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Article Open Access

Efficacy and safety of proton pump inhibitors and H2 receptor antagonists in the initial non‑eradication treatment of duodenal ulcer: A network meta‑analysis

  • Authors:
    • Xiangbo Meng
    • Xiuying Zhu
    • Baixue Li
    • Jibin Liu
    • Jiawei Zhao
    • Hua Wang
    • Quansheng Feng
    • Yue Su
  • View Affiliations / Copyright

    Affiliations: School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, P.R. China, Acupuncture‑Moxibustion and Orthopedic College, Hubei University of Chinese Medicine, Wuhan, Hubei 430061, P.R. China
    Copyright: © Meng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 273
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    Published online on: April 21, 2023
       https://doi.org/10.3892/etm.2023.11971
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Abstract

The present network meta‑analysis aimed to enhance the corresponding evidence with respect to the efficacy and safety of pharmaceuticals treatments. Frequentist network meta‑analysis was used. Medical literature up to November 2022 was searched for randomized clinical trials assessing the efficacy and safety of these pharmaceuticals, either compared with each other or compared with placebo. With the exception of ranitidine (300 mg four times daily) and vonoprazan (20 mg once daily) having lower safety than placebo, the efficacy and safety of the remaining treatments were superior to placebo. Cimetidine (400 mg four times daily) and pantoprazole (40 mg once daily) were ranked first in terms of efficacy. The frequentist network meta‑analysis shows that for cimetidine (except 400 mg once daily), famotidine, rabeprazole, ilaprazole, lansoprazole (except 7.5 mg once daily) and omeprazole (except 10 mg once daily or 30 mg once daily), the efficacy comparison between the different doses of each of the aforementioned pharmaceuticals did not indicate statistically significant differences. In conclusion, pantoprazole (40 mg once daily) was the best choice for the initial non‑eradication treatment of patients with duodenal ulcer, and cimetidine (400 mg twice daily), omeprazole (20 mg once daily), lansoprazole (15 mg once daily), ilaprazole (5 mg once daily) and rabeprazole (10 mg once daily) could be used as the first choice. If the aforementioned pharmaceuticals cannot be prescribed, famotidine (40 mg twice daily) is recommended.
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1 

Kavitt RT, Lipowska AM, Anyane-Yeboa A and Gralnek IM: Diagnosis and treatment of peptic ulcer disease. Am J Med. 132:447–456. 2019.PubMed/NCBI View Article : Google Scholar

2 

Lau JY, Barkun A, Fan DM, Kuipers EJ, Yang YS and Chan FK: Challenges in the management of acute peptic ulcer bleeding. Lancet. 381:2033–2043. 2013.PubMed/NCBI View Article : Google Scholar

3 

Dadfar A and Edna TH: Epidemiology of perforating peptic ulcer: A population-based retrospective study over 40 years. World J Gastroenterol. 26:5302–5313. 2020.PubMed/NCBI View Article : Google Scholar

4 

Thorsen K, Søreide JA, Kvaløy JT, Glomsaker T and Søreide K: Epidemiology of perforated peptic ulcer: Age- and gender-adjusted analysis of incidence and mortality. World J Gastroenterol. 19:347–354. 2013.PubMed/NCBI View Article : Google Scholar

5 

Malfertheiner P, Chan FK and McColl KE: Peptic ulcer disease. Lancet. 374:1449–1461. 2009.PubMed/NCBI View Article : Google Scholar

6 

Zheng Y, Xue M, Cai Y, Liao S, Yang H, Wang Z, Wang X, Zhang X, Qian J and Wang L: Hospitalizations for peptic ulcer disease in China: Current features and outcomes. J Gastroenterol Hepatol. 35:2122–2130. 2020.PubMed/NCBI View Article : Google Scholar

7 

Ford AC, Delaney BC, Forman D and Moayyedi P: Eradication therapy in Helicobacter pylori positive peptic ulcer disease: Systematic review and economic analysis. Am J Gastroenterol. 99:1833–1855. 2004.PubMed/NCBI View Article : Google Scholar

8 

Treiber G and Lambert JR: The impact of Helicobacter pylori eradication on peptic ulcer healing. Am J Gastroenterol. 93:1080–1084. 1998.PubMed/NCBI View Article : Google Scholar

9 

Sung JJ, Kuipers EJ and El-Serag HB: Systematic review: The global incidence and prevalence of peptic ulcer disease. Aliment Pharmacol Ther. 29:938–946. 2009.PubMed/NCBI View Article : Google Scholar

