Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2024 Volume 27 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2024 Volume 27 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Echinacoside ameliorates doxorubicin‑induced cardiac injury by regulating GPX4 inhibition‑induced ferroptosis

  • Authors:
    • Yan Ma
    • Xiaoli Yang
    • Nianxin Jiang
    • Cheng Lu
    • Jiehan Zhang
    • Shaowei Zhuang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200137, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 29
    |
    Published online on: November 23, 2023
       https://doi.org/10.3892/etm.2023.12317
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Echinacoside (ECH) is a compound derived from the natural herbs Cistanche and Echinacea, which has considerable protective effects on heart failure (HF). HF is characterized by myocardial damage and abnormal ferroptosis. Glutathione peroxidase 4 (GPX4) is an important regulator of ferroptosis, which plays a role in ferroptosis‑related diseases. Despite this, the therapeutic mechanisms of ECH against HF remain unknown. Therefore, the aim of the present study was to investigate the cardioprotective effect and underlying mechanisms of ECH in the treatment of doxorubicin (DOX)‑induced chronic HF (CHF). Cell proliferation was assessed using a CCK‑8 assay. Furthermore, cardiac cell injury and oxidative stress were determined by measuring the lactate dehydrogenase (LDH), malondialdehyde (MDA), and glutathione (GSH) levels. The levels of Fe2+ and lipid reactive oxygen species (ROS), and expression of the biomarkers of ferroptosis, including GPX4 and prostaglandin‑endoperoxide synthase 2 (PTGS2), were measured to examine cardiomyocyte ferroptosis. Additionally, RNA interference was used to silence Gpx4. In vitro and in vivo, ECH considerably reduced the MDA and LDH levels and increased the GSH level, thereby attenuating DOX‑induced cardiac injury and oxidative stress. Meanwhile, ECH treatment decreased the lipid ROS levels and PTGS2 expression while increasing GPX4 expression, thereby alleviating DOX‑induced cardiomyocyte ferroptosis. Moreover, knockdown of Gpx4 inhibited the protective effects of ECH on DOX‑induced accumulation of lipid ROS in cardiomyocytes. These findings indicate that ECH can reduce DOX‑induced cardiac injury by inhibiting ferroptosis via GPX4, highlighting its value as a potentially valuable therapeutic target in the management of CHF.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Sola S, Mir MQS, Lerakis S, Tandon N and Khan BV: Atorvastatin improves left ventricular systolic function and serum markers of inflammation in nonischemic heart failure. J Am Coll Cardiol. 47:332–337. 2006.PubMed/NCBI View Article : Google Scholar

2 

Wen W, Zhang Z, She J, Bai X, Wu Y, Gao L, Zhou J and Yuan Z: The predictive values of white blood cell indices (lymphocyte and eosinophilic granulocyte) for heart failure in acute coronary syndrome patients following percutaneous coronary intervention: A prospective cohort study. Clin Interv Aging. 18:951–962. 2023.PubMed/NCBI View Article : Google Scholar

3 

Khan H, Anker SD, Januzzi JL Jr, McGuire DK, Sattar N, Woerle HJ and Butler J: Heart failure epidemiology in patients with diabetes mellitus without coronary heart disease. J Card Fail. 25:78–86. 2019.PubMed/NCBI View Article : Google Scholar

4 

Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, et al: ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: A report of the American college of cardiology/American heart association task force on practice guidelines (writing committee to update the 2001 guidelines for the evaluation and management of heart failure): Developed in collaboration with the American college of chest physicians and the international society for heart and lung transplantation: Endorsed by the heart rhythm society. Circulation. 112:e154–e235. 2005.PubMed/NCBI View Article : Google Scholar

5 

Long K, Zhao Z, Chen J, Zhi L, Wang C, Liao D, Wang M and Gao P: Yang-xin-xue keli exerts therapeutic effects via regulating mitochondrial homeostasis and function in doxorubicin-induced rat heart failure. Front Pharmacol. 13(931453)2022.PubMed/NCBI View Article : Google Scholar

6 

Ermis N, Ulutas Z, Ozhan O, Yildiz A, Vardi N, Colak C and Parlakpinar H: Angiotensin II type 2 receptor agonist treatment of doxorubicin induced heart failure. Biotech Histochem. 98:326–335. 2023.PubMed/NCBI View Article : Google Scholar

7 

Zhuang S, Ma Y, Zeng Y, Lu C, Yang F, Jiang N, Ge J, Ju H, Zhong C, Wang J, et al: METTL14 promotes doxorubicin-induced cardiomyocyte ferroptosis by regulating the KCNQ1OT1-miR-7-5p-TFRC axis. Cell Biol Toxicol. 39:1015–1035. 2023.PubMed/NCBI View Article : Google Scholar

