Downregulation of nucleoporin 88 and 214 induced by oridonin may protect OCIM2 acute erythroleukemia cells from apoptosis through regulation of nucleocytoplasmic transport of NF-κB

FP SantosCE Bueso-RamosF RavandiAcute erythroleukemia: diagnosis and managementExpert Rev Hematol3705718201010.1586/ehm.10.6221091147

MS HaydenS GhoshShared principles in NF-kappaB signalingCell132344362200810.1016/j.cell.2008.01.02018267068

KM RyanMK ErnstNR RiceKH VousdenRole of NF-kappaB in p53-mediated programmed cell deathNature404892897200010.1038/3500913010786798

V BaudM KarinIs NF-kappaB a good target for cancer therapy?Hopes and pitfalls Nat Rev Drug Discov83340200910.1038/nrd278119116625

ND PerkinsTD GilmoreGood cop, bad cop: the different faces of NF-kappaBCell Death Differ13759772200610.1038/sj.cdd.440183816410803

K WeisNucleocytoplasmic transport: cargo trafficking across the borderCurr Opin Cell Biol14328335200210.1016/S0955-0674(02)00337-X12067655

VE GouldA OrucevicH ZentgrafP GattusoN MartinezA AlonsoNup88 (karyoporin) in human malignant neoplasms and dysplasias: correlations of immunostaining of tissue sections, cytologic smears, and immunoblot analysisHum Pathol33536544200210.1053/hupa.2002.124785

VE GouldN MartinezA OrucevicJ SchneiderA AlonsoA novel, nuclear pore-associated, widely distributed molecule overexpressed in oncogenesis and developmentAm J Pathol15716051613200010.1016/S0002-9440(10)64798-011073820

A EmterlingJ SkoglundG ArbmanClinicopathological significance of Nup88 expression in patients with colorectal cancerOncology64361369200310.1159/00007029412759533

M FornerodM OhnoM YoshidaIW MattajCRM1 is an export receptor for leucine-rich nuclear export signalsCell9010511060199710.1016/S0092-8674(00)80371-29323133

F GaoQ TangP YangY FangW LiY WuApoptosis inducing and differentiation enhancement effect of oridonin on the all-trans-retinoic acid-sensitive and -resistant acute promyelocytic leukemia cellsInt J Lab Hematol32e114e122201010.1111/j.1751-553X.2009.01147.x

GB ZhouSJ ChenZY WangZ ChenBack to the future of oridonin: again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivoCell Res17274276200710.1038/cr.2007.2117426700

FH GaoF LiuW WeiOridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cellsInt J Mol Med29649655201222294162

Z JiQJ TangJS ZhangY YangYF LiuYJ PanOridonin-induced apoptosis in SW620 human colorectal adenocarcinoma cellsOncol Lett213031307201122848306

S GhoshM KarinMissing pieces in the NF-kappaB puzzleCell109SupplS81S96200210.1016/S0092-8674(02)00703-111983155

V KirkinS JoosM ZornigThe role of Bcl-2 family members in tumorigenesisBiochim Biophys Acta1644229249200410.1016/j.bbamcr.2003.08.00914996506

NA ThornberryCaspases: key mediators of apoptosisChem Biol5R97R103199810.1016/S1074-5521(98)90615-99578633

R BernadD EngelsmaH SandersonH PickersgillM FornerodNup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear exportJ Biol Chem2811937819386200610.1074/jbc.M51258520016675447

S HuttenRH KehlenbachNup214 is required for CRM1-dependent nuclear protein export in vivoMol Cell Biol2667726785200610.1128/MCB.00342-0616943420

AE UvP RothN XylourgidisA WickbergR CanteraC Samakovlismembers only encodes a Drosophila nucleoporin required for rel protein import and immune response activationGenes Dev1419451957200010921908

P RothN XylourgidisN SabriA UvM FornerodC SamakovlisThe Drosophila nucleoporin DNup88 localizes DNup214 and CRM1 on the nuclear envelope and attenuates NES-mediated nuclear exportJ Cell Biol1637017062003

N XylourgidisP RothN SabriV TsarouhasC SamakovlisThe nucleoporin Nup214 sequesters CRM1 at the nuclear rim and modulates NFkappaB activation in DrosophilaJ Cell Sci11944094419200610.1242/jcs.0320117032737