10 

Kamada T, Satoh K, Itoh T, Ito M, Iwamoto J, Okimoto T, Kanno T, Sugimoto M, Chiba T, Nomura S, et al: Evidence-based clinical practice guidelines for peptic ulcer disease 2020. J Gastroenterol. 56:303–322. 2021.PubMed/NCBI View Article : Google Scholar

11 

Savarino V, Mela GS, Zentilin P, Bisso G, Pivari M, Vigneri S, Termini R, Fiorucci S, Usai P, Malesci A and Celle G: Comparison of 24-h control of gastric acidity by three different dosages of pantoprazole in patients with duodenal ulcer. Aliment Pharmacol Ther. 12:1241–1247. 1998.PubMed/NCBI View Article : Google Scholar

12 

Lamers CB: The changing role of H2-receptor antagonists in acid-related diseases. Eur J Gastroenterol Hepatol. 8 (Suppl 1):S3–S7. 1996.PubMed/NCBI View Article : Google Scholar

13 

Ji XQ, Du JF, Chen G, Chen G and Yu B: Efficacy of ilaprazole in the treatment of duodenal ulcers: A meta-analysis. World J Gastroenterol. 20:5119–5123. 2014.PubMed/NCBI View Article : Google Scholar

14 

Poynard T, Lemaire M and Agostini H: Meta-analysis of randomized clinical trials comparing lansoprazole with ranitidine or famotidine in the treatment of acute duodenal ulcer. Eur J Gastroenterol Hepatol. 7:661–665. 1995.PubMed/NCBI

15 

Eriksson S, Långström G, Rikner L, Carlsson R and Naesdal J: Omeprazole and H2-receptor antagonists in the acute treatment of duodenal ulcer, gastric ulcer and reflux oesophagitis: A meta-analysis. Eur J Gastroenterol Hepatol. 7:467–475. 1995.PubMed/NCBI

16 

Bamberg P, Caswell CM, Frame MH, Lam SK and Wong EC: A meta-analysis comparing the efficacy of omeprazole with H2-receptor antagonists for acute treatment of duodenal ulcer in Asian patients. J Gastroenterol Hepatol. 7:577–585. 1992.PubMed/NCBI View Article : Google Scholar

17 

Hou XH, Meng F, Wang J, Sha W, Chiu CT, Chung WC, Gu L, Kudou K, Chong CF and Zhang S: 995 phase 3 Study evaluating the efficacy and safety of Vonoprazan 20 mg versus lansoprazole 30 mg in the treatment of endoscopically confirmed duodenal ulcers in Asian subjects with or without Helicobacter pylori infection. Gastroenterology. 158:S197–S198. 2020.

18 

Hawkey CJ, Long RG, Bardhan KD, Wormsley KG, Cochran KM, Christian J and Moules IK: Improved symptom relief and duodenal ulcer healing with lansoprazole, a new proton pump inhibitor, compared with ranitidine. Gut. 34:1458–1462. 1993.PubMed/NCBI View Article : Google Scholar

19 

McFarland RJ, Bateson MC, Green JR, O'Donoghue DP, Dronfield MW, Keeling PW, Burke GJ, Dickinson RJ, Shreeve DR, Peers EM, et al: Omeprazole provides quicker symptom relief and duodenal ulcer healing than ranitidine. Gastroenterology. 98:278–283. 1990.PubMed/NCBI View Article : Google Scholar

20 

Chaimani A, Caldwell DM, Li T, Higgins JPT and Salanti G: Additional considerations are required when preparing a protocol for a systematic review with multiple interventions. J Clin Epidemiol. 83:65–74. 2017.PubMed/NCBI View Article : Google Scholar

21 

Cumpston M, Li T, Page MJ, Chandler J, Welch VA, Higgins JP and Thomas J: Updated guidance for trusted systematic reviews: A new edition of the Cochrane Handbook for systematic reviews of interventions. Cochrane Database Syst Rev. 10(ED000142)2019.PubMed/NCBI View Article : Google Scholar

22 

Salanti G, Del Giovane C, Chaimani A, Caldwell DM and Higgins JP: Evaluating the quality of evidence from a network meta-analysis. PLoS One. 9(e99682)2014.PubMed/NCBI View Article : Google Scholar