8 

Liao HH, Ding W, Zhang N, Zhou ZY, Ling Z, Li WJ, Chen S and Tang QZ: Activation of AMPKα2 attenuated doxorubicin-induced cardiotoxicity via inhibiting lipid peroxidation associated ferroptosis. Free Radic Biol Med. 205:275–290. 2023.PubMed/NCBI View Article : Google Scholar

9 

Syamprasad NP, Jain S, Rajdev B, Panda SR, Gangasani JK, Challa VS, Vaidya JR, Kundu GC and Naidu VGM: AKR1B1 inhibition using NARI-29-an epalrestat analogue-alleviates doxorubicin-induced cardiotoxicity via modulating calcium/CaMKII/MuRF-1 axis. Chem Biol Interact. 381(110566)2023.PubMed/NCBI View Article : Google Scholar

10 

Yang J, Ma S, Xu R, Wei Y, Zhang J, Zuo T, Wang Z, Deng H, Yang N and Shen Q: Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy. J Control Release. 334:21–33. 2021.PubMed/NCBI View Article : Google Scholar

11 

Wang R, Chen X, Li X and Wang K: Molecular therapy of cardiac ischemia-reperfusion injury based on mitochondria and ferroptosis. J Mol Med (Berl): Jul 28, 2023 (Epub ahead of print).

12 

Kumarswamy R and Thum T: Non-coding RNAs in cardiac remodeling and heart failure. Circ Res. 113:676–689. 2013.PubMed/NCBI View Article : Google Scholar

13 

Matsumoto T, Wada A, Tsutamoto T, Ohnishi M, Isono T and Kinoshita M: Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure. Circulation. 107:2555–2558. 2003.PubMed/NCBI View Article : Google Scholar

14 

Zy A, Gd A, Xu CA, Qin X, Xu H, Zeng B, Ren J, Zheng Q and Wang S: Beclin1 haploinsufficiency rescues low ambient temperature-induced cardiac remodeling and contractile dysfunction through inhibition of ferroptosis and mitochondrial injury. Metabolism. 113(154397)2020.PubMed/NCBI View Article : Google Scholar

15 

Chen X, Xu S, Zhao C and Liu B: Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure. Biochem Biophys Res Commun. 516:37–43. 2019.PubMed/NCBI View Article : Google Scholar

16 

Zhang H, Zhabyeyev P, Wang S and Oudit GY: Role of iron metabolism in heart failure: From iron deficiency to iron overload. Biochim Biophys Acta Mol Basis Dis. 1865:1925–1937. 2019.PubMed/NCBI View Article : Google Scholar

17 

Zhang D, Li H and Wang JB: Echinacoside inhibits amyloid fibrillization of HEWL and protects against Aβ-induced neurotoxicity. Int J Biol Macromol. 72:243–253. 2015.PubMed/NCBI View Article : Google Scholar

18 

Yang X, Li F, Yang Y, Shen J, Zou R, Zhu P, Zhang C, Yang Z and Li P: Efficacy and safety of echinacoside in a rat osteopenia model. Evid Based Complement Alternat Med. 2013(926928)2013.PubMed/NCBI View Article : Google Scholar

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

20 

Yao L, Gui M, Li J, Lu B, Wang J, Zhou X and Fu D: Shengxian decoction decreases doxorubicin-induced cardiac apoptosis by regulating the TREM1/NF-κB signaling pathway. Mol Med Rep. 23(219)2021.PubMed/NCBI View Article : Google Scholar

21 

Chen H, Wang L, Liu J, Wan Z, Zhou L, Liao H and Wan R: LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis. Cancer Biol Ther. 24(2223377)2023.PubMed/NCBI View Article : Google Scholar

22 

Yuan H, Xia P, Sun X, Ma J, Xu X, Fu C, Zhou H, Guan Y, Li Z, Zhao S, et al: Photothermal nanozymatic nanoparticles induce ferroptosis and apoptosis through tumor microenvironment manipulation for cancer therapy. Small. 18(e2202161)2022.PubMed/NCBI View Article : Google Scholar

23 

Aurigemma GP, Gottdiener JS, Shemanski L, Gardin J and Kitzman D: Predictive value of systolic and diastolic function for incident congestive heart failure in the elderly: The cardiovascular health study. J Am Coll Cardiol. 37:1042–1048. 2001.PubMed/NCBI View Article : Google Scholar

