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International Journal of Molecular Medicine
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August 2012 Volume 30 Issue 2

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Article

Oral administration of Enterococcus faecalis FK-23 suppresses Th17 cell development and attenuates allergic airway responses in mice

  • Authors:
    • Bei Zhang
    • Jun An
    • Takashi Shimada
    • Shuang Liu
    • Kazutaka Maeyama
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Informational Biomedicine, Ehime University Graduate School of Medicine, Shitsugawa, Toon-shi, Ehime 791-0295, Japan, Central Research Laboratories, Nichinichi Pharmaceutical Co., Ltd., Mie 518-1417, Japan
  • Pages: 248-254
    |
    Published online on: May 24, 2012
       https://doi.org/10.3892/ijmm.2012.1010
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Abstract

Evidence is increasing that oral administration of probiotics can attenuate asthmatic responses both in murine models and clinical trials. T-helper 17 (Th17) cells, a subset of CD4+ T cells have been implicated as having an important role in the development of several allergic disorders, but the relationship between oral administration of probiotics and Th17 development has not been well studied. BALB/c mice were given lysed Enterococcus faecalis FK-23 (LFK) orally for 28 days. After sensitization by subcutaneous injection of ovalbumin (OVA) on Days 14 and 21 and 1% OVA inhalation on Days 25, 26 and 27, they were challenged with a 5% OVA aerosol on Day 28. Twenty-four hours later, airway resistance and accumulation of inflammatory cells in bronchoalveolar lavage fluid (BALF) and lung tissues were determined. Ιnterleukin (IL)-17-expressing CD4+ lymphocytes isolated from lung, spleen and lamina propria of the intestine were detected by flow cytometry. The expression of IL-6 and TGF-β mRNA was assessed by real-time PCR. Increases in airway hyperresponsiveness, and numbers of total leukocytes and mast cells in BALF induced by OVA challenge were significantly suppressed by oral administration of LFK. The increased percentage of IL-17-expressing CD4+ cells from lung, spleen and intestine in OVA-challenged mice was reduced following LFK treatment. We conclude that the oral administration of LFK suppresses the asthmatic response and that this is associated with attenuation of Th17 cell development.
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1. 

Y IwakuraS NakaeS SaijoH IshigameThe roles of IL-17A in inflammatory immune responses and host defense against pathogensImmunol Rev2265779200810.1111/j.1600-065X.2008.00699.x19161416

2. 

SD HurstT MuchamuelDM GormanNew IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25J Immunol169443453200210.4049/jimmunol.169.1.44312077275

3. 

N OdaPB CanelosDM EssayanBA PlunkettAC MyersSK HuangInterleukin-17F induces pulmonary neutrophilia and amplifies antigen-induced allergic responseAm J Respir Crit Care Med1711218200510.1164/rccm.200406-778OC15477493

4. 

H ParkZ LiXO YangA distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Nat Immunol611331141200510.1038/ni126116200068

5. 

XO YangSH ChangH ParkRegulation of inflammatory responses by IL-17FJ Exp Med20510631075200810.1084/jem.2007197818411338

6. 

K ObokiT OhnoH SaitoS NakaeTh17 and allergyAllergol Int57121134200810.2332/allergolint.R-07-16018427165

7. 

N BlumerS SelS VirnaPerinatal maternal application of Lactobacillus rhamnosus GG suppresses allergic airway inflammation in mouse offspringClin Exp Allergy37348357200717359385

8. 

W FeleszkoJ JaworskaRD RhaProbiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthmaClin Exp Allergy37498505200710.1111/j.1365-2222.2006.02629.x

9. 

P ForsytheMD InmanJ BienenstockOral treatment with live Lactobacillus reuteri inhibits the allergic airway response in miceAm J Respir Crit Care Med1755615692007

10. 

K KarimiMD InmanJ BienenstockP ForsytheLactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in miceAm J Respir Crit Care Med179186193200910.1164/rccm.200806-951OC

11. 

T ShimadaL ChengM IdeS FukudaT EnomotoT ShirakawaEffect of lysed Enterococcus faecalis FK-23 (LFK) on allergen-induced peritoneal accumulation of eosinophils in miceClin Exp Allergy336846872003

12. 

T ShimadaL ChengA YamasakiEffects of lysed Enterococcus faecalis FK-23 on allergen-induced serum antibody responses and active cutaneous anaphylaxis in miceClin Exp Allergy34178417882004

13. 

MH CatoIW YauRC RickertMagnetic-based purification of untouched mouse germinal center B cells for ex vivo manipulation and biochemical analysisNat Protoc6953960201110.1038/nprot.2011.34421720310

14. 

KA SauerP ScholtesR KarwotS FinottoIsolation of CD4+ cells from murine lungs: a method to analyze ongoing immune responses in the lungNat Protoc128702875200617406546

15. 

K AtarashiT TanoueK HondaInduction of lamina propria Th17 cells by intestinal commensal bacteriaVaccine2880368038201010.1016/j.vaccine.2010.09.02620849872

16. 

JR HuntR MartinelliVC AdamsGA RookLR BrunetIntragastric administration of Mycobacterium vaccae inhibits severe pulmonary allergic inflammation in a mouse modelClin Exp Allergy35685690200515898994

17. 

