Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2023 Volume 25 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2023 Volume 25 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

COL4A1 promotes the proliferation and migration of oral squamous cell carcinoma cells by binding to NID1

  • Authors:
    • Xiaobei Tian
    • Jian Sun
    • Changshun Li
    • Kun Zhang
  • View Affiliations / Copyright

    Affiliations: The Affiliated Stomatological Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China
    Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 176
    |
    Published online on: March 7, 2023
       https://doi.org/10.3892/etm.2023.11875
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Collagen type IV α1 chain (COL4A1) is a collagen protein that acts as a tumor‑promoting factor in several types of cancer. However, the role and the potential mechanisms involving COL4A1 in oral squamous cell carcinoma (OSCC) remain unclear. Using reverse transcription‑quantitative PCR and western blotting, the expression levels of COL4A1 and (nidogen‑1) NID1 in OSCC cells were assessed. Cell Counting Kit‑8, EdU staining and colony formation assays were used to evaluate cell proliferation. Cell migration and invasion were assessed using wound healing and Transwell invasion assays, respectively. The expression levels of proteins involved in epithelial‑mesenchymal transition (EMT) were assessed using western blotting. In addition, the association between COL4A1 and NID1 was analyzed using TNMplot and the STRING database and verified by co‑immunoprecipitation analysis. COL4A1 expression was found to be significantly increased in OSCC cells. Knockdown of COL4A1 expression decreased SCC‑4 cell proliferation, migration and invasion, as well as the progression of EMT. In addition, COL4A1 was shown to be significantly positively associated with NID1 in OSCC and to bind to NID1. NID1 overexpression reversed the inhibitory effects of COL4A1 knockdown on cell proliferation, migration and invasion as well as on the progression of EMT in OSCC cells. In summary, the present findings demonstrated that COL4A1 promoted cell proliferation and migration as well as the progression of EMT in OSCC cells by binding to NID1, highlighting a potential avenue for therapeutic management of OSCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Perera M, Al-Hebshi NN, Perera I, Ipe D, Ulett GC, Speicher DJ, Chen T and Johnson NW: Inflammatory bacteriome and oral squamous cell carcinoma. J Dent Res. 97:725–732. 2018.PubMed/NCBI View Article : Google Scholar

2 

Almangush A, Mäkitie AA, Triantafyllou A, de Bree R, Strojan P, Rinaldo A, Hernandez-Prera JC, Suárez C, Kowalski LP, Ferlito A and Leivo I: Staging and grading of oral squamous cell carcinoma: An update. Oral Oncol. 107(104799)2020.PubMed/NCBI View Article : Google Scholar

3 

Satgunaseelan L, Allanson BM, Asher R, Reddy R, Low HTH, Veness M, Gopal Iyer N, Smee RI, Palme CE, Gupta R and Clark JR: The incidence of squamous cell carcinoma of the oral tongue is rising in young non-smoking women: An international multi-institutional analysis. Oral Oncol. 110(104875)2020.PubMed/NCBI View Article : Google Scholar

4 

Thomson PJ: Perspectives on oral squamous cell carcinoma prevention-proliferation, position, progression and prediction. J Oral Pathol Med. 47:803–807. 2018.PubMed/NCBI View Article : Google Scholar

5 

Mumtaz M, Bijnsdorp IV, Böttger F, Piersma SR, Pham TV, Mumtaz S, Brakenhoff RH, Akhtar MW and Jimenez CR: Secreted protein markers in oral squamous cell carcinoma (OSCC). Clin Proteomics. 19(4)2022.PubMed/NCBI View Article : Google Scholar

6 

Brands MT, Brennan PA, Verbeek ALM, Merkx MAW and Geurts SME: Follow-up after curative treatment for oral squamous cell carcinoma. A critical appraisal of the guidelines and a review of the literature. Eur J Surg Oncol. 44:559–565. 2018.PubMed/NCBI View Article : Google Scholar

7 

Ezhilarasan D, Lakshmi T, Subha M, Deepak Nallasamy V and Raghunandhakumar S: The ambiguous role of sirtuins in head and neck squamous cell carcinoma. Oral Dis. 28:559–567. 2022.PubMed/NCBI View Article : Google Scholar