24 

Bonsu KO, Owusu IK, Buabeng KO, Reidpath DD and Kadirvelu A: Review of novel therapeutic targets for improving heart failure treatment based on experimental and clinical studies. Ther Clin Risk Manag. 12:887–906. 2016.PubMed/NCBI View Article : Google Scholar

25 

Ni Y, Zhang J, Zhu W, Duan Y, Bai H and Luan C: Echinacoside inhibited cardiomyocyte pyroptosis and improved heart function of HF rats induced by isoproterenol via suppressing NADPH/ROS/ER stress. J Cell Mol Med. 26:5414–5425. 2022.PubMed/NCBI View Article : Google Scholar

26 

Landmesser U, Spiekermann S, Dikalov S, Tatge H, Wilke R, Kohler C, Harrison DG, Hornig B and Drexler H: Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: Role of xanthine-oxidase and extracellular superoxide dismutase. Circulation. 106:3073–3078. 2002.PubMed/NCBI View Article : Google Scholar

27 

Xiang XY, Yang XC, Su J, Kang JS, Wu Y, Xue YN, Dong YT and Sun LK: Inhibition of autophagic flux by ROS promotes apoptosis during DTT-induced ER/oxidative stress in HeLa cells. Oncol Rep. 35:3471–3479. 2016.PubMed/NCBI View Article : Google Scholar

28 

Ergüç A, Karakuş F, Arzuk E, Mutlu N and Orhan H: Role of oxidative stress and reactive metabolites in cytotoxicity & mitotoxicity of clozapine, diclofenac and nifedipine in CHO-K1 cells in vitro. Endocr Metab Immune Disord Drug Targets: Apr 19, 2023 (Epub ahead of print).

29 

Granieri MC, Rocca C, De Bartolo A, Nettore IC, Rago V, Romeo N, Ceramella J, Mariconda A, Macchia PE, Ungaro P, et al: Quercetin and its derivative counteract palmitate-dependent lipotoxicity by inhibiting oxidative stress and inflammation in cardiomyocytes. Int J Environ Res Public Health. 20(3492)2023.PubMed/NCBI View Article : Google Scholar

30 

Turk R, Juretić D, Geres D, Svetina A, Turk N and Flegar-Mestrić Z: Influence of oxidative stress and metabolic adaptation on PON1 activity and MDA level in transition dairy cows. Anim Reprod Sci. 108:98–106. 2008.PubMed/NCBI View Article : Google Scholar

31 

Ichihara S, Yamada Y, Kawai Y, Osawa T, Furuhashi K, Duan Z and Ichihara G: Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity. Biochem Biophys Res Commun. 359:27–33. 2007.PubMed/NCBI View Article : Google Scholar

32 

Birari L, Wagh S, Patil KR, Mahajan UB, Unger B, Belemkar S, Goyal SN, Ojha S and Patil CR: Aloin alleviates doxorubicin-induced cardiotoxicity in rats by abrogating oxidative stress and pro-inflammatory cytokines. Cancer Chemother Pharmacol. 86:419–426. 2020.PubMed/NCBI View Article : Google Scholar

33 

Gaggin HK and Januzzi JL Jr: Biomarkers and diagnostics in heart failure. Biochim Biophys Acta. 1832:2442–2450. 2013.PubMed/NCBI View Article : Google Scholar

34 

Salah K, Stienen S, Pinto YM, Eurlings LW, Metra M, Bayes-Genis A, Verdiani V, Tijssen JGP and Kok WE: Prognosis and NT-proBNP in heart failure patients with preserved versus reduced ejection fraction. Heart. 105:1182–1189. 2019.PubMed/NCBI View Article : Google Scholar

35 

Liu B, Zhao C, Li H, Chen X, Ding Y and Xu S: Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis. Biochem Biophys Res Commun. 497:233–240. 2018.PubMed/NCBI View Article : Google Scholar

36 

Conrad M and Proneth B: Broken hearts: Iron overload, ferroptosis and cardiomyopathy. Cell Res. 29:263–264. 2019.PubMed/NCBI View Article : Google Scholar

37 

Fang X, Cai Z, Wang H, Han D, Cheng Q, Zhang P, Gao F, Yu Y, Song Z, Wu Q, et al: Loss of cardiac ferritin H facilitates cardiomyopathy via Slc7a11-mediated ferroptosis. Circ Res. 127:486–501. 2020.PubMed/NCBI View Article : Google Scholar

38 

Fang X, Wang H, Han D, Xie E, Yang X, Wei J, Gu S, Gao F, Zhu N, Yin X, et al: Ferroptosis as a target for protection against cardiomyopathy. Proc Natl Acad Sci USA. 116:2672–2680. 2019.PubMed/NCBI View Article : Google Scholar

