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CKLF1, transcriptionally activated by FOXC1, promotes hypoxia/reoxygenation‑induced oxidative stress and inflammation in H9c2 cells by NLRP3 inflammasome activation

  • Authors:
    • Yinfeng Jia
    • Jiansheng Pan
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    Affiliations: Department of Cardiovascular Medicine, The Second People's Hospital of Yueqing, Wenzhou, Zhejiang 325608, P.R. China
    Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 59
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    Published online on: December 11, 2023
       https://doi.org/10.3892/etm.2023.12347
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Abstract

Myocardial ischemia/reperfusion (I/R) injury is a clinical challenge in the treatment of ischemic heart disease. The present study aimed to establish a hypoxia/reoxygenation (H/R)‑induced H9c2 cell model to explore the role and mechanism of chemokine‑like factor 1 (CKLF1) in myocardial I/R injury. First, CKLF1 expression was measured in H/R‑induced H9c2 cells by reverse transcription‑quantitative PCR and western blotting. Subsequently, after CKLF1 silencing, cell viability and apoptosis were evaluated by Cell Counting Kit‑8 assay and flow cytometry. In addition, 2,7‑dichlorodihydrofluorescein diacetate staining was used to assess the levels of cellular reactive oxygen species. Additionally, the levels of superoxide dismutase, glutathione peroxidase and malondialdehyde, and the contents of inflammatory factors IL‑6, IL‑1β and TNF‑α were detected using corresponding commercially available kits. Western blotting was used to examine the expression levels of proteins involved in the NOD‑like receptor family, pyrin domain containing 3 (NLRP3) inflammasome. The JASPAR database predicted that forkhead box protein C1 (FOXC1) would bind to the CKLF1 promoter region, and dual luciferase and chromatin immunoprecipitation assays were performed to verify it. Subsequently, FOXC1 overexpression and CKLF1 silencing were used to clarify the regulatory mechanism of FOXC1 on CKLF1 in H/R‑induced H9c2 cells. The results revealed that CKLF1 expression was markedly enhanced in H/R‑stimulated H9c2 cells. CKLF1 knockdown enhanced the viability and inhibited the apoptosis of H9c2 cells exposed to H/R. Moreover, the oxidative stress and inflammation induced by H/R were alleviated following CKLF1 silencing. CKLF1 knockdown also inhibited NLRP3 inflammasome activation. Furthermore, FOXC1 bound to the CKLF1 promoter region to upregulate CKLF1 expression, and FOXC1 overexpression alleviated the effects of CKLF1 knockdown on H9c2 cell damage induced by H/R via activation of the NLRP3 inflammasome. In conclusion, CKLF1 transcriptionally activated by FOXC1 may promote H/R‑induced oxidative stress and inflammation in H9c2 cells via NLRP3 inflammasome activation.
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1 

Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R, et al: Heart disease and stroke statistics-2018 Update: A report from the american heart association. Circulation. 137:e67–e492. 2018.PubMed/NCBI View Article : Google Scholar

2 

Jennings RB: Historical perspective on the pathology of myocardial ischemia/reperfusion injury. Circ Res. 113:428–438. 2013.PubMed/NCBI View Article : Google Scholar

3 

Gonzalez-Montero J, Brito R, Gajardo AI and Rodrigo R: Myocardial reperfusion injury and oxidative stress: Therapeutic opportunities. World J Cardiol. 10:74–86. 2018.PubMed/NCBI View Article : Google Scholar

4 

Kalogeris T, Baines CP, Krenz M and Korthuis RJ: Ischemia/Reperfusion. Compr Physiol. 7:113–170. 2016.PubMed/NCBI View Article : Google Scholar

5 

Mokhtari-Zaer A, Marefati N, Atkin SL, Butler AE and Sahebkar A: The protective role of curcumin in myocardial ischemia-reperfusion injury. J Cell Physiol. 234:214–222. 2018.PubMed/NCBI View Article : Google Scholar

6 

Han W, Lou Y, Tang J, Zhang Y, Chen Y, Li Y, Gu W, Huang J, Gui L, Tang Y, et al: Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity. Biochem J. 357:127–135. 2001.PubMed/NCBI View Article : Google Scholar

7 

Tan Y, Wang Y, Li L, Xia J, Peng S and He Y: Chemokine-like factor 1-derived C-terminal peptides induce the proliferation of dermal microvascular endothelial cells in psoriasis. PLoS One. 10(e0125073)2015.PubMed/NCBI View Article : Google Scholar

