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Article Open Access

Elastin expression in the conjoint fascial sheath and levator palpebrae superioris muscle of children with unilateral severe congenital ptosis with different muscle strengths

  • Authors:
    • Xin Jia
    • Zhaochuan Liu
    • Junhu Shi
    • Runhui Pang
    • Huixing Wang
    • Mengmeng Wang
    • Hongbin Zhang
    • Shan Liu
    • Ping Bai
  • View Affiliations / Copyright

    Affiliations: Hebei Provincial Key Laboratory of Ophthalmology, Hebei Provincial Clinical Research Center for Eye Diseases, Hebei Eye Hospital, Xingtai, Hebei 054000, P.R. China, Department of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Laboratory, Capital Medical University, Beijing 100000, P.R. China, Department of Ocular Plastics, Hebei Eye Hospital, Xingtai, Hebei 054000, P.R. China
    Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 196
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    Published online on: March 12, 2024
       https://doi.org/10.3892/etm.2024.12484
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Abstract

Elastin expression in the conjoint facial sheath (CFS) of patients of different ages with severe ptosis has been extensively studied, but its expression in the CFS of pediatric patients with severe ptosis with different muscle strengths remains poorly understood. The aim of the present study was to investigate the expression of elastin in the CFS and levator palpebrae superioris muscle (LM) of children with severe congenital ptosis with different LM strengths. In total, 20 pediatric patients with unilateral severe congenital ptosis (20 eyes) were included, who underwent CFS + LM complex suspension surgery from June 2020 to February 2022. Among these patients, the LM strength was 0‑1 mm in 10 patients and 2‑3 mm in the other 10 patients. Excess CFS and LM tissue samples were obtained from the patients during surgery, before the protein expression levels of elastin in the specimens were measured by western blotting. During the 6‑month postoperative follow‑up period, the good correction rate, the degree of incomplete eyelid closure and the incidence of complications were observed. Western blotting results showed that, compared with that in the 0‑1 mm group, elastin expression was not significantly different in the CFS, whereas it was significantly increased (P=0.021) in the LM of the 2‑3 mm group. In addition, elastin expression in the CFS was markedly higher compared with that in the LM in both groups (in the 0‑1 mm group, P=0.005; in the 2‑3 mm group, P=0.009). Additionally, the curative effect evaluation revealed that the good correction rates in the 0‑1 and 2‑3 mm groups were 90 and 100%, respectively. In total, 3 patients experienced conjunctival prolapse during the follow‑up period, including 2 patients in the 0‑1 mm group and 1 patient in the 2‑3 mm group, but there were no other complications. To conclude, elastin expression in the CFS was found to be higher compared with that in the LM of children with severe congenital ptosis. Although elastin expression in the LM was positively associated with LM strength, its expression in the CFS displayed no clear association with LM function. Therefore, these observations suggested that CFS + LM complex suspension surgery is viable to correct severe congenital ptosis in pediatric patients.
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1 

Finsterer J: Ptosis: Causes, presentation, and management. Aesthetic Plast Surg. 27:193–204. 2003.PubMed/NCBI View Article : Google Scholar

2 

Hwang K, Shin YH and Kim DJ: Conjoint fascial sheath of the levator and superior rectus attached to the conjunctival fornix. J Craniofac Surg. 19:241–245. 2008.PubMed/NCBI View Article : Google Scholar

3 

Holmstrom H and Santanelli F: Suspension of the eyelid to the check ligament of the superior fornix for congenital blepharoptosis. Scand J Plast Reconstr Surg Hand Surg. 36:149–156. 2002.PubMed/NCBI View Article : Google Scholar

4 

Sang PF, Fang MS, Li X, Liu C and Xi Q: Treatment of severe ptosis by conjoint fascial sheath suspension. Biomed Res Int. 19(1837458)2021.PubMed/NCBI View Article : Google Scholar

5 

Yue Q, Fu A and Wang TL: Efficacy and safety of surgical procedures for congenital moderate and severe Blepharoptosis: A network meta-analysis. J Craniofac Surg. 34:2363–2368. 2023.PubMed/NCBI View Article : Google Scholar

6 

Shi J, Liu Z, Li Y, Song L, Li Y, Yang J, Pang R, Zhang H, Xiao L and Bai P: Efficacy of combined conjoint fascial sheath and levator muscle composite flap suspension for congenital severe ptosis. Plast Reconstr Surg Jul: 25, 2023 (Epub ahead of print). doi: 10.1097/PRS.0000000000010947, 2023.

7 

Shi JH, Liu S and Liu ZC: Effect of the novel combined fascial sheath and levator palpebrae muscle composite flap suspension for congenital severe blepharoptosis. Chi J Aesthet Med. 29:23–27. 2020.(In Chinese).

