|
1
|
Goodenberger ML and Jenkins RB: Genetics
of adult glioma. Cancer Genet. 205:613–621. 2012.PubMed/NCBI View Article : Google Scholar
|
|
2
|
WHO Classification of Tumours Editorial
Board. World Health Organization classification of tumours of the
central nervous system. 5th edition. Lyon: International Agency for
Research on Cancer, 2021.
|
|
3
|
Ostrom QT, Price M, Neff C, Cioffi G,
Waite KA, Kruchko C and Barnholtz-Sloan JS: CBTRUS statistical
report: Primary brain and other central nervous system tumors
diagnosed in the United States in 2015-2019. Neuro Oncol. 24 (Suppl
5):v1–v95. 2022.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Ohgaki H and Kleihues P: Epidemiology and
etiology of gliomas. Acta Neuropathol. 109:93–108. 2005.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Verhaak RGW, Hoadley KA, Purdom E, Wang V,
Qi Y, Wilkerson MD, Miller CR, Ding L, Golub T, Mesirov JP, et al:
Integrated genomic analysis identifies clinically relevant subtypes
of glioblastoma characterized by abnormalities in PDGFRA, IDH1,
EGFR, and NF1. Cancer Cell. 17:98–110. 2010.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Lee E, Yong RL, Paddison P and Zhu J:
Comparison of glioblastoma (GBM) molecular classification methods.
Semin Cancer Biol. 53:201–211. 2018.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Basters A, Knobeloch KP and Fritz G:
USP18-a multifunctional component in the interferon response.
Biosci Rep. 38(BSR20180250)2018.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Liu LQ, Ilaria R Jr, Kingsley PD, Iwama A,
van Etten RA, Palis J and Zhang DE: A novel ubiquitin-specific
protease, UBP43, cloned from leukemia fusion protein
AML1-ETO-expressing mice, functions in hematopoietic cell
differentiation. Mol Cell Biol. 19:3029–3038. 1999.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Zhang X, Shin J, Molitor TW, Schook LB and
Rutherford MS: Molecular responses of macrophages to porcine
reproductive and respiratory syndrome virus infection. Virology.
262:152–162. 1999.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Kang D, Jiang H, Wu Q, Pestka S and Fisher
PB: Cloning and characterization of human ubiquitin-processing
protease-43 from terminally differentiated human melanoma cells
using a rapid subtraction hybridization protocol RaSH. Gene.
267:233–242. 2001.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Malakhov MP, Malakhova OA, Kim KI, Ritchie
KJ and Zhang DE: UBP43 (USP18) specifically removes ISG15 from
conjugated proteins. J Biol Chem. 277:9976–9981. 2002.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Malakhova OA, Yan M, Malakhov MP, Yuan Y,
Ritchie KJ, Kim KI, Peterson LF, Shuai K and Zhang DE: Protein
ISGylation modulates the JAK-STAT signaling pathway. Genes Dev.
17:455–560. 2003.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Malakhova OA, Kim KI, Luo J-K, Zou W,
Kumar KGS, Fuchs SY, Shuai K and Zhang DE: UBP43 is a novel
regulator of interferon signaling independent of its ISG15
isopeptidase activity. EMBO J. 25:2358–2367. 2006.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Arimoto KI, Miyauchi S, Troutman TD, Zhang
Y, Liu M, Stoner SA, Davis AG, Fan JB, Huang YJ, Yan M, et al:
Expansion of interferon inducible gene pool via USP18 inhibition
promotes cancer cell pyroptosis. Nat Commun. 14(251)2023.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Cai X, Feng S, Zhang J, Qiu W, Qian M and
Wang Y: USP18 deubiquitinates and stabilizes Twist1 to promote
epithelial-mesenchymal transition in glioblastoma cells. Am J
Cancer Res. 10:1156–1169. 2020.PubMed/NCBI
|
|
16
|
Vivian J, Rao AA, Nothaft FA, Ketchum C,
Armstrong J, Novak A, Pfeil J, Narkizian J, Deran AD,
Musselman-Brown A, et al: Toil enables reproducible, open source,
big biomedical data analyses. Nat Biotechnol. 35:314–316.
