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Estrogen alleviates acute and chronic itch in mice

  • Authors:
    • Jinhua Jin
    • Li Li
    • Yuhui Wang
    • Keyan Li
    • Aihua Qian
    • Weiou Li
    • Qing Liu
    • Chao Wen
    • Quanle Liu
    • Guanghai Yan
    • Fushan Xue
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, P.R. China, Department of Anatomy, Yanbian University of Medicine, Yanji, Jilin 133002, P.R. China, Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China, Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China, Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China
    Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 255
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    Published online on: April 18, 2023
       https://doi.org/10.3892/etm.2023.11954
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Abstract

Itching is associated with various skin diseases, including atopic dermatitis and allergic dermatitis, and leads to repeated scratching behavior and unpleasant sensation. Although clinical and laboratory research data have shown that estrogen is involved in regulating itch, the molecular and cellular basis of estrogen in itch sensation remains elusive. In the present study, it was found that estrogen‑treated mice exhibited reduced scratching bouts when challenged with histamine, chloroquine, the proteinase‑activated receptor‑2 activating peptide SLIGRL‑NH2 (SLIGRL), compound 48/80, and 5‑hydroxytryptamine when compared with mice in the placebo group. Moreover, estrogen also suppressed scratching bouts in the mouse model of chronic itch induced by acetone‑ether‑water treatment. Notably, consistent with the behavioral tests, the present RNA‑seq analysis showed that estrogen treatment caused significantly reduced expression levels of itch‑related molecules such as Mas‑related G‑protein coupled receptor member A3, neuromedin B and natriuretic polypeptide b. In addition, estradiol attenuated histamine‑induced and chloroquine‑induced calcium influx in dorsal root ganglion neurons. Collectively, the data of the present study suggested that estrogen modulates the expression of itch‑related molecules and suppresses both acute and chronic itch in mice.
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Copy and paste a formatted citation
Spandidos Publications style
Jin J, Li L, Wang Y, Li K, Qian A, Li W, Liu Q, Wen C, Liu Q, Yan G, Yan G, et al: Estrogen alleviates acute and chronic itch in mice. Exp Ther Med 25: 255, 2023.
APA
Jin, J., Li, L., Wang, Y., Li, K., Qian, A., Li, W. ... Xue, F. (2023). Estrogen alleviates acute and chronic itch in mice. Experimental and Therapeutic Medicine, 25, 255. https://doi.org/10.3892/etm.2023.11954
MLA
Jin, J., Li, L., Wang, Y., Li, K., Qian, A., Li, W., Liu, Q., Wen, C., Liu, Q., Yan, G., Xue, F."Estrogen alleviates acute and chronic itch in mice". Experimental and Therapeutic Medicine 25.6 (2023): 255.
Chicago
Jin, J., Li, L., Wang, Y., Li, K., Qian, A., Li, W., Liu, Q., Wen, C., Liu, Q., Yan, G., Xue, F."Estrogen alleviates acute and chronic itch in mice". Experimental and Therapeutic Medicine 25, no. 6 (2023): 255. https://doi.org/10.3892/etm.2023.11954
Copy and paste a formatted citation
x
Spandidos Publications style
Jin J, Li L, Wang Y, Li K, Qian A, Li W, Liu Q, Wen C, Liu Q, Yan G, Yan G, et al: Estrogen alleviates acute and chronic itch in mice. Exp Ther Med 25: 255, 2023.
APA
Jin, J., Li, L., Wang, Y., Li, K., Qian, A., Li, W. ... Xue, F. (2023). Estrogen alleviates acute and chronic itch in mice. Experimental and Therapeutic Medicine, 25, 255. https://doi.org/10.3892/etm.2023.11954
MLA
Jin, J., Li, L., Wang, Y., Li, K., Qian, A., Li, W., Liu, Q., Wen, C., Liu, Q., Yan, G., Xue, F."Estrogen alleviates acute and chronic itch in mice". Experimental and Therapeutic Medicine 25.6 (2023): 255.
Chicago
Jin, J., Li, L., Wang, Y., Li, K., Qian, A., Li, W., Liu, Q., Wen, C., Liu, Q., Yan, G., Xue, F."Estrogen alleviates acute and chronic itch in mice". Experimental and Therapeutic Medicine 25, no. 6 (2023): 255. https://doi.org/10.3892/etm.2023.11954
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