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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November 2012 Volume 30 Issue 5

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Review

microRNAs and thyroid cancer: Biological and clinical significance (Review)

  • Authors:
    • Giulia Costanza Leonardi
    • Saverio Candido
    • Maurizio Carbone
    • Valeria Colaianni
    • Sebastiano F. Garozzo
    • Diana Cinà
    • Massimo Libra
  • View Affiliations / Copyright

    Affiliations: Laboratory of Translational Oncology and Functional Genomics, Section of Pathology and Oncology, Department of Biomedical Sciences, University of Catania, Catania, Italy, Clinical Pathology Laboratory, Garibaldi Hospital, Catania, Italy
  • Pages: 991-999
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    Published online on: August 8, 2012
       https://doi.org/10.3892/ijmm.2012.1089
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Abstract

Despite recent advances in the management of thyroid cancer, the survival rate of this tumor may still be improved. Therefore, the identification of biological and molecular features of indolent and aggressive disease would be critical to define clinically useful predictors of high-risk lesions. microRNAs (miRNAs) are small RNA molecules with regulatory function and marked tissue specificity that modulate multiple targets belonging to several pathways. They are frequently deregulated in cancer and constitute a new class of blood-based biomarkers useful for cancer detection and prognosis definition, including thyroid cancer. In this review, the role of miRNAs in thyroid cancer development is described. The most common miRNAs detected in thyroid cancer along with their clinical significance are also discussed. Further studies aimed to detect plasma-based miRNA biomarkers in thyroid cancer patients may provide further insight into the management of thyroid cancer.
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1. 

PS MeltzerCancer genomics: small RNAs with big impactsNature435745746200510.1038/435745a15944682

2. 

L HeGJ HannonMicroRNAs: small RNAs with a big role in gene regulationNat Rev Genet5522531200410.1038/nrg137915211354

3. 

I BentwichA AvnielY KarovR AharonovS GiladO BaradA BarzilaiP EinatU EinavE MeiriIdentification of hundreds of conserved and nonconserved human microRNAsNat Genet37766770200510.1038/ng159015965474

4. 

DP BartelMicroRNAs: target recognition and regulatory functionsCell136215233200910.1016/j.cell.2009.01.00219167326

5. 

MT McManusMicroRNAs and cancerSemin Cancer Biol13253258200310.1016/S1044-579X(03)00038-5

6. 

CM CroceGA CalinmiRNAs, cancer, and stem cell divisionCell12267200510.1016/j.cell.2005.06.03616009126

7. 

C SevignaniGA CalinLD SiracusaCM CroceMammalian micro-RNAs: a small world for fine-tuning gene expressionMamm Genome17189202200610.1007/s00335-005-0066-316518686

8. 

GA CalinCM CroceMicroRNA-cancer connection: the beginning of a new taleCancer Res6673907394200610.1158/0008-5472.CAN-06-080016885332

9. 

JA ChanAM KrichevskyKS KosikMicroRNA-21 is an antiapoptotic factor in human glioblastoma cellsCancer Res6560296033200510.1158/0008-5472.CAN-05-013716024602

10. 

RA DeLellisRV LloydPU HeitzC EngWorld Health Organization Classification of Tumors. Pathology and Genetics of Tumors of Endocrine OrgansIARC PressLyon2004

11. 

B WightmanI HaG RuvkunPosttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegansCell75855862199310.1016/0092-8674(93)90530-48252622

12. 

RC LeeRL FeinbaumV AmbrosThe C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14Cell758438541993

13. 

BJ ReinhartFJ SlackM BassonAE PasquinelliJC BettingerAE RougvieHR HorvitzG RuvkunThe 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegansNature403901906200010.1038/3500260710706289

14. 

AE PasquinelliBJ ReinhartF SlackMQ MartindaleMI KurodaB MallerDC HaywardEE BallB DegnanP MüllerConservation of the sequence and temporal expression of let-7 heterochronic regulatory RNANature4088689200010.1038/3504055611081512

15. 

RC LeeV AmbrosAn extensive class of small RNAs in Caenorhabditis elegansScience294862864200110.1126/science.106532911679672

16. 