S NakaeY KomiyamaA NambuAntigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responsesImmunity17375387200210.1016/S1074-7613(02)00391-612354389

18. 

S MoletQ HamidF DavoineIL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokinesJ Allergy Clin Immunol108430438200110.1067/mai.2001.11792911544464

19. 

A BarczykW PierzchalaE SozanskaInterleukin-17 in sputum correlates with airway hyperresponsiveness to methacholineRespir Med97726733200310.1053/rmed.2003.150712814161

20. 

L ZhouIvanov IIR SpolskiIL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathwaysNat Immunol8967974200710.1038/ni148817581537

21. 

K GhoreschiA LaurenceXP YangGeneration of pathogenic T(H)17 cells in the absence of TGF-beta signallingNature467967971201010.1038/nature0944720962846

22. 

E BettelliY CarrierW GaoReciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsNature441235238200610.1038/nature04753

23. 

L ZhouJE LopesMM ChongTGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat functionNature453236240200810.1038/nature0687818368049

24. 

S TanabeY KinutaY SaitoBifidobacterium infantis suppresses proinflammatory interleukin-17 production in murine splenocytes and dextran sodium sulfate-induced intestinal inflammationInt J Mol Med221811852008

25. 

RL JanKC YehMH HsiehLactobacillus gasseri suppresses Th17 pro-inflammatory response and attenuates allergen-induced airway inflammation in a mouse model of allergic asthmaBr J NutrOct142011(Epub ahead of print).

26. 

B FoligneG ZoumpopoulouJ DewulfA key role of dendritic cells in probiotic functionalityPLoS One2e313200710.1371/journal.pone.000031317375199

27. 

HK KwonCG LeeJS SoGeneration of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disordersProc Natl Acad Sci USA10721592164201020080669

28. 

P PuccettiU GrohmannIDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activationNat Rev Immunol7817823200710.1038/nri216317767193

29. 

AL HartK LammersP BrigidiModulation of human dendritic cell phenotype and function by probiotic bacteriaGut5316021609200410.1136/gut.2003.03732515479680

30. 

Y BelkaidThe role of CD4(+)CD25(+) regulatory T cells in Leishmania infectionExpert Opin Biol Ther38758852003

31. 

E SchiaviB BarlettaC ButteroniS CorintiM BoirivantG Di FeliceOral therapeutic administration of a probiotic mixture suppresses established Th2 responses and systemic anaphylaxis in a murine model of food allergyAllergy66499508201110.1111/j.1398-9995.2010.02501.x21058959

32. 

P ForsytheProbiotics and lung diseasesChest139901908201110.1378/chest.10-186121467057

33. 

S MichailThe role of probiotics in allergic diseasesAllergy Asthma Clin Immunol55200910.1186/1710-1492-5-5

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Copy and paste a formatted citation
Spandidos Publications style
Zhang B, An J, Shimada T, Liu S and Maeyama K: Oral administration of Enterococcus faecalis FK-23 suppresses Th17 cell development and attenuates allergic airway responses in mice. Int J Mol Med 30: 248-254, 2012.
APA
Zhang, B., An, J., Shimada, T., Liu, S., & Maeyama, K. (2012). Oral administration of Enterococcus faecalis FK-23 suppresses Th17 cell development and attenuates allergic airway responses in mice. International Journal of Molecular Medicine, 30, 248-254. https://doi.org/10.3892/ijmm.2012.1010
MLA
Zhang, B., An, J., Shimada, T., Liu, S., Maeyama, K."Oral administration of Enterococcus faecalis FK-23 suppresses Th17 cell development and attenuates allergic airway responses in mice". International Journal of Molecular Medicine 30.2 (2012): 248-254.
Chicago
Zhang, B., An, J., Shimada, T., Liu, S., Maeyama, K."Oral administration of Enterococcus faecalis FK-23 suppresses Th17 cell development and attenuates allergic airway responses in mice". International Journal of Molecular Medicine 30, no. 2 (2012): 248-254. https://doi.org/10.3892/ijmm.2012.1010
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang B, An J, Shimada T, Liu S and Maeyama K: Oral administration of Enterococcus faecalis FK-23 suppresses Th17 cell development and attenuates allergic airway responses in mice. Int J Mol Med 30: 248-254, 2012.
APA
Zhang, B., An, J., Shimada, T., Liu, S., & Maeyama, K. (2012). Oral administration of Enterococcus faecalis FK-23 suppresses Th17 cell development and attenuates allergic airway responses in mice. International Journal of Molecular Medicine, 30, 248-254. https://doi.org/10.3892/ijmm.2012.1010
MLA
Zhang, B., An, J., Shimada, T., Liu, S., Maeyama, K."Oral administration of Enterococcus faecalis FK-23 suppresses Th17 cell development and attenuates allergic airway responses in mice". International Journal of Molecular Medicine 30.2 (2012): 248-254.
Chicago
Zhang, B., An, J., Shimada, T., Liu, S., Maeyama, K."Oral administration of Enterococcus faecalis FK-23 suppresses Th17 cell development and attenuates allergic airway responses in mice". International Journal of Molecular Medicine 30, no. 2 (2012): 248-254. https://doi.org/10.3892/ijmm.2012.1010
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