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Article

Triiodothyronine supplementation in a sheep model of intensive care

  • Authors:
    • Matthew J. Maiden
    • David J. Torpy
    • Guy L. Ludbrook
    • Iain J. Clarke
    • Binila Chacko
    • Coralie H. Nash
    • Loren Matthews
    • Susan Porter
    • Tim R. Kuchel
  • View Affiliations / Copyright

    Affiliations: Discipline of Acute Care Medicine, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia 5005, Australia, Endocrine and Metabolic Unit, Department of Medicine, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, South Australia 5000, Australia, Department of Physiology, Faculty of Science, Monash University, Clayton, Victoria 3800, Australia, Intensive Care Unit, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, South Australia 5000, Australia, Preclinical, Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Hillcrest, South Australia 5086, Australia
  • Article Number: 321
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    Published online on: June 17, 2024
       https://doi.org/10.3892/etm.2024.12611
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Abstract

Triiodothyronine (T3) concentrations in plasma decrease during acute illness and it is unclear if this contributes to disease. Clinical and laboratory studies of T3 supplementation in disease have revealed little or no effect. It is uncertain if short term supplementation of T3 has any discernible effect in a healthy animals. Observational study of intravenous T3 (1 µg/kg/h) for 24 h in a healthy sheep model receiving protocol‑guided intensive care supports (T3 group, n=5). A total of 45 endpoints were measured including hemodynamic, respiratory, renal, hematological, metabolic and endocrine parameters. Data were compared with previously published studies of sheep subject to the same support protocol without administered T3 (No T3 group, n=5). Plasma free T3 concentrations were elevated 8‑fold by the infusion (pmol/l at 24 h; T3 group 34.9±9.9 vs. No T3 group 4.4±0.3, P<0.01, reference range 1.6 to 6.8). There was no significant physiological response to administration of T3 over the study duration. Supplementation of intravenous T3 for 24 h has no physiological effect on relevant physiological endpoints in healthy sheep. Further research is required to understand if the lack of effect of short‑term T3 may be related to kinetics of T3 cellular uptake, metabolism and action, or acute counterbalancing hormone resistance. This information may be helpful in design of clinical T3 supplementation trials.
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Copy and paste a formatted citation
Spandidos Publications style
Maiden MJ, Torpy DJ, Ludbrook GL, Clarke IJ, Chacko B, Nash CH, Matthews L, Porter S and Kuchel TR: Triiodothyronine supplementation in a sheep model of intensive care. Exp Ther Med 28: 321, 2024.
APA
Maiden, M.J., Torpy, D.J., Ludbrook, G.L., Clarke, I.J., Chacko, B., Nash, C.H. ... Kuchel, T.R. (2024). Triiodothyronine supplementation in a sheep model of intensive care. Experimental and Therapeutic Medicine, 28, 321. https://doi.org/10.3892/etm.2024.12611
MLA
Maiden, M. J., Torpy, D. J., Ludbrook, G. L., Clarke, I. J., Chacko, B., Nash, C. H., Matthews, L., Porter, S., Kuchel, T. R."Triiodothyronine supplementation in a sheep model of intensive care". Experimental and Therapeutic Medicine 28.2 (2024): 321.
Chicago
Maiden, M. J., Torpy, D. J., Ludbrook, G. L., Clarke, I. J., Chacko, B., Nash, C. H., Matthews, L., Porter, S., Kuchel, T. R."Triiodothyronine supplementation in a sheep model of intensive care". Experimental and Therapeutic Medicine 28, no. 2 (2024): 321. https://doi.org/10.3892/etm.2024.12611
Copy and paste a formatted citation
x
Spandidos Publications style
Maiden MJ, Torpy DJ, Ludbrook GL, Clarke IJ, Chacko B, Nash CH, Matthews L, Porter S and Kuchel TR: Triiodothyronine supplementation in a sheep model of intensive care. Exp Ther Med 28: 321, 2024.
APA
Maiden, M.J., Torpy, D.J., Ludbrook, G.L., Clarke, I.J., Chacko, B., Nash, C.H. ... Kuchel, T.R. (2024). Triiodothyronine supplementation in a sheep model of intensive care. Experimental and Therapeutic Medicine, 28, 321. https://doi.org/10.3892/etm.2024.12611
MLA
Maiden, M. J., Torpy, D. J., Ludbrook, G. L., Clarke, I. J., Chacko, B., Nash, C. H., Matthews, L., Porter, S., Kuchel, T. R."Triiodothyronine supplementation in a sheep model of intensive care". Experimental and Therapeutic Medicine 28.2 (2024): 321.
Chicago
Maiden, M. J., Torpy, D. J., Ludbrook, G. L., Clarke, I. J., Chacko, B., Nash, C. H., Matthews, L., Porter, S., Kuchel, T. R."Triiodothyronine supplementation in a sheep model of intensive care". Experimental and Therapeutic Medicine 28, no. 2 (2024): 321. https://doi.org/10.3892/etm.2024.12611
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