23 

Greco T, Edefonti V, Biondi-Zoccai G, Decarli A, Gasparini M, Zangrillo A and Landoni G: A multilevel approach to network meta-analysis within a frequentist framework. Contemp Clin Trials. 42:51–59. 2015.PubMed/NCBI View Article : Google Scholar

24 

Devall AJ, Papadopoulou A, Podesek M, Haas DM, Price MJ, Coomarasamy A and Gallos ID: Progestogens for preventing miscarriage: A network meta-analysis. Cochrane Database Syst Rev. 4(CD013792)2021.PubMed/NCBI View Article : Google Scholar

25 

Burr NE, Gracie DJ, Black CJ and Ford AC: Efficacy of biological therapies and small molecules in moderate to severe ulcerative colitis: Systematic review and network meta-analysis. Gut. 71:1976–1987. 2021.PubMed/NCBI View Article : Google Scholar

26 

Higgins JP, Jackson D, Barrett JK, Lu G, Ades AE and White IR: Consistency and inconsistency in network meta-analysis: Concepts and models for multi-arm studies. Res Synth Methods. 3:98–110. 2012.PubMed/NCBI View Article : Google Scholar

27 

Chaimani A, Higgins JP, Mavridis D, Spyridonos P and Salanti G: Graphical tools for network meta-analysis in STATA. PLoS One. 8(e76654)2013.PubMed/NCBI View Article : Google Scholar

28 

Blackwood WS, Maudgal DP, Pickard RG, Lawrence D and Northfield TC: Cimetidine in duodenal ulcer: Controlled trial. Lancet. 2:174–176. 1976.PubMed/NCBI View Article : Google Scholar

29 

Gustavsson S, Adami HO, Lööf L, Nyberg A and Nyrén O: Rapid healing of duodenal ulcers with omeprazole: Double-blind dose-comparative trial. Lancet. 2:124–125. 1983.PubMed/NCBI View Article : Google Scholar

30 

Barbara L, Corinaldesi R, Bianchi Porro G, Lazzaroni M, Blasi A, Mangiameli A, Carratelli L, Wilkins A, Cheli R, Bovero E, et al: Famotidine in the management of duodenal ulcer: Experience in Italy. Digestion. 32 (Suppl 1):S24–S31. 1985.PubMed/NCBI View Article : Google Scholar

31 

Prichard PJ, Rubinstein D, Jones DB, Dudley FJ, Smallwood RA, Louis WJ and Yeomans ND: Double blind comparative study of omeprazole 10 mg and 30 mg daily for healing duodenal ulcers. Br Med J. 290:601–603. 1985.PubMed/NCBI View Article : Google Scholar

32 

Simon B, Dammann HG, Jakob G, Miederer SE, Müller P, Ottenjann R, Paul F, Scholten T, Schütz E, Seifert E, et al: Famotidine versus ranitidine for the short-term treatment of duodenal ulcer. Digestion. 32 (Suppl 1):S32–S37. 1985.PubMed/NCBI View Article : Google Scholar

33 

Arcidiacono R, Benvestito V, Bonomo GM, Bottari M, Buscarini L, Camarri E, Celle G, Coltorti M, Di Matteo S, Dobrilla G, et al: Comparison between ranitidine 150 mg b.d. and ranitidine 300 mg nocte in the treatment of duodenal ulcer. Int J Clin Pharmacol Ther Toxicol. 24:381–384. 1986.PubMed/NCBI

34 

Bardhan KD, Bianchi Porro G, Bose K, Daly M, Hinchliffe RF, Jonsson E, Lazzaroni M, Naesdal J, Rikner L and Walan A: A comparison of two different doses of omeprazole versus ranitidine in treatment of duodenal ulcers. J Clin Gastroenterol. 8:408–413. 1986.PubMed/NCBI View Article : Google Scholar

35 

Hirschowitz BI, Berenson MM, Berkowitz JM, Bright-Asare P, DeLuca VA Jr, Eshelman FN, Font RG, Griffin JW Jr, Kozarek RA, McCray RS, et al: A multicenter study of ranitidine treatment of duodenal ulcers in the United States. J Clin Gastroenterol. 8:359–366. 1986.PubMed/NCBI View Article : Google Scholar

36 

Lee FI, Reed PI, Crowe JP, McIsaac RL and Wood JR: Acute treatment of duodenal ulcer: A multicentre study to compare ranitidine 150 mg twice daily with ranitidine 300 mg once at night. Gut. 27:1091–1095. 1986.PubMed/NCBI View Article : Google Scholar