2017.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Charoentong P, Finotello F, Angelova M,
Mayer C, Efremova M, Rieder D, Hackl H and Trajanoski Z: Pan-cancer
immunogenomic analyses reveal genotype-immunophenotype
relationships and predictors of response to checkpoint blockade.
Cell Rep. 18:248–262. 2017.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Ceccarelli M, Barthel FP, Malta TM,
Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh
A, Pagnotta SM, et al: Molecular profiling reveals biologically
discrete subsets and pathways of progression in diffuse glioma.
Cell. 164:550–563. 2016.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Wang L, Babikir H, Müller S, Yagnik G,
Shamardani K, Catalan F, Kohanbash G, Alvarado B, Di Lullo E,
Kriegstein A, et al: The phenotypes of proliferating glioblastoma
cells reside on a single axis of variation. Cancer Discov.
9:1708–1719. 2019.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Sun D, Wang J, Han Y, Dong X, Ge J, Zheng
R, Shi X, Wang B, Li Z, Ren P, et al: TISCH: A comprehensive web
resource enabling interactive single-cell transcriptome
visualization of tumor microenvironment. Nucleic Acids Res. 49
(D1):D1420–D1430. 2021.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Butler A, Hoffman P, Smibert P, Papalexi E
and Satija R: Integrating single-cell transcriptomic data across
different conditions, technologies, and species. Nat Biotechnol.
36:411–420. 2018.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Yu G, Wang LG, Han Y and He QY:
clusterProfiler: An R package for comparing biological themes among
gene clusters. OMICS. 16:284–287. 2012.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Liu J, Lichtenberg T, Hoadley KA, Poisson
LM, Lazar AJ, Cherniack AD, Kovatich AJ, Benz CC, Levine DA, Lee
AV, et al: An integrated TCGA pan-cancer clinical data resource to
drive high-quality survival outcome analytics. Cell.
173:400–416.e11. 2018.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Hänzelmann S, Castelo R and Guinney J:
GSVA: Gene set variation analysis for microarray and RNA-seq data.
BMC Bioinformatics. 14(7)2013.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Bindea G, Mlecnik B, Tosolini M,
Kirilovsky A, Waldner M, Obenauf AC, Angell H, Fredriksen T,
Lafontaine L, Berger A, et al: Spatiotemporal dynamics of
intratumoral immune cells reveal the immune landscape in human
cancer. Immunity. 39:782–795. 2013.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Yoshihara K, Shahmoradgoli M, Martínez E,
Vegesna R, Kim H, Torres-Garcia W, Treviño V, Shen H, Laird PW,
Levine DA, et al: Inferring tumour purity and stromal and immune
cell admixture from expression data. Nat Commun.
4(2612)2013.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Kanehisa M and Goto S: KEGG: Kyoto
encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30.
2000.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Subramanian A, Tamayo P, Mootha VK,
Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub
TR, Lander ES and Mesirov JP: Gene set enrichment analysis: A
knowledge-based approach for interpreting genome-wide expression
profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Gene Ontology Consortium. Gene ontology
consortium: Going forward. Nucleic Acids Res. 43 (Database
Issue):D1049–D1056. 2015.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Li R, Wang YY, Wang SL, Li XP, Chen Y, Li
ZA, He JH, Zhou ZH, Li JY, Guo XL, et al: GBP2 as a potential
prognostic predictor with immune-related characteristics in glioma.
Front Genet. 13(956632)2022.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408.
2001.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Ren Y, Yang B, Guo G, Zhang J, Sun Y, Liu
D, Guo S, Wu Y, Wang X, Wang S, et al: GBP2 facilitates the
progression of glioma via regulation of KIF22/EGFR signaling. Cell
Death Discov. 8(208)2022.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Sun Q, Li J, Wang R, Sun T, Zong Y, Wang
C, Liu Y, Li X, Song Y and Zhang Y: Coxsackievirus A6 infection
causes neurogenic pathogenesis in a neonatal murine model. Viruses
15: 511, 223.
|
|
34
|
Selinger M, Věchtová P, Tykalová H,
Ošlejšková P, Rumlová M, Štěrba J and Grubhoffer L: Integrative RNA
profiling of TBEV-infected neurons and astrocytes reveals potential
pathogenic effectors. Comput Struct Biotechnol J. 20:2759–2777.
