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Cancer‑associated fibroblasts under therapy‑induced senescence in the tumor microenvironment (Review)

  • Authors:
    • Qiuhua Zhang
    • Yijie Lou
    • Hao Fang
    • Shaopeng Sun
    • Rijuan Jin
    • Yunxi Ji
    • Zhe Chen
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China, Department of General Practice, First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang 310003, P.R. China, Key Laboratory of Digestive Pathophysiology of Zhejiang Province, Institute of Cancer Research, First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang 310003, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 150
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    Published online on: February 20, 2024
       https://doi.org/10.3892/etm.2024.12438
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Abstract

Current cancer treatments target tumor cells; however, the tumor microenvironment (TME) induces therapeutic resistance, tumor development and metastasis, thus rendering these treatments ineffective. Research on the TME has therefore concentrated on nonmalignant cells. Cancer‑associated fibroblasts (CAFs) are a major TME component, which contribute to cancer progression due to their diverse origins, phenotypes and functions, including cancer cell invasion and migration, extracellular matrix remodeling, tumor metabolism modulation and therapeutic resistance. Standard cancer treatment typically exacerbates the senescence‑associated secretory phenotype (SASP) of senescent cancer cells and nonmalignant cells that actively leak proinflammatory signals in the TME. Therapy‑induced senescence may impair cancer cell activity and compromise treatment responsiveness. CAFs and SASP are well‑studied in the formation and progression of cancer. The present review discusses the current data on CAF senescence caused by anticancer treatment and assesses how senescence‑like CAFs affect tumor formation. The development of senolytic medication for aging stromal cells is also highlighted. Combining cancer therapies with senolytics may boost therapeutic effects and provide novel possibilities for research.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Lou Y, Fang H, Sun S, Jin R, Ji Y and Chen Z: Cancer‑associated fibroblasts under therapy‑induced senescence in the tumor microenvironment (Review). Exp Ther Med 27: 150, 2024.
APA
Zhang, Q., Lou, Y., Fang, H., Sun, S., Jin, R., Ji, Y., & Chen, Z. (2024). Cancer‑associated fibroblasts under therapy‑induced senescence in the tumor microenvironment (Review). Experimental and Therapeutic Medicine, 27, 150. https://doi.org/10.3892/etm.2024.12438
MLA
Zhang, Q., Lou, Y., Fang, H., Sun, S., Jin, R., Ji, Y., Chen, Z."Cancer‑associated fibroblasts under therapy‑induced senescence in the tumor microenvironment (Review)". Experimental and Therapeutic Medicine 27.4 (2024): 150.
Chicago
Zhang, Q., Lou, Y., Fang, H., Sun, S., Jin, R., Ji, Y., Chen, Z."Cancer‑associated fibroblasts under therapy‑induced senescence in the tumor microenvironment (Review)". Experimental and Therapeutic Medicine 27, no. 4 (2024): 150. https://doi.org/10.3892/etm.2024.12438
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Lou Y, Fang H, Sun S, Jin R, Ji Y and Chen Z: Cancer‑associated fibroblasts under therapy‑induced senescence in the tumor microenvironment (Review). Exp Ther Med 27: 150, 2024.
APA
Zhang, Q., Lou, Y., Fang, H., Sun, S., Jin, R., Ji, Y., & Chen, Z. (2024). Cancer‑associated fibroblasts under therapy‑induced senescence in the tumor microenvironment (Review). Experimental and Therapeutic Medicine, 27, 150. https://doi.org/10.3892/etm.2024.12438
MLA
Zhang, Q., Lou, Y., Fang, H., Sun, S., Jin, R., Ji, Y., Chen, Z."Cancer‑associated fibroblasts under therapy‑induced senescence in the tumor microenvironment (Review)". Experimental and Therapeutic Medicine 27.4 (2024): 150.
Chicago
Zhang, Q., Lou, Y., Fang, H., Sun, S., Jin, R., Ji, Y., Chen, Z."Cancer‑associated fibroblasts under therapy‑induced senescence in the tumor microenvironment (Review)". Experimental and Therapeutic Medicine 27, no. 4 (2024): 150. https://doi.org/10.3892/etm.2024.12438
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