen RG, Balin S, Balin A and Cristofalo VJ: Is beta-galactosidase staining a marker of senescence in vitro and in vivo? Exp Cell Res. 257:162–171. 2000.PubMed/NCBI View Article : Google Scholar

10 

Lee BY, Han JA, Im JS, Morrone A, Johung K, Goodwin EC, Kleijer WJ, DiMaio D and Hwang ES: Senescence-associated beta-galactosidase is lysosomal beta-galactosidase. Aging Cell. 5:187–195. 2006.PubMed/NCBI View Article : Google Scholar

11 

Gary RK and Kindell SM: Quantitative assay of senescence-associated beta-galactosidase activity in mammalian cell extracts. Anal Biochem. 343:329–334. 2005.PubMed/NCBI View Article : Google Scholar

12 

Gohil KJ, Patel JA and Gajjar AK: Pharmacological review on centella asiatica: A potential herbal cure-all. Indian J Pharm Sci. 72:546–556. 2010.PubMed/NCBI View Article : Google Scholar

13 

George M, Joseph L and Ramaswamy  : Anti-allergic, anti-pruritic and anti-inflammatory activities of Centella asiatica extracts. Afr J Tradit Complement Altern Med. 6:554–559. 2009.PubMed/NCBI View Article : Google Scholar

14 

Namviriyachote N, Muangman P, Chinaroonchai K, Chuntrasakul C and Ritthidej GC: Polyurethane-biomacromolecule combined foam dressing containing asiaticoside: Fabrication, characterization and clinical efficacy for traumatic dermal wound treatment. Int J Biol Macromol. 143:510–520. 2020.PubMed/NCBI View Article : Google Scholar

15 

Brinkhaus B, Lindner M, Schuppan D and Hahn EG: Chemical, pharmacological and clinical profile of the East Asian medical plant Centella aslatica. Phytomedicine. 7:427–448. 2000.PubMed/NCBI View Article : Google Scholar

16 

Gao X, Lin J, Sun L and Ren Y: Clinical effects of dermatix ultra silica gel and asiaticoside cream on hyperplastic scar tissue in patients after epicanthoplasty. Chinese J Medical Aesthetics and Cosmetology. 6:508–511. 2019.

17 

Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK and Dhawan BN: In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J Ethnopharmacol. 65:1–11. 1999.PubMed/NCBI View Article : Google Scholar

18 

Kimura Y, Sumiyoshi M, Samukawa KI, Satake N and Sakanaka M: Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism. Eur J Pharmacol. 584:415–423. 2008.PubMed/NCBI View Article : Google Scholar

19 

Wijeweera P, Arnason JT, Koszycki D and Merali Z: Evaluation of anxiolytic properties of Gotukola-(Centella asiatica) extracts and asiaticoside in rat behavioral models. Phytomedicine. 13:668–676. 2006.PubMed/NCBI View Article : Google Scholar

20 

Shubhra QTH, Oyane A, Araki H, Nakamura M and Tsurushima H: Calcium phosphate nanoparticles prepared from infusion fluids for stem cell transfection: Process optimization and cytotoxicity analysis. Biomater Sci. 5:972–981. 2017.PubMed/NCBI View Article : Google Scholar

21 

Shubhra QTH, Kardos AF, Feczkó T, Mackova H, Horák D, Tóth J, Dósa G and Gyenis J: Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part I. Effect of process variables on the mean size. J Microencapsul. 31:147–155. 2014.PubMed/NCBI View Article : Google Scholar

22 

Liu Y, Ding M, Guo K, Wang Z, Zhang C and Shubhra QTH: Systemic Co-delivery of drugs by a pH- and photosensitive smart nanocarrier to treat cancer by chemo-photothermal-starvation combination therapy. Smart Materials in Medicine. 3:390–403. 2022.