37 

McCullough AJ: A multicenter, randomized, double-blind study comparing famotidine with ranitidine in the treatment of active duodenal ulcer disease. Am J Med. 81:17–24. 1986.PubMed/NCBI View Article : Google Scholar

38 

Rohner HG and Gugler R: Treatment of active duodenal ulcers with famotidine. A double-blind comparison with ranitidine. Am J Med. 81:13–16. 1986.PubMed/NCBI View Article : Google Scholar

39 

Barbara L, Blasi A, Cheli R, Corinaldesi R, Dobrilla G, Francavilla A, Rinetti M, Vezzaldini P, Abbiati R, Gradnik R, et al: Omeprazole vs. ranitidine in the short-term treatment of duodenal ulcer: An Italian multicenter study. Hepatogastroenterology. 34:229–232. 1987.PubMed/NCBI

40 

Dobrilla G, De Pretis G, Piazzi L, Boero A, Camarri E, Crespi M, Fontana G, Ideo G, Manenti F, Marenco G, et al: Comparison of once-daily bedtime administration of famotidine and ranitidine in the short-term treatment of duodenal ulcer. A multicenter, double-blind, controlled study. Scand J Gastroenterol Suppl. 134:21–28. 1987.PubMed/NCBI View Article : Google Scholar

41 

Gitlin N, McCullough AJ, Smith JL, Mantell G and Berman R: A multicenter, double-blind, randomized, placebo-controlled comparison of nocturnal and twice-a-day famotidine in the treatment of active duodenal ulcer disease. Gastroenterology. 92:48–53. 1987.PubMed/NCBI View Article : Google Scholar

42 

Kimmig JM: Acute therapy of duodenal ulcer. Comparison of famotidine with ranitidine in a single evening dosage. Fortschritte der Medizin. 105:72–76. 1987.PubMed/NCBI

43 

Archambault AP, Pare P, Bailey RJ, Navert H, Williams CN, Freeman HJ, Baker SJ, Marcon NE, Hunt RH, Sutherland L, et al: Omeprazole (20 mg daily) versus cimetidine (1200 mg daily) in duodenal ulcer healing and pain relief. Gastroenterology. 94:1130–1134. 1988.PubMed/NCBI View Article : Google Scholar

44 

Hartmann H and Fölsch UR: Famotidine versus cimetidine in the treatment of acute duodenal ulcer. Double-blind, randomized clinical trial comparing nocturnal administration of 40 mg famotidine to 800 mg cimetidine. Digestion. 39:156–161. 1988.PubMed/NCBI View Article : Google Scholar

45 

Young MD, Lottes SR and Webb LA: An evaluation of cimetidine and ranitidine in the pain relief and acute healing of duodenal ulcer disease. Clin Ther. 10:543–552. 1988.PubMed/NCBI

46 

Alcalá Santaella R, Guardia J, Pajares J, Piqué J, Pita L, Alvárez E, Castellanos P, Guarner L, Ortiz J, Pesquera R, et al: A multicentre, randomized, double-blind study comparing nocte famotidine or ranitidine for the treatment of active duodenal ulceration. Aliment Pharmacol Ther. 3:103–110. 1989.PubMed/NCBI View Article : Google Scholar

47 

Al-Mofleh I, Mayet I, Al-Rashed R, Al-Faleh F, Al-Aska AK and Laajam MA: Efficacy of single-daily doses of H2-blockers in duodenal ulcer: Comparison of cimetidine and ranitidine in a double-blind controlled trial. Curr Ther Res Clin Exp. 46:399–403. 1989.

48 

Chelvam P, Goh KL, Leong YP, Leela MP, Yin TP, Ahmad H, Jalleh R, Wong NW, Lee HB and Mahendran T: Omeprazole compared with ranitidine once daily in the treatment of duodenal ulcer. J Gastroenterol Hepatol. 4 (Suppl 2):S53–S61. 1989.PubMed/NCBI

49 

Crowe JP, Wilkinson SP, Bate CM, Willoughby CP, Peers EM and Richardson PD: Symptom relief and duodenal ulcer healing with omeprazole or cimetidine. Aliment Pharmacol Ther. 3:83–91. 1989.PubMed/NCBI View Article : Google Scholar

50 

Delvaux M, Hagège CG and Ribet A: Comparative efficacy of famotidine and ranitidine in the treatment of acute-phase duodenal ulcer. A French comparative therapeutic trial. Gastroenterol Clin Biol. 13:1055–1059. 1989.PubMed/NCBI

