Open Access

Effects of irbesartan on 24-h blood pressure changes and urinary albumin levels in Japanese outpatients

  • Authors:
    • Tadashi Arai
    • Mihoko Senda
    • Hitomi Yokoyama
    • Kikuko Yasuda
  • View Affiliations

  • Published online on: July 1, 2010     https://doi.org/10.3892/etm_00000105
  • Pages: 669-673
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Abstract

In Japan, ambulatory blood pressure monitoring (ABPM) became covered by health insurance in April 2008. In The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH2009), the importance of 24-h blood pressure monitoring was also described in an additional section. Therefore, ABPM may be increasingly applied in hypertension treatment. However, in Japan, few studies have presented data on the effects of various anti-hypertensive agents on 24-h blood pressure changes. Irbesartan became commercially available in July 2008 as the sixth angiotensin II type 1 receptor blocker in Japan. In the present study, 24-h blood pressure control was examined using ABPM in Japanese patients with essential hypertension who were treated with irbesartan, and its efficacy was evaluated. This study was completed in 30 of the 32 subjects. This agent decreased both the nocturnal and daytime blood pressures and reduced the rate of change in the systolic blood pressure early in the morning, resulting in favorable blood pressure control. It also significantly decreased the urinary albumin level, suggesting that it exhibits renoprotective effects at doses approved in Japan.
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July-August 2010
Volume 1 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Arai T, Senda M, Yokoyama H and Yasuda K: Effects of irbesartan on 24-h blood pressure changes and urinary albumin levels in Japanese outpatients . Exp Ther Med 1: 669-673, 2010
APA
Arai, T., Senda, M., Yokoyama, H., & Yasuda, K. (2010). Effects of irbesartan on 24-h blood pressure changes and urinary albumin levels in Japanese outpatients . Experimental and Therapeutic Medicine, 1, 669-673. https://doi.org/10.3892/etm_00000105
MLA
Arai, T., Senda, M., Yokoyama, H., Yasuda, K."Effects of irbesartan on 24-h blood pressure changes and urinary albumin levels in Japanese outpatients ". Experimental and Therapeutic Medicine 1.4 (2010): 669-673.
Chicago
Arai, T., Senda, M., Yokoyama, H., Yasuda, K."Effects of irbesartan on 24-h blood pressure changes and urinary albumin levels in Japanese outpatients ". Experimental and Therapeutic Medicine 1, no. 4 (2010): 669-673. https://doi.org/10.3892/etm_00000105