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Article

Updated meta‑analysis on the therapeutic effects of botanical extract interventions for chronic lower back pain

  • Authors:
    • Ru-Yin Tsai
    • Chin-Chang Chen
    • Sheng-Yi Lin
    • Jhen-You Hu
    • Yao Hsiao
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan, R.O.C., Taichung Municipal Taichung Girls Senior High School, Taichung 40302, Taiwan, R.O.C., School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan, R.O.C.
  • Article Number: 107
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    Published online on: March 31, 2025
       https://doi.org/10.3892/etm.2025.12857
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Abstract

Chronic lower back pain (CLBP) severely affects an individual's quality of life and increases reliance on healthcare services. Previous meta‑analyses have primarily examined the effects of essential oils and herbal remedies separately, without considering their combined therapeutic potential. The present meta‑analysis integrated both treatment modalities to evaluate the efficacy of botanical extract‑based therapies for CLBP management. A systematic review and meta‑analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta‑Analyses guidelines, with data extracted from randomized controlled trials (RCTs) conducted up to July 2024. A comprehensive search of several databases identified 13 RCTs that met the inclusion criteria, focusing on interventions using plant extracts, including various herbal formulations and essential oils. The meta‑analysis demonstrated that botanical extract‑based treatments, whether applied topically, combined with massage or administered orally, were more effective compared with a placebo in reducing pain, enhancing lumbar flexibility and extending walking duration in patients with CLBP. These findings support the role of botanical extracts as viable therapeutic options for CLBP management, emphasizing their potential integration into comprehensive pain management strategies. However, further research is necessary to explore their long‑term efficacy and underlying mechanisms. The present study is registered in PROSPERO (registration no. CRD42024554015).
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Copy and paste a formatted citation
Spandidos Publications style
Tsai R, Chen C, Lin S, Hu J and Hsiao Y: Updated meta‑analysis on the therapeutic effects of botanical extract interventions for chronic lower back pain. Exp Ther Med 29: 107, 2025.
APA
Tsai, R., Chen, C., Lin, S., Hu, J., & Hsiao, Y. (2025). Updated meta‑analysis on the therapeutic effects of botanical extract interventions for chronic lower back pain. Experimental and Therapeutic Medicine, 29, 107. https://doi.org/10.3892/etm.2025.12857
MLA
Tsai, R., Chen, C., Lin, S., Hu, J., Hsiao, Y."Updated meta‑analysis on the therapeutic effects of botanical extract interventions for chronic lower back pain". Experimental and Therapeutic Medicine 29.6 (2025): 107.
Chicago
Tsai, R., Chen, C., Lin, S., Hu, J., Hsiao, Y."Updated meta‑analysis on the therapeutic effects of botanical extract interventions for chronic lower back pain". Experimental and Therapeutic Medicine 29, no. 6 (2025): 107. https://doi.org/10.3892/etm.2025.12857
Copy and paste a formatted citation
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Spandidos Publications style
Tsai R, Chen C, Lin S, Hu J and Hsiao Y: Updated meta‑analysis on the therapeutic effects of botanical extract interventions for chronic lower back pain. Exp Ther Med 29: 107, 2025.
APA
Tsai, R., Chen, C., Lin, S., Hu, J., & Hsiao, Y. (2025). Updated meta‑analysis on the therapeutic effects of botanical extract interventions for chronic lower back pain. Experimental and Therapeutic Medicine, 29, 107. https://doi.org/10.3892/etm.2025.12857
MLA
Tsai, R., Chen, C., Lin, S., Hu, J., Hsiao, Y."Updated meta‑analysis on the therapeutic effects of botanical extract interventions for chronic lower back pain". Experimental and Therapeutic Medicine 29.6 (2025): 107.
Chicago
Tsai, R., Chen, C., Lin, S., Hu, J., Hsiao, Y."Updated meta‑analysis on the therapeutic effects of botanical extract interventions for chronic lower back pain". Experimental and Therapeutic Medicine 29, no. 6 (2025): 107. https://doi.org/10.3892/etm.2025.12857
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