2022.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Ritchie KJ, Hahn CS, Kim KI, Yan M,
Rosario D, Li L, de la Torre JC and Zhang DE: Role of ISG15
protease UBP43 (USP18) in innate immunity to viral infection. Nat
Med. 10:1374–1378. 2004.PubMed/NCBI View
Article : Google Scholar
|
|
36
|
Hong B, Li H, Lu Y, Zhang M, Zheng Y, Qian
J and Yi Q: USP18 is crucial for IFN-γ-mediated inhibition of B16
melanoma tumorigenesis and antitumor immunity. Mol Cancer.
13(132)2014.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Mustachio LM, Kawakami M, Lu Y,
Rodriguez-Canales J, Mino B, Behrens C, Wistuba I, Bota-Rabassedas
N, Yu J, Lee JJ, et al: The ISG15-specific protease USP18 regulates
stability of PTEN. Oncotarget. 8:3–14. 2017.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Tan Y, Zhou G, Wang X, Chen W and Gao H:
USP18 promotes breast cancer growth by upregulating EGFR and
activating the AKT/Skp2 pathway. Int J Oncol. 53:371–383.
2018.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Tong HV, Hoan NX, Binh MT, Quyen DT, Meyer
CG, Hang DTT, Hang DTD, Son HA, Van Luong H, Thuan ND, et al:
Upregulation of Enzymes involved in ISGylation and ubiquitination
in patients with hepatocellular carcinoma. Int J Med Sci.
17:347–353. 2020.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Zhang X, Bogunovic D, Payelle-Brogard B,
Francois-Newton V, Speer SD, Yuan C, Volpi S, Li Z, Sanal O,
Mansouri D, et al: Human intracellular ISG15 prevents
interferon-α/β over-amplification and auto-inflammation. Nature.
517:89–93. 2015.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Liu X, Li H, Zhong B, Blonska M,
Gorjestani S, Yan M, Tian Q, Zhang DE, Lin X and Dong C: USP18
inhibits NF-κB and NFAT activation during Th17 differentiation by
deubiquitinating the TAK1-TAB1 complex. J Exp Med. 210:1575–1590.
2013.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Zheng C, Zheng Z, Zhang Z, Meng J, Liu Y,
Ke X, Hu Q and Wang H: IFIT5 positively regulates NF-κB signaling
through synergizing the recruitment of IκB kinase (IKK) to
TGF-β-activated kinase 1 (TAK1). Cell Signal. 27:2343–2354.
2015.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Numajiri Haruki A, Naito T, Nishie T,
Saito S and Nagata K: Interferon-inducible antiviral protein MxA
enhances cell death triggered by endoplasmic reticulum stress. J
Interferon Cytokine Res. 31:847–856. 2011.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Arimoto KI, Löchte S, Stoner SA, Burkart
C, Zhang Y, Miyauchi S, Wilmes S, Fan JB, Heinisch JJ, Li Z, et al:
STAT2 is an essential adaptor in USP18-mediated suppression of type
I interferon signaling. Nat Struct Mol Biol. 24:279–289.
2017.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Molinaro AM, Taylor JW, Wiencke JK and
Wrensch MR: Genetic and molecular epidemiology of adult diffuse
glioma. Nat Rev Neurol. 15:405–417. 2019.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Nicholson JG and Fine HA: Diffuse glioma
heterogeneity and its therapeutic implications. Cancer Discov.
11:575–590. 2021.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Hernández A, Domènech M, Muñoz-Mármol AM,
Carrato C and Balana C: Glioblastoma: Relationship between
metabolism and immunosuppressive microenvironment. Cells.
