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Anti‑BCMA CAR‑T cell immunotherapy for relapsed or refractory multiple myeloma

  • Authors:
    • Xiaohui Zhang
    • Chenxi Ouyang
    • Guofeng Sun
    • Hongfeng Liu
    • Junyuan Qi
    • Xiaohui Suo
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Handan Central Hospital, Handan, Hebei 056001, P.R. China, Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Beijing 100037, P.R. China, Department of Hematology, Handan Central Hospital, Handan, Hebei 056001, P.R. China, Good Clinic Practice, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin 300020, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 471
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    Published online on: August 17, 2023
       https://doi.org/10.3892/etm.2023.12170
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Abstract

The present study aimed to study the efficacy and adverse effects of anti‑B‑cell maturation antigen (BCMA) chimeric antigen receptor T (CAR‑T) cell therapy in relapsed or refractory multiple myeloma. Patients were divided into three dose groups based on cell therapy concentration. After CAR‑T cell therapy for 10 patients with recurrent or refractory multiple myeloma, the patients were monitored and evaluated regularly to observe the efficacy and adverse reactions of CAR‑T cell therapy. At a median follow‑up of 337 (253‑504) days, one patient succumbed 24 days due to rapidly progressing disease. The overall response rate of nine patients was 88.9%, including 77.8% (7/9) with minimal residual disease negative complete remission (CR) and 11.1% (1/9) with partial remission. A total of three patients were maintained in remission state for more than a year and eight were maintained for more than six months. Among the three patients with extramedullary invasion, two extramedullary lesions disappeared and one was stable. The highest copy number of CAR‑T cells in seven patients with CR was >1x105 copies/µl gDNA, and the best therapeutic effect can be achieved within 30 (7‑30) days after the copy number of CAR‑T cells reached 1x105 copies/µl genomic DNA. The median onset time in the nine patients was 43 (22‑169) days, and the median progression‑free survival was 337 (253‑504). Among the 10 patients, nine (90%) had cytokine release syndrome, all of which were below grade II. There were nine (90%) patients with hematological adverse reactions, six (60%) patients with severe anemia, five (50%) patients with grade III and above leukopenia, five (50%) patients with granulocytopenia, four (40%) patients with grade III and above thrombocytopenia, and three (30%) patients with grade III and above pancytopenia. It was concluded that anti‑BCMA CAR‑T cell therapy is a promising treatment method for relapsed or refractory multiple myeloma and extramedullary invasion, with stable efficacy and controllable adverse effects.
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1 

Cowan AJ, Allen C, Barac A, Basaleem H, Bensenor I, Curado MP, Foreman K, Gupta R, Harvey J, Hosgood HD, et al: Global burden of multiple myeloma: A systematic analysis for the global burden of disease study 2016. JAMA Oncol. 4:1221–1227. 2018.PubMed/NCBI View Article : Google Scholar

2 

van Beurden-Tan CHY, Franken MG, Blommestein HM, Uyl-de Groot CA and Sonneveld P: Systematic literature review and network meta-analysis of treatment outcomes in relapsed and/or refractory multiple myeloma. J Clin Oncol. 35:1312–1319. 2017.PubMed/NCBI View Article : Google Scholar

3 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar

4 

Furukawa Y and Kikuchi J: Molecular basis of clonal evolution in multiple myeloma. Int J Hematol. 111:496–511. 2020.PubMed/NCBI View Article : Google Scholar

5 

Dai H, Wu Z, Jia H, Tong C, Guo Y, Ti D, Han X, Liu Y, Zhang W, Wang C, et al: Correction to: Bispecific CAR-T cells targeting both CD19 and CD22 for therapy of adults with relapsed or refractory B cell acute lymphoblastic leukemia. J Hematol Oncol. 13(53)2020.PubMed/NCBI View Article : Google Scholar

6 

Finney OC, Brakke HM, Rawlings-Rhea S, Hicks R, Doolittle D, Lopez M, Futrell RB, Orentas RJ, Li D, Gardner RA and Jensen MC: CD19 CAR T cell product and disease attributes predict leukemia remission durability. J Clin Invest. 129:2123–2132. 2019.PubMed/NCBI View Article : Google Scholar

7 

Abramson JS: Anti-CD19 CAR T-cell therapy for B-cell non-hodgkin lymphoma. Transfus Med Rev. 34:29–33. 2020.PubMed/NCBI View Article : Google Scholar

8 

van de Donk NWCJ, Usmani SZ and Yong K: CAR T-cell therapy for multiple myeloma: State of the art and prospects. Lancet Haematol. 8:e446–e461. 2021.PubMed/NCBI View Article : Google Scholar