8 

Zhang T, Zhang X, Yu W, Chen J, Li Q, Jiao Y, He P and Shen C: Effects of chemokine-like factor 1 on vascular smooth muscle cell migration and proliferation in vascular inflammation. Atherosclerosis. 226:49–57. 2013.PubMed/NCBI View Article : Google Scholar

9 

Chen C, Chu SF, Ai QD, Zhang Z, Guan FF, Wang SS, Dong YX, Zhu J, Jian WX and Chen NH: CKLF1 aggravates focal cerebral ischemia injury at early stage partly by modulating Microglia/Macrophage toward M1 polarization through CCR4. Cell Mol Neurobiol. 39:651–669. 2019.PubMed/NCBI View Article : Google Scholar

10 

Kong LL, Wang ZY, Hu JF, Yuan YH, Han N, Li H and Chen NH: Inhibition of chemokine-like factor 1 protects against focal cerebral ischemia through the promotion of energy metabolism and anti-apoptotic effect. Neurochem Int. 76:91–98. 2014.PubMed/NCBI View Article : Google Scholar

11 

Ai QD, Chen C, Chu S, Zhang Z, Luo Y, Guan F, Lin M, Liu D, Wang S and Chen N: IMM-H004 therapy for permanent focal ischemic cerebral injury via CKLF1/CCR4-mediated NLRP3 inflammasome activation. Transl Res. 212:36–53. 2019.PubMed/NCBI View Article : Google Scholar

12 

Li FF, Zhou X, Chu SF and Chen NH: Inhibition of CKLF1 ameliorates hepatic ischemia-reperfusion injury via MAPK pathway. Cytokine. 141(155429)2021.PubMed/NCBI View Article : Google Scholar

13 

Yang B, Hong T, Liu QZ, Feng XR, Gong YJ, Bu DF, Li XM, Xue L, Zhao CY and Huo Y: Effects of in vivo transfer of human chemokine-like factor 1 gene on cardiac function after acute myocardial infarction in rats. Beijing Da Xue Xue Bao Yi Xue Ban. 41:144–147. 2009.PubMed/NCBI(In Chinese).

14 

Feng XR, Hong T, Gong YJ, Bu DF, Yuan JY, Xue L, Zhao CY and Huo Y: In vivo transfer of human chemokine-like factor 1 gene increases peripheral blood CD34+ stem cells after myocardial infarction in rats. Beijing Da Xue Xue Bao Yi Xue Ban. 38:592–596. 2006.PubMed/NCBI(In Chinese).

15 

Lin YJ, Shyu WC, Chang CW, Wang CC, Wu CP, Lee HT, Chen LJ and Hsieh CH: Tumor hypoxia regulates forkhead box C1 to promote lung cancer progression. Theranostics. 7:1177–1191. 2017.PubMed/NCBI View Article : Google Scholar

16 

Zhang SP, Yang RH, Shang J, Gao T, Wang R, Peng XD, Miao X, Pan L, Yuan WJ, Lin L and Hu QK: FOXC1 up-regulates the expression of toll-like receptors in myocardial ischaemia. J Cell Mol Med. 23:7566–7580. 2019.PubMed/NCBI View Article : Google Scholar

17 

Zhao B, Li GP, Peng JJ, Ren LH, Lei LC, Ye HM, Wang ZY and Zhao S: Schizandrin B attenuates hypoxia/reoxygenation injury in H9c2 cells by activating the AMPK/Nrf2 signaling pathway. Exp Ther Med. 21(220)2021.PubMed/NCBI View Article : Google Scholar

18 

Xu J, Huang J, He X, Hu M, Su S and Liu P: Myosin 1b Participated in the Modulation of Hypoxia/Reoxygenation-Caused H9c2 Cell Apoptosis and Autophagy. Anal Cell Pathol (Amst). 2022(5187304)2022.PubMed/NCBI View Article : Google Scholar

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

20 

Del Re DP, Amgalan D, Linkermann A, Liu Q and Kitsis RN: Fundamental mechanisms of regulated cell death and implications for heart disease. Physiol Rev. 99:1765–1817. 2019.PubMed/NCBI View Article : Google Scholar

21 

Badalzadeh R, Mokhtari B and Yavari R: Contribution of apoptosis in myocardial reperfusion injury and loss of cardioprotection in diabetes mellitus. J Physiol Sci. 65:201–215. 2015.PubMed/NCBI View Article : Google Scholar