23 

Shubhra QTH, Guo K, Liu Y, Razzak M, Manir MS and Alam AKM: Dual targeting smart drug delivery system for multimodal synergistic combination cancer therapy with reduced cardiotoxicity. Acta Biomater. 131:493–507. 2021.PubMed/NCBI View Article : Google Scholar

24 

Livak KJ and Schmittgen TD: . Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

25 

Guo K, Liu Y, Tang L and Shubhra QTH: Homotypic biomimetic coating synergizes chemo-photothermal combination therapy to treat breast cancer overcoming drug resistance. Chemical Engineering J. 428(131120)2022.

26 

Su J, Guo K, Huang M, Liu Y, Zhang J, Sun L, Li D, Pang KL, Wang G, Chen L, et al: Fucoxanthin, a marine xanthophyll isolated from conticribra weissflogii ND-8: Preventive anti-inflammatory effect in a mouse model of sepsis. Front Pharmacol. 10(906)2019.PubMed/NCBI View Article : Google Scholar

27 

Guo K, Xiao N, Liu Y, Wang Z, Tóth J, Gyenis J, Thakur VK, Oyane A and Shubhra QTH: Engineering polymer nanoparticles using cell membrane coating technology and their application in cancer treatments: Opportunities and challenges. Nano Materials Science 2021.

28 

Ji L, Xu J, Liu J, Amjad A, Zhang K, Liu Q, Zhou L, Xiao J and Li X: Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor beta (TGF-beta) pathway. J Biol Chem. 290:11729–11740. 2015.PubMed/NCBI View Article : Google Scholar

29 

Higgins SP, Tang Y, Higgins CE, Mian B, Zhang W, Czekay RP, Samarakoon R, Conti DJ and Higgins PJ: TGF-β1/p53 signaling in renal fibrogenesis. Cell Signal. 43:1–10. 2018.PubMed/NCBI View Article : Google Scholar

30 

Kuilman T, Michaloglou C, Mooi WJ and Peeper DS: The essence of senescence. Genes Dev. 24:2463–2479. 2010.PubMed/NCBI View Article : Google Scholar

31 

Cavinato M and Jansen-Durr P: Molecular mechanisms of UVB-induced senescence of dermal fibroblasts and its relevance for photoaging of the human skin. Exp Gerontol. 94:78–82. 2017.PubMed/NCBI View Article : Google Scholar

32 

Wang SQ, Setlow R, Berwick M, Polsky D, Marghoob AA, Kopf AW and Bart RS: Ultraviolet A and melanoma: A review. J Am Acad Dermatol. 44:837–846. 2001.PubMed/NCBI View Article : Google Scholar

33 

Debacq-Chainiaux F, Borlon C, Pascal T, Royer V, Eliaers F, Ninane N, Carrard G, Friguet B, de Longueville F, Boffe S, et al: Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway. J Cell Sci. 118:743–758. 2005.PubMed/NCBI View Article : Google Scholar

34 

Chainiaux F, Magalhaes JP, Eliaers F, Remacle J and Toussaint O: UVB-induced premature senescence of human diploid skin fibroblasts. Int J Biochem Cell Biol. 34:1331–1339. 2002.PubMed/NCBI View Article : Google Scholar

35 

Georgetti SR, Casagrande R, Vicentini FT, Baracat MM, Verri WA Jr and Fonseca MJ: Protective effect of fermented soybean dried extracts against TPA-induced oxidative stress in hairless mice skin. Biomed Res Int. 2013(340626)2013.PubMed/NCBI View Article : Google Scholar

36 

Ribeiro FM, Ratti BA, Dos Santos Rando F, Fernandez MA, Ueda-Nakamura T, de Oliveira Silva Lautenschlager S and Nakamura CV: Metformin effect on driving cell survival pathway through inhibition of UVB-induced ROS formation in human keratinocytes. Mech Ageing Dev. 192(111387)2020.PubMed/NCBI View Article : Google Scholar