9 

Cho SF, Anderson KC and Tai YT: Targeting B cell maturation antigen (BCMA) in multiple myeloma: Potential uses of BCMA-Based immunotherapy. Front Immunol. 9(1821)2018.PubMed/NCBI View Article : Google Scholar

10 

Friedman KM, Garrett TE, Evans JW, Horton HM, Latimer HJ, Seidel SL, Horvath CJ and Morgan RA: Effective targeting of multiple B-Cell maturation antigen-expressing hematological malignances by Anti-B-Cell maturation antigen chimeric antigen receptor T cells. Hum Gene Ther. 29:585–601. 2018.PubMed/NCBI View Article : Google Scholar

11 

Mei H, Li C, Jiang H, Zhao X, Huang Z, Jin D, Guo T, Kou H, Liu L, Tang L, et al: A bispecific CAR-T cell therapy targeting BCMA and CD38 in relapsed or refractory multiple myeloma. J Hematol Oncol. 14(161)2021.PubMed/NCBI View Article : Google Scholar

12 

Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, Kumar S, Hillengass J, Kastritis E, Richardson P, et al: International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 15:e538–e548. 2014.PubMed/NCBI View Article : Google Scholar

13 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

14 

Lee DW, Gardner R, Porter DL, Louis CU, Ahmed N, Jensen M, Grupp SA and Mackall CL: Current concepts in the diagnosis and management of cytokine release syndrome. Blood. 124:188–195. 2014.PubMed/NCBI View Article : Google Scholar

15 

Bao L, Bo XC, Cao HW, Qian C, Wang Z and Li B: Engineered T cells and their therapeutic applications in autoimmune diseases. Zool Res. 43:150–165. 2022.PubMed/NCBI View Article : Google Scholar

16 

June CH and Sadelain M: Chimeric antigen receptor therapy. N Engl J Med. 379:64–73. 2018.PubMed/NCBI View Article : Google Scholar

17 

Brudno JN, Lam N, Vanasse D, Shen YW, Rose JJ, Rossi J, Xue A, Bot A, Scholler N, Mikkilineni L, et al: Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma. Nat Med. 26:270–280. 2020.PubMed/NCBI View Article : Google Scholar

18 

Majzner RG and Mackall CL: Clinical lessons learned from the first leg of the CAR T cell journey. Nat Med. 25:1341–1355. 2019.PubMed/NCBI View Article : Google Scholar

19 

Kersten MJ, Spanjaart AM and Thieblemont C: CD19-directed CAR T-cell therapy in B-cell NHL. Curr Opin Oncol. 32:408–417. 2020.PubMed/NCBI View Article : Google Scholar

20 

Mikkilineni L and Kochenderfer JN: Chimeric antigen receptor T-cell therapies for multiple myeloma. Blood. 130:2594–2602. 2017.PubMed/NCBI View Article : Google Scholar

21 

Tai YT and Anderson KC: B cell maturation antigen (BCMA)-based immunotherapy for multiple myeloma. Expert Opin Biol Ther. 19:1143–1156. 2019.PubMed/NCBI View Article : Google Scholar

22 

Berdeja JG, Madduri D, Usmani SZ, Jakubowiak A, Agha M, Cohen AD, Stewart AK, Hari P, Htut M, Lesokhin A, et al: Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): A phase 1b/2 open-label study. Lancet. 398:314–324. 2021.PubMed/NCBI View Article : Google Scholar

23 

Bahlis NJ, Dimopoulos MA, White DJ, Benboubker L, Cook G, Leiba M, Ho PJ, Kim K, Takezako N, Moreau P, et al: Daratumumab plus lenalidomide and dexamethasone in relapsed/refractory multiple myeloma: Extended follow-up of POLLUX, a randomized, open-label, phase 3 study. Leukemia. 34:1875–1884. 2020.PubMed/NCBI View Article : Google Scholar

24 

Usmani SZ, Nahi H, Legiec W, Grosicki S, Vorobyev V, Spicka I, Hungria V, Korenkova S, Bahlis NJ, Flogegard M, et al: Final analysis of the phase III non-inferiority COLUMBA study of subcutaneous versus intravenous daratumumab in patients with relapsed or refractory multiple myeloma. Haematologica. 107:2408–2417. 2022.PubMed/NCBI View Article : Google Scholar

25 

Stork M, Spicka I, Radocha J, Minarik J, Jelinek T, Jungova A, Pavlicek P, Pospisilova L, Sedlak F, Straub J, et al: Daratumumab with lenalidomide and dexamethasone in relapsed or refractory multiple myeloma patients-real world evidence analysis. Ann Hematol. 102:1501–1511. 2023.PubMed/NCBI View Article : Google Scholar

