Open Access

Estrogen alleviates acute and chronic itch in mice

  • Authors:
    • Jinhua Jin
    • Li Li
    • Yuhui Wang
    • Keyan Li
    • Aihua Qian
    • Weiou Li
    • Qing Liu
    • Chao Wen
    • Quanle Liu
    • Guanghai Yan
    • Fushan Xue
  • View Affiliations

  • Published online on: April 18, 2023     https://doi.org/10.3892/etm.2023.11954
  • Article Number: 255
  • Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Itching is associated with various skin diseases, including atopic dermatitis and allergic dermatitis, and leads to repeated scratching behavior and unpleasant sensation. Although clinical and laboratory research data have shown that estrogen is involved in regulating itch, the molecular and cellular basis of estrogen in itch sensation remains elusive. In the present study, it was found that estrogen‑treated mice exhibited reduced scratching bouts when challenged with histamine, chloroquine, the proteinase‑activated receptor‑2 activating peptide SLIGRL‑NH2 (SLIGRL), compound 48/80, and 5‑hydroxytryptamine when compared with mice in the placebo group. Moreover, estrogen also suppressed scratching bouts in the mouse model of chronic itch induced by acetone‑ether‑water treatment. Notably, consistent with the behavioral tests, the present RNA‑seq analysis showed that estrogen treatment caused significantly reduced expression levels of itch‑related molecules such as Mas‑related G‑protein coupled receptor member A3, neuromedin B and natriuretic polypeptide b. In addition, estradiol attenuated histamine‑induced and chloroquine‑induced calcium influx in dorsal root ganglion neurons. Collectively, the data of the present study suggested that estrogen modulates the expression of itch‑related molecules and suppresses both acute and chronic itch in mice.
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June-2023
Volume 25 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Jin J, Li L, Wang Y, Li K, Qian A, Li W, Liu Q, Wen C, Liu Q, Yan G, Yan G, et al: Estrogen alleviates acute and chronic itch in mice. Exp Ther Med 25: 255, 2023
APA
Jin, J., Li, L., Wang, Y., Li, K., Qian, A., Li, W. ... Xue, F. (2023). Estrogen alleviates acute and chronic itch in mice. Experimental and Therapeutic Medicine, 25, 255. https://doi.org/10.3892/etm.2023.11954
MLA
Jin, J., Li, L., Wang, Y., Li, K., Qian, A., Li, W., Liu, Q., Wen, C., Liu, Q., Yan, G., Xue, F."Estrogen alleviates acute and chronic itch in mice". Experimental and Therapeutic Medicine 25.6 (2023): 255.
Chicago
Jin, J., Li, L., Wang, Y., Li, K., Qian, A., Li, W., Liu, Q., Wen, C., Liu, Q., Yan, G., Xue, F."Estrogen alleviates acute and chronic itch in mice". Experimental and Therapeutic Medicine 25, no. 6 (2023): 255. https://doi.org/10.3892/etm.2023.11954