10(3529)2021.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Louveau A, Smirnov I, Keyes TJ, Eccles JD,
Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, et
al: Structural and functional features of central nervous system
lymphatic vessels. Nature. 523:337–341. 2015.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Quail DF and Joyce JA: The
microenvironmental landscape of brain tumors. Cancer Cell.
31:326–341. 2017.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Sprooten J, Agostinis P and Garg AD: Type
I interferons and dendritic cells in cancer immunotherapy. Int Rev
Cell Mol Biol. 348:217–262. 2019.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Pyfferoen L, Brabants E, Everaert C, De
Cabooter N, Heyns K, Deswarte K, Vanheerswynghels M, De Prijck S,
Waegemans G, Dullaers M, et al: The transcriptome of lung
tumor-infiltrating dendritic cells reveals a tumor-supporting
phenotype and a microRNA signature with negative impact on clinical
outcome. Oncoimmunology. 6(e1253655)2016.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Chen Z, Feng X, Herting CJ, Garcia VA, Nie
K, Pong WW, Rasmussen R, Dwivedi B, Seby S, Wolf SA, et al:
Cellular and molecular identity of tumor-associated macrophages in
glioblastoma. Cancer Res. 77:2266–228. 2017.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Dapash M, Hou D, Castro B, Lee-Chang C and
Lesniak MS: The interplay between glioblastoma and its
microenvironment. Cells. 10(2257)2021.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Wu L and Zhang XHF: Tumor-associated
neutrophils and macrophages-heterogenous but not chaotic. Front
Immunol. 11(553967)2020.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Broekman ML, Maas SLN, Abels ER, Mempel
TR, Krichevsky AM and Breakefield XO: Multidimensional
communication in the microenvirons of glioblastoma. Nat Rev Neurol.
14:482–495. 2018.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Blanchett S, Boal-Carvalho I, Layzell S
and Seddon B: NF-κB and extrinsic cell death pathways-entwined
do-or-die decisions for T cells. Trends Immunol. 42:76–88.
2021.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Kim CH: FOXP3 and its role in the immune
system. Adv Exp Med Biol. 665:17–29. 2009.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Lu L, Barbi J and Pan F: The regulation of
immune tolerance by FOXP3. Nat Rev Immunol. 17:703–717.
2017.PubMed/NCBI View Article : Google Scholar
|
|
59
|
Yang Z, Xian H, Hu J, Tian S, Qin Y, Wang
RF and Cui J: USP18 negatively regulates NF-κB signaling by
targeting TAK1 and NEMO for deubiquitination through distinct
mechanisms. Sci Rep. 5(12738)2015.PubMed/NCBI View Article : Google Scholar
|
|
60
|
Cui P, Wei F, Hou J, Su Y, Wang J and Wang
S: STAT3 inhibition induced temozolomide-resistant glioblastoma
apoptosis via triggering mitochondrial STAT3 translocation and
respiratory chain dysfunction. Cell Signal.
71(109598)2020.PubMed/NCBI View Article : Google Scholar
|
|
61
|
Schneider WM, Chevillotte MD and Rice CM:
Interferon-stimulated genes: A complex web of host defenses. Annu
Rev Immunol. 32:513–545. 2014.PubMed/NCBI View Article : Google Scholar
|
|
62
|
Bracci L, Sistigu A, Proietti E and
Moschella F: The added value of type I interferons to cytotoxic
treatments of cancer. Cytokine Growth Factor Rev. 36:89–97.
2017.PubMed/NCBI View Article : Google Scholar
|
|
63
|
Parker BS, Rautela J and Hertzog PJ:
Antitumour actions of interferons: Implications for cancer therapy.
