Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2024 Volume 27 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2024 Volume 27 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.xlsx
    • Supplementary_Data2.xlsx
    • Supplementary_Data3.pdf
    • Supplementary_Data4.xlsx
    • Supplementary_Data5.xlsx
    • Supplementary_Data6.xlsx
Article Open Access

Novel underlying genetic markers for asthenozoospermia due to abnormal spermatogenesis and reproductive organ inflammation

  • Authors:
    • Yaodong Zhang
    • Yun Peng
    • Yao Wang
    • Jian Xu
    • Hongli Yan
  • View Affiliations / Copyright

    Affiliations: Reproductive Medicine Center, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 146
    |
    Published online on: February 19, 2024
       https://doi.org/10.3892/etm.2024.12434
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Asthenozoospermia, a male fertility disorder, has a complex and multifactorial etiology. Moreover, the effectiveness of different treatments for asthenozoospermia remains uncertain. Hence, by using bioinformatics techniques, the present study aimed to determine the underlying genetic markers and pathogenetic mechanisms associated with asthenozoospermia due to abnormal spermatogenesis and inflammation of the reproductive tract. GSE160749 dataset was downloaded from the Gene Expression Omnibus database, and the data were filtered to obtain 1336 differentially expressed genes (DEGs) associated with asthenozoospermia. These DEGs were intersected with the epithelial mesenchymal transition datasets to yield 61 candidate DEGs. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed, and the results revealed that these candidate DEGs were significantly enriched in the enzyme‑linked receptor pathway and the thyroid hormone pathway. A protein‑protein interaction network was constructed to identify the key genes of asthenozoospermia. A total of five key genes were identified, among which SOX9 was significantly upregulated, while HSPA4, SMAD2, HIF1A and GSK3B were significantly downregulated. These findings were validated by conducting reverse transcription‑quantitative PCR for clinical semen samples. To determine the underlying molecular mechanisms, a regulatory network of transcription factors and miRNA‑mRNA interactions was predicted. The expression levels of HSPA4, SMAD2 and GSK3B were positively associated with several related etiological genes of asthenozoospermia. In total, five key genes were closely associated with the level and type of immune cells; higher levels of activated B cells and CD8 T cells were observed in asthenozoospermia. Thus, the findings of the present study may provide clues to determine the underlying novel diagnostic genetic markers and treatment strategies for asthenozoospermia.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Agarwal A, Baskaran S, Parekh N, Cho CL, Henkel R, Vij S, Arafa M, Panner Selvam MK and Shah R: Male infertility. Lancet. 397:319–333. 2021.PubMed/NCBI View Article : Google Scholar

2 

WHO-World Health Organization. WHO Laboratory Manual for the Examination and Processing of Human Semen (6th ed). In: Examination and post-examination procedures. WHO. 2021. https://apps.who.int/iris/rest/bitstreams/1358672/retrieve. Accessed 27 Jul, 2021.

3 

Mehra BL, Skandhan KP, Prasad BS, Pawankumar G, Singh G and Jaya V: Male infertility rate: A retrospective study. Urologia. 85:22–24. 2018.PubMed/NCBI View Article : Google Scholar

4 

Guzick DS, Overstreet JW, Factor-Litvak P, Brazil CK, Nakajima ST, Coutifaris C, Carson SA, Cisneros P, Steinkampf MP, Hill JA, et al: Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med. 345:1388–1393. 2001.PubMed/NCBI View Article : Google Scholar

5 

Cho CL, Esteves SC and Agarwal A: Novel insights into the pathophysiology of varicocele and its association with reactive oxygen species and sperm DNA fragmentation. Asian J Androl. 18:186–193. 2016.PubMed/NCBI View Article : Google Scholar

6 

Belet U, Danaci M, Sarikaya S, Odabaş F, Utaş C, Tokgöz B, Sezer T, Turgut T, Erdoğan N and Akpolat T: Prevalence of epididymal, seminal vesicle, prostate, and testicular cysts in autosomal dominant polycystic kidney disease. Urology. 60:138–141. 2002.PubMed/NCBI View Article : Google Scholar

7 

Li N, Wang T and Han D: Structural, cellular and molecular aspects of immune privilege in the testis. Front Immunol. 3(152)2012.PubMed/NCBI View Article : Google Scholar

8 

Touré A, Martinez G, Kherraf ZE, Cazin C, Beurois J, Arnoult C, Ray PF and Coutton C: The genetic architecture of morphological abnormalities of the sperm tail. Hum Genet. 140:21–42. 2021.PubMed/NCBI View Article : Google Scholar