22 

Zhang Q, Dang YY, Luo X, Fu JJ, Zou ZC, Jia XJ, Zheng GD and Li CW: Kazinol B protects H9c2 cardiomyocytes from hypoxia/reoxygenation-induced cardiac injury by modulating the AKT/AMPK/Nrf2 signalling pathway. Pharm Biol. 61:362–371. 2023.PubMed/NCBI View Article : Google Scholar

23 

Zhang Y, Wang Y, Ma Z, Liang Q, Tang X, Tan H, Xiao C and Gao Y: Ginsenoside Rb1 inhibits Doxorubicin-Triggered H9C2 cell apoptosis via aryl hydrocarbon receptor. Biomol Ther (Seoul). 25:202–212. 2017.PubMed/NCBI View Article : Google Scholar

24 

Chen C, Ai Q and Wei Y: Hydroxytyrosol protects against cisplatin-induced nephrotoxicity via attenuating CKLF1 mediated inflammation, and inhibiting oxidative stress and apoptosis. Int Immunopharmacol. 96(107805)2021.PubMed/NCBI View Article : Google Scholar

25 

Chen YE, Yang H, Pang HB and Shang FQ: Circ-CBFB exacerbates hypoxia/reoxygenation-triggered cardiomyocyte injury via regulating miR-495-3p in a VDAC1-dependent manner. J Biochem Mol Toxicol. 36(e23189)2022.PubMed/NCBI View Article : Google Scholar

26 

Yang H, Wang C, Zhang L, Lv J and Ni H: Rutin alleviates hypoxia/reoxygenation-induced injury in myocardial cells by up-regulating SIRT1 expression. Chem Biol Interact. 297:44–49. 2019.PubMed/NCBI View Article : Google Scholar

27 

Radak Z, Zhao Z, Goto S and Koltai E: Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA. Mol Aspects Med. 32:305–315. 2011.PubMed/NCBI View Article : Google Scholar

28 

Cadenas S: ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection. Free Radic Biol Med. 117:76–89. 2018.PubMed/NCBI View Article : Google Scholar

29 

Zhao Q, Liu Z, Huang B, Yuan Y, Liu X, Zhang H, Qiu F, Zhang Y, Li Y, Miao H, et al: PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF-R. Int J Mol Med. 41:3243–3252. 2018.PubMed/NCBI View Article : Google Scholar

30 

Zhou T, Chuang CC and Zuo L: Molecular characterization of reactive oxygen species in myocardial Ischemia-Reperfusion Injury. Biomed Res Int. 2015(864946)2015.PubMed/NCBI View Article : Google Scholar

31 

Algoet M, Janssens S, Himmelreich U, Gsell W, Pusovnik M, Van den Eynde J and Oosterlinck W: Myocardial ischemia-reperfusion injury and the influence of inflammation. Trends Cardiovasc Med. 33:357–366. 2023.PubMed/NCBI View Article : Google Scholar

32 

Ai Q, Chen C, Chu S, Luo Y, Zhang Z, Zhang S, Yang P, Gao Y, Zhang X and Chen N: IMM-H004 protects against cerebral ischemia injury and cardiopulmonary complications via CKLF1 mediated inflammation pathway in adult and aged rats. Int J Mol Sci. 20(1661)2019.PubMed/NCBI View Article : Google Scholar

33 

Lambers E, Arnone B, Fatima A, Qin G, Wasserstrom JA and Kume T: Foxc1 regulates early cardiomyogenesis and functional properties of embryonic stem cell derived cardiomyocytes. Stem Cells. 34:1487–1500. 2016.PubMed/NCBI View Article : Google Scholar

34 

Chen HY, Xiao ZZ, Ling X, Xu RN, Zhu P and Zheng SY: ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy. Mol Med. 27(14)2021.PubMed/NCBI View Article : Google Scholar

35 

He X and Deng L: miR-204-5p inhibits inflammation of synovial fibroblasts in osteoarthritis by suppressing FOXC1. J Orthop Sci. 27:921–928. 2022.PubMed/NCBI View Article : Google Scholar

36 

Oka S, Tsuzuki T, Hidaka M, Ohno M, Nakatsu Y and Sekiguchi M: Endogenous ROS production in early differentiation state suppresses endoderm differentiation via transient FOXC1 expression. Cell Death Discov. 8(150)2022.PubMed/NCBI View Article : Google Scholar

37 

Fouad AA, Abdel-Aziz AM and Hamouda AAH: Diacerein downregulates NLRP3/Caspase-1/IL-1beta and IL-6/STAT3 pathways of inflammation and apoptosis in a rat model of cadmium testicular toxicity. Biol Trace Elem Res. 195:499–505. 2020.PubMed/NCBI View Article : Google Scholar

