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Article

Natural history of eosinophil‑derived neurotoxin levels and the onset of allergic airway disease in preschool children

  • Authors:
    • Yoshihide Terashi
    • Chang-Keun Kim
    • Zak Callaway
    • Jin-Sung Park
    • Shinya Yoshihara
    • Masaya Kato
    • Shigemi Yoshihara
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Dokkyo Medical University, Mibu, Tochigi 3210293, Japan, Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul 01757, Republic of Korea, Department of Pediatrics, Kangwon National University School of Medicine, Chuncheon, Gangwon 24341, Republic of Korea
  • Article Number: 565
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    Published online on: October 20, 2023
       https://doi.org/10.3892/etm.2023.12264
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Abstract

Atopic march’ is the progression of allergic conditions through infancy and childhood. The present study investigated the association between blood eosinophil‑derived neurotoxin (EDN) levels in preschool children with food allergy (FA) or atopic dermatitis (AD) and the onset of allergic airway disease [bronchial asthma (BA), allergic rhinitis (AR)]. A total of 123 children below the age of 1 year were enrolled in the present study, along with controls (n=37). Blood specimens were taken, serum EDN levels were measured and immunoglobulin E was quantified. Finally, a total of 86 subjects were analyzed. EDN values were measured at 3 time‑points: before 1 year of age, before 2 years of age and before 3 years of age. The EDN levels were initially similar between those patients who did and those who did not develop allergic airway disease but then markedly diverged at the 2‑year time‑point (226.6 vs. 65.0 ng/ml; P<0.01) and remained divergent at the 3‑year time‑point (173.9 vs. 62.7 ng/ml; P<0.01). EDN levels prior to diagnosis were compared between the two groups and they were much higher in the Onset group (n=10) compared to the Non‑onset group (n=67) (171.2±34.28 vs. 81.3±10.02 ng/ml; P=0.003), with 4 cases of BA and 6 cases of AR in the Onset group. After diagnosis, EDN levels were compared twice: i) At 1 and 2 years of age; and ii) 1 and 3 years of age. A significant difference was found only in the comparison at 2 years (P=0.001). In conclusion, young children with elevated EDN levels during the FA/AD disease period were more likely to develop allergic airway disease (BA, AR) in their first three years of life. A factor leading to this progression may be increased eosinophil activity.
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1 

Hill DA and Spergel JM: The atopic march: Critical evidence and clinical relevance. Ann Allergy Asthma Immunol. 120:131–137. 2018.PubMed/NCBI View Article : Google Scholar

2 

Hill DA, Grundmeier RW, Ram G and Spergel JM: The epidemiologic characteristics of healthcare provider-diagnosed eczema, asthma, allergic rhinitis, and food allergy in children: A retrospective cohort study. BMC Pediatr. 16(133)2016.PubMed/NCBI View Article : Google Scholar

3 

Renz H, Allen KJ, Sicherer SH, Sampson HA, Lack G, Beyer K and Oettgen HC: Food allergy. Nat Rev Dis Primers. 4(17098)2018.PubMed/NCBI View Article : Google Scholar

4 

Hogan SP, Rosenberg HF, Moqbel R, Phipps S, Foster PS, Lacy P, Kay AB and Rothenberg ME: Eosinophils: Biological properties and role in health and disease. Clin Exp Allergy. 38:709–750. 2008.PubMed/NCBI View Article : Google Scholar

5 

Venge P: Monitoring the allergic inflammation. Allergy. 59:26–32. 2004.PubMed/NCBI View Article : Google Scholar

6 

Kim H, Kwon GE, Kim YH, Callaway Z, Han YS, Seo JJ, Jiao F and Kim CK: Comparison of serum eosinophil-derived neurotoxin levels between wheezing and non-wheezing groups in children with respiratory tract infection. J Asthma. 57:1211–1215. 2020.PubMed/NCBI View Article : Google Scholar

7 

Kim CK, Callaway Z, Park JS, Nishimori H, Ogino T, Nagao M and Fujisawa T: Montelukast reduces serum levels of eosinophil-derived neurotoxin in preschool asthma. Allergy Asthma Immunol Res. 10:686–697. 2018.PubMed/NCBI View Article : Google Scholar

8 

Kim CK, Callaway Z, Park JS and Kwon E: Utility of serum eosinophil-derived neurotoxin (EDN) measurement by ELISA in young children with asthma. Allergol Int. 66:70–74. 2017.PubMed/NCBI View Article : Google Scholar

9 

Kim CK, Callaway Z, Kim DW and Kita H: Eosinophil degranulation is more important than eosinophilia in identifying asthma in chronic cough. J Asthma. 48:994–1000. 2011.PubMed/NCBI View Article : Google Scholar

10 

Kim CK, Callaway Z, Fletcher R and Koh YY: Eosinophil-derived neurotoxin in childhood asthma: correlation with disease severity. J Asthma. 47:568–573. 2010.PubMed/NCBI View Article : Google Scholar