9 

Condorelli RA, Russo GI, Calogero AE, Morgia G and La Vignera S: Chronic prostatitis and its detrimental impact on sperm parameters: A systematic review and meta-analysis. J Endocrinol Invest. 40:1209–1218. 2017.PubMed/NCBI View Article : Google Scholar

10 

Zhang J, Cai Z, Ma C, Xiong J and Li H: Impacts of outdoor air pollution on human semen quality: A meta-analysis and systematic review. Biomed Res Int. 2020(7528901)2020.PubMed/NCBI View Article : Google Scholar

11 

Rahman MS, Kwon WS, Lee JS, Yoon SJ, Ryu BY and Pang MG: Bisphenol-A affects male fertility via fertility-related proteins in spermatozoa. Sci Rep. 5(9169)2015.PubMed/NCBI View Article : Google Scholar

12 

Pant N, Kumar G, Upadhyay AD, Patel DK, Gupta YK and Chaturvedi PK: Reproductive toxicity of lead, cadmium, and phthalate exposure in men. Environ Sci Pollut Res Int. 21:11066–11074. 2014.PubMed/NCBI View Article : Google Scholar

13 

Aboulmaouahib S, Madkour A, Kaarouch I, Sefrioui O, Saadani B, Copin H, Benkhalifa M, Louanjli N and Cadi R: Impact of alcohol and cigarette smoking consumption in male fertility potential: Looks at lipid peroxidation, enzymatic antioxidant activities and sperm DNA damage. Andrologia: Nov 21, 2018 (Epub ahead of print).

14 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43(e47)2015.PubMed/NCBI View Article : Google Scholar

15 

Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, Feng T, Zhou L, Tang W, Zhan L, et al: clusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innovation (Camb). 2(100141)2021.PubMed/NCBI View Article : Google Scholar

16 

Aibar S, Hulselmans G and Aerts S: RcisTarget: Identify transcription factor binding motifs enriched on a gene list. Laboratory of Computational Biology; VIB-KU Leuven Center for Brain & Disease Research. 2016. Available from: https://bioconductor.org/packages/3.12/bioc/html/RcisTarget.html.

17 

Goodrich R, Johnson G and Krawetz SA: The preparation of human spermatozoal RNA for clinical analysis. Arch Androl. 53:161–167. 2007.PubMed/NCBI View Article : Google Scholar

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

19 

Krausz C and Riera-Escamilla A: Genetics of male infertility. Nat Rev Urol. 15:369–384. 2018.PubMed/NCBI View Article : Google Scholar

20 

Cunha GR, Cao M, Aksel S, Derpinghaus A and Baskin LS: Mouse-human species differences in early testicular development and its implications. Differentiation. 129:79–95. 2023.PubMed/NCBI View Article : Google Scholar

21 

Klein B, Pant S, Bhushan S, Kautz J, Rudat C, Kispert A, Pilatz A, Wijayarathna R, Middendorff R, Loveland KL, et al: Dexamethasone improves therapeutic outcomes in a preclinical bacterial epididymitis mouse model. Hum Reprod. 34:1195–1205. 2019.PubMed/NCBI View Article : Google Scholar

22 

Chen Y, Sun T, Liu K, Yuan P and Liu C: Exploration of the common genetic landscape of COVID-19 and male infertility. Front Immunol. 14(1123913)2023.PubMed/NCBI View Article : Google Scholar

23 

Major AT, Estermann MA and Smith CA: Anatomy, endocrine regulation, and embryonic development of the rete testis. Endocrinology. 162(bqab046)2021.PubMed/NCBI View Article : Google Scholar

24 

Jedidi I, Ouchari M and Yin Q: Autosomal single-gene disorders involved in human infertility. Saudi J Biol Sci. 25:881–887. 2018.PubMed/NCBI View Article : Google Scholar

25 

Ferlin A, Speltra E, Patassini C, Pati MA, Garolla A, Caretta N and Foresta C: Heat shock protein and heat shock factor expression in sperm: relation to oligozoospermia and varicocele. J Urol. 183:1248–1252. 2010.PubMed/NCBI View Article : Google Scholar

26 

Held T, Barakat AZ, Mohamed BA, Paprotta I, Meinhardt A, Engel W and Adham IM: Heat-shock protein HSPA4 is required for progression of spermatogenesis. Reproduction. 142:133–144. 2011.PubMed/NCBI View Article : Google Scholar

