Open Access

Role of Takeda G protein‑coupled receptor 5 in microvascular endothelial cell dysfunction in diabetic retinopathy (Review)

  • Authors:
    • Miao Zhang
    • Zhenghao Dong
    • Wenkang Dong
    • Dongdong Zhou
    • Xiang Ren
  • View Affiliations

  • Published online on: September 15, 2022     https://doi.org/10.3892/etm.2022.11610
  • Article Number: 674
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Diabetic retinopathy (DR) is a frequent microvascular complication of advanced‑stage diabetes. Endothelial cell dysfunction (ED) induced by diabetes plays an important role in the development of DR. It is considered that inflammation and mitochondrial homeostasis are associated with the progression of ED. Takeda G protein‑coupled receptor 5 (TGR5) is a membrane receptor for bile acids (BAs) that plays an important role in regulating BA metabolism. Recent studies have shown that TGR5 is involved in regulating various mediators of ED and improving the dysfunction of vascular endothelial cells in DR; however, the exploration of specific related mechanisms remains an active research area in this field, which suggests that TGR5 may be one of the potential targets for the treatment of associated ED in DR. In the present review, the association between TGR5 and mitochondrial homeostasis was investigated. The extent of inflammation in DR‑induced ED was assessed to provide possible evidence for the development of targeted therapies against DR.
View Figures
View References

Related Articles

Journal Cover

November-2022
Volume 24 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhang M, Dong Z, Dong W, Zhou D and Ren X: Role of Takeda G protein‑coupled receptor 5 in microvascular endothelial cell dysfunction in diabetic retinopathy (Review). Exp Ther Med 24: 674, 2022
APA
Zhang, M., Dong, Z., Dong, W., Zhou, D., & Ren, X. (2022). Role of Takeda G protein‑coupled receptor 5 in microvascular endothelial cell dysfunction in diabetic retinopathy (Review). Experimental and Therapeutic Medicine, 24, 674. https://doi.org/10.3892/etm.2022.11610
MLA
Zhang, M., Dong, Z., Dong, W., Zhou, D., Ren, X."Role of Takeda G protein‑coupled receptor 5 in microvascular endothelial cell dysfunction in diabetic retinopathy (Review)". Experimental and Therapeutic Medicine 24.5 (2022): 674.
Chicago
Zhang, M., Dong, Z., Dong, W., Zhou, D., Ren, X."Role of Takeda G protein‑coupled receptor 5 in microvascular endothelial cell dysfunction in diabetic retinopathy (Review)". Experimental and Therapeutic Medicine 24, no. 5 (2022): 674. https://doi.org/10.3892/etm.2022.11610