11 

Kim CK, Seo JK, Ban SH, Fujisawa T, Kim DW and Callaway Z: Eosinophil-derived neurotoxin levels at 3 months post-respiratory syncytial virus bronchiolitis are a predictive biomarker of recurrent wheezing. Biomarkers. 18:230–235. 2013.PubMed/NCBI View Article : Google Scholar

12 

Peterson CG, Enander I, Nystrand J, Anderson AS, Nilsson L and Venge P: Radioimmunoassay of human eosinophil cationic protein (ECP) by an improved method. Establishment of normal levels in serum and turnover in vivo. Clin Exp Allergy. 21:561–567. 1991.PubMed/NCBI View Article : Google Scholar

13 

Murphy KP: The detection, measurement, and characterization of antibodies, and their use as research and diagnostic tools. Janeway's immunobiology. 8th edition. Garland Science, New York, NY, 2012.

14 

Morioka J, Kurosawa M, Inamura H, Nakagami R, Mizushima Y, Chihara J, Yokoseki T, Kitamura S, Omura Y and Shibata M: Development of a novel enzyme-linked immunosorbent assay for blood and urinary eosinophil-derived neurotoxin: A preliminary study in patients with bronchial asthma. Int Arch Allergy Immunol. 122:49–57. 2000.PubMed/NCBI View Article : Google Scholar

15 

Tran MM, Lefebvre DL, Dharma C, Dai D, Lou WYW, Subbarao P, Becker AB, Mandhane PJ, Turvey SE and Sears MR: Canadian Healthy Infant Longitudinal Development Study Investigators. Predicting the atopic march: Results from the Canadian health infant longitudinal development study. J Allergy Clin Immunol. 141:601–607. 2018.PubMed/NCBI View Article : Google Scholar

16 

Schenider L, Hanifin J, Boguniewicz M, Eichenfield LF, Spergel JM, Dakovic R and Paller AS: Study of the atopic march: development of atopic comorbidities. Pediatr Dermatol. 33:388–398. 2016.PubMed/NCBI View Article : Google Scholar

17 

Kim NY, Kim GR, Kim JH, Baek JH, Yoon JW, Jee HM, Baek HS, Jung YH, Choi SH, Kim KE, et al: Food allergen sensitization in young children with typical signs and symptoms of immediate-type food allergies: A comparison between monosensitized and polysensitized children. Korean J Pediatr. 58:330–335. 2015.PubMed/NCBI View Article : Google Scholar

18 

de Moira AP, Strandberg-Larsen K, Bishop T, Pedersen M, Avraam D, Cadman T, Calas L, Casas M, Guillain BL, et al: Associations of early-life pet ownership with asthma and allergic sensitization: A meta-analysis of more than 77,000 children from the EU Chil Cohort Network. J Allergy Clin Immunol. 150:82–92. 2022.PubMed/NCBI View Article : Google Scholar

19 

Anyo G, Brunekreef de Meer G, Aarts F, Janssen NA and van Vliet P: Early, current and past pet ownership: Associations with sensitization, bronchial responsiveness and allergic symtpoms in school children. Clin Exp Allergy. 32:361–366. 2002.PubMed/NCBI View Article : Google Scholar

20 

Lødrop Carlsen KC, Roll S, Carlsen KH, Mowinckel P, Wijga AH, Brunekreef B, Torrent M, Roberts G, Arshad SH, Kull I, et al: Does pet ownership in infancy lead to asthma or allergy at school age? Poole analysis of individual participant data from 11 European birth cohorts. PLoS One. 7(e43214)2012.PubMed/NCBI View Article : Google Scholar

21 

Fall T, Lundholm C, Ortquvist AK, Fall K, Fang F, Hedhammar A, Kämpe O, Ilgelsson E and Almqvist C: Early exposure to dogs and farm animals and the risk of childhood asthma. JAMA Pediatr. 169(e153219)2015.PubMed/NCBI View Article : Google Scholar

22 

Hesselmar B, Hicke-Roberts A, Lundell AC, Adlerberth I, Rudin A, Saalman R, Wennergren G and Wold AE: Pet-keeping in early life reduces the risk of allergy in a dose-dependent fashion. PLoS One. 13(e0208472)2018.PubMed/NCBI View Article : Google Scholar

23 

Ownby DR, Johnson CC and Peterson EL: Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age. JAMA. 288:963–972. 2002.PubMed/NCBI View Article : Google Scholar

24 

Jatakanon A, Lim S and Barnes PJ: Changes in sputum eosinophils predict loss of asthma control. Am J Respir Crit Care Med. 161:64–72. 2000.PubMed/NCBI View Article : Google Scholar

25 

Agache I and Rogozea L: Asthma biomarkers: Do they bring precision medicine closer to the clinic? Allergy Asthma Immunol Res. 9:466–476. 2017.PubMed/NCBI View Article : Google Scholar

