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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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June-2023 Volume 25 Issue 6

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Case Report

Malignant behavior of a well‑differentiated digestive neuroendocrine tumor with peritoneal carcinomatosis: A case report

  • Authors:
    • Klara Wyffels
    • Charlotte De Wilde
    • Jacques Van Huysse
    • Vincent De Wilde
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, AZ Sint‑Jan, 8000 Bruges, Belgium, Department of Radiology, AZ Sint‑Jan, 8000 Bruges, Belgium, Department of Anatomopathology, AZ Sint‑Jan, 8000 Bruges, Belgium
  • Article Number: 283
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    Published online on: April 26, 2023
       https://doi.org/10.3892/etm.2023.11982
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Abstract

Neuroendocrine neoplasms (NENs) are a heterogenous group of tumors, arising from enterochromaffin cells, with different biological and clinical characteristics. Well‑differentiated Grade 1 (G1) small intestinal NENs are often characterized by a slow progression rate and a good prognosis. Peritoneal carcinomatosis of a G1 digestive NEN is not a very common finding, and thus there is little published evidence regarding its progression and management. The complex, multistage interplay between the peritoneum and the metastasizing neuroendocrine cells is not well understood, and a reliable predictive tool to identify these patients earlier in their disease course is lacking. The present study describes the case of a 68‑year‑old woman presenting with an oligosymptomatic, stage IV, small intestinal G1 NEN (pTxpN1pM1) with synchronous liver metastases, multifocal mesenteric tumor deposits and a low Ki67 labeling index (1%). Over a period of 15 months, the patient developed rapidly progressive peritoneal metastatic disease with repetitive self‑limiting obstructive symptoms and eventually succumbed to her illness. The present case report discusses the potential relationship between low‑grade NEN, location of the primary tumor and the metastatic site, and also speculates on the role of the underlying subcellular mechanisms, specific micro‑environment, spreading modalities and therapeutic strategy.
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Copy and paste a formatted citation
Spandidos Publications style
Wyffels K, De Wilde C, Van Huysse J and De Wilde V: Malignant behavior of a well‑differentiated digestive neuroendocrine tumor with peritoneal carcinomatosis: A case report. Exp Ther Med 25: 283, 2023.
APA
Wyffels, K., De Wilde, C., Van Huysse, J., & De Wilde, V. (2023). Malignant behavior of a well‑differentiated digestive neuroendocrine tumor with peritoneal carcinomatosis: A case report. Experimental and Therapeutic Medicine, 25, 283. https://doi.org/10.3892/etm.2023.11982
MLA
Wyffels, K., De Wilde, C., Van Huysse, J., De Wilde, V."Malignant behavior of a well‑differentiated digestive neuroendocrine tumor with peritoneal carcinomatosis: A case report". Experimental and Therapeutic Medicine 25.6 (2023): 283.
Chicago
Wyffels, K., De Wilde, C., Van Huysse, J., De Wilde, V."Malignant behavior of a well‑differentiated digestive neuroendocrine tumor with peritoneal carcinomatosis: A case report". Experimental and Therapeutic Medicine 25, no. 6 (2023): 283. https://doi.org/10.3892/etm.2023.11982
Copy and paste a formatted citation
x
Spandidos Publications style
Wyffels K, De Wilde C, Van Huysse J and De Wilde V: Malignant behavior of a well‑differentiated digestive neuroendocrine tumor with peritoneal carcinomatosis: A case report. Exp Ther Med 25: 283, 2023.
APA
Wyffels, K., De Wilde, C., Van Huysse, J., & De Wilde, V. (2023). Malignant behavior of a well‑differentiated digestive neuroendocrine tumor with peritoneal carcinomatosis: A case report. Experimental and Therapeutic Medicine, 25, 283. https://doi.org/10.3892/etm.2023.11982
MLA
Wyffels, K., De Wilde, C., Van Huysse, J., De Wilde, V."Malignant behavior of a well‑differentiated digestive neuroendocrine tumor with peritoneal carcinomatosis: A case report". Experimental and Therapeutic Medicine 25.6 (2023): 283.
Chicago
Wyffels, K., De Wilde, C., Van Huysse, J., De Wilde, V."Malignant behavior of a well‑differentiated digestive neuroendocrine tumor with peritoneal carcinomatosis: A case report". Experimental and Therapeutic Medicine 25, no. 6 (2023): 283. https://doi.org/10.3892/etm.2023.11982
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