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Article

Onodera's prognostic nutritional index: Comparison of its role in the severity and outcomes of patients with COVID‑19 during the periods of alpha, delta and omicron variant predominance

  • Authors:
    • Nikolaos Mathioudakis
    • Marinos Zachiotis
    • Stavros Papadakos
    • Maria Triantafyllou
    • Amalia Karapanou
    • Stamatia Samara
    • Georgios Karamanakos
    • Demetrios A. Spandidos
    • Petros Papalexis
    • Christos Damaskos
    • Kyriakos Tarantinos
    • George Fotakopoulos
    • Pagona Sklapani
    • Nikolaos Trakas
    • Nikolaos V. Sipsas
    • Vasiliki Epameinondas Georgakopoulou
  • View Affiliations / Copyright

    Affiliations: Renal Transplantation Unit, Laiko General Hospital, 11527 Athens, Greece, Renal Transplantation Unit, Laiko General Hospital, 11527 Athens, Greece, Department of Gastroenterology, Laiko General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece, Department of Infectious Diseases‑COVID‑19 Unit, Laiko General Hospital, 11527 Athens, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Unit of Endocrinology, First Department of Internal Medicine, Laiko General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece, 1st Pulmonology Department Sismanogleio Hospital, 15126 Athens, Greece, Department of Neurosurgery, General University Hospital of Larisa, 41221 Larisa, Greece, Department of Cytology, Mitera Hospital, 15123 Athens, Greece, Department of Biochemistry, Sismanogleio Hospital, 15126 Athens, Greece, Department of Infectious Diseases‑COVID‑19 Unit, Laiko General Hospital, 11527 Athens, Greece
  • Article Number: 675
    |
    Published online on: September 16, 2022
       https://doi.org/10.3892/etm.2022.11611
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Abstract

Coronavirus disease 2019 (COVID‑19) has posed a severe public health threat worldwide, affecting the function of multiple organs in affected individuals, in addition to respiratory function. Several strains of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) have been circulating worldwide since it first arose, with some of these having the ability to escape from natural or vaccine‑mediated immunity. The Onodera's prognostic nutritional index (OPNI), which is derived from the peripheral lymphocyte count and serum albumin, has been reported to be significantly associated with a poor survival rate and post‑operative complications in patients with various diseases and in some studies on patients with COVID‑19. The aim of the present retrospective study was to evaluate and compare the efficacy of OPNI as a prognostic indicator in patients with COVID‑19 during the periods of alpha, delta and omicron variant predominance. Adult patients who visited or were hospitalized due to SARS‑CoV‑2 infection were included, covering the second, third (alpha variant), fourth (delta variant) and fifth (omicron variant) pandemic waves. According to the results obtained, OPNI exhibited a statistically significant difference among patients with mild/moderate, severe and critical disease, with the lowest values observed in patients with critical disease in all the pandemic waves examined. Moreover, OPNI was found to be an independent prognostic biomarker of intubation and mortality in patients with COVID‑19, according to multivariate logistic regression analysis, including as confounders an age >65 years, the male sex and the presence of comorbidities in all periods examined.
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Copy and paste a formatted citation
Spandidos Publications style
Mathioudakis N, Zachiotis M, Papadakos S, Triantafyllou M, Karapanou A, Samara S, Karamanakos G, Spandidos DA, Papalexis P, Damaskos C, Damaskos C, et al: Onodera's prognostic nutritional index: Comparison of its role in the severity and outcomes of patients with COVID‑19 during the periods of alpha, delta and omicron variant predominance. Exp Ther Med 24: 675, 2022.
APA
Mathioudakis, N., Zachiotis, M., Papadakos, S., Triantafyllou, M., Karapanou, A., Samara, S. ... Georgakopoulou, V.E. (2022). Onodera's prognostic nutritional index: Comparison of its role in the severity and outcomes of patients with COVID‑19 during the periods of alpha, delta and omicron variant predominance. Experimental and Therapeutic Medicine, 24, 675. https://doi.org/10.3892/etm.2022.11611
MLA
Mathioudakis, N., Zachiotis, M., Papadakos, S., Triantafyllou, M., Karapanou, A., Samara, S., Karamanakos, G., Spandidos, D. A., Papalexis, P., Damaskos, C., Tarantinos, K., Fotakopoulos, G., Sklapani, P., Trakas, N., Sipsas, N. V., Georgakopoulou, V. E."Onodera's prognostic nutritional index: Comparison of its role in the severity and outcomes of patients with COVID‑19 during the periods of alpha, delta and omicron variant predominance". Experimental and Therapeutic Medicine 24.5 (2022): 675.
Chicago
Mathioudakis, N., Zachiotis, M., Papadakos, S., Triantafyllou, M., Karapanou, A., Samara, S., Karamanakos, G., Spandidos, D. A., Papalexis, P., Damaskos, C., Tarantinos, K., Fotakopoulos, G., Sklapani, P., Trakas, N., Sipsas, N. V., Georgakopoulou, V. E."Onodera's prognostic nutritional index: Comparison of its role in the severity and outcomes of patients with COVID‑19 during the periods of alpha, delta and omicron variant predominance". Experimental and Therapeutic Medicine 24, no. 5 (2022): 675. https://doi.org/10.3892/etm.2022.11611
Copy and paste a formatted citation
x
Spandidos Publications style
Mathioudakis N, Zachiotis M, Papadakos S, Triantafyllou M, Karapanou A, Samara S, Karamanakos G, Spandidos DA, Papalexis P, Damaskos C, Damaskos C, et al: Onodera's prognostic nutritional index: Comparison of its role in the severity and outcomes of patients with COVID‑19 during the periods of alpha, delta and omicron variant predominance. Exp Ther Med 24: 675, 2022.
APA
Mathioudakis, N., Zachiotis, M., Papadakos, S., Triantafyllou, M., Karapanou, A., Samara, S. ... Georgakopoulou, V.E. (2022). Onodera's prognostic nutritional index: Comparison of its role in the severity and outcomes of patients with COVID‑19 during the periods of alpha, delta and omicron variant predominance. Experimental and Therapeutic Medicine, 24, 675. https://doi.org/10.3892/etm.2022.11611
MLA
Mathioudakis, N., Zachiotis, M., Papadakos, S., Triantafyllou, M., Karapanou, A., Samara, S., Karamanakos, G., Spandidos, D. A., Papalexis, P., Damaskos, C., Tarantinos, K., Fotakopoulos, G., Sklapani, P., Trakas, N., Sipsas, N. V., Georgakopoulou, V. E."Onodera's prognostic nutritional index: Comparison of its role in the severity and outcomes of patients with COVID‑19 during the periods of alpha, delta and omicron variant predominance". Experimental and Therapeutic Medicine 24.5 (2022): 675.
Chicago
Mathioudakis, N., Zachiotis, M., Papadakos, S., Triantafyllou, M., Karapanou, A., Samara, S., Karamanakos, G., Spandidos, D. A., Papalexis, P., Damaskos, C., Tarantinos, K., Fotakopoulos, G., Sklapani, P., Trakas, N., Sipsas, N. V., Georgakopoulou, V. E."Onodera's prognostic nutritional index: Comparison of its role in the severity and outcomes of patients with COVID‑19 during the periods of alpha, delta and omicron variant predominance". Experimental and Therapeutic Medicine 24, no. 5 (2022): 675. https://doi.org/10.3892/etm.2022.11611
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