37 

Graindorge D, Martineau S, Machon C, Arnoux P, Guitton J, Francesconi S, Frochot C, Sage E and Girard PM: Singlet oxygen-mediated oxidation during UVA radiation alters the dynamic of genomic DNA replication. PLoS One. 10(e0140645)2015.PubMed/NCBI View Article : Google Scholar

38 

Zhao J, Shi J, Shan Y, Yu M, Zhu X, Zhu Y, Liu L and Sheng M: Asiaticoside inhibits TGF-β1-induced mesothelial-mesenchymal transition and oxidative stress via the Nrf2/HO-1 signaling pathway in the human peritoneal mesothelial cell line HMrSV5. Cell Mol Biol Lett. 25(33)2020.PubMed/NCBI View Article : Google Scholar

39 

Luo P, Huang Q, Chen S, Wang Y and Dou H: Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway. Int Immunopharmacol. 108(108864)2022.PubMed/NCBI View Article : Google Scholar

40 

Proksch E, Schunck M, Zague V, Segger D, Degwert J and Oesser S: Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol. 27:113–119. 2014.PubMed/NCBI View Article : Google Scholar

41 

Chen CC, Chiang AN, Liu HN and Chang YT: EGb-761 prevents ultraviolet B-induced photoaging via inactivation of mitogen-activated protein kinases and proinflammatory cytokine expression. J Dermatol Sci. 75:55–62. 2014.PubMed/NCBI View Article : Google Scholar

42 

Pittayapruek P, Meephansan J, Prapapan O, Komine M and Ohtsuki M: Role of matrix metalloproteinases in photoaging and photocarcinogenesis. Int J Mol Sci. 17(868)2016.PubMed/NCBI View Article : Google Scholar

43 

Nagase H, Visse R and Murphy G: Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res. 69:562–573. 2006.PubMed/NCBI View Article : Google Scholar

44 

Kim MS, Kim YK, Cho KH and Chung JH: Regulation of type I procollagen and MMP-1 expression after single or repeated exposure to infrared radiation in human skin. Mech Ageing Dev. 127:875–882. 2006.PubMed/NCBI View Article : Google Scholar

45 

Brennan M, Bhatti H, Nerusu KC, Bhagavathula N, Kang SW, Fisher GJ, Varani J and Voorhees JJ: Matrix metalloproteinase-1 is the major collagenolytic enzyme responsible for collagen damage in UV-irradiated human skin. Photochem Photobiol. 78:43–48. 2003.PubMed/NCBI View Article : Google Scholar

46 

Vedrenne N, Coulomb B, Danigo A, Bonte F and Desmouliere A: The complex dialogue between (myo)fibroblasts and the extracellular matrix during skin repair processes and ageing. Pathol Biol (Paris). 60:20–27. 2012.PubMed/NCBI View Article : Google Scholar

47 

Quan T, Qin Z, Xia W, Shao Y, Voorhees JJ and Fisher GJ: Matrix-degrading metalloproteinases in photoaging. J Investig Dermatol Symp Proc. 14:20–24. 2009.PubMed/NCBI View Article : Google Scholar

48 

Qin H, Zhang G and Zhang L: GSK126 (EZH2 inhibitor) interferes with ultraviolet A radiation-induced photoaging of human skin fibroblast cells. Exp Ther Med. 15:3439–3448. 2018.PubMed/NCBI View Article : Google Scholar

49 

Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I and Pereira-Smith O: A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA. 92:9363–9367. 1995.PubMed/NCBI View Article : Google Scholar

50 

Hernandez-Segura A, Nehme J and Demaria M: Hallmarks of cellular senescence. Trends Cell Biol. 28:436–453. 2018.PubMed/NCBI View Article : Google Scholar

51 

Xu YR and Fisher GJ: Ultraviolet (UV) light irradiation induced signal transduction in skin photoaging. J Dermatol Sci. 1:S1–S8. 2005.