M Lagos-QuintanaR RauhutW LendeckelT TuschlIdentification of novel genes coding for small expressed RNAsScience294853858200110.1126/science.106492111679670

17. 

NC LauLP LimEG WeinsteinDP BartelAn abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegansScience294858862200110.1126/science.106506211679671

18. 

X XieJ LuEJ KulbokasTR GolubV MoothaK Lindblad-TohES LanderM KellisSystematic discovery of regulatory motifs in human promoters and 30 UTRs by comparison of several mammalsNature434338345200510.1038/nature0344115735639

19. 

DP BartelMicroRNAs: genomics, biogenesis, mechanism and functionCell116281297200410.1016/S0092-8674(04)00045-514744438

20. 

VN KimJW NamGenomics of microRNATrends Genet22165173200610.1016/j.tig.2006.01.00316446010

21. 

J HanY LeeKH YeomJW NamI HeoJK RheeSY SohnY ChoBT ZhangVN KimMolecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complexCell125887901200610.1016/j.cell.2006.03.04316751099

22. 

Y LeeK JeonJT LeeS KimVN KimMicroRNA maturation: stepwise processing and subcellular localizationEMBO J2146634670200210.1093/emboj/cdf47612198168

23. 

Y LeeC AhnJ HanH ChoiJ KimJ YimJ LeeP ProvostO RadmarkS KimVN KimThe nuclear RNase III Drosha initiates microRNA processingNature425415419200310.1038/nature0195714508493

24. 

E LundS GuttingerA CaladoJE DahlbergU KutayNuclear export of microRNA precursorsScience3039598200410.1126/science.1090599

25. 

R YiY QinIG MacaraBR CullenExportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAsGenes Dev1730113016200310.1101/gad.115880314681208

26. 

MT BohnsackK CzaplinskiD GorlichExportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of premiRNAsRNA10185191200410.1261/rna.516760414730017

27. 

TP ChendrimadaRI GregoryE KumaraswamyJ NormanN CoochK NishikuraR ShiekhattarTRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencingNature436740744200510.1038/nature0386815973356

28. 

RI GregoryTP ChendrimadaN CoochR ShiekhattarHuman RISC couples microRNA biogenesis and post-transcriptional gene silencingCell123631640200510.1016/j.cell.2005.10.02216271387

29. 

G MeisterM LandthalerA PatkaniowskaY DorsettG TengT TuschlHuman Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAsMol Cell15185197200410.1016/j.molcel.2004.07.00715260970

30. 

SC HammondE BernsteinD BeachGJ HannonAn RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cellsNature404293296200010.1038/3500510710749213

31. 

Y ZengEJ WagnerBR CullenBoth natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cellsMol Cell913271333200210.1016/S1097-2765(02)00541-512086629

32. 

Y ZengBR CullenSequence requirements for microRNA processing and function in human cellsRNA9112123200310.1261/rna.278050312554881

33. 

A Esquela-KerscherFJ SlackOncomirs - microRNAs with a role in cancerNat Rev6259269200610.1038/nrc1840

34. 

GA CalinC SevignaniCD DumitruT HyslopE NochS YendamuriM ShimizuS RattanF BullrichM NegriniCM CroceHuman microRNA genes are frequently located at fragile sites and genomic regions involved in cancersProc Natl Acad Sci USA10129993004200410.1073/pnas.030732310114973191

35. 

J LuG GetzEA MiskaE Alvarez-SaavedraJ LambD PeckA Sweet-CorderoBL EbertRH MakAA FerrandoMicroRNA expression profiles classify human cancersNature435834838200510.1038/nature0370215944708

36. 

BP LewisIH ShihMW Jones-RhoadesDP BartelCB BurgePrediction of mammalian microRNA targetsCell115787798200310.1016/S0092-8674(03)01018-314697198

37. 

SM HammondMicroRNAs as oncogenesCurr Opin Genet Dev1649200610.1016/j.gde.2005.12.005

38. 