51 

Lauritsen K, Andersen BN, Havelund T, Laursen LS, Hansen J, Eriksen J, Jørgensen T and Rask-Madsen J: Effect of 10 mg and 20 mg omeprazole daily on duodenal ulcer: Double-blind comparative trial. Aliment Pharmacol Ther. 3:59–67. 1989.PubMed/NCBI View Article : Google Scholar

52 

Lee FI, Booth SN, Cochran KM, Crowe J, Dickinson RJ, Kennedy NP, Cottrell J and Mann SG: Single night-time doses of 40 mg famotidine or 800 mg cimetidine in the treatment of duodenal ulcer. Aliment Pharmacol Ther. 3:505–512. 1989.PubMed/NCBI View Article : Google Scholar

53 

Mulder CJ, Tijtgat GN, Cluysenaer OJ, Nicolai JJ, Meyer WW, Hazenberg BP, Vogten AJ, Gerrits C and Stuifbergen WH: Omeprazole (20 mg o.m.) versus ranitidine (150 mg b.d.) in duodenal ulcer healing and pain relief. Aliment Pharmacol Ther. 3:445–451. 1989.PubMed/NCBI View Article : Google Scholar

54 

Page MC, Lacey LA, Mills JG and Wood JR: Can higher doses of an H2-receptor antagonist accelerate duodenal ulcer healing? Aliment Pharmacol Ther. 3:425–433. 1989.PubMed/NCBI View Article : Google Scholar

55 

Rodrigo L, Viver J, Conchillo F, Barrio E, Forné M, Zozaya JM, Alvarez A, Dieguez P, Muñoz M, Panés J, et al: A multicenter, randomized, double-blind study comparing famotidine with cimetidine in the treatment of active duodenal ulcer disease. Digestion. 42:86–92. 1989.PubMed/NCBI View Article : Google Scholar

56 

Kang JY, Guan R, Tay HH, Yap I, Wee A, Math MV and Labrooy SJ: Low-dose cimetidine in the acute treatment of duodenal ulcer. Comparison of a single nocturnal dose regimen with a twice daily regimen. J Gastroenterol Hepatol. 5:669–674. 1990.PubMed/NCBI View Article : Google Scholar

57 

Double blind comparative study of omeprazole and ranitidine in patients with duodenal or gastric ulcer: A multicentre trial. Gut. 31:653–656. 1990.PubMed/NCBI View Article : Google Scholar

58 

Popovic O, Dzambas D, Tasic T, Bidikov V, Jesenski T and Janosevic S: Omeprazole 20 mg o.m. vs. famotidine 40 mg h.s. in the treatment of duodenal ulcer. Multicenter double-blind randomized trial. Gastroenterohepatoloski Arhiv. 9:26–34. 1990.

59 

Cochran KM: Famotidine, ranitidine and cimetidine in the treatment of duodenal ulcer: Two large international studies. Eur J Gastroenterol Hepatol. 3:527–531. 1991.

60 

Londong W, Barth H, Dammann HG, Hengels KJ, Kleinert R, Müller P, Rohde H and Simon B: Dose-related healing of duodenal ulcer with the proton pump inhibitor lansoprazole. Aliment Pharmacol Ther. 5:245–254. 1991.PubMed/NCBI View Article : Google Scholar

61 

Delle Fave G, Annibale B, Franceschi M, Quatrini M, Cassetta MR and Torsoli A: Omeprazole versus famotidine in the short-term treatment of duodenal ulcer disease. Aliment Pharmacol Ther. 6:469–478. 1992.PubMed/NCBI View Article : Google Scholar

62 

Hotz J, Kleinert R, Grymbowski T, Hennig U and Schwarz JA: Lansoprazole versus famotidine: Efficacy and tolerance in the acute management of duodenal ulceration. Aliment Pharmacol Ther. 6:87–95. 1992.PubMed/NCBI View Article : Google Scholar

63 

Kumar TR, Naidu MU, Shobha JC, Reddy DN, Subhash S, Chaubal C, Prasad R and Babu S: Comparative study of omeprazole and famotidine in the treatment of duodenal ulcer. Indian J Gastroenterol. 11:73–75. 1992.PubMed/NCBI