52 

Feczko T, Fodor-Kardos A, Sivakumaran M and Haque Shubhra QT: In vitro IFN-alpha release from IFN-alpha- and pegylated IFN-α-loaded poly(lactic-co-glycolic acid) and pegylated poly(lactic-co-glycolic acid) nanoparticles. Nanomedicine (Lond). 11:2029–2034. 2016.PubMed/NCBI View Article : Google Scholar

53 

Derynck R and Zhang YE: Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature. 425:577–584. 2003.PubMed/NCBI View Article : Google Scholar

54 

Sun ZW, Hwang E, Lee HJ, Lee TY, Song HG, Park SY, Shin HS, Lee DG and Yi TH: Effects of Galla chinensis extracts on UVB-irradiated MMP-1 production in hairless mice. J Nat Med. 69:22–34. 2015.PubMed/NCBI View Article : Google Scholar

55 

Hwang E, Lee DG, Park SH, Oh MS and Kim SY: Coriander leaf extract exerts antioxidant activity and protects against UVB-induced photoaging of skin by regulation of procollagen type I and MMP-1 expression. J Med Food. 17:985–995. 2014.PubMed/NCBI View Article : Google Scholar

56 

Varga J, Rosenbloom J and Jimenez SA: Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts. Biochem J. 247:597–604. 1987.PubMed/NCBI View Article : Google Scholar

57 

Park DW, Lee YG, Jeong YJ, Jeon H and Kang SC: Preventive effects against retinal degeneration by centella asiatica extract (CA-HE50) and asiaticoside through apoptosis suppression by the Nrf2/HO-1 signaling pathway. Antioxidants (Basel). 10(613)2021.PubMed/NCBI View Article : Google Scholar

58 

Gao L, Yang M, Cai S, Gao L, Gui C and Zhang Q: Asiaticoside regulates toll-like receptor 4/nuclear factor-Kappa B signaling pathway to relieve lipopolysccharide-lnduced inflammation and apoptosis in ATDC5 cells. Current Topics in Nutraceutical Research. 19(432)2021.

59 

Raharjo AB, Putra RDA, Indayaningsih N, Srifiana Y, Hardiansyah A, Irmawati Y, Widodo H and Destyorini F: Preparation of polyvinyl alcohol/asiaticoside/chitosan membrane nano-composite using electrospinning technique for wound dressing. AIP Conference Proceedings. 2256(030023)2020.

60 

Anand S, Rajinikanth PS, Arya DK, Pandey P, Gupta RK, Sankhwar R and Chidambaram K: Multifunctional biomimetic nanofibrous scaffold loaded with asiaticoside for rapid diabetic wound healing. Pharmaceutics. 14(273)2022.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jiang H, Zhou X and Chen L: Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway. Exp Ther Med 24: 667, 2022.
APA
Jiang, H., Zhou, X., & Chen, L. (2022). Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway. Experimental and Therapeutic Medicine, 24, 667. https://doi.org/10.3892/etm.2022.11603
MLA
Jiang, H., Zhou, X., Chen, L."Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway". Experimental and Therapeutic Medicine 24.5 (2022): 667.
Chicago
Jiang, H., Zhou, X., Chen, L."Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway". Experimental and Therapeutic Medicine 24, no. 5 (2022): 667. https://doi.org/10.3892/etm.2022.11603
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang H, Zhou X and Chen L: Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway. Exp Ther Med 24: 667, 2022.
APA
Jiang, H., Zhou, X., & Chen, L. (2022). Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway. Experimental and Therapeutic Medicine, 24, 667. https://doi.org/10.3892/etm.2022.11603
MLA
Jiang, H., Zhou, X., Chen, L."Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway". Experimental and Therapeutic Medicine 24.5 (2022): 667.
Chicago
Jiang, H., Zhou, X., Chen, L."Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway". Experimental and Therapeutic Medicine 24, no. 5 (2022): 667. https://doi.org/10.3892/etm.2022.11603
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team