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Prognostic significance of HER2 status evaluation using immunohistochemistry in patients with urothelial carcinoma of the bladder: A retrospective single‑center experience

  • Authors:
    • Xuesong Bai
    • Weiyang He
    • Hubin Yin
    • Xinyuan Li
    • Xiang Zhou
    • Zongjie Wei
    • Haitao Yu
    • Xin Gou
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
    Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 704
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    Published online on: October 4, 2022
       https://doi.org/10.3892/etm.2022.11640
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Abstract

In recent years, antibody‑drug conjugate (ADC) therapy targeting human epidermal growth factor receptor 2 (HER2) has been proven to be beneficial in patients with advanced urothelial carcinoma of the bladder (UCB); however, the role of HER2 in UCB remains obscure. Thus, the present retrospective single‑center study was performed to evaluate the expression of HER2 in UCB and its prognostic significance. The HER2 status of 108 patients with UCB who underwent radical cystectomy was assessed using immunohistochemistry, and its association with the recurrence and survival rates of patients was analyzed. HER2 overexpression was observed in 57.4% of the patients; this was significantly associated with higher tumor grades (P=0.006) and stages (P<0.001). Kaplan‑Meier analysis suggested that patients with HER2 overexpression had a shorter 5‑year overall survival rate (P=0.005) and recurrence‑free survival rate (P=0.003). Multivariate Cox regression analysis indicated that HER2 overexpression was a high‑risk independent predictor of UCB recurrence (hazard ratio, 3.61; 95% confidence interval, 1.07‑12.18; P=0.039). On the whole, these findings demonstrate that evaluating the HER2 status may improve the prediction of cancer recurrence and may thus guide the selection of patients that will benefit the most from HER2‑ADC therapies.
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Copy and paste a formatted citation
Spandidos Publications style
Bai X, He W, Yin H, Li X, Zhou X, Wei Z, Yu H and Gou X: Prognostic significance of HER2 status evaluation using immunohistochemistry in patients with urothelial carcinoma of the bladder: A retrospective single‑center experience. Exp Ther Med 24: 704, 2022.
APA
Bai, X., He, W., Yin, H., Li, X., Zhou, X., Wei, Z. ... Gou, X. (2022). Prognostic significance of HER2 status evaluation using immunohistochemistry in patients with urothelial carcinoma of the bladder: A retrospective single‑center experience. Experimental and Therapeutic Medicine, 24, 704. https://doi.org/10.3892/etm.2022.11640
MLA
Bai, X., He, W., Yin, H., Li, X., Zhou, X., Wei, Z., Yu, H., Gou, X."Prognostic significance of HER2 status evaluation using immunohistochemistry in patients with urothelial carcinoma of the bladder: A retrospective single‑center experience". Experimental and Therapeutic Medicine 24.5 (2022): 704.
Chicago
Bai, X., He, W., Yin, H., Li, X., Zhou, X., Wei, Z., Yu, H., Gou, X."Prognostic significance of HER2 status evaluation using immunohistochemistry in patients with urothelial carcinoma of the bladder: A retrospective single‑center experience". Experimental and Therapeutic Medicine 24, no. 5 (2022): 704. https://doi.org/10.3892/etm.2022.11640
Copy and paste a formatted citation
x
Spandidos Publications style
Bai X, He W, Yin H, Li X, Zhou X, Wei Z, Yu H and Gou X: Prognostic significance of HER2 status evaluation using immunohistochemistry in patients with urothelial carcinoma of the bladder: A retrospective single‑center experience. Exp Ther Med 24: 704, 2022.
APA
Bai, X., He, W., Yin, H., Li, X., Zhou, X., Wei, Z. ... Gou, X. (2022). Prognostic significance of HER2 status evaluation using immunohistochemistry in patients with urothelial carcinoma of the bladder: A retrospective single‑center experience. Experimental and Therapeutic Medicine, 24, 704. https://doi.org/10.3892/etm.2022.11640
MLA
Bai, X., He, W., Yin, H., Li, X., Zhou, X., Wei, Z., Yu, H., Gou, X."Prognostic significance of HER2 status evaluation using immunohistochemistry in patients with urothelial carcinoma of the bladder: A retrospective single‑center experience". Experimental and Therapeutic Medicine 24.5 (2022): 704.
Chicago
Bai, X., He, W., Yin, H., Li, X., Zhou, X., Wei, Z., Yu, H., Gou, X."Prognostic significance of HER2 status evaluation using immunohistochemistry in patients with urothelial carcinoma of the bladder: A retrospective single‑center experience". Experimental and Therapeutic Medicine 24, no. 5 (2022): 704. https://doi.org/10.3892/etm.2022.11640
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