64 

Lysy J, Karmeli F, Wengrower D and Rachmilewitz D: Effect of duodenal ulcer healing induced by omeprazole and ranitidine on the generation of gastroduodenal eicosanoids, platelet-activating factor, pepsinogen A, and gastrin in duodenal ulcer patients. Scand J Gastroenterol. 27:13–19. 1992.PubMed/NCBI View Article : Google Scholar

65 

Wang CY, Wang TH, Lai KH, Siauw CP, Chen PC, Yang KC, Tsai YT and Sung JL: Double-blind comparison of omeprazole 20 mg OM and ranitidine 300 mg NOCTE in duodenal ulcer: A Taiwan multi-centre study. J Gastroenterol Hepatol. 7:572–576. 1992.PubMed/NCBI View Article : Google Scholar

66 

Ahmed W, Qureshi H, Zuberi SJ and Alam SE: Omeprazole vs ranitidine in the healing of duodenal ulcer. J Pak Med Assoc. 43:111–112. 1993.PubMed/NCBI

67 

Misra SC, Dasarathy S and Sharma MP: Omeprazole versus famotidine in the healing and relapse of duodenal ulcer. Aliment Pharmacol Ther. 7:443–449. 1993.PubMed/NCBI View Article : Google Scholar

68 

Judmaier G and Koelz HR: Comparison of pantoprazole and ranitidine in the treatment of acute duodenal ulcer. Pantoprazole-Duodenal Ulcer-Study Group. Aliment Pharmacol Ther. 8:81–86. 1994.PubMed/NCBI View Article : Google Scholar

69 

Lanza F, Goff J, Scowcroft C, Jennings D and Greski-Rose P: Double-blind comparison of lansoprazole, ranitidine, and placebo in the treatment of acute duodenal ulcer. Lansoprazole Study Group. Am J Gastroenterol. 89:1191–1200. 1994.PubMed/NCBI

70 

Porro GB, Lazzaroni M, Cardelli A, Gasperoni S, De Berardinis F, Delle Fave G, Annibale B, Galeazzi R, Novelli G, Mazzeo F, et al: Pantoprazole vs omeprazole in the treatment of duodenal ulcer. Argomenti di Gastroenterologia Clin. 7:271–275. 1994.

71 

Avner DL, Dorsch ER, Jennings DE and Greski-Rose PA: A comparison of three doses of lansoprazole (15, 30 and 60 mg) and placebo in the treatment of duodenal ulcer. The Lansoprazole Study Group. Aliment Pharmacol Ther. 9:521–528. 1995.PubMed/NCBI View Article : Google Scholar

72 

Beker JA, Bianchi Porro G, Bigard MA, Delle Fave G, Devis G, Gouerou H and Maier C: Double-blind comparison of pantoprazole and omeprazole for the treatment of acute duodenal ulcer. Eur J Gastroenterol Hepatol. 7:407–410. 1995.PubMed/NCBI

73 

Chang FY, Chiang CY, Tam TN, Ng WW and Lee SD: Comparison of lansoprazole and omeprazole in the short-term management of duodenal ulcers in Taiwan. J Gastroenterol Hepatol. 10:595–601. 1995.PubMed/NCBI View Article : Google Scholar

74 

Ekström P, Carling L, Unge P, Anker-Hansen O, Sjöstedt S and Sellström H: Lansoprazole versus omeprazole in active duodenal ulcer. A double-blind, randomized, comparative study. Scand J Gastroenterol. 30:210–215. 1995.PubMed/NCBI View Article : Google Scholar

75 

Rehner M, Rohner HG and Schepp W: Comparison of pantoprazole versus omeprazole in the treatment of acute duodenal ulceration-a multicentre study. Aliment Pharmacol Ther. 9:411–416. 1995.PubMed/NCBI View Article : Google Scholar

76 

Schepp W and Classen M: Pantoprazole and ranitidine in the treatment of acute duodenal ulcer. A multicentre study. Scand J Gastroenterol. 30:511–514. 1995.PubMed/NCBI View Article : Google Scholar

77 

Miszputen SJ, De PVM, Kondo M, Ferrari A, Zaterka S, Eisig JN, Chinzon D, De M, Maguilnik I, Vieira FEF, et al: Comparative multicentric study between omeprazole and ranitidine in duodenal ulcer. GED. 16:127–134. 1997.

78 

Papp J, Döbrönte Z, Juhász L and Lonovics J: Evaluation of the effectiveness of pantoprazole and ranitidine in the treatment of duodenal ulcer. Result of an international multicenter study. Orv Hetil. 138:2863–2866. 1997.PubMed/NCBI(In Hungarian).