8 

Liu Z, Jia X, Pang R, Wang H, Shi J and Bai P: Research on the expression of elastin in the conjoint fascial sheath for the correction of severe unilateral congenital blepharoptosis. BMC Ophthalmol. 22(256)2022.PubMed/NCBI View Article : Google Scholar

9 

Xing Y, Wang X, Cao Y, Ding X, Lin M, Li J and Fan X: Modified combined fascial sheath and levator muscle complex suspension with Müller muscle preservation on treating severe congenital ptosis. Ann Plast Surg. 82:39–45. 2019.PubMed/NCBI View Article : Google Scholar

10 

Li B, Yang J, Wu W, Chai C, Gu Z, He Z, Tan Z, Cheng S, Lu P and Zeng L: Anatomical and histological study of the conjoint fascial sheath of the levator and superior rectus for ptosis surgery. Ophthalmic Plast Reconstr Surg. 36:617–620. 2020.PubMed/NCBI View Article : Google Scholar

11 

Pang RH, Wang J and Shi JH: Pathological and clinical observation of conjoint fascial sheath in severe ptosis. J Pract Med. 37:1641–1644. 2021.

12 

Mithieux SM and Weiss AS: Elastin. Adv Protein Chem. 70:437–461. 2005.PubMed/NCBI View Article : Google Scholar

13 

Harvey DJ, Iamphongsai S and Gosain AK: Unilateral congenital blepharoptosis repair by anterior levator advancement and resection: An educational review. Plast Reconstr Surg. 126:1325–1331. 2010.PubMed/NCBI View Article : Google Scholar

14 

Patel K, Carballo S and Thompson L: Ptosis. Dis Mon. 63:74–79. 2017.PubMed/NCBI View Article : Google Scholar

15 

Harvey DJ, Iamphongsai S and Gosain AK: Unilateral congenital blepharoptosis repair by anterior levator advancement and resection: An educational review. Plast Reconstr Surg. 126:1325–1331. 2010.PubMed/NCBI View Article : Google Scholar

16 

Qiu Y, Sun D, Pan P, Jin Y, Cai L, Yang J, Lin D and Liu F: Conjoint fascial sheath suspension for severe blepharoptosis through palpebral margin incision. Aesthetic Plast Surg. 46:2301–2309. 2022.PubMed/NCBI View Article : Google Scholar

17 

Griepentrog GJ, Diehl N and Mohney BG: Amblyopia in childhood eyelid ptosis. Am J Ophthalmol. 155:1125–1128. 2013.PubMed/NCBI View Article : Google Scholar

18 

Hsia NY, Wen LY, Chou CY, Lin CL, Wan L and Lin HJ: Increased risk of refractive errors and amblyopia among children with ptosis: A nationwide population-based study. J Clin Med. 11(2334)2022.PubMed/NCBI View Article : Google Scholar

19 

Bremond-Gignac D: Unilateral ptosis in children. Rev Prat. 70:993–996. 2020.PubMed/NCBI(In French).

20 

Bee YS, Tsai PJ, Lin MC and Chu MY: Factors related to amblyopia in congenital ptosis after frontalis sling surgery. BMC Ophthalmol. 18(302)2018.PubMed/NCBI View Article : Google Scholar

21 

Lee JH and Kim YD: Surgical treatment of unilateral severe simple congenital ptosis. Taiwan J Ophthalmol. 8:3–8. 2018.PubMed/NCBI View Article : Google Scholar

22 

Bing L: Progress in the operative therapy of congenital blepharoptosis. J Tissue Engineering and Reconstructive Surgery. 13:279–282. 2017.

23 

Wang H, Liu L and Wang ZJ: Conjoint fascial sheath suspension for early correction of severe blepharoptosis after double-eyelid blepharoplasty. Br J Oral Maxillofac Surg. 58:966–969. 2020.PubMed/NCBI View Article : Google Scholar

24 

Zhou J, Chen W, Qi Z and Jin X: Minimally invasive conjoint fascial sheath suspension for blepharoptosis correction. Aesthetic Plast Surg. 43:956–963. 2019.PubMed/NCBI View Article : Google Scholar

25 

Zhao YN, Ge HG and Shen QL: Comparative study on conjoint fascial sheath suspension and the simple frontalis muscle suspension for moderate or severe ptosis. Int Eye Sci. 17:1790–1792. 2017.

