Open Access

Anti‑inflammatory effects of Nypa fruticans Wurmb via NF‑κB and MAPK signaling pathways in macrophages

  • Authors:
    • Hye Jeong Park
    • Tae Won Jang
    • So Yeon Han
    • Song Soo Oh
    • Jung Bok Lee
    • Sung Min Myoung
    • Jae Ho Park
  • View Affiliations

  • Published online on: November 8, 2022     https://doi.org/10.3892/etm.2022.11690
  • Article Number: 755
  • Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The inflammatory defense response of macrophages is a natural protective reaction in the immune system. Antioxidant and anti‑inflammatory activities are closely related. In addition, the cell signaling pathway regulating inflammation is associated with MAPK and NF‑κB signaling pathway phosphorylation. The present study aimed to evaluate whether the ethyl acetate fraction from N. fruticans (ENF) has a modulatory role in the MAPK signaling pathway and inhibition of the IκB/NF‑κB signaling pathways, including translocation of NF‑κB p65. Antioxidant and anti‑inflammatory activities are closely related. In addition, the cell signaling pathway regulating inflammation is associated with MAPK and NF‑κB signaling pathway phosphorylation. The results revealed that ENF exhibited antioxidant capacity, attenuated the cytokine levels and blocked nitric oxide production. ENF downregulated cyclooxygenase‑2 and inducible nitric oxide synthase expression. We hypothesized that ENF treatment alleviated the various proinflammatory mediators via IκB phosphorylation and transcription of NF‑κB compared with the untreated control. In conclusion, the present study demonstrated that the inhibitory effect of ENF treatment was attributed to the inhibition of MAPK and Akt/IκB/NF‑κB signaling pathways.

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December-2022
Volume 24 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Park HJ, Jang TW, Han SY, Oh SS, Lee JB, Myoung SM and Park JH: Anti‑inflammatory effects of <em>Nypa fruticans</em> Wurmb via NF‑κB and MAPK signaling pathways in macrophages. Exp Ther Med 24: 755, 2022
APA
Park, H.J., Jang, T.W., Han, S.Y., Oh, S.S., Lee, J.B., Myoung, S.M., & Park, J.H. (2022). Anti‑inflammatory effects of <em>Nypa fruticans</em> Wurmb via NF‑κB and MAPK signaling pathways in macrophages. Experimental and Therapeutic Medicine, 24, 755. https://doi.org/10.3892/etm.2022.11690
MLA
Park, H. J., Jang, T. W., Han, S. Y., Oh, S. S., Lee, J. B., Myoung, S. M., Park, J. H."Anti‑inflammatory effects of <em>Nypa fruticans</em> Wurmb via NF‑κB and MAPK signaling pathways in macrophages". Experimental and Therapeutic Medicine 24.6 (2022): 755.
Chicago
Park, H. J., Jang, T. W., Han, S. Y., Oh, S. S., Lee, J. B., Myoung, S. M., Park, J. H."Anti‑inflammatory effects of <em>Nypa fruticans</em> Wurmb via NF‑κB and MAPK signaling pathways in macrophages". Experimental and Therapeutic Medicine 24, no. 6 (2022): 755. https://doi.org/10.3892/etm.2022.11690