Nat Rev Cancer. 16:131–144. 2016.PubMed/NCBI View Article : Google Scholar
|
|
64
|
Zitvogel L, Galluzzi L, Kepp O, Smyth MJ
and Kroemer G: Type I interferons in anticancer immunity. Nat Rev
Immunol. 15:405–414. 2015.PubMed/NCBI View Article : Google Scholar
|
|
65
|
Furnari FB, Fenton T, Bachoo RM, Mukasa A,
Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, et al:
Malignant astrocytic glioma: Genetics, biology, and paths to
treatment. Genes Dev. 21:2683–2710. 2007.PubMed/NCBI View Article : Google Scholar
|
|
66
|
Stewart LA: Chemotherapy in adult
high-grade glioma: A systematic review and meta-analysis of
individual patient data from 12 randomised trials. Lancet.
359:1011–1018. 2002.PubMed/NCBI View Article : Google Scholar
|
|
67
|
Yung WK, Prados M, Levin VA, Fetell MR,
Bennett J, Mahaley MS, Salcman M and Etcubanas E: Intravenous
recombinant interferon beta in patients with recurrent malignant
gliomas: A phase I/II study. J Clin Oncol. 9:1945–1949.
1991.PubMed/NCBI View Article : Google Scholar
|
|
68
|
Fine HA, Wen PY, Robertson M, O'Neill A,
Kowal J, Loeffler JS and Black PM: A phase I trial of a new
recombinant human beta-interferon (BG9015) for the treatment of
patients with recurrent gliomas. Clin Cancer Res. 3:381–387.
1997.PubMed/NCBI
|
|
69
|
Manini I, Sgorbissa A, Potu H, Tomasella A
and Brancolini C: The DeISGylase USP18 limits TRAIL-induced
apoptosis through the regulation of TRAIL levels: Cellular levels
of TRAIL influences responsiveness to TRAIL-induced apoptosis.
Cancer Biol Ther. 14:1158–1166. 2013.PubMed/NCBI View Article : Google Scholar
|
|
70
|
Dimberg LY, Anderson CK, Camidge R,
Behbakht K, Thorburn A and Ford HL: On the TRAIL to successful
cancer therapy? Predicting and counteracting resistance against
TRAIL-based therapeutics. Oncogene. 32:1341–1350. 2013.PubMed/NCBI View Article : Google Scholar
|
|
71
|
Potu H, Sgorbissa A and Brancolini C:
Identification of USP18 as an important regulator of the
susceptibility to IFN-alpha and drug-induced apoptosis. Cancer Res.
70:655–665. 2010.PubMed/NCBI View Article : Google Scholar
|
|
72
|
Sgorbissa A, Tomasella A, Potu H, Manini I
and Brancolini C: Type I IFNs signaling and apoptosis resistance in
glioblastoma cells. Apoptosis. 16:1229–1244. 2011.PubMed/NCBI View Article : Google Scholar
|
|
73
|
Zong H, Verhaak RGW and Canoll P: The
cellular origin for malignant glioma and prospects for clinical
advancements. Expert Rev Mol Diagn. 12:383–394. 2012.PubMed/NCBI View Article : Google Scholar
|
|
74
|
Omuro A and DeAngelis LM: Glioblastoma and
other malignant gliomas: A clinical review. JAMA. 310:1842–1850.
2013.PubMed/NCBI View Article : Google Scholar
|
|
75
|
Nieto MA, Huang RYJ, Jackson RA and Thiery
JP: EMT: 2016. Cell. 166:21–45. 2016.PubMed/NCBI View Article : Google Scholar
|
|
76
|
Nieto MA: Epithelial-mesenchymal
transitions in development and disease: Old views and new
perspectives. Int J Dev Biol. 53:1541–1547. 2009.PubMed/NCBI View Article : Google Scholar
|
|
77
|
Noronha C, Ribeiro AS, Taipa R, Castro DS,
Reis J, Faria C and Paredes J: Cadherin expression and EMT: A focus
on gliomas. Biomedicines. 9(1328)2021.PubMed/NCBI View Article : Google Scholar
|
|
78
|
Li L, Yin Y, Zhang J, Wu X, Liu J, Chai J,
Yang Y, Li M, Jia Q and Liu Y: USP18 regulates the malignant
phenotypes of glioblastoma stem cells. Pathol Res Pract.
247(154572)2023.PubMed/NCBI View Article : Google Scholar
|