79 

Bardhan KD, Crowe J, Thompson RP, Trewby PN, Keeling PN, Weir D and Crouch SL: Lansoprazole is superior to ranitidine as maintenance treatment for the prevention of duodenal ulcer relapse. Aliment Pharmacol Ther. 13:827–832. 1999.PubMed/NCBI View Article : Google Scholar

80 

Dekkers CP, Beker JA, Thjodleifsson B, Gabryelewicz A, Bell NE and Humphries TJ: Comparison of rabeprazole 20 mg versus omeprazole 20 mg in the treatment of active duodenal ulcer: A European multicentre study. Aliment Pharmacol Ther. 13:179–186. 1999.PubMed/NCBI View Article : Google Scholar

81 

Dobrilla G, Piazzi L and Fiocca R: Lansoprazole versus omeprazole for duodenal ulcer healing and prevention of relapse: A randomized, multicenter, double-masked trial. Clin Ther. 21:1321–1332. 1999.PubMed/NCBI View Article : Google Scholar

82 

Breiter JR, Riff D and Humphries TJ: Rabeprazole is superior to ranitidine in the management of active duodenal ulcer disease: Results of a Double-Blind, randomized North American study. Am J Gastroenterol. 95:936–942. 2000.PubMed/NCBI View Article : Google Scholar

83 

Meneghelli UG, Zaterka S, de Paula Castro L, Malafaia O and Lyra LG: Pantoprazole versus ranitidine in the treatment of duodenal ulcer: A multicenter study in Brazil. Am J Gastroenterol. 95:62–66. 2000.PubMed/NCBI View Article : Google Scholar

84 

Shim CS, Cho JY, Chung IS, Yang YS, Kim SW and Choi MG: Rabeprazole 10 mg versus omeprazole 20 mg in the treatment of duodenal ulcer: The Korean multicenter, comparative trial. Korean J Gastrointestinal Endoscopy. 24:76–83. 2002.

85 

Ji S, Kim HS, Kim JW, Jee MK, Park KW, Uh Y, Lee DK, Song JS, Baik SK and Kwon SO: Comparison of the efficacy of rabeprazole 10 mg and omeprazole 20 mg for the healing rapidity of peptic ulcer diseases. J Gastroenterol Hepatol. 21:1381–1387. 2006.PubMed/NCBI View Article : Google Scholar

86 

Ho KY, Kuan A, Zaño F, Goh KL, Mahachai V, Kim DY and Yoon HM: Randomized, parallel, double-blind comparison of the ulcer-healing effects of ilaprazole and omeprazole in the treatment of gastric and duodenal ulcers. J Gastroenterol. 44:697–707. 2009.PubMed/NCBI View Article : Google Scholar

87 

Wang L, Zhou L, Lin S, Hu H and Xia J: A New PPI, Ilaprazole compared with omeprazole in the treatment of duodenal ulcer a randomized double-blind multicenter trial. J Clin Gastroenterol. 45:322–329. 2011.PubMed/NCBI View Article : Google Scholar

88 

Wang L, Zhou L, Hu H, Lin S and Xia J: Ilaprazole for the treatment of duodenal ulcer: A randomized, double-blind and controlled phase III trial. Curr Med Res Opin. 28:101–109. 2012.PubMed/NCBI View Article : Google Scholar

89 

Miwa H, Uedo N, Watari J, Mori Y, Sakurai Y, Takanami Y, Nishimura A, Tatsumi T and Sakaki N: Randomised clinical trial: Efficacy and safety of vonoprazan vs. lansoprazole in patients with gastric or duodenal ulcers-results from two phase 3, non-inferiority randomised controlled trials. Aliment Pharmacol Ther. 45:240–252. 2017.PubMed/NCBI View Article : Google Scholar

90 

Fan L, Xianghong Q, Ling W, Ying H, Jielai X and Haitang H: Ilaprazole compared with rabeprazole in the treatment of duodenal ulcer: A randomized, double-blind, active-controlled, multicenter study. J Clin Gastroenterol. 53:641–647. 2019.PubMed/NCBI View Article : Google Scholar

91 

Wu HN: Comparison of different combinations of triple therapy in the treatment of Helicobacter pylori positive duodenal ulcer. Yunnan Med. 38:242–244. 2017.

92 

Huang HY, Liu GF, Qi CX, Zhao YH and Wu J: Comparison of the efficacy of proton pump inhibitor high-dose combination and bismuth combination in the eradication of Helicobacter pylori. Clin Focus. 37:230–233. 2022.