26 

Pan XH, Wei T, Wang XD and Xu C: Clinical efficacy of conjoint fascial sheath suspension and frontalis muscle suspension in treating moderate or severe congenital ptosis and the effects on ocular surface and refractive status. Exp Ther Med. 20:3278–3284. 2020.PubMed/NCBI View Article : Google Scholar

27 

Hwang K: Surgical anatomy of the upper eyelid relating to upper blepharoplasty or blepharoptosis surgery. Anat Cell Biol. 46:93–100. 2013.PubMed/NCBI View Article : Google Scholar

28 

Zhuang W, Fang S, Fan H, Zhu W, Chen Y, Tang W, Liu C, Liu X, Zhang Z, Xing X and Yang C: Anatomical study of the extraocular check ligament system. J Plast Reconstr Aesthet Surg. 72:2017–2026. 2019.PubMed/NCBI View Article : Google Scholar

29 

Li Y, Wang HX and Bai P: Changes of ocular surface before and after treatment of blepharoptosis with combined fascial sheath suspension and frontal muscle flap suspension. J Craniofac Surg. 32:e698–e701. 2021.PubMed/NCBI View Article : Google Scholar

30 

Vindin H, Mithieux SM and Weiss AS: Elastin architecture. Matrix Biol. 84:4–16. 2019.PubMed/NCBI View Article : Google Scholar

31 

Ng SK, Chan W, Marcet MM, Kakizaki H and Selva D: Levator palpebrae superioris: An anatomical update. Orbit. 32:76–84. 2013.PubMed/NCBI View Article : Google Scholar

32 

Pereira LS, Hwang TN, Kersten RC, Ray K and McCulley TJ: Levator superioris muscle function in involutional Blepharoptosis. Am J Ophthalmol. 145:1095–1098. 2008.PubMed/NCBI View Article : Google Scholar

33 

Lai HT, Weng SF, Chang CH, Huang SH, Lee SS, Chang KP and Lai CS: Analysis of levator function and ptosis severity in involutional Blepharoptosis. Ann Plast Surg. 78 (Suppl 23):S58–S60. 2017.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Jia X, Liu Z, Shi J, Pang R, Wang H, Wang M, Zhang H, Liu S and Bai P: Elastin expression in the conjoint fascial sheath and levator palpebrae superioris muscle of children with unilateral severe congenital ptosis with different muscle strengths. Exp Ther Med 27: 196, 2024.
APA
Jia, X., Liu, Z., Shi, J., Pang, R., Wang, H., Wang, M. ... Bai, P. (2024). Elastin expression in the conjoint fascial sheath and levator palpebrae superioris muscle of children with unilateral severe congenital ptosis with different muscle strengths. Experimental and Therapeutic Medicine, 27, 196. https://doi.org/10.3892/etm.2024.12484
MLA
Jia, X., Liu, Z., Shi, J., Pang, R., Wang, H., Wang, M., Zhang, H., Liu, S., Bai, P."Elastin expression in the conjoint fascial sheath and levator palpebrae superioris muscle of children with unilateral severe congenital ptosis with different muscle strengths". Experimental and Therapeutic Medicine 27.5 (2024): 196.
Chicago
Jia, X., Liu, Z., Shi, J., Pang, R., Wang, H., Wang, M., Zhang, H., Liu, S., Bai, P."Elastin expression in the conjoint fascial sheath and levator palpebrae superioris muscle of children with unilateral severe congenital ptosis with different muscle strengths". Experimental and Therapeutic Medicine 27, no. 5 (2024): 196. https://doi.org/10.3892/etm.2024.12484
Copy and paste a formatted citation
x
Spandidos Publications style
Jia X, Liu Z, Shi J, Pang R, Wang H, Wang M, Zhang H, Liu S and Bai P: Elastin expression in the conjoint fascial sheath and levator palpebrae superioris muscle of children with unilateral severe congenital ptosis with different muscle strengths. Exp Ther Med 27: 196, 2024.
APA
Jia, X., Liu, Z., Shi, J., Pang, R., Wang, H., Wang, M. ... Bai, P. (2024). Elastin expression in the conjoint fascial sheath and levator palpebrae superioris muscle of children with unilateral severe congenital ptosis with different muscle strengths. Experimental and Therapeutic Medicine, 27, 196. https://doi.org/10.3892/etm.2024.12484
MLA
Jia, X., Liu, Z., Shi, J., Pang, R., Wang, H., Wang, M., Zhang, H., Liu, S., Bai, P."Elastin expression in the conjoint fascial sheath and levator palpebrae superioris muscle of children with unilateral severe congenital ptosis with different muscle strengths". Experimental and Therapeutic Medicine 27.5 (2024): 196.
Chicago
Jia, X., Liu, Z., Shi, J., Pang, R., Wang, H., Wang, M., Zhang, H., Liu, S., Bai, P."Elastin expression in the conjoint fascial sheath and levator palpebrae superioris muscle of children with unilateral severe congenital ptosis with different muscle strengths". Experimental and Therapeutic Medicine 27, no. 5 (2024): 196. https://doi.org/10.3892/etm.2024.12484
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