8 

Solomon B, Young RJ and Rischin D: Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments. Semin Cancer Biol. 52:228–240. 2018.PubMed/NCBI View Article : Google Scholar

9 

Labelle-Dumais C, Schuitema V, Hayashi G, Hoff K, Gong W, Dao DQ, Ullian EM, Oishi P, Margeta M and Gould DB: COL4A1 mutations cause neuromuscular disease with tissue-specific mechanistic heterogeneity. Am J Hum Genet. 104:847–860. 2019.PubMed/NCBI View Article : Google Scholar

10 

Shannon P, Hum C, Parks T, Schauer GM, Chitayat D, Chong K, Shinar S, Blaser S, Moore G and Van Mieghem T: Brain and placental pathology in fetal COL4A1 related disease. Pediatr Dev Pathol. 24:175–186. 2021.PubMed/NCBI View Article : Google Scholar

11 

Li F, Wang NN, Chang X, Wang SL, Wang LS, Yao J, Li ZS and Bai Y: Bioinformatics analysis suggests that COL4A1 may play an important role in gastric carcinoma recurrence. J Dig Dis. 20:391–400. 2019.PubMed/NCBI View Article : Google Scholar

12 

Wang H, Liu Z, Li A, Wang J, Liu J, Liu B, Lian X, Zhang B, Pang B, Liu L and Gao Y: COL4A1 as a novel oncogene associated with the clinical characteristics of malignancy predicts poor prognosis in glioma. Exp Ther Med. 22(1224)2021.PubMed/NCBI View Article : Google Scholar

13 

Wang SM, Chen PM, Sung YW, Huang WC, Huang HS and Chu PY: Effect of COL4A1 expression on the survival of neoadjuvant chemotherapy breast cancer patients. J Oncol. 2020(5209695)2020.PubMed/NCBI View Article : Google Scholar

14 

Xie X, He H, Zhang N, Wang X, Rui W, Xu D and Zhu Y: Overexpression of DDR1 promotes migration, invasion, though EMT-related molecule expression and COL4A1/DDR1/MMP-2 signaling axis. Technol Cancer Res Treat. 19(1533033820973277)2020.PubMed/NCBI View Article : Google Scholar

15 

Chen C, Méndez E, Houck J, Fan W, Lohavanichbutr P, Doody D, Yueh B, Futran ND, Upton M, Farwell DG, et al: Gene expression profiling identifies genes predictive of oral squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 17:2152–2162. 2008.PubMed/NCBI View Article : Google Scholar

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

17 

Wong T and Wiesenfeld D: Oral cancer. Aust Dent J. 63 (Suppl 1):S91–S99. 2018.PubMed/NCBI View Article : Google Scholar

18 

Fan T, Wang X, Zhang S, Deng P, Jiang Y, Liang Y, Jie S, Wang Q, Li C, Tian G, et al: NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy. Signal Transduct Target Ther. 7(130)2022.PubMed/NCBI View Article : Google Scholar

19 

Bugshan A and Farooq I: Oral squamous cell carcinoma: metastasis, potentially associated malignant disorders, etiology and recent advancements in diagnosis. F1000Res. 9(229)2020.PubMed/NCBI View Article : Google Scholar

20 

Valastyan S and Weinberg RA: Tumor metastasis: molecular insights and evolving paradigms. Cell. 147:275–292. 2011.PubMed/NCBI View Article : Google Scholar

21 

Yeung KT and Yang J: Epithelial-mesenchymal transition in tumor metastasis. Mol Oncol. 11:28–39. 2017.PubMed/NCBI View Article : Google Scholar

22 

Zeeshan R and Mutahir Z: Cancer metastasis-tricks of the trade. Bosn J Basic Med Sci. 17:172–182. 2017.PubMed/NCBI View Article : Google Scholar

23 

Majidpoor J and Mortezaee K: Steps in metastasis: An updated review. Med Oncol. 38(3)2021.PubMed/NCBI View Article : Google Scholar

