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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September 2012 Volume 30 Issue 3

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Article

Effects on inflammatory responses by the sphingoid base 4,8-sphingadienine

  • Authors:
    • Evelien Rozema
    • Markus Binder
    • Murty Bulusu
    • Valery Bochkov
    • Georg Krupitza
    • Brigitte Kopp
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacognosy, University of Vienna, A-1090 Vienna, Austria, Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, A-1090 Vienna, Austria, Institute of Clinical Pathology, Medical University of Vienna, A-1090 Vienna, Austria
  • Pages: 703-707
    |
    Published online on: June 15, 2012
       https://doi.org/10.3892/ijmm.2012.1035
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Abstract

Sphingolipids (SLs) are a class of lipids, which are structural cell components involved in the regulation of cellular processes such as cell proliferation, differentiation, apoptosis and inflammation. Dietary SLs are enzymatically hydrolyzed in the gut lumen into metabolites, namely ceramides and sphingoid bases. The sphingoid base 4,8-sphingadienine (4,8-SD) is the metabolite of glucocerebrosides derived from plants that are part of the human diet. The present findings provide insight into the effects of 4,8-SD on inflammatory responses that may be of nutritional and therapeutic benefit. We demonstrated that 4,8-SD significantly inhibited tumor necrosis factor-α (TNF-α)- and lipopolysaccharide (LPS)-induced expression of IL-8 and E-selectin in human endothelial cells in a dose-dependent manner. The anti-inflammatory effect was observed at significantly lower concentrations of 4,8-SD compared those affecting cell viability as judged by the LDH and WST-1 assays.
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Copy and paste a formatted citation
Spandidos Publications style
Rozema E, Binder M, Bulusu M, Bochkov V, Krupitza G and Kopp B: Effects on inflammatory responses by the sphingoid base 4,8-sphingadienine. Int J Mol Med 30: 703-707, 2012.
APA
Rozema, E., Binder, M., Bulusu, M., Bochkov, V., Krupitza, G., & Kopp, B. (2012). Effects on inflammatory responses by the sphingoid base 4,8-sphingadienine. International Journal of Molecular Medicine, 30, 703-707. https://doi.org/10.3892/ijmm.2012.1035
MLA
Rozema, E., Binder, M., Bulusu, M., Bochkov, V., Krupitza, G., Kopp, B."Effects on inflammatory responses by the sphingoid base 4,8-sphingadienine". International Journal of Molecular Medicine 30.3 (2012): 703-707.
Chicago
Rozema, E., Binder, M., Bulusu, M., Bochkov, V., Krupitza, G., Kopp, B."Effects on inflammatory responses by the sphingoid base 4,8-sphingadienine". International Journal of Molecular Medicine 30, no. 3 (2012): 703-707. https://doi.org/10.3892/ijmm.2012.1035
Copy and paste a formatted citation
x
Spandidos Publications style
Rozema E, Binder M, Bulusu M, Bochkov V, Krupitza G and Kopp B: Effects on inflammatory responses by the sphingoid base 4,8-sphingadienine. Int J Mol Med 30: 703-707, 2012.
APA
Rozema, E., Binder, M., Bulusu, M., Bochkov, V., Krupitza, G., & Kopp, B. (2012). Effects on inflammatory responses by the sphingoid base 4,8-sphingadienine. International Journal of Molecular Medicine, 30, 703-707. https://doi.org/10.3892/ijmm.2012.1035
MLA
Rozema, E., Binder, M., Bulusu, M., Bochkov, V., Krupitza, G., Kopp, B."Effects on inflammatory responses by the sphingoid base 4,8-sphingadienine". International Journal of Molecular Medicine 30.3 (2012): 703-707.
Chicago
Rozema, E., Binder, M., Bulusu, M., Bochkov, V., Krupitza, G., Kopp, B."Effects on inflammatory responses by the sphingoid base 4,8-sphingadienine". International Journal of Molecular Medicine 30, no. 3 (2012): 703-707. https://doi.org/10.3892/ijmm.2012.1035
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