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Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta‑analysis

  • Authors:
    • George Fotakopoulos
    • Vasiliki Epameinondas Georgakopoulou
    • Petros Papalexis
    • Demetrios A. Spandidos
    • Nikolaos Trakas
    • Pagona Sklapani
    • Kostas N. Fountas
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, General University Hospital of Larissa, 41221 Larissa, Greece, Department of Pathophysiology, Laiko General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece, Unit of Endocrinology, First Department of Propedeutic and Internal Medicine, Laiko General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Department of Biochemistry, Sismanogleio Hospital, 15126 Athens, Greece
    Copyright: © Fotakopoulos et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 215
    |
    Published online on: March 20, 2024
       https://doi.org/10.3892/etm.2024.12503
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Abstract

Intracranial cavernous malformations (CMs) are vascular lesions with a high bleeding rate. At present, the debate regarding their treatment is still ongoing. The present systematic review and meta‑analysis aimed to evaluate the safety of surgery or radiosurgery (SRS) for the management of CMs and to determine their potential outcomes compared with conservative treatment. The present systematic review and meta‑analysis investigated the relative articles involving the management of intracranial CMs, namely their natural history (conservative treatment) vs. surgical/SRS treatment through electronic databases until June, 2023. The collected variables included the first author's name, the study period covered, the year of publication, the total number of patients examined and their age, and the number of males. In total, six articles met the eligibility criteria. The total number of patients was 399 (157 in the surgery/SRS group and 242 in the conservative treatment group). The results revealed that surgical or SRS management is a safe procedure for CMs compared with conservative treatment. Notably, the use of hemosiderin in the pre‑MRI, the free of seizures parameter and the neurological deficit parameters were associated with improved outcomes in the surgical or SRS group of patients.
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Copy and paste a formatted citation
Spandidos Publications style
Fotakopoulos G, Georgakopoulou VE, Papalexis P, Spandidos DA, Trakas N, Sklapani P and Fountas KN: Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta‑analysis. Exp Ther Med 27: 215, 2024.
APA
Fotakopoulos, G., Georgakopoulou, V.E., Papalexis, P., Spandidos, D.A., Trakas, N., Sklapani, P., & Fountas, K.N. (2024). Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 27, 215. https://doi.org/10.3892/etm.2024.12503
MLA
Fotakopoulos, G., Georgakopoulou, V. E., Papalexis, P., Spandidos, D. A., Trakas, N., Sklapani, P., Fountas, K. N."Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 27.5 (2024): 215.
Chicago
Fotakopoulos, G., Georgakopoulou, V. E., Papalexis, P., Spandidos, D. A., Trakas, N., Sklapani, P., Fountas, K. N."Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 27, no. 5 (2024): 215. https://doi.org/10.3892/etm.2024.12503
Copy and paste a formatted citation
x
Spandidos Publications style
Fotakopoulos G, Georgakopoulou VE, Papalexis P, Spandidos DA, Trakas N, Sklapani P and Fountas KN: Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta‑analysis. Exp Ther Med 27: 215, 2024.
APA
Fotakopoulos, G., Georgakopoulou, V.E., Papalexis, P., Spandidos, D.A., Trakas, N., Sklapani, P., & Fountas, K.N. (2024). Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 27, 215. https://doi.org/10.3892/etm.2024.12503
MLA
Fotakopoulos, G., Georgakopoulou, V. E., Papalexis, P., Spandidos, D. A., Trakas, N., Sklapani, P., Fountas, K. N."Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 27.5 (2024): 215.
Chicago
Fotakopoulos, G., Georgakopoulou, V. E., Papalexis, P., Spandidos, D. A., Trakas, N., Sklapani, P., Fountas, K. N."Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 27, no. 5 (2024): 215. https://doi.org/10.3892/etm.2024.12503
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