93 

Shi RL: Evaluation of rational use of proton pump inhibitors in 300 inpatients. Chin Modern Doctor. 60:92–95. 2022.

94 

Li CY, Zhang J, Wang XH and Wang YN: Investigation and analysis of proton pump inhibitors in 3005 hospitalized patients. Evaluation and Analysis of Drug Use in Chinese Hospitals. 17:406–409. 2017.

95 

Zhang J, Ge L, Hill M, Liang Y, Xie J, Cui D, Li X, Zheng W and He R: Standard-dose proton pump inhibitors in the initial Non-eradication treatment of duodenal ulcer: Systematic review, network Meta-analysis, and Cost-effectiveness analysis. Front Pharmacol. 9(1512)2018.PubMed/NCBI View Article : Google Scholar

96 

Huang YZ: Clinical effect of gastric mucosal protector combined with proton pump inhibitor in the treatment of peptic ulcer with hemorrhage. Chin Med Guide. 20:29–32. 2022.

97 

Satoh K, Yoshino J, Akamatsu T, Itoh T, Kato M, Kamada T, Takagi A, Chiba T, Nomura S, Mizokami Y, et al: Evidence-based clinical practice guidelines for peptic ulcer disease. J Gastroenterol. 51:177–94. 2016.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Meng X, Zhu X, Li B, Liu J, Zhao J, Wang H, Feng Q and Su Y: Efficacy and safety of proton pump inhibitors and H2 receptor antagonists in the initial non‑eradication treatment of duodenal ulcer: A network meta‑analysis. Exp Ther Med 25: 273, 2023.
APA
Meng, X., Zhu, X., Li, B., Liu, J., Zhao, J., Wang, H. ... Su, Y. (2023). Efficacy and safety of proton pump inhibitors and H2 receptor antagonists in the initial non‑eradication treatment of duodenal ulcer: A network meta‑analysis. Experimental and Therapeutic Medicine, 25, 273. https://doi.org/10.3892/etm.2023.11971
MLA
Meng, X., Zhu, X., Li, B., Liu, J., Zhao, J., Wang, H., Feng, Q., Su, Y."Efficacy and safety of proton pump inhibitors and H2 receptor antagonists in the initial non‑eradication treatment of duodenal ulcer: A network meta‑analysis". Experimental and Therapeutic Medicine 25.6 (2023): 273.
Chicago
Meng, X., Zhu, X., Li, B., Liu, J., Zhao, J., Wang, H., Feng, Q., Su, Y."Efficacy and safety of proton pump inhibitors and H2 receptor antagonists in the initial non‑eradication treatment of duodenal ulcer: A network meta‑analysis". Experimental and Therapeutic Medicine 25, no. 6 (2023): 273. https://doi.org/10.3892/etm.2023.11971
Copy and paste a formatted citation
x
Spandidos Publications style
Meng X, Zhu X, Li B, Liu J, Zhao J, Wang H, Feng Q and Su Y: Efficacy and safety of proton pump inhibitors and H2 receptor antagonists in the initial non‑eradication treatment of duodenal ulcer: A network meta‑analysis. Exp Ther Med 25: 273, 2023.
APA
Meng, X., Zhu, X., Li, B., Liu, J., Zhao, J., Wang, H. ... Su, Y. (2023). Efficacy and safety of proton pump inhibitors and H2 receptor antagonists in the initial non‑eradication treatment of duodenal ulcer: A network meta‑analysis. Experimental and Therapeutic Medicine, 25, 273. https://doi.org/10.3892/etm.2023.11971
MLA
Meng, X., Zhu, X., Li, B., Liu, J., Zhao, J., Wang, H., Feng, Q., Su, Y."Efficacy and safety of proton pump inhibitors and H2 receptor antagonists in the initial non‑eradication treatment of duodenal ulcer: A network meta‑analysis". Experimental and Therapeutic Medicine 25.6 (2023): 273.
Chicago
Meng, X., Zhu, X., Li, B., Liu, J., Zhao, J., Wang, H., Feng, Q., Su, Y."Efficacy and safety of proton pump inhibitors and H2 receptor antagonists in the initial non‑eradication treatment of duodenal ulcer: A network meta‑analysis". Experimental and Therapeutic Medicine 25, no. 6 (2023): 273. https://doi.org/10.3892/etm.2023.11971
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