27 

Xu J, Beyer AR, Walker WH and McGee EA: Developmental and stage-specific expression of Smad2 and Smad3 in rat testis. J Androl. 24:192–200. 2003.PubMed/NCBI View Article : Google Scholar

28 

Takahashi N, Davy PM, Gardner LH, Mathews J, Yamazaki Y and Allsopp RC: Hypoxia inducible factor 1 alpha is expressed in germ cells throughout the murine life cycle. PLoS One. 11(e0154309)2016.PubMed/NCBI View Article : Google Scholar

29 

Gorga A, Rindone G, Regueira M, Riera MF, Pellizzari EH, Cigorraga SB, Meroni SB and Galardo MN: HIF involvement in the regulation of rat Sertoli cell proliferation by FSH. Biochem Biophys Res Commun. 502:508–514. 2018.PubMed/NCBI View Article : Google Scholar

30 

Ghandehari-Alavijeh R, Zohrabi D, Tavalaee M and Nasr-Esfahani MH: Association between expression of TNF-α, P53 and HIF1α with asthenozoospermia. Hum Fertil (Camb). 22:145–151. 2019.PubMed/NCBI View Article : Google Scholar

31 

Freitas MJ, Silva JV, Brothag C, Regadas-Correia B, Fardilha M and Vijayaraghavan S: Isoform-specific GSK3A activity is negatively correlated with human sperm motility. Mol Hum Reprod. 25:171–183. 2019.PubMed/NCBI View Article : Google Scholar

32 

Bhattacharjee R, Goswami S, Dudiki T, Popkie AP, Phiel CJ, Kline D and Vijayaraghavan S: Targeted disruption of glycogen synthase kinase 3A (GSK3A) in mice affects sperm motility resulting in male infertility. Biol Reprod. 92(65)2015.PubMed/NCBI View Article : Google Scholar

33 

La Vignera S and Vita R: Thyroid dysfunction and semen quality. Int J Immunopathol Pharmacol. 32(2058738418775241)2018.PubMed/NCBI View Article : Google Scholar

34 

Condorelli RA, La Vignera S, Mongioì LM, Alamo A, Giacone F, Cannarella R and Calogero AE: Thyroid hormones and spermatozoa: In VitroEffects on Sperm mitochondria, viability and DNA Integrity. J Clin Med. 8(756)2019.PubMed/NCBI View Article : Google Scholar

35 

Zhao S, Tang L, Fu J, Yang Z, Su C and Rao M: Subclinical Hypothyroidism and Sperm DNA Fragmentation: A Cross-sectional Study of 5401 men seeking infertility care. J Clin Endocrinol Metab. 107:e4027–e4036. 2022.PubMed/NCBI View Article : Google Scholar

36 

Silver-Morse L and Li WX: The role of receptor tyrosine kinases in primordial germ cell migration. Methods Mol Biol. 750:291–306. 2011.PubMed/NCBI View Article : Google Scholar

37 

Ni FD, Hao SL and Yang WX: Multiple signaling pathways in Sertoli cells: Recent findings in spermatogenesis. Cell Death Dis. 10(541)2019.PubMed/NCBI View Article : Google Scholar

38 

Liang G and Wang Q, Zhang G, Li Z and Wang Q: Differentially expressed miRNAs and potential therapeutic targets for asthenospermia. Andrologia. 54(e14265)2022.PubMed/NCBI View Article : Google Scholar

39 

Parte PP, Rao P, Redij S, Lobo V, D'Souza SJ, Gajbhiye R and Kulkarni V: Sperm phosphoproteome profiling by ultra performance liquid chromatography followed by data independent analysis (LC-MS(E)) reveals altered proteomic signatures in asthenozoospermia. J Proteomics. 75:5861–5871. 2012.PubMed/NCBI View Article : Google Scholar

40 

Demyashkin GA: Inhibin B in seminiferous tubules of human testes in normal spermatogenesis and in idiopathic infertility. Syst Biol Reprod Med. 65:20–28. 2019.PubMed/NCBI View Article : Google Scholar

41 

Li J, Zhang L and Li B: Correlative study on the JAK-STAT/PSMβ3 signal transduction pathway in asthenozoospermia. Exp Ther Med. 13:127–130. 2017.PubMed/NCBI View Article : Google Scholar

