Neutrophil‑to‑lymphocyte, platelet‑to‑lymphocyte and lymphocyte‑to‑monocyte ratios are associated with amputation rates in patients with peripheral arterial disease and diabetes mellitus who underwent revascularization: A Romanian regional center study

Cosarca,Mircea Catalin; Hălmaciu,Ioana; Muresan,Adrian Vasile; Suciu,Bogdan Andrei; Molnar,Calin; Russu,Eliza; Horvath,Emoke; Niculescu,Raluca; Puscasiu,Lucian; Bacalbașa,Nicolae; Balescu,Irina; Bud,Ioan Teodor

doi:10.3892/etm.2022.11639

November-2022 Volume 24 Issue 5

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November-2022 Volume 24 Issue 5

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Neutrophil‑to‑lymphocyte, platelet‑to‑lymphocyte and lymphocyte‑to‑monocyte ratios are associated with amputation rates in patients with peripheral arterial disease and diabetes mellitus who underwent revascularization: A Romanian regional center study

Authors:
- Mircea Catalin Cosarca
- Ioana Hălmaciu
- Adrian Vasile Muresan
- Bogdan Andrei Suciu
- Calin Molnar
- Eliza Russu
- Emoke Horvath
- Raluca Niculescu
- Lucian Puscasiu
- Nicolae Bacalbașa
- Irina Balescu
- Ioan Teodor Bud
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Affiliations: Department of Anatomy and Embryology, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 540139 Targu Mures, Romania, Department of General Surgery, Targu Mures County Emergency Clinical Hospital, 540136 Targu Mures, Romania, Department of Vascular Surgery, Targu Mures County Emergency Clinical Hospital, 540136 Targu Mures, Romania, Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 40139 Targu Mures, Romania, Department of Pathology, Targu Mures County Clinical Hospital, 540072 Targu Mures, Romania, Department of Obstetrics and Gynecology, Targu Mures County Emergency Clinical Hospital, 540136 Targu Mures, Romania, Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of General Surgery, Ponderas Academic Hospital, 014142 Bucharest, Romania

Copyright: © Cosarca et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 703
|
Published online on: October 3, 2022

https://doi.org/10.3892/etm.2022.11639
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Abstract

Inflammation plays an important role in peripheral artery disease (PAD), contributing to the onset and progression of atherosclerosis, as well as to the rupture of atherosclerotic plaques. Studies have revealed that due to their inflammatory nature, leucocytes play an important role in the development of atherosclerosis. A retrospective study was conducted involving 203 patients with PAD admitted to Targu Mures Emergency County Hospital for revascularization surgery between January 2017 and June 2019 (of which 47 were treated by endovascular intervention, and 156 underwent classical surgical intervention). Among all patients included in the study, 47 patients required amputation following the revascularization intervention. The results indicated that though the mean patient age in the non‑amputation group was higher than that in the amputation group, that the difference was not significant. With regard to sex distribution, 72% of the patients from the amputation group were male, while from the non‑amputation group, 74% were male. The neutrophil‑to‑lymphocyte ratio (NLR) cut‑off value for the prediction of amputation in PAD was 3.485 (sensitivity, 60.42%; specificity 72.44%), whereas the platelet‑to‑lymphocyte ratio (PLR) value was 152, (sensitivity, 54.17%; specificity, 71.79%), and was 2.55 for the lymphocyte‑to‑monocyte ration (LMR; sensitivity, 56.25%; specificity, 66.88%). The study concluded that in patients with PAD, the NLR and PLR were increased, while the LMR was decreased, which was also associated with a higher rate of amputation after revascularization, despite the lack of correlation between these factors, Fontaine classification and the number of damaged vessels. Therefore, pre‑operative alterations in NLR, PLR and LMR may predict the need for amputation in patients with PAD, or those who underwent a revascularization intervention.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Neutrophil‑to‑lymphocyte, platelet‑to‑lymphocyte and lymphocyte‑to‑monocyte ratios are associated with amputation rates in patients with peripheral arterial disease and diabetes mellitus who underwent revascularization: A Romanian regional center study

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