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Case Report Open Access

Multicentric Castleman disease of hyaline‑vascular variant with paraneoplastic pemphigus results in abnormal lung function: Report of 3 cases

  • Authors:
    • Jiemei Cen
    • Wen Zeng
    • Mianluan Pan
    • Ye Qiu
    • Jianquan Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, The Eighth Affiliated Hospital, Sun Yat‑Sen University, Shenzhen, Guangdong 518033, P.R. China, Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530000, P.R. China
    Copyright: © Cen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 269
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    Published online on: April 20, 2023
       https://doi.org/10.3892/etm.2023.11968
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Abstract

Castleman disease (CD) is clinically divided into unicentric CD (UCD) and multicentric CD (MCD). Hyaline‑vascular variant (HV) is the most common pathological type of UCD, while the plasma cell type (PC) is the most common type of MCD and thus, hyaline‑vascular variant multicentric CD (HV‑MCD) is a rare type of CD. In addition, its etiology has remained elusive. The present study retrospectively analyzed the medical records of 3 patients diagnosed as HV‑MCD admitted to The First Affiliated Hospital of Guangxi Medical University (Guangxi, China) between January 2007 and September 2020. A total of 2 males and 1 female were admitted. The areas involved varied considerably. Respiratory symptoms were seen in 3 cases, along with fever, weight loss and splenomegaly. Damage to the skin and mucous membranes resulted in oral ulcers when accompanied by paraneoplastic pemphigus (PNP). Dry and wet rales were found in all patients. All 3 cases were complicated with PNP and had hypoxemia and obstructive ventilation dysfunction. In accordance with PC‑MCD, it manifested as lymph node enlargement and may involve several lymph nodes. Computed tomography mainly indicated bronchiectasis and mediastinal lymph node enlargement. In 1 case, chemotherapy failed after local mass excision, 1 case remitted after chemotherapy but the lung lesion was irreversible and 1 case was untreated and soon died of respiratory failure. The cases of HV‑MCD with pulmonary involvement were induced by small airway lesions and associated with poor prognosis. Respiratory symptoms along with systemic symptoms were common.
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Copy and paste a formatted citation
Spandidos Publications style
Cen J, Zeng W, Pan M, Qiu Y and Zhang J: Multicentric Castleman disease of hyaline‑vascular variant with paraneoplastic pemphigus results in abnormal lung function: Report of 3 cases. Exp Ther Med 25: 269, 2023.
APA
Cen, J., Zeng, W., Pan, M., Qiu, Y., & Zhang, J. (2023). Multicentric Castleman disease of hyaline‑vascular variant with paraneoplastic pemphigus results in abnormal lung function: Report of 3 cases. Experimental and Therapeutic Medicine, 25, 269. https://doi.org/10.3892/etm.2023.11968
MLA
Cen, J., Zeng, W., Pan, M., Qiu, Y., Zhang, J."Multicentric Castleman disease of hyaline‑vascular variant with paraneoplastic pemphigus results in abnormal lung function: Report of 3 cases". Experimental and Therapeutic Medicine 25.6 (2023): 269.
Chicago
Cen, J., Zeng, W., Pan, M., Qiu, Y., Zhang, J."Multicentric Castleman disease of hyaline‑vascular variant with paraneoplastic pemphigus results in abnormal lung function: Report of 3 cases". Experimental and Therapeutic Medicine 25, no. 6 (2023): 269. https://doi.org/10.3892/etm.2023.11968
Copy and paste a formatted citation
x
Spandidos Publications style
Cen J, Zeng W, Pan M, Qiu Y and Zhang J: Multicentric Castleman disease of hyaline‑vascular variant with paraneoplastic pemphigus results in abnormal lung function: Report of 3 cases. Exp Ther Med 25: 269, 2023.
APA
Cen, J., Zeng, W., Pan, M., Qiu, Y., & Zhang, J. (2023). Multicentric Castleman disease of hyaline‑vascular variant with paraneoplastic pemphigus results in abnormal lung function: Report of 3 cases. Experimental and Therapeutic Medicine, 25, 269. https://doi.org/10.3892/etm.2023.11968
MLA
Cen, J., Zeng, W., Pan, M., Qiu, Y., Zhang, J."Multicentric Castleman disease of hyaline‑vascular variant with paraneoplastic pemphigus results in abnormal lung function: Report of 3 cases". Experimental and Therapeutic Medicine 25.6 (2023): 269.
Chicago
Cen, J., Zeng, W., Pan, M., Qiu, Y., Zhang, J."Multicentric Castleman disease of hyaline‑vascular variant with paraneoplastic pemphigus results in abnormal lung function: Report of 3 cases". Experimental and Therapeutic Medicine 25, no. 6 (2023): 269. https://doi.org/10.3892/etm.2023.11968
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