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Impact of preoperative carbohydrate loading on postoperative course and morbidity in debulking surgery for epithelial ovarian cancer

  • Authors:
    • Tayfun Toptas
    • Isin Ureyen
    • Alper Kahraman
    • Mustafa Gokkaya
    • Necim Yalcin
    • Aysun Alci
    • Merve Cakir Kole
    • Selim Kandemi̇r
    • Mehmet Goksu
    • Nedim Akgul
    • Selen Dogan
  • View Affiliations / Copyright

    Affiliations: Department of Gynecologic Oncology, Saglik Bilimleri University Antalya Training and Research Hospital, Antalya 07100, Turkey, Department of General Surgery, Saglik Bilimleri University Antalya Training and Research Hospital, Antalya 07100, Turkey, Department of Gynecologic Oncology, Akdeniz University Medical School, Antalya 07070, Turkey
    Copyright: © Toptas et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 181
    |
    Published online on: March 4, 2024
       https://doi.org/10.3892/etm.2024.12469
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Abstract

Despite the theoretical benefits, the favorable effect of preoperative carbohydrate loading on postoperative morbidity remains controversial. Most of the outcomes reported in the literature are derived from non‑gynecologic surgery data, with only one study involving a limited number of patients specifically in gynecological oncology. The present study aimed to investigate the impact of carbohydrate loading, as a single element of enhanced recovery after surgery protocols, on postoperative course and morbidity in patients undergoing debulking surgery for epithelial ovarian cancer (EOC). The present study was a non‑randomized, prospective cohort trial enrolling patients with EOC who underwent surgery between June 2018 and December 2021. An oral carbohydrate supplement with a dose of 50 g was given to patients 2‑3 h before anesthesia. Data on postoperative course and morbidity were collected and compared with data of a historical cohort including consecutive patients who underwent surgery without a carbohydrate loading between January 2015 and June 2018. Analyses were performed on a total of 162 patients, including 72 patients in the carbohydrate loading group and 90 patients in the control group. Median length of hospital stay (11 days vs. 11 days; P=0.555), postoperative days 1‑7 serum c‑reactive protein levels (P=0.213), 30‑day readmission (11.6% vs. 11.5%, P=0.985), 30‑day relaparotomy (2.8% vs. 3.4%, P=0.809) and 30‑day morbidity (48.6% vs. 46.7%; P=0.805) were comparable between the cohorts. No significant differences in grades of morbidities were identified between the cohorts (P=0.511). Multivariate analysis revealed that the sole independent risk factor for any postoperative morbidity was operative time. In conclusion, based on the results of the present study, postoperative course and morbidity seemed to be unaffected by carbohydrate loading in patients undergoing debulking surgery for EOC.
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Copy and paste a formatted citation
Spandidos Publications style
Toptas T, Ureyen I, Kahraman A, Gokkaya M, Yalcin N, Alci A, Kole MC, Kandemi̇r S, Goksu M, Akgul N, Akgul N, et al: Impact of preoperative carbohydrate loading on postoperative course and morbidity in debulking surgery for epithelial ovarian cancer. Exp Ther Med 27: 181, 2024.
APA
Toptas, T., Ureyen, I., Kahraman, A., Gokkaya, M., Yalcin, N., Alci, A. ... Dogan, S. (2024). Impact of preoperative carbohydrate loading on postoperative course and morbidity in debulking surgery for epithelial ovarian cancer. Experimental and Therapeutic Medicine, 27, 181. https://doi.org/10.3892/etm.2024.12469
MLA
Toptas, T., Ureyen, I., Kahraman, A., Gokkaya, M., Yalcin, N., Alci, A., Kole, M. C., Kandemi̇r, S., Goksu, M., Akgul, N., Dogan, S."Impact of preoperative carbohydrate loading on postoperative course and morbidity in debulking surgery for epithelial ovarian cancer". Experimental and Therapeutic Medicine 27.5 (2024): 181.
Chicago
Toptas, T., Ureyen, I., Kahraman, A., Gokkaya, M., Yalcin, N., Alci, A., Kole, M. C., Kandemi̇r, S., Goksu, M., Akgul, N., Dogan, S."Impact of preoperative carbohydrate loading on postoperative course and morbidity in debulking surgery for epithelial ovarian cancer". Experimental and Therapeutic Medicine 27, no. 5 (2024): 181. https://doi.org/10.3892/etm.2024.12469
Copy and paste a formatted citation
x
Spandidos Publications style
Toptas T, Ureyen I, Kahraman A, Gokkaya M, Yalcin N, Alci A, Kole MC, Kandemi̇r S, Goksu M, Akgul N, Akgul N, et al: Impact of preoperative carbohydrate loading on postoperative course and morbidity in debulking surgery for epithelial ovarian cancer. Exp Ther Med 27: 181, 2024.
APA
Toptas, T., Ureyen, I., Kahraman, A., Gokkaya, M., Yalcin, N., Alci, A. ... Dogan, S. (2024). Impact of preoperative carbohydrate loading on postoperative course and morbidity in debulking surgery for epithelial ovarian cancer. Experimental and Therapeutic Medicine, 27, 181. https://doi.org/10.3892/etm.2024.12469
MLA
Toptas, T., Ureyen, I., Kahraman, A., Gokkaya, M., Yalcin, N., Alci, A., Kole, M. C., Kandemi̇r, S., Goksu, M., Akgul, N., Dogan, S."Impact of preoperative carbohydrate loading on postoperative course and morbidity in debulking surgery for epithelial ovarian cancer". Experimental and Therapeutic Medicine 27.5 (2024): 181.
Chicago
Toptas, T., Ureyen, I., Kahraman, A., Gokkaya, M., Yalcin, N., Alci, A., Kole, M. C., Kandemi̇r, S., Goksu, M., Akgul, N., Dogan, S."Impact of preoperative carbohydrate loading on postoperative course and morbidity in debulking surgery for epithelial ovarian cancer". Experimental and Therapeutic Medicine 27, no. 5 (2024): 181. https://doi.org/10.3892/etm.2024.12469
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