26 

Brudno JN, Maric I, Hartman SD, Rose JJ, Wang M, Lam N, Stetler-Stevenson M, Salem D, Yuan C, Pavletic S, et al: T cells genetically modified to express an Anti-B-Cell maturation antigen chimeric antigen receptor cause remissions of poor-prognosis relapsed multiple myeloma. J Clin Oncol. 36:2267–2280. 2018.PubMed/NCBI View Article : Google Scholar

27 

Raje N, Berdeja J, Lin Y, Siegel D, Jagannath S, Madduri D, Liedtke M, Rosenblatt J, Maus MV, Turka A, et al: Anti-BCMA CAR T-Cell Therapy bb2121 in relapsed or refractory multiple myeloma. N Engl J Med. 380:1726–1737. 2019.PubMed/NCBI View Article : Google Scholar

28 

Zhao WH, Liu J, Wang BY, Chen YX, Cao XM, Yang Y, Zhang YL, Wang FX, Zhang PY, Lei B, et al: A phase 1, open-label study of LCAR-B38M, a chimeric antigen receptor T cell therapy directed against B cell maturation antigen, in patients with relapsed or refractory multiple myeloma. J Hematol Oncol. 11(141)2018.PubMed/NCBI View Article : Google Scholar

29 

Maus MV and June CH: Making better chimeric antigen receptors for adoptive T-cell therapy. Clin Cancer Res. 22:1875–1884. 2016.PubMed/NCBI View Article : Google Scholar

30 

Enblad G, Karlsson H, Gammelgard G, Wenthe J, Lövgren T, Amini RM, Wikstrom KI, Essand M, Savoldo B, Hallböök H, et al: A Phase I/IIa trial using CD19-Targeted Third-Generation CAR T cells for lymphoma and leukemia. Clin Cancer Res. 24:6185–6194. 2018.PubMed/NCBI View Article : Google Scholar

31 

Schultz L and Mackall C: Driving CAR T cell translation forward. Sci Transl Med. 11(eaaw2127)2019.PubMed/NCBI View Article : Google Scholar

32 

Kansal R, Richardson N, Neeli I, Khawaja S, Chamberlain D, Ghani M, Ghani QU, Balazs L, Beranova-Giorgianni S, Giorgianni F, et al: Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus. Sci Transl Med. 11(eaav1648)2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Ouyang C, Sun G, Liu H, Qi J and Suo X: Anti‑BCMA CAR‑T cell immunotherapy for relapsed or refractory multiple myeloma. Exp Ther Med 26: 471, 2023.
APA
Zhang, X., Ouyang, C., Sun, G., Liu, H., Qi, J., & Suo, X. (2023). Anti‑BCMA CAR‑T cell immunotherapy for relapsed or refractory multiple myeloma. Experimental and Therapeutic Medicine, 26, 471. https://doi.org/10.3892/etm.2023.12170
MLA
Zhang, X., Ouyang, C., Sun, G., Liu, H., Qi, J., Suo, X."Anti‑BCMA CAR‑T cell immunotherapy for relapsed or refractory multiple myeloma". Experimental and Therapeutic Medicine 26.4 (2023): 471.
Chicago
Zhang, X., Ouyang, C., Sun, G., Liu, H., Qi, J., Suo, X."Anti‑BCMA CAR‑T cell immunotherapy for relapsed or refractory multiple myeloma". Experimental and Therapeutic Medicine 26, no. 4 (2023): 471. https://doi.org/10.3892/etm.2023.12170
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Ouyang C, Sun G, Liu H, Qi J and Suo X: Anti‑BCMA CAR‑T cell immunotherapy for relapsed or refractory multiple myeloma. Exp Ther Med 26: 471, 2023.
APA
Zhang, X., Ouyang, C., Sun, G., Liu, H., Qi, J., & Suo, X. (2023). Anti‑BCMA CAR‑T cell immunotherapy for relapsed or refractory multiple myeloma. Experimental and Therapeutic Medicine, 26, 471. https://doi.org/10.3892/etm.2023.12170
MLA
Zhang, X., Ouyang, C., Sun, G., Liu, H., Qi, J., Suo, X."Anti‑BCMA CAR‑T cell immunotherapy for relapsed or refractory multiple myeloma". Experimental and Therapeutic Medicine 26.4 (2023): 471.
Chicago
Zhang, X., Ouyang, C., Sun, G., Liu, H., Qi, J., Suo, X."Anti‑BCMA CAR‑T cell immunotherapy for relapsed or refractory multiple myeloma". Experimental and Therapeutic Medicine 26, no. 4 (2023): 471. https://doi.org/10.3892/etm.2023.12170
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