Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2026 Volume 31 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2026 Volume 31 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
Article Open Access

N‑(p‑Coumaroyl) serotonin mitigates inflammatory responses in lipopolysaccharide‑stimulated RAW264.7 cells and phorbol 12‑myristate 13‑acetate‑stimulated A549 cells through NF‑κB and MAPK inactivation

  • Authors:
    • Seok Han Yun
    • Chang Hyeon Jeon
    • Soo-Jin Park
    • Hee Jae Lee
    • Ok-Kyoung Kwon
    • Jae-Won Lee
  • View Affiliations / Copyright

    Affiliations: Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungcheongbuk 28116, Republic of Korea, Department of Pharmacology, College of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea
    Copyright: © Yun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 58
    |
    Published online on: December 22, 2025
       https://doi.org/10.3892/etm.2025.13053
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Inflammation is a protective response of the body, but excessive inflammation can exacerbate conditions such as acute lung injury and asthma. N‑(p‑Coumaroyl) serotonin (CS) is known to have anti‑inflammatory effects. The present study aimed to explore the anti‑inflammatory effects of CS on lipopolysaccharide (LPS)‑induced inflammatory responses in macrophages and lung epithelial cells. Cellular inflammatory responses and associated signaling pathways were analyzed using ELISA, Western blotting and immunocytochemistry. Initial increase in cytokine (including IL‑6 and TNF‑α) and chemokine [including monocyte chemoattractant protein‑1 (MCP‑1)] levels, nitric oxide formation and inducible NO synthase expression in lipopolysaccharide (LPS)‑stimulated RAW264.7 macrophages, was reduced by CS pretreatment. In addition, CS blocked LPS‑induced MAPK/NF‑κB activation in RAW264.7 cells. CS led to heme oxygenase‑1 (HO‑1) upregulation in RAW264.7 cells. In PMA‑stimulated A549 lung epithelial cells, the increase in IL‑6, TNF‑α and MCP‑1 expression was also attenuated by CS. This was accompanied by decreased MAPK/NF‑κB activation. Furthermore, CS elevated the expression of HO‑1 in A549 cells. Collectively, the present study confirmed that CS exhibited anti‑inflammatory effects in both macrophages and lung epithelial cell lines, suggesting that CS may alleviate systemic or lung inflammation.

Related Articles

  • Abstract
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yun SH, Jeon CH, Park S, Lee HJ, Kwon O and Lee J: <em>N</em>‑(p‑Coumaroyl) serotonin mitigates inflammatory responses in lipopolysaccharide‑stimulated RAW264.7 cells and phorbol 12‑myristate 13‑acetate‑stimulated A549 cells through NF‑&kappa;B and MAPK inactivation. Exp Ther Med 31: 58, 2026.
APA
Yun, S.H., Jeon, C.H., Park, S., Lee, H.J., Kwon, O., & Lee, J. (2026). <em>N</em>‑(p‑Coumaroyl) serotonin mitigates inflammatory responses in lipopolysaccharide‑stimulated RAW264.7 cells and phorbol 12‑myristate 13‑acetate‑stimulated A549 cells through NF‑&kappa;B and MAPK inactivation. Experimental and Therapeutic Medicine, 31, 58. https://doi.org/10.3892/etm.2025.13053
MLA
Yun, S. H., Jeon, C. H., Park, S., Lee, H. J., Kwon, O., Lee, J."<em>N</em>‑(p‑Coumaroyl) serotonin mitigates inflammatory responses in lipopolysaccharide‑stimulated RAW264.7 cells and phorbol 12‑myristate 13‑acetate‑stimulated A549 cells through NF‑&kappa;B and MAPK inactivation". Experimental and Therapeutic Medicine 31.2 (2026): 58.
Chicago
Yun, S. H., Jeon, C. H., Park, S., Lee, H. J., Kwon, O., Lee, J."<em>N</em>‑(p‑Coumaroyl) serotonin mitigates inflammatory responses in lipopolysaccharide‑stimulated RAW264.7 cells and phorbol 12‑myristate 13‑acetate‑stimulated A549 cells through NF‑&kappa;B and MAPK inactivation". Experimental and Therapeutic Medicine 31, no. 2 (2026): 58. https://doi.org/10.3892/etm.2025.13053
Copy and paste a formatted citation
x
Spandidos Publications style
Yun SH, Jeon CH, Park S, Lee HJ, Kwon O and Lee J: <em>N</em>‑(p‑Coumaroyl) serotonin mitigates inflammatory responses in lipopolysaccharide‑stimulated RAW264.7 cells and phorbol 12‑myristate 13‑acetate‑stimulated A549 cells through NF‑&kappa;B and MAPK inactivation. Exp Ther Med 31: 58, 2026.
APA
Yun, S.H., Jeon, C.H., Park, S., Lee, H.J., Kwon, O., & Lee, J. (2026). <em>N</em>‑(p‑Coumaroyl) serotonin mitigates inflammatory responses in lipopolysaccharide‑stimulated RAW264.7 cells and phorbol 12‑myristate 13‑acetate‑stimulated A549 cells through NF‑&kappa;B and MAPK inactivation. Experimental and Therapeutic Medicine, 31, 58. https://doi.org/10.3892/etm.2025.13053
MLA
Yun, S. H., Jeon, C. H., Park, S., Lee, H. J., Kwon, O., Lee, J."<em>N</em>‑(p‑Coumaroyl) serotonin mitigates inflammatory responses in lipopolysaccharide‑stimulated RAW264.7 cells and phorbol 12‑myristate 13‑acetate‑stimulated A549 cells through NF‑&kappa;B and MAPK inactivation". Experimental and Therapeutic Medicine 31.2 (2026): 58.
Chicago
Yun, S. H., Jeon, C. H., Park, S., Lee, H. J., Kwon, O., Lee, J."<em>N</em>‑(p‑Coumaroyl) serotonin mitigates inflammatory responses in lipopolysaccharide‑stimulated RAW264.7 cells and phorbol 12‑myristate 13‑acetate‑stimulated A549 cells through NF‑&kappa;B and MAPK inactivation". Experimental and Therapeutic Medicine 31, no. 2 (2026): 58. https://doi.org/10.3892/etm.2025.13053
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team