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Article

Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia

  • Authors:
    • Huseyin Gobut
    • Selin Erel
    • Cagri Ozdemir
    • Tulay Mortas
    • Mustafa Arslan
    • Aysegul Kucuk
    • Esat Kasapbasi
    • Mustafa Kavutcu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Faculty of Medicine, Gazi University, Ankara 06510, Turkey, Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Ankara 06510, Turkey, Department of Histology and Embryology, Faculty of Medicine, Kirikkale University, Kirikkale 71450, Turkey, Department of Medical Physiology, Faculty of Medicine, Kutahya Health Sciences University, Kutahya 43020, Turkey, Department of Medical Biochemistry, Faculty of Medicine, Gazi University, Ankara 06510, Turkey
  • Article Number: 164
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    Published online on: February 24, 2023
       https://doi.org/10.3892/etm.2023.11863
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Abstract

During liver surgery and transplantation, periods of partial or total vascular occlusion are inevitable and result in ischemia‑reperfusion (IR) injury. Nanomedicine uses the latest technological advancement, which has emerged from interdisciplinary efforts involving biomedical sciences, physics and engineering to protect and improve human health. Antioxidant nanoparticles are potential therapeutic agents. The present study investigated the effects of cerium oxide (Co) administration and sevoflurane anesthesia on liver tissue with IR injury. A total of 36 rats were randomly divided into control, Co, IR, IR‑Sevoflurane (IRS), Co + IR and Co + IRS groups. In the IR, IRS and Co + IRS groups, hepatic IR was induced. Intraperitoneal Co was administered to the Co groups 30 min before ischemia. Sevoflurane was administered to the IRS and Co + IRS groups during IR injury. Liver tissue samples were examined under the light microscope by staining with hematoxylin and eosin. Thiobarbituric acid (TBARS) levels as well as catalase (CAT) and glutathione‑S‑transferase (GST) enzyme activity were evaluated in liver tissue samples. The IR group had considerably more hydropic degeneration, sinusoidal dilatation and parenchymal neutrophil infiltration than the Co, IRS, Co + IR and Co + IRS groups. CAT and GST enzyme activity were significantly higher in Co and Co + IR groups compared with the IR group. TBARS levels were significantly lower in Co, IRS, Co + IR and Co + IRS groups compared whit those in the IR group. Intraperitoneal injection of Co with sevoflurane decreased oxidative stress and damage to the liver.
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Copy and paste a formatted citation
Spandidos Publications style
Gobut H, Erel S, Ozdemir C, Mortas T, Arslan M, Kucuk A, Kasapbasi E and Kavutcu M: Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia. Exp Ther Med 25: 164, 2023.
APA
Gobut, H., Erel, S., Ozdemir, C., Mortas, T., Arslan, M., Kucuk, A. ... Kavutcu, M. (2023). Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia. Experimental and Therapeutic Medicine, 25, 164. https://doi.org/10.3892/etm.2023.11863
MLA
Gobut, H., Erel, S., Ozdemir, C., Mortas, T., Arslan, M., Kucuk, A., Kasapbasi, E., Kavutcu, M."Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia". Experimental and Therapeutic Medicine 25.4 (2023): 164.
Chicago
Gobut, H., Erel, S., Ozdemir, C., Mortas, T., Arslan, M., Kucuk, A., Kasapbasi, E., Kavutcu, M."Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia". Experimental and Therapeutic Medicine 25, no. 4 (2023): 164. https://doi.org/10.3892/etm.2023.11863
Copy and paste a formatted citation
x
Spandidos Publications style
Gobut H, Erel S, Ozdemir C, Mortas T, Arslan M, Kucuk A, Kasapbasi E and Kavutcu M: Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia. Exp Ther Med 25: 164, 2023.
APA
Gobut, H., Erel, S., Ozdemir, C., Mortas, T., Arslan, M., Kucuk, A. ... Kavutcu, M. (2023). Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia. Experimental and Therapeutic Medicine, 25, 164. https://doi.org/10.3892/etm.2023.11863
MLA
Gobut, H., Erel, S., Ozdemir, C., Mortas, T., Arslan, M., Kucuk, A., Kasapbasi, E., Kavutcu, M."Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia". Experimental and Therapeutic Medicine 25.4 (2023): 164.
Chicago
Gobut, H., Erel, S., Ozdemir, C., Mortas, T., Arslan, M., Kucuk, A., Kasapbasi, E., Kavutcu, M."Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia". Experimental and Therapeutic Medicine 25, no. 4 (2023): 164. https://doi.org/10.3892/etm.2023.11863
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