Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia

  • Authors:
    • Huseyin Gobut
    • Selin Erel
    • Cagri Ozdemir
    • Tulay Mortas
    • Mustafa Arslan
    • Aysegul Kucuk
    • Esat Kasapbasi
    • Mustafa Kavutcu
  • View Affiliations

  • Published online on: February 24, 2023     https://doi.org/10.3892/etm.2023.11863
  • Article Number: 164
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

During liver surgery and transplantation, periods of partial or total vascular occlusion are inevitable and result in ischemia‑reperfusion (IR) injury. Nanomedicine uses the latest technological advancement, which has emerged from interdisciplinary efforts involving biomedical sciences, physics and engineering to protect and improve human health. Antioxidant nanoparticles are potential therapeutic agents. The present study investigated the effects of cerium oxide (Co) administration and sevoflurane anesthesia on liver tissue with IR injury. A total of 36 rats were randomly divided into control, Co, IR, IR‑Sevoflurane (IRS), Co + IR and Co + IRS groups. In the IR, IRS and Co + IRS groups, hepatic IR was induced. Intraperitoneal Co was administered to the Co groups 30 min before ischemia. Sevoflurane was administered to the IRS and Co + IRS groups during IR injury. Liver tissue samples were examined under the light microscope by staining with hematoxylin and eosin. Thiobarbituric acid (TBARS) levels as well as catalase (CAT) and glutathione‑S‑transferase (GST) enzyme activity were evaluated in liver tissue samples. The IR group had considerably more hydropic degeneration, sinusoidal dilatation and parenchymal neutrophil infiltration than the Co, IRS, Co + IR and Co + IRS groups. CAT and GST enzyme activity were significantly higher in Co and Co + IR groups compared with the IR group. TBARS levels were significantly lower in Co, IRS, Co + IR and Co + IRS groups compared whit those in the IR group. Intraperitoneal injection of Co with sevoflurane decreased oxidative stress and damage to the liver.
View Figures
View References

Related Articles

Journal Cover

April-2023
Volume 25 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gobut H, Erel S, Ozdemir C, Mortas T, Arslan M, Kucuk A, Kasapbasi E and Kavutcu M: Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia. Exp Ther Med 25: 164, 2023
APA
Gobut, H., Erel, S., Ozdemir, C., Mortas, T., Arslan, M., Kucuk, A. ... Kavutcu, M. (2023). Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia. Experimental and Therapeutic Medicine, 25, 164. https://doi.org/10.3892/etm.2023.11863
MLA
Gobut, H., Erel, S., Ozdemir, C., Mortas, T., Arslan, M., Kucuk, A., Kasapbasi, E., Kavutcu, M."Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia". Experimental and Therapeutic Medicine 25.4 (2023): 164.
Chicago
Gobut, H., Erel, S., Ozdemir, C., Mortas, T., Arslan, M., Kucuk, A., Kasapbasi, E., Kavutcu, M."Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia". Experimental and Therapeutic Medicine 25, no. 4 (2023): 164. https://doi.org/10.3892/etm.2023.11863