SM JohnsonH GrosshansJ ShingaraM ByromR JarvisA ChengE LabourierKL ReinertD BrownFJ SlackRAS is regulated by the let-7 microRNA familyCell120635647200510.1016/j.cell.2005.01.01415766527

39. 

GA CalinCG LiuC SevignaniM FerracinN FelliCD DumitruM ShimizuA CimminoS ZupoM DonoMicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemiasProc Natl Acad Sci USA1011175511760200410.1073/pnas.040443210115284443

40. 

L HeJM ThomsonMT HemannE Hernando-MongeD MuS GoodsonS PowersC Cordon-CardoSW LoweGJ HannonSM HammondA microRNA polycistron as a potential human oncogeneNature435828833200510.1038/nature0355215944707

41. 

N YanaiharaN CaplenE BowmanM SeikeK KumamotoM YiRM StephensA OkamotoJ YokotaT TanakaUnique microRNA molecular profiles in lung cancer diagnosis and prognosisCancer Cell9189198200610.1016/j.ccr.2006.01.02516530703

42. 

A CimminoGA CalinM FabbriMV IorioM FerracinM ShimizuSE WojcikRI AqeilanS ZupoM DonomiR-15 and miR-16 induce apoptosis by targeting BCL2Proc Natl Acad Sci USA1021394413949200510.1073/pnas.050665410216166262

43. 

MV IorioM FerracinCG LiuA VeroneseR SpizzoS SabbioniE MagriM PedrialiM FabbriM CampiglioMicroRNA gene expression deregulation in human breast cancerCancer Res6570657070200510.1158/0008-5472.CAN-05-178316103053

44. 

N FelliL FontanaE PelosiR BottaD BonciF FacchianoF LiuzziV LulliO MorsilliS SantoroMicro-RNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulationProc Natl Acad Sci USA1021808118086200510.1073/pnas.050621610216330772

45. 

S VoliniaGA CalinCG LiuS AmbsA CimminoF PetroccaR VisoneM IorioC RoldoM FerracinA microRNA expression signature of human solid tumors defines cancer gene targetsProc Natl Acad Sci USA10322572261200610.1073/pnas.051056510316461460

46. 

PM VoorhoeveC le SageM SchrierAJ GillisH StoopR NagelYP LiuJ van DuijseJ DrostA GriekspoorA genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumorsCell12411691181200610.1016/j.cell.2006.02.037

47. 

F WeberRE TeresiCE BroelschA FrillingC EngA limited set of human MicroRNA is deregulated in follicular thyroid carcinomaJ Clin Endocrinol Metab9135843591200610.1210/jc.2006-069316822819

48. 

WS ArgravesLM GreeneMA CooleyWM GallagherFibulins: physiological and disease perspectivesEMBO Rep411271131200310.1038/sj.embor.740003314647206

49. 

WM GallagherLM GreeneMP RyanV SierraA BergerP Laurent-PuigE ConseillerHuman fibulin-4: analysis of its biosynthetic processing and mRNA expression in normal and tumour tissuesFEBS Lett4895966200110.1016/S0014-5793(00)02389-911231014

50. 

KM SchulteC JonasR KrebsHD RöherActivin A and activin receptors in thyroid cancerThyroid11314200110.1089/1050725015050060311272093

51. 

MN NikiforovaGC TsengD StewardD DiorioYE NikiforovMicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utilityJ Clin Endocrinol Metab9316001608200810.1210/jc.2007-269618270258

52. 

M ColamaioE BorboneL RussoM BiancoA FedericoD CalifanoG ChiappettaP PallanteG TronconeS BattistaA FuscomiR-191 down-regulation plays a role in thyroid follicular tumors through CDK6 targetingJ Clin Endocrinol Metab9619151924201110.1210/jc.2011-040821956418

53. 

A JemalLX CleggE WardLA RiesX WuPM JamisonPA WingoHL HoweRN AndersonBK EdwardsAnnual report to the nation on the status of cancer, 1975–2001, with a special feature regarding survivalCancer1013272004

54. 

