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Apatinib beyond first progression is associated with prolonged overall survival in patients with advanced breast cancer: Results from an observational study

  • Authors:
    • Jing Wang
    • Jinghao Jia
    • Jingjing Liu
    • Xuemin Yao
    • Zhiyong Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, P.R. China, Department of Chemoradiotherapy, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei 063000, P.R. China, Department of Chemoradiotherapy, Tangshan People's Hospital, Tangshan, Hebei 063000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 200
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    Published online on: March 14, 2024
       https://doi.org/10.3892/etm.2024.12488
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Abstract

In the present study, the efficacy and safety of a low dose of apatinib in the treatment of patients with advanced breast cancer (ABC) in a real‑world setting were assessed, the impact of continuous anti‑angiogenic therapy beyond progression was determined and the factors associated with efficacy were evaluated. A total of 63 patients with ABC who were treated with apatinib and for whom several lines of treatment had failed were retrospectively analyzed in Tangshan People's Hospital (Tangshan, China) between January 2016 and October 2022. Apatinib was administered orally combined with chemotherapy, endocrine therapy, targeted therapy or monotherapy at a dose of 250 mg per day. Apatinib administration was continued in certain patients beyond first progressive disease (PD), and these patients were defined as the continued anti‑angiogenic treatment beyond first progression (CABF) group, while those who discontinued apatinib were defined as the non‑CABF group. In the evaluation of the first efficacy, the objective response rate was 33.3%. A total of 26 patients continued to receive apatinib post‑first PD and were allocated to the CABF group. The median overall survival (OS) time of the 63 patients was 16 months. Log‑rank univariate analysis revealed that the OS time was significantly associated with molecular subtype (P=0.014), CABF (P=0.004), and the neutrophil‑to‑lymphocyte ratio (NLR) (P=0.011). Multivariate Cox regression analysis revealed that being in the non‑CABF group and a high NLR were independent risk factors for lower OS time (P=0.017 and P=0.041, respectively). These results support the continued administration of low‑dose apatinib beyond progression and the use of NLR as an easily accessible prognostic marker in patients with ABC treated with apatinib.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Jia J, Liu J, Yao X and Yuan Z: Apatinib beyond first progression is associated with prolonged overall survival in patients with advanced breast cancer: Results from an observational study. Exp Ther Med 27: 200, 2024.
APA
Wang, J., Jia, J., Liu, J., Yao, X., & Yuan, Z. (2024). Apatinib beyond first progression is associated with prolonged overall survival in patients with advanced breast cancer: Results from an observational study. Experimental and Therapeutic Medicine, 27, 200. https://doi.org/10.3892/etm.2024.12488
MLA
Wang, J., Jia, J., Liu, J., Yao, X., Yuan, Z."Apatinib beyond first progression is associated with prolonged overall survival in patients with advanced breast cancer: Results from an observational study". Experimental and Therapeutic Medicine 27.5 (2024): 200.
Chicago
Wang, J., Jia, J., Liu, J., Yao, X., Yuan, Z."Apatinib beyond first progression is associated with prolonged overall survival in patients with advanced breast cancer: Results from an observational study". Experimental and Therapeutic Medicine 27, no. 5 (2024): 200. https://doi.org/10.3892/etm.2024.12488
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Jia J, Liu J, Yao X and Yuan Z: Apatinib beyond first progression is associated with prolonged overall survival in patients with advanced breast cancer: Results from an observational study. Exp Ther Med 27: 200, 2024.
APA
Wang, J., Jia, J., Liu, J., Yao, X., & Yuan, Z. (2024). Apatinib beyond first progression is associated with prolonged overall survival in patients with advanced breast cancer: Results from an observational study. Experimental and Therapeutic Medicine, 27, 200. https://doi.org/10.3892/etm.2024.12488
MLA
Wang, J., Jia, J., Liu, J., Yao, X., Yuan, Z."Apatinib beyond first progression is associated with prolonged overall survival in patients with advanced breast cancer: Results from an observational study". Experimental and Therapeutic Medicine 27.5 (2024): 200.
Chicago
Wang, J., Jia, J., Liu, J., Yao, X., Yuan, Z."Apatinib beyond first progression is associated with prolonged overall survival in patients with advanced breast cancer: Results from an observational study". Experimental and Therapeutic Medicine 27, no. 5 (2024): 200. https://doi.org/10.3892/etm.2024.12488
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