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Article

Prophylactic effect of peptide vaccination against hepatocellular carcinoma associated with hepatitis C virus

  • Authors:
    • Nobukazu Komatsu
    • Shigeru Yutani
    • Akira Yamada
    • Shigeki Shichijo
    • Kazumi Yoshida
    • Minoru Itou
    • Ryoko Kuromatsu
    • Tatsuya Ide
    • Masatoshi Tanaka
    • Michio Sata
    • Kyogo Itoh
  • View Affiliations / Copyright

    Affiliations: Department of Immunology and Immunotherapy, Kurume University School of Medicine, Kurume University, Kurume, Fukuoka 830-0011, Japan. kom@med.kurume-u.ac.jp
  • Pages: 619-626
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/etm_00000097
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Abstract

The purpose of the present study was to investigate the prophylactic effects of peptide vaccination against hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV). Two different Phase I clinical trials of HCV-derived peptides for 40 HCV-positive patients with chronic hepatitis (CH) and liver cirrhosis (LC) were conducted from November 2003 to November 2008. Among the patients, 39 (33 CH and 6 LC) received prolonged peptide vaccination with a median vaccination of 26 rounds (range 6-89). Median vaccination and observation periods were 16 months (range 2-61) and 47 months (range 10-69), respectively. Three CH and all 6 LC patients had space-occupying lesions (SOLs) or a history of HCC, respectively. HCC became detectable during the vaccination period in 2 of the 3 CH patients with SOLs prior to vaccination. By contrast, HCC was undetectable throughout the vaccination period in the remaining 36 patients without SOLs. However, HCC became detectable in 4 of these 36 patients, i.e., 2 CH patients at 46 and 29 months after the end of the vaccination period, and 2 LC patients at 49 and 18 months after the end of vaccination. The development of HCC was associated with a reduction in boosted IgG responses to the vaccinated peptides. These results may provide new information on peptide vaccination for HCV-positive CH or LC patients lacking SOLs. Further studies are recommended to confirm the prophylactic effects of peptide vaccination against HCC associated with HCV.
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Copy and paste a formatted citation
Spandidos Publications style
Komatsu N, Yutani S, Yamada A, Shichijo S, Yoshida K, Itou M, Kuromatsu R, Ide T, Tanaka M, Sata M, Sata M, et al: Prophylactic effect of peptide vaccination against hepatocellular carcinoma associated with hepatitis C virus . Exp Ther Med 1: 619-626, 2010.
APA
Komatsu, N., Yutani, S., Yamada, A., Shichijo, S., Yoshida, K., Itou, M. ... Itoh, K. (2010). Prophylactic effect of peptide vaccination against hepatocellular carcinoma associated with hepatitis C virus . Experimental and Therapeutic Medicine, 1, 619-626. https://doi.org/10.3892/etm_00000097
MLA
Komatsu, N., Yutani, S., Yamada, A., Shichijo, S., Yoshida, K., Itou, M., Kuromatsu, R., Ide, T., Tanaka, M., Sata, M., Itoh, K."Prophylactic effect of peptide vaccination against hepatocellular carcinoma associated with hepatitis C virus ". Experimental and Therapeutic Medicine 1.4 (2010): 619-626.
Chicago
Komatsu, N., Yutani, S., Yamada, A., Shichijo, S., Yoshida, K., Itou, M., Kuromatsu, R., Ide, T., Tanaka, M., Sata, M., Itoh, K."Prophylactic effect of peptide vaccination against hepatocellular carcinoma associated with hepatitis C virus ". Experimental and Therapeutic Medicine 1, no. 4 (2010): 619-626. https://doi.org/10.3892/etm_00000097
Copy and paste a formatted citation
x
Spandidos Publications style
Komatsu N, Yutani S, Yamada A, Shichijo S, Yoshida K, Itou M, Kuromatsu R, Ide T, Tanaka M, Sata M, Sata M, et al: Prophylactic effect of peptide vaccination against hepatocellular carcinoma associated with hepatitis C virus . Exp Ther Med 1: 619-626, 2010.
APA
Komatsu, N., Yutani, S., Yamada, A., Shichijo, S., Yoshida, K., Itou, M. ... Itoh, K. (2010). Prophylactic effect of peptide vaccination against hepatocellular carcinoma associated with hepatitis C virus . Experimental and Therapeutic Medicine, 1, 619-626. https://doi.org/10.3892/etm_00000097
MLA
Komatsu, N., Yutani, S., Yamada, A., Shichijo, S., Yoshida, K., Itou, M., Kuromatsu, R., Ide, T., Tanaka, M., Sata, M., Itoh, K."Prophylactic effect of peptide vaccination against hepatocellular carcinoma associated with hepatitis C virus ". Experimental and Therapeutic Medicine 1.4 (2010): 619-626.
Chicago
Komatsu, N., Yutani, S., Yamada, A., Shichijo, S., Yoshida, K., Itou, M., Kuromatsu, R., Ide, T., Tanaka, M., Sata, M., Itoh, K."Prophylactic effect of peptide vaccination against hepatocellular carcinoma associated with hepatitis C virus ". Experimental and Therapeutic Medicine 1, no. 4 (2010): 619-626. https://doi.org/10.3892/etm_00000097
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