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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December 2005 Volume 16 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2005 Volume 16 Issue 6

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Article

Vitamin B6 suppresses NF-κB activation in LPS-stimulated mouse macrophages

  • Authors:
    • Noriyuki Yanaka
    • Taka-Aki Koyama
    • Shun-Ichiro Komatsu
    • Eri Nakamura
    • Mayumi Kanda
    • Norihisa Kato

  • View Affiliations / Copyright

    Affiliations: Department of Bioresource Science and Technology, Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima 739-8528, Japan
  • Pages: 1071-1075
    |
    Published online on: December 1, 2005
       https://doi.org/10.3892/ijmm.16.6.1071
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Abstract

Although vitamin B6 has been supposed to have anti-inflammatory effects, the molecular mechanism is not fully understood. To explore the mechanism of anti-inflammatory effects of vitamin B6, we have examined the effect of vitamin B6 on lipopolysaccharide (LPS)-stimulated inflammatory response in RAW 264.7 macrophages. This study demonstrated that vitamin B6 (pyridoxal) pretreatment of RAW cells inhibited LPS-induced expression of iNOS and COX-2 at the mRNA and protein levels. Vitamin B6 inhibited LPS-induced nuclear translocation of the NF-κB, the proinflammatory transcription factor, with reduction of the extent of LPS-induced IκBα degradation in RAW cells. Although vitamin B6 did not affect cellular proteasome activity, in vitro phosphorylation analysis with glutathione S-transferase-fused IκBα has shown that vitamin B6 suppressed LPS-induced IκB kinase activation. Furthermore, we demonstrated that elevating dietary vitamin B6 suppressed NO production in vivo in response to LPS administration. These observations suggest that the anti-inflammatory effect of vitamin B6 is mediated by suppression of NF-κB activation.

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Copy and paste a formatted citation
Spandidos Publications style
Yanaka N, Koyama T, Komatsu S, Nakamura E, Kanda M and Kato N: Vitamin B6 suppresses NF-κB activation in LPS-stimulated mouse macrophages. Int J Mol Med 16: 1071-1075, 2005.
APA
Yanaka, N., Koyama, T., Komatsu, S., Nakamura, E., Kanda, M., & Kato, N. (2005). Vitamin B6 suppresses NF-κB activation in LPS-stimulated mouse macrophages. International Journal of Molecular Medicine, 16, 1071-1075. https://doi.org/10.3892/ijmm.16.6.1071
MLA
Yanaka, N., Koyama, T., Komatsu, S., Nakamura, E., Kanda, M., Kato, N."Vitamin B6 suppresses NF-κB activation in LPS-stimulated mouse macrophages". International Journal of Molecular Medicine 16.6 (2005): 1071-1075.
Chicago
Yanaka, N., Koyama, T., Komatsu, S., Nakamura, E., Kanda, M., Kato, N."Vitamin B6 suppresses NF-κB activation in LPS-stimulated mouse macrophages". International Journal of Molecular Medicine 16, no. 6 (2005): 1071-1075. https://doi.org/10.3892/ijmm.16.6.1071
Copy and paste a formatted citation
x
Spandidos Publications style
Yanaka N, Koyama T, Komatsu S, Nakamura E, Kanda M and Kato N: Vitamin B6 suppresses NF-κB activation in LPS-stimulated mouse macrophages. Int J Mol Med 16: 1071-1075, 2005.
APA
Yanaka, N., Koyama, T., Komatsu, S., Nakamura, E., Kanda, M., & Kato, N. (2005). Vitamin B6 suppresses NF-κB activation in LPS-stimulated mouse macrophages. International Journal of Molecular Medicine, 16, 1071-1075. https://doi.org/10.3892/ijmm.16.6.1071
MLA
Yanaka, N., Koyama, T., Komatsu, S., Nakamura, E., Kanda, M., Kato, N."Vitamin B6 suppresses NF-κB activation in LPS-stimulated mouse macrophages". International Journal of Molecular Medicine 16.6 (2005): 1071-1075.
Chicago
Yanaka, N., Koyama, T., Komatsu, S., Nakamura, E., Kanda, M., Kato, N."Vitamin B6 suppresses NF-κB activation in LPS-stimulated mouse macrophages". International Journal of Molecular Medicine 16, no. 6 (2005): 1071-1075. https://doi.org/10.3892/ijmm.16.6.1071
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