24 

Burr R, Gilles C, Thompson EW and Maheswaran S: Epithelial-mesenchymal plasticity in circulating tumor cells, the precursors of metastasis. Adv Exp Med Biol. 1220:11–34. 2020.PubMed/NCBI View Article : Google Scholar

25 

Gelse K, Pöschl E and Aigner T: Collagens-structure, function, and biosynthesis. Adv Drug Deliv Rev. 55:1531–1546. 2003.PubMed/NCBI View Article : Google Scholar

26 

Gilkes DM, Chaturvedi P, Bajpai S, Wong CC, Wei H, Pitcairn S, Hubbi ME, Wirtz D and Semenza GL: Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Res. 73:3285–3296. 2013.PubMed/NCBI View Article : Google Scholar

27 

Rømer AMA, Thorseth ML and Madsen DH: Immune modulatory properties of collagen in cancer. Front Immunol. 12(791453)2021.PubMed/NCBI View Article : Google Scholar

28 

Hu YZ, Hu ZL, Liao TY, Li Y and Pan YL: LncRNA SND1-IT1 facilitates TGF-β1-induced epithelial-to-mesenchymal transition via miR-124/COL4A1 axis in gastric cancer. Cell Death Discov. 8(73)2022.PubMed/NCBI View Article : Google Scholar

29 

Zhang H, Wang Y and Ding H: COL4A1, negatively regulated by XPD and miR-29a-3p, promotes cell proliferation, migration, invasion and epithelial-mesenchymal transition in liver cancer cells. Clin Transl Oncol. 23:2078–2089. 2021.PubMed/NCBI View Article : Google Scholar

30 

Wang T, Jin H, Hu J, Li X, Ruan H, Xu H, Wei L, Dong W, Teng F, Gu J, et al: COL4A1 promotes the growth and metastasis of hepatocellular carcinoma cells by activating FAK-Src signaling. J Exp Clin Cancer Res. 39(148)2020.PubMed/NCBI View Article : Google Scholar

31 

Jin R, Shen J, Zhang T, Liu Q, Liao C, Ma H, Li S and Yu Z: The highly expressed COL4A1 genes contributes to the proliferation and migration of the invasive ductal carcinomas. Oncotarget. 8:58172–58183. 2017.PubMed/NCBI View Article : Google Scholar

32 

Jin Y and Qin X: Comprehensive analysis of transcriptome data for identifying biomarkers and therapeutic targets in head and neck squamous cell carcinoma. Ann Transl Med. 8(282)2020.PubMed/NCBI View Article : Google Scholar

33 

Reis PP, Tokar T, Goswami RS, Xuan Y, Sukhai M, Seneda AL, Móz LES, Perez-Ordonez B, Simpson C, Goldstein D, et al: A 4-gene signature from histologically normal surgical margins predicts local recurrence in patients with oral carcinoma: Clinical validation. Sci Rep. 10(1713)2020.PubMed/NCBI View Article : Google Scholar

34 

Kuo CL, Lai KC, Ma YS, Weng SW, Lin JP and Chung JG: Gallic acid inhibits migration and invasion of SCC-4 human oral cancer cells through actions of NF-κB, Ras and matrix metalloproteinase-2 and -9. Oncol Rep. 32:355–361. 2014.PubMed/NCBI View Article : Google Scholar

35 

Pineiro NM, Carneiro A and Crema VO: Rho GTPases are involved on regulation of cytodifferentiation of SCC-4 oral squamous cell carcinoma cell line: A preliminary study. Asian Pac J Cancer Prev. 21:3–6. 2020.PubMed/NCBI View Article : Google Scholar

36 

Timpl R and Brown JC: Supramolecular assembly of basement membranes. Bioessays. 18:123–132. 1996.PubMed/NCBI View Article : Google Scholar

37 

Fox MA, Ho MS, Smyth N and Sanes JR: A synaptic nidogen: developmental regulation and role of nidogen-2 at the neuromuscular junction. Neural Dev. 3(24)2008.PubMed/NCBI View Article : Google Scholar

