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Efficacy and safety of covered versus uncovered self‑expandable metal stents for the palliative treatment of malignant distal biliary stricture: A long‑term retrospective study

  • Authors:
    • Liang Zhu
    • Zhenwen Wang
    • Zhiquan Huang
    • Xueping Yang
    • Zhengping Yu
    • Ronglai Cao
    • Youxiang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 297
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    Published online on: May 5, 2023
       https://doi.org/10.3892/etm.2023.11996
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Abstract

Both covered self‑expandable metal stents (CSEMSs) and uncovered self‑expandable metal stents (USEMSs) have been tried in the palliation of malignant distal biliary strictures by means of endoscopic retrograde cholangiopancreatography (ERCP); however, the comparison of efficacy and safety between them remains contested. To the best of our knowledge, no similar studies have assessed this in the Chinese population. In the present study, the clinical and endoscopic data of 238 patients (CSEMSs, n=55; USEMSs, n=183) with malignant distal biliary strictures from 2014 to 2019 were collected. The efficacy indicated by mean stent patency, stent patency rate, mean patient survival time and survival rate, and the safety indicated by adverse events after CSEMS or USEMS placement were retrospectively analyzed and compared. The mean stent patency time was significantly longer in the CSEMSs group than that in the USEMSs group (262.8±195.3 days vs. 169.5±155.7 days, P=0.002). The mean patient survival time was significantly longer in the CSEMSs group than that in the USEMSs group (273.9±197.6 days vs. 184.9±167.6 days, P=0.003). The stent patency rate and patient survival rate were significantly higher in the CSEMSs group than those in the USEMSs group at 6 and 12 months, but not at 1 and 3 months. There was no significant difference in stent dysfunction and adverse events between the two groups, although post‑ERCP pancreatitis (PEP) occurred more frequently in the CSEMSs group than in the USEMSs group (18.1% vs. 8.8%, P=0.049). In conclusion, CSEMSs were better than USEMSs for malignant distal biliary strictures in terms of stent patency time and patient survival time as well as stent patency rate and patient survival rate in the long term (>6 months). Adverse events in the two groups occurred at a similar rate, although the incidence of PEP was higher in the CSEMSs group.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu L, Wang Z, Huang Z, Yang X, Yu Z, Cao R and Chen Y: Efficacy and safety of covered versus uncovered self‑expandable metal stents for the palliative treatment of malignant distal biliary stricture: A long‑term retrospective study. Exp Ther Med 25: 297, 2023.
APA
Zhu, L., Wang, Z., Huang, Z., Yang, X., Yu, Z., Cao, R., & Chen, Y. (2023). Efficacy and safety of covered versus uncovered self‑expandable metal stents for the palliative treatment of malignant distal biliary stricture: A long‑term retrospective study. Experimental and Therapeutic Medicine, 25, 297. https://doi.org/10.3892/etm.2023.11996
MLA
Zhu, L., Wang, Z., Huang, Z., Yang, X., Yu, Z., Cao, R., Chen, Y."Efficacy and safety of covered versus uncovered self‑expandable metal stents for the palliative treatment of malignant distal biliary stricture: A long‑term retrospective study". Experimental and Therapeutic Medicine 25.6 (2023): 297.
Chicago
Zhu, L., Wang, Z., Huang, Z., Yang, X., Yu, Z., Cao, R., Chen, Y."Efficacy and safety of covered versus uncovered self‑expandable metal stents for the palliative treatment of malignant distal biliary stricture: A long‑term retrospective study". Experimental and Therapeutic Medicine 25, no. 6 (2023): 297. https://doi.org/10.3892/etm.2023.11996
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu L, Wang Z, Huang Z, Yang X, Yu Z, Cao R and Chen Y: Efficacy and safety of covered versus uncovered self‑expandable metal stents for the palliative treatment of malignant distal biliary stricture: A long‑term retrospective study. Exp Ther Med 25: 297, 2023.
APA
Zhu, L., Wang, Z., Huang, Z., Yang, X., Yu, Z., Cao, R., & Chen, Y. (2023). Efficacy and safety of covered versus uncovered self‑expandable metal stents for the palliative treatment of malignant distal biliary stricture: A long‑term retrospective study. Experimental and Therapeutic Medicine, 25, 297. https://doi.org/10.3892/etm.2023.11996
MLA
Zhu, L., Wang, Z., Huang, Z., Yang, X., Yu, Z., Cao, R., Chen, Y."Efficacy and safety of covered versus uncovered self‑expandable metal stents for the palliative treatment of malignant distal biliary stricture: A long‑term retrospective study". Experimental and Therapeutic Medicine 25.6 (2023): 297.
Chicago
Zhu, L., Wang, Z., Huang, Z., Yang, X., Yu, Z., Cao, R., Chen, Y."Efficacy and safety of covered versus uncovered self‑expandable metal stents for the palliative treatment of malignant distal biliary stricture: A long‑term retrospective study". Experimental and Therapeutic Medicine 25, no. 6 (2023): 297. https://doi.org/10.3892/etm.2023.11996
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