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International Journal of Molecular Medicine
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Article

Sparassis crispa suppresses mast cell-mediated allergic inflammation: Role of calcium, mitogen-activated protein kinase and nuclear factor-κB

  • Authors:
    • Hui-Hun Kim
    • Soyoung Lee
    • Thoudam S.K. Singh
    • Jin Kyeong Choi
    • Tae-Yong Shin
    • Sang-Hyun Kim
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea, College of Pharmacy, Woosuk University, Jeonju 565-701, Republic of Korea
  • Pages: 344-350
    |
    Published online on: May 14, 2012
       https://doi.org/10.3892/ijmm.2012.1000
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Abstract

Allergic inflammatory disease such as food allergy, asthma and atopic dermatitis are increasing worldwide. In this study, we investigated the effect of water extract of Sparassis crispa (WESC) Fr. (Aphyllophoromycetideae) on mast cell-mediated allergic inflammation and the possible mechanisms of action. WESC inhibited compound 48/80-induced systemic anaphylaxis and serum histamine release in mice. WESC decreased immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis. Additionally, WESC reduced histamine release and intracellular calcium in human mast cells activated by phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187. WESC decreased PMA and A23187-stimulated expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, inlerleukin (IL)-6 and IL-1β. The inhibitory effect of WESC on pro-inflammatory cytokines was nuclear factor-κB, extracellular signal-regulated kinase and p38 mitogen-activated protein kinase-dependent. Our results suggest potential therapeutic application of WESC in allergic inflammatory diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Kim H, Lee S, Singh TS, Choi JK, Shin T and Kim S: Sparassis crispa suppresses mast cell-mediated allergic inflammation: Role of calcium, mitogen-activated protein kinase and nuclear factor-κB. Int J Mol Med 30: 344-350, 2012.
APA
Kim, H., Lee, S., Singh, T.S., Choi, J.K., Shin, T., & Kim, S. (2012). Sparassis crispa suppresses mast cell-mediated allergic inflammation: Role of calcium, mitogen-activated protein kinase and nuclear factor-κB. International Journal of Molecular Medicine, 30, 344-350. https://doi.org/10.3892/ijmm.2012.1000
MLA
Kim, H., Lee, S., Singh, T. S., Choi, J. K., Shin, T., Kim, S."Sparassis crispa suppresses mast cell-mediated allergic inflammation: Role of calcium, mitogen-activated protein kinase and nuclear factor-κB". International Journal of Molecular Medicine 30.2 (2012): 344-350.
Chicago
Kim, H., Lee, S., Singh, T. S., Choi, J. K., Shin, T., Kim, S."Sparassis crispa suppresses mast cell-mediated allergic inflammation: Role of calcium, mitogen-activated protein kinase and nuclear factor-κB". International Journal of Molecular Medicine 30, no. 2 (2012): 344-350. https://doi.org/10.3892/ijmm.2012.1000
Copy and paste a formatted citation
x
Spandidos Publications style
Kim H, Lee S, Singh TS, Choi JK, Shin T and Kim S: Sparassis crispa suppresses mast cell-mediated allergic inflammation: Role of calcium, mitogen-activated protein kinase and nuclear factor-κB. Int J Mol Med 30: 344-350, 2012.
APA
Kim, H., Lee, S., Singh, T.S., Choi, J.K., Shin, T., & Kim, S. (2012). Sparassis crispa suppresses mast cell-mediated allergic inflammation: Role of calcium, mitogen-activated protein kinase and nuclear factor-κB. International Journal of Molecular Medicine, 30, 344-350. https://doi.org/10.3892/ijmm.2012.1000
MLA
Kim, H., Lee, S., Singh, T. S., Choi, J. K., Shin, T., Kim, S."Sparassis crispa suppresses mast cell-mediated allergic inflammation: Role of calcium, mitogen-activated protein kinase and nuclear factor-κB". International Journal of Molecular Medicine 30.2 (2012): 344-350.
Chicago
Kim, H., Lee, S., Singh, T. S., Choi, J. K., Shin, T., Kim, S."Sparassis crispa suppresses mast cell-mediated allergic inflammation: Role of calcium, mitogen-activated protein kinase and nuclear factor-κB". International Journal of Molecular Medicine 30, no. 2 (2012): 344-350. https://doi.org/10.3892/ijmm.2012.1000
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