38 

Zhou S, Zhang S, Wang L, Huang S, Yuan Y, Yang J, Wang H, Li X, Wang P, Zhou L, et al: BET protein inhibitor JQ1 downregulates chromatin accessibility and suppresses metastasis of gastric cancer via inactivating RUNX2/NID1 signaling. Oncogenesis. 9(33)2020.PubMed/NCBI View Article : Google Scholar

39 

Urooj T, Wasim B, Mushtaq S, Haider G, Shah SNN, Ghani R and Qureshi MFH: Increased NID1 expression among breast cancer lung metastatic women; A comparative analysis between naive and treated cases. Recent Pat Anticancer Drug Discov. 15:59–69. 2020.PubMed/NCBI View Article : Google Scholar

40 

Vaes N, Schonkeren SL, Rademakers G, Holland AM, Koch A, Gijbels MJ, Keulers TG, de Wit M, Moonen L, Van der Meer JRM, et al: Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2. EMBO Rep. 22(e51913)2021.PubMed/NCBI View Article : Google Scholar

41 

Xu X, Ban Y, Zhao Z, Pan Q and Zou J: MicroRNA-1298-3p inhibits proliferation and invasion of glioma cells by downregulating Nidogen-1. Aging (Albany NY). 12:7761–7773. 2020.PubMed/NCBI View Article : Google Scholar

42 

Yuan D, Qian H, Guo T, Ye J, Jin C, Liu X, Jiang L, Wang X, Lin M and Yu H: LncRNA-ATB promotes the tumorigenesis of ovarian cancer via targeting miR-204-3p. Onco Targets Ther. 13:573–583. 2020.PubMed/NCBI View Article : Google Scholar

43 

Hsu CW, Chang KP, Huang Y, Liu HP, Hsueh PC, Gu PW, Yen WC and Wu CC: Proteomic profiling of paired interstitial fluids reveals dysregulated pathways and salivary NID1 as a biomarker of oral cavity squamous cell carcinoma. Mol Cell Proteomics. 18:1939–1949. 2019.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tian X, Sun J, Li C and Zhang K: COL4A1 promotes the proliferation and migration of oral squamous cell carcinoma cells by binding to NID1. Exp Ther Med 25: 176, 2023.
APA
Tian, X., Sun, J., Li, C., & Zhang, K. (2023). COL4A1 promotes the proliferation and migration of oral squamous cell carcinoma cells by binding to NID1. Experimental and Therapeutic Medicine, 25, 176. https://doi.org/10.3892/etm.2023.11875
MLA
Tian, X., Sun, J., Li, C., Zhang, K."COL4A1 promotes the proliferation and migration of oral squamous cell carcinoma cells by binding to NID1". Experimental and Therapeutic Medicine 25.4 (2023): 176.
Chicago
Tian, X., Sun, J., Li, C., Zhang, K."COL4A1 promotes the proliferation and migration of oral squamous cell carcinoma cells by binding to NID1". Experimental and Therapeutic Medicine 25, no. 4 (2023): 176. https://doi.org/10.3892/etm.2023.11875
Copy and paste a formatted citation
x
Spandidos Publications style
Tian X, Sun J, Li C and Zhang K: COL4A1 promotes the proliferation and migration of oral squamous cell carcinoma cells by binding to NID1. Exp Ther Med 25: 176, 2023.
APA
Tian, X., Sun, J., Li, C., & Zhang, K. (2023). COL4A1 promotes the proliferation and migration of oral squamous cell carcinoma cells by binding to NID1. Experimental and Therapeutic Medicine, 25, 176. https://doi.org/10.3892/etm.2023.11875
MLA
Tian, X., Sun, J., Li, C., Zhang, K."COL4A1 promotes the proliferation and migration of oral squamous cell carcinoma cells by binding to NID1". Experimental and Therapeutic Medicine 25.4 (2023): 176.
Chicago
Tian, X., Sun, J., Li, C., Zhang, K."COL4A1 promotes the proliferation and migration of oral squamous cell carcinoma cells by binding to NID1". Experimental and Therapeutic Medicine 25, no. 4 (2023): 176. https://doi.org/10.3892/etm.2023.11875
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team