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Early enteral nutrition may reduce the incidence of refeeding syndrome for patients with severe corona virus disease 2019 and high nutritional risk

  • Authors:
    • Liuniu Xiao
    • Xiao Ran
    • Shusheng Li
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 34
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    Published online on: November 28, 2025
       https://doi.org/10.3892/etm.2025.13029
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Abstract

Nutritional therapy is an essential supportive intervention for patients with COVID‑19 who are at high nutritional risk, although the optimal timing for initiating nutritional support remains unclear. The present study investigated the association between the initiation of enteral nutrition (EN) and the incidence of refeeding syndrome (RS) in severely ill patients with COVID‑19 and high nutritional risk. Patients from Tongji Hospital (Wuhan, China), with a Nutrition Risk Screening‑2002 score ≥3 and who received EN, were retrospectively analyzed and categorized into an early EN (EEN) group and a late EN (LEN) group based on the time‑frame of EN initiation. Serum electrolyte levels were assessed on the third day after EN initiation to evaluate the incidence of RS. A total of 211 patients were included in this analysis (EEN group, n=125; LEN group, n=86). The mean time to EN initiation was 2 days in the EEN group and 5 days in the LEN group. Both the incidence and severity of RS were markedly higher in the LEN group, and serum potassium, sodium, phosphorus and magnesium levels were significantly lower in the LEN group on the third day after EN initiation. These findings suggest that early EN initiation may help reduce the risk of RS in critically ill patients with COVID‑19 and high nutritional risk.
View Figures

Figure 1

Flow diagram of participant selection
procedure. COVID-19, coronavirus disease 2019; NRS-2002, Nutrition
Risk Screen-2002; PN, parenteral nutrition; EN, enteral nutrition;
EEN, early EN; LEN, late EN.

Figure 2

Laboratory examinations on admission
and 3 days after EN initiation. *P<0.05 and
**P<0.05. EN, enteral nutrition; EEN, early EN; LEN,
late EN.

Figure 3

Kaplan-Meier survival curve for
3-month overall survival. EN, enteral nutrition; EEN, early EN;
LEN, late EN.

Figure 4

ROC curves for predicting the
refeeding syndrome incidence. ROC, receiver operating
characteristic; EN, enteral nutrition.
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Spandidos Publications style
Xiao L, Ran X and Li S: Early enteral nutrition may reduce the incidence of refeeding syndrome for patients with severe corona virus disease 2019 and high nutritional risk. Exp Ther Med 31: 34, 2026.
APA
Xiao, L., Ran, X., & Li, S. (2026). Early enteral nutrition may reduce the incidence of refeeding syndrome for patients with severe corona virus disease 2019 and high nutritional risk. Experimental and Therapeutic Medicine, 31, 34. https://doi.org/10.3892/etm.2025.13029
MLA
Xiao, L., Ran, X., Li, S."Early enteral nutrition may reduce the incidence of refeeding syndrome for patients with severe corona virus disease 2019 and high nutritional risk". Experimental and Therapeutic Medicine 31.2 (2026): 34.
Chicago
Xiao, L., Ran, X., Li, S."Early enteral nutrition may reduce the incidence of refeeding syndrome for patients with severe corona virus disease 2019 and high nutritional risk". Experimental and Therapeutic Medicine 31, no. 2 (2026): 34. https://doi.org/10.3892/etm.2025.13029
Copy and paste a formatted citation
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Spandidos Publications style
Xiao L, Ran X and Li S: Early enteral nutrition may reduce the incidence of refeeding syndrome for patients with severe corona virus disease 2019 and high nutritional risk. Exp Ther Med 31: 34, 2026.
APA
Xiao, L., Ran, X., & Li, S. (2026). Early enteral nutrition may reduce the incidence of refeeding syndrome for patients with severe corona virus disease 2019 and high nutritional risk. Experimental and Therapeutic Medicine, 31, 34. https://doi.org/10.3892/etm.2025.13029
MLA
Xiao, L., Ran, X., Li, S."Early enteral nutrition may reduce the incidence of refeeding syndrome for patients with severe corona virus disease 2019 and high nutritional risk". Experimental and Therapeutic Medicine 31.2 (2026): 34.
Chicago
Xiao, L., Ran, X., Li, S."Early enteral nutrition may reduce the incidence of refeeding syndrome for patients with severe corona virus disease 2019 and high nutritional risk". Experimental and Therapeutic Medicine 31, no. 2 (2026): 34. https://doi.org/10.3892/etm.2025.13029
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