42 

Chen L, Wen CW, Deng MJ, Ping-Li Zhang ZD, Zhou ZH and Wang X: Metabolic and transcriptional changes in seminal plasma of asthenozoospermia patients. Biomed Chromatogr. 34(e4769)2020.PubMed/NCBI View Article : Google Scholar

43 

Zhu S, Huang J, Xu R, Wang Y, Wan Y, McNeel R, Parker E, Kolson D, Yam M, Webb B, et al: Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal viability. J Biol Chem. 298(102387)2022.PubMed/NCBI View Article : Google Scholar

44 

Kang W, Harada Y, Yamatoya K, Kawano N, Kanai S, Miyamoto Y, Nakamura A, Miyado M, Hayashi Y, Kuroki Y, et al: Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction. Lab Invest. 100:583–595. 2020.PubMed/NCBI View Article : Google Scholar

45 

Eslamian G, Amirjannati N, Rashidkhani B, Sadeghi MR, Baghestani AR and Hekmatdoost A: Dietary fatty acid intakes and asthenozoospermia: A case-control study. Fertil Steril. 103:190–198. 2015.PubMed/NCBI View Article : Google Scholar

46 

Salas-Huetos A, Moraleda R, Giardina S, Anton E, Blanco J, Salas-Salvadó J and Bulló M: Effect of nut consumption on semen quality and functionality in healthy men consuming a Western-style diet: A randomized controlled trial. Am J Clin Nutr. 108:953–962. 2018.PubMed/NCBI View Article : Google Scholar

47 

Qi X, Shang M, Chen C, Chen Y, Hua J, Sheng X, Wang X, Xing K, Ni H and Guo Y: Dietary supplementation with linseed oil improves semen quality, reproductive hormone, gene and protein expression related to testosterone synthesis in aging layer breeder roosters. Theriogenology. 131:9–15. 2019.PubMed/NCBI View Article : Google Scholar

48 

Gianzo M and Subirán N: Regulation of male fertility by the renin-angiotensin system. Int J Mol Sci. 21(7943)2020.PubMed/NCBI View Article : Google Scholar

49 

Ma P, Zhang Z, Zhou X, Luo J, Lu H and Wang Y: Characterizing semen abnormality male infertility using non-targeted blood plasma metabolomics. PLoS One. 14(e0219179)2019.PubMed/NCBI View Article : Google Scholar

50 

Malik IA, Durairajanayagam D and Singh HJ: Leptin and its actions on reproduction in males. Asian J Androl. 21:296–299. 2019.PubMed/NCBI View Article : Google Scholar

51 

Haron MN, D'Souza UJ, Jaafar H, Zakaria R and Singh HJ: Exogenous leptin administration decreases sperm count and increases the fraction of abnormal sperm in adult rats. Fertil Steril. 93:322–324. 2010.PubMed/NCBI View Article : Google Scholar

52 

Barbagallo F, Condorelli RA, Mongioì LM, Cannarella R, Cimino L, Magagnini MC, Crafa A, La Vignera S and Calogero AE: Molecular mechanisms underlying the relationship between obesity and male infertility. Metabolites. 11(840)2021.PubMed/NCBI View Article : Google Scholar

53 

Leisegang K, Sengupta P, Agarwal A and Henkel R: Obesity and male infertility: Mechanisms and management. Andrologia. 53(e13617)2021.PubMed/NCBI View Article : Google Scholar

54 

Wang H, Lv Y, Hu K, Feng T, Jin Y, Wang Y, Huang Y and Chen B: Seminal plasma leptin and spermatozoon apoptosis in patients with varicocele and leucocytospermia. Andrologia. 47:655–661. 2015.PubMed/NCBI View Article : Google Scholar

55 

Martin LJ: Implications of adiponectin in linking metabolism to testicular function. Endocrine. 46:16–28. 2014.PubMed/NCBI View Article : Google Scholar

56 

Choubey M, Ranjan A, Bora PS, Baltazar F, Martin LJ and Krishna A: Role of adiponectin as a modulator of testicular function during aging in mice. Biochim Biophys Acta Mol Basis Dis. 1865:413–427. 2019.PubMed/NCBI View Article : Google Scholar

57 

Zhang HZ, Hao SL and Yang WX: How does retinoic acid (RA) signaling pathway regulate spermatogenesis? Histol Histopathol. 37:1053–1064. 2022.PubMed/NCBI View Article : Google Scholar

58 

Hernández-Silva G, Caballero-Campo P and Chirinos M: Sperm mRNAs as potential markers of male fertility. Reprod Biol. 22(100636)2022.PubMed/NCBI View Article : Google Scholar