39 

Miess H, Dankworth B, Gouw AM, Rosenfeldt M, Schmitz W, Jiang M, Saunders B, Howell M, Downward J, Felsher DW, et al: The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene. 37:5435–5450. 2018.PubMed/NCBI View Article : Google Scholar

40 

Wu T, Liang X, Liu X, Li Y, Wang Y, Kong L and Tang M: Induction of ferroptosis in response to graphene quantum dots through mitochondrial oxidative stress in microglia. Part Fibre Toxicol. 17(30)2020.PubMed/NCBI View Article : Google Scholar

41 

Paterek A, Mackiewicz U and Mączewski M: Iron and the heart: A paradigm shift from systemic to cardiomyocyte abnormalities. J Cell Physiol. 234:21613–21629. 2019.PubMed/NCBI View Article : Google Scholar

42 

Cheng CF and Lian WS: Prooxidant mechanisms in iron overload cardiomyopathy. Biomed Res Int. 2013(740573)2013.PubMed/NCBI View Article : Google Scholar

43 

Chen L, Yin Z, Qin X, Zhu X, Chen X, Ding G, Sun D, Wu NN, Fei J, Bi Y, et al: CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis. Pharmacol Res. 176:2022.PubMed/NCBI View Article : Google Scholar

44 

Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, et al: Regulation of ferroptotic cancer cell death by GPX4. Cell. 156:317–331. 2014.PubMed/NCBI View Article : Google Scholar

45 

Wu J, Minikes AM, Gao M, Bian H, Li Y, Stockwell BR, Chen ZN and Jiang X: Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling. Nature. 572:402–406. 2019.PubMed/NCBI View Article : Google Scholar

46 

Ren J, Privratsky JR, Yang X, Dong F and Carlson EC: Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts. Crit Care Med. 36:2106–2116. 2008.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ma Y, Yang X, Jiang N, Lu C, Zhang J and Zhuang S: Echinacoside ameliorates doxorubicin‑induced cardiac injury by regulating GPX4 inhibition‑induced ferroptosis. Exp Ther Med 27: 29, 2024.
APA
Ma, Y., Yang, X., Jiang, N., Lu, C., Zhang, J., & Zhuang, S. (2024). Echinacoside ameliorates doxorubicin‑induced cardiac injury by regulating GPX4 inhibition‑induced ferroptosis. Experimental and Therapeutic Medicine, 27, 29. https://doi.org/10.3892/etm.2023.12317
MLA
Ma, Y., Yang, X., Jiang, N., Lu, C., Zhang, J., Zhuang, S."Echinacoside ameliorates doxorubicin‑induced cardiac injury by regulating GPX4 inhibition‑induced ferroptosis". Experimental and Therapeutic Medicine 27.1 (2024): 29.
Chicago
Ma, Y., Yang, X., Jiang, N., Lu, C., Zhang, J., Zhuang, S."Echinacoside ameliorates doxorubicin‑induced cardiac injury by regulating GPX4 inhibition‑induced ferroptosis". Experimental and Therapeutic Medicine 27, no. 1 (2024): 29. https://doi.org/10.3892/etm.2023.12317
Copy and paste a formatted citation
x
Spandidos Publications style
Ma Y, Yang X, Jiang N, Lu C, Zhang J and Zhuang S: Echinacoside ameliorates doxorubicin‑induced cardiac injury by regulating GPX4 inhibition‑induced ferroptosis. Exp Ther Med 27: 29, 2024.
APA
Ma, Y., Yang, X., Jiang, N., Lu, C., Zhang, J., & Zhuang, S. (2024). Echinacoside ameliorates doxorubicin‑induced cardiac injury by regulating GPX4 inhibition‑induced ferroptosis. Experimental and Therapeutic Medicine, 27, 29. https://doi.org/10.3892/etm.2023.12317
MLA
Ma, Y., Yang, X., Jiang, N., Lu, C., Zhang, J., Zhuang, S."Echinacoside ameliorates doxorubicin‑induced cardiac injury by regulating GPX4 inhibition‑induced ferroptosis". Experimental and Therapeutic Medicine 27.1 (2024): 29.
Chicago
Ma, Y., Yang, X., Jiang, N., Lu, C., Zhang, J., Zhuang, S."Echinacoside ameliorates doxorubicin‑induced cardiac injury by regulating GPX4 inhibition‑induced ferroptosis". Experimental and Therapeutic Medicine 27, no. 1 (2024): 29. https://doi.org/10.3892/etm.2023.12317
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team