38 

Bian Y, Li X, Pang P, Hu XL, Yu ST, Liu YN, Li X, Wang N, Wang JH, Xiao W, et al: Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis. Acta Pharmacol Sin. 41:319–326. 2020.PubMed/NCBI View Article : Google Scholar

39 

Shi H, Gao Y, Dong Z, Yang J, Gao R, Li X, Zhang S, Ma L, Sun X, Wang Z, et al: GSDMD-mediated cardiomyocyte pyroptosis promotes Myocardial I/R injury. Circ Res. 129:383–396. 2021.PubMed/NCBI View Article : Google Scholar

40 

Qiu Z, He Y, Ming H, Lei S, Leng Y and Xia ZY: Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated pyroptosis in H9C2 cardiomyocytes. J Diabetes Res. 2019(8151836)2019.PubMed/NCBI View Article : Google Scholar

41 

Toldo S and Abbate A: The NLRP3 inflammasome in acute myocardial infarction. Nat Rev Cardiol. 15:203–214. 2018.PubMed/NCBI View Article : Google Scholar

42 

Wang Y, Yan X, Mi S, Li Z, Wang Y, Zhu H, Sun X, Zhao B, Zhao C, Zou Y, et al: Naoxintong attenuates Ischaemia/reperfusion Injury through inhibiting NLRP3 inflammasome activation. J Cell Mol Med. 21:4–12. 2017.PubMed/NCBI View Article : Google Scholar

43 

Toldo S, Marchetti C, Mauro AG, Chojnacki J, Mezzaroma E, Carbone S, Zhang S, Van Tassell B, Salloum FN and Abbate A: Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia-reperfusion in the mouse. Int J Cardiol. 209:215–220. 2016.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Jia Y and Pan J: CKLF1, transcriptionally activated by FOXC1, promotes hypoxia/reoxygenation‑induced oxidative stress and inflammation in H9c2 cells by NLRP3 inflammasome activation. Exp Ther Med 27: 59, 2024.
APA
Jia, Y., & Pan, J. (2024). CKLF1, transcriptionally activated by FOXC1, promotes hypoxia/reoxygenation‑induced oxidative stress and inflammation in H9c2 cells by NLRP3 inflammasome activation. Experimental and Therapeutic Medicine, 27, 59. https://doi.org/10.3892/etm.2023.12347
MLA
Jia, Y., Pan, J."CKLF1, transcriptionally activated by FOXC1, promotes hypoxia/reoxygenation‑induced oxidative stress and inflammation in H9c2 cells by NLRP3 inflammasome activation". Experimental and Therapeutic Medicine 27.2 (2024): 59.
Chicago
Jia, Y., Pan, J."CKLF1, transcriptionally activated by FOXC1, promotes hypoxia/reoxygenation‑induced oxidative stress and inflammation in H9c2 cells by NLRP3 inflammasome activation". Experimental and Therapeutic Medicine 27, no. 2 (2024): 59. https://doi.org/10.3892/etm.2023.12347
Copy and paste a formatted citation
x
Spandidos Publications style
Jia Y and Pan J: CKLF1, transcriptionally activated by FOXC1, promotes hypoxia/reoxygenation‑induced oxidative stress and inflammation in H9c2 cells by NLRP3 inflammasome activation. Exp Ther Med 27: 59, 2024.
APA
Jia, Y., & Pan, J. (2024). CKLF1, transcriptionally activated by FOXC1, promotes hypoxia/reoxygenation‑induced oxidative stress and inflammation in H9c2 cells by NLRP3 inflammasome activation. Experimental and Therapeutic Medicine, 27, 59. https://doi.org/10.3892/etm.2023.12347
MLA
Jia, Y., Pan, J."CKLF1, transcriptionally activated by FOXC1, promotes hypoxia/reoxygenation‑induced oxidative stress and inflammation in H9c2 cells by NLRP3 inflammasome activation". Experimental and Therapeutic Medicine 27.2 (2024): 59.
Chicago
Jia, Y., Pan, J."CKLF1, transcriptionally activated by FOXC1, promotes hypoxia/reoxygenation‑induced oxidative stress and inflammation in H9c2 cells by NLRP3 inflammasome activation". Experimental and Therapeutic Medicine 27, no. 2 (2024): 59. https://doi.org/10.3892/etm.2023.12347
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