59 

Corral-Vazquez C, Salas-Huetos A, Blanco J, Vidal F, Sarrate Z and Anton E: Sperm microRNA pairs: New perspectives in the search for male fertility biomarkers. Fertil Steril. 112:831–841. 2019.PubMed/NCBI View Article : Google Scholar

60 

Courey-Ghaouzi AD, Kleberg L and Sundling C: Alternative B cell differentiation during infection and inflammation. Front Immunol. 13(908034)2022.PubMed/NCBI View Article : Google Scholar

61 

Tohyama Y, Takano T and Yamamura H: B cell responses to oxidative stress. Curr Pharm Des. 10:835–839. 2004.PubMed/NCBI View Article : Google Scholar

62 

Yu W, Li C, Zhang D, Li Z, Xia P, Liu X, Cai X, Yang P, Ling J, Zhang J, et al: Advances in T cells based on inflammation in metabolic diseases. Cells. 11(3554)2022.PubMed/NCBI View Article : Google Scholar

63 

Seshadri S, Flanagan B, Vince G and Lewis-Jones DJ: Detection of subpopulations of leucocytes in different subgroups of semen sample qualities. Andrologia. 44 (Suppl 1):S354–S361. 2012.PubMed/NCBI View Article : Google Scholar

64 

Chu DS and Shakes DC: Spermatogenesis. Adv Exp Med Biol. 757:171–203. 2013.PubMed/NCBI View Article : Google Scholar

65 

Coutton C, Vargas AS, Amiri-Yekta A, Kherraf ZE, Ben Mustapha SF, Le Tanno P, Wambergue-Legrand C, Karaouzène T, Martinez G, Crouzy S, et al: Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human. Nat Commun. 9(686)2018.PubMed/NCBI View Article : Google Scholar

66 

Ben Khelifa M, Coutton C, Zouari R, Karaouzène T, Rendu J, Bidart M, Yassine S, Pierre V, Delaroche J, Hennebicq S, et al: Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella. Am J Hum Genet. 94:95–104. 2014.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Peng Y, Wang Y, Xu J and Yan H: Novel underlying genetic markers for asthenozoospermia due to abnormal spermatogenesis and reproductive organ inflammation. Exp Ther Med 27: 146, 2024.
APA
Zhang, Y., Peng, Y., Wang, Y., Xu, J., & Yan, H. (2024). Novel underlying genetic markers for asthenozoospermia due to abnormal spermatogenesis and reproductive organ inflammation. Experimental and Therapeutic Medicine, 27, 146. https://doi.org/10.3892/etm.2024.12434
MLA
Zhang, Y., Peng, Y., Wang, Y., Xu, J., Yan, H."Novel underlying genetic markers for asthenozoospermia due to abnormal spermatogenesis and reproductive organ inflammation". Experimental and Therapeutic Medicine 27.4 (2024): 146.
Chicago
Zhang, Y., Peng, Y., Wang, Y., Xu, J., Yan, H."Novel underlying genetic markers for asthenozoospermia due to abnormal spermatogenesis and reproductive organ inflammation". Experimental and Therapeutic Medicine 27, no. 4 (2024): 146. https://doi.org/10.3892/etm.2024.12434
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Peng Y, Wang Y, Xu J and Yan H: Novel underlying genetic markers for asthenozoospermia due to abnormal spermatogenesis and reproductive organ inflammation. Exp Ther Med 27: 146, 2024.
APA
Zhang, Y., Peng, Y., Wang, Y., Xu, J., & Yan, H. (2024). Novel underlying genetic markers for asthenozoospermia due to abnormal spermatogenesis and reproductive organ inflammation. Experimental and Therapeutic Medicine, 27, 146. https://doi.org/10.3892/etm.2024.12434
MLA
Zhang, Y., Peng, Y., Wang, Y., Xu, J., Yan, H."Novel underlying genetic markers for asthenozoospermia due to abnormal spermatogenesis and reproductive organ inflammation". Experimental and Therapeutic Medicine 27.4 (2024): 146.
Chicago
Zhang, Y., Peng, Y., Wang, Y., Xu, J., Yan, H."Novel underlying genetic markers for asthenozoospermia due to abnormal spermatogenesis and reproductive organ inflammation". Experimental and Therapeutic Medicine 27, no. 4 (2024): 146. https://doi.org/10.3892/etm.2024.12434
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team