26 

Diamant Z, Vijverberg S, Alving K, Bakirtas A, Bjermer L, Custovic A, Dahlen SE, Gaga M, van Wijk RG, Del Giacco S, et al: Toward clinically applicable biomarkers for asthma: an EAACI position paper. Allergy. 74:1835–1851. 2019.PubMed/NCBI View Article : Google Scholar

27 

Kim KW, Lee KE, Kim ES, Song TW, Sohn MH and Kim KE: Serum eosinophil-derived neurotoxin (EDN) in diagnosis and evaluation of severity and bronchial hyperresponsiveness in childhood asthma. Lung. 185:97–103. 2007.PubMed/NCBI View Article : Google Scholar

28 

Taniuchi S, Chihara J, Kojima T, Yamamoto A, Sasai M and Kobayashi Y: Serum eosinohil derived neurotoxin may reflect more strongly disease severity in childhood atopic dermatitis than eosinophil cationic protein. J Dermatol Sci. 26:79–82. 2001.PubMed/NCBI View Article : Google Scholar

29 

Goto T, Morioka J, Inamura H, Yano M, Kodaira K, Igarashi Y, Abe S and Kurosawa M: Urinary eosinophil-derived neurotoxin concentrations in patients with atopic dermatitis: A useful clinical marker for disease activity. Allergol Int. 56:433–438. 2007.PubMed/NCBI View Article : Google Scholar

30 

Kim CK, Kita H, Callaway Z, Kim HB, Choi J, Fujisawa T, Shin BM and Koh YY: The roles of a Th2 cytokine and CC chemokine in children with stable asthma: Potential implication in eosinphil degranulation. Pediatr Allergy Immunol. 21:e697–e704. 2010.PubMed/NCBI View Article : Google Scholar

31 

Amer OT, Naguib MS, Allam AA and Fouad EMI: Evaluation of serum eosinophil-derived neurotoxin level in children with bronchial asthma and its relation to disease severity. Egypt J Hosp Med. 80:951–957. 2020.

32 

Malinovschi A, Rydell N, Fujisawa T, Borres MP and Kim CK: Clinical potential of eosinophil-derived neurotoxin in asthma management. J Allergy Clin Immunol Pract. 11:750–761. 2023.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Terashi Y, Kim C, Callaway Z, Park J, Yoshihara S, Kato M and Yoshihara S: Natural history of eosinophil‑derived neurotoxin levels and the onset of allergic airway disease in preschool children. Exp Ther Med 26: 565, 2023.
APA
Terashi, Y., Kim, C., Callaway, Z., Park, J., Yoshihara, S., Kato, M., & Yoshihara, S. (2023). Natural history of eosinophil‑derived neurotoxin levels and the onset of allergic airway disease in preschool children. Experimental and Therapeutic Medicine, 26, 565. https://doi.org/10.3892/etm.2023.12264
MLA
Terashi, Y., Kim, C., Callaway, Z., Park, J., Yoshihara, S., Kato, M., Yoshihara, S."Natural history of eosinophil‑derived neurotoxin levels and the onset of allergic airway disease in preschool children". Experimental and Therapeutic Medicine 26.6 (2023): 565.
Chicago
Terashi, Y., Kim, C., Callaway, Z., Park, J., Yoshihara, S., Kato, M., Yoshihara, S."Natural history of eosinophil‑derived neurotoxin levels and the onset of allergic airway disease in preschool children". Experimental and Therapeutic Medicine 26, no. 6 (2023): 565. https://doi.org/10.3892/etm.2023.12264
Copy and paste a formatted citation
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Spandidos Publications style
Terashi Y, Kim C, Callaway Z, Park J, Yoshihara S, Kato M and Yoshihara S: Natural history of eosinophil‑derived neurotoxin levels and the onset of allergic airway disease in preschool children. Exp Ther Med 26: 565, 2023.
APA
Terashi, Y., Kim, C., Callaway, Z., Park, J., Yoshihara, S., Kato, M., & Yoshihara, S. (2023). Natural history of eosinophil‑derived neurotoxin levels and the onset of allergic airway disease in preschool children. Experimental and Therapeutic Medicine, 26, 565. https://doi.org/10.3892/etm.2023.12264
MLA
Terashi, Y., Kim, C., Callaway, Z., Park, J., Yoshihara, S., Kato, M., Yoshihara, S."Natural history of eosinophil‑derived neurotoxin levels and the onset of allergic airway disease in preschool children". Experimental and Therapeutic Medicine 26.6 (2023): 565.
Chicago
Terashi, Y., Kim, C., Callaway, Z., Park, J., Yoshihara, S., Kato, M., Yoshihara, S."Natural history of eosinophil‑derived neurotoxin levels and the onset of allergic airway disease in preschool children". Experimental and Therapeutic Medicine 26, no. 6 (2023): 565. https://doi.org/10.3892/etm.2023.12264
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