ET KimuraMN NikiforovaZ ZhuJA KnaufYE NikiforovJA FaginHigh prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinomaCancer Res6314541457200312670889

55. 

RM MelilloMD CastelloneV GuarinoV De FalcoAM CiraficiG SalvatoreF CaiazzoF BasoloR GianniniM KruhofferThe RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cellsJ Clin Invest11510681081200510.1172/JCI20052275815761501

56. 

Y CohenM XingE MamboZ GuoG WuB TrinkU BellerWH WestraPW LadensonD SidranskyBRAF mutation in papillary thyroid carcinomaJ Natl Cancer Inst95625627200310.1093/jnci/95.8.62512697856

57. 

MN NikiforovaET KimuraM GandhiPW BiddingerJA KnaufF BasoloZ ZhuR GianniniG SalvatoreA FuscoBRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomasJ Clin Endocrinol Metab8853995404200310.1210/jc.2003-03083814602780

58. 

K CzeneP LichtensteinK HemminkiEnvironmental and heritable causes of cancer among 9.6 million individuals in the Swedish Family-Cancer DatabaseInt J Cancer99260266200210.1002/ijc.1033211979442

59. 

H HeK JazdzewskiW LiS LiyanarachchiR NagyS VoliniaGA CalinCG LiuK FranssilaS SusterThe role of microRNA genes in papillary thyroid carcinomaProc Natl Acad Sci USA1021907519080200510.1073/pnas.050960310216365291

60. 

S CahillP SmythSP FinnK DenningR FlavinEM O’ReganJ LiA PotratzSM GuentherR HenfreyEffect of ret/PTC 1 rearrangement on transcription and post-transcriptional regulation in a papillary thyroid carcinoma modelMol Cancer570200610.1186/1476-4598-5-7017156473

61. 

JC Ricarte-FilhoCS FuziwaraAS YamashitaE RezendeMJ da-SilvaET KimuraEffects of let-7 microRNA on cell growth and differentiation of papillary thyroid cancerTransl Oncol2236241200910.1593/tlo.0915119956384

62. 

P PallanteR VisoneM FerracinA FerraroMT BerlingieriG TronconeG ChiappettaCG LiuM SantoroM NegriniMicroRNA deregulation in human thyroid papillary carcinomasEndocr Relat Cancer13497508200610.1677/erc.1.0120916728577

63. 

HR ChiangLW SchoenfeldJG RubyVC AuyeungN SpiesD BaekWK JohnstonC RussS LuoJE BabiarzMammalian microRNAs: experimental evaluation of novel and previously annotated genesGenes Dev249921009201010.1101/gad.188471020413612

64. 

MT TetzlaffA LiuX XuSR MasterDA BaldwinJW TobiasVA LivolsiZW BalochDifferential expression of miRNAs in papillary thyroid carcinoma compared to multinodular goiter using formalin fixed paraffin embedded tissuesEndocr Pathol18163173200710.1007/s12022-007-0023-7

65. 

YT ChenN KitabayashiXK ZhouTJ Fahey IIIT ScognamiglioMicroRNA analysis as a potential diagnostic tool for papillary thyroid carcinomaMod Pathol2111391146200810.1038/modpathol.2008.10518587330

66. 

SY SheuF GrabellusS SchwertheimS HandkeK WormKW SchmidLack of correlation between BRAF V600E mutational status and the expression profile of a distinct set of miRNAs in papillary thyroid carcinomaHorm Metab Res41482487200910.1055/s-0029-121555819370505

67. 

SY SheuF GrabellusS SchwertheimK WormM Broecker-PreussKW SchmidDifferential miRNA expression profiles in variants of papillary thyroid carcinoma and encapsulated follicular thyroid tumoursBr J Cancer102376382201010.1038/sj.bjc.660549320029416

68. 

SY SheuE VogelK WormF GrabellusS SchwertheimKW SchmidHyalinizing trabecular tumour of the thyroid-differential expression of distinct miRNAs compared with papillary thyroid carcinomaHistopathology56632640201010.1111/j.1365-2559.2010.03526.x20459574

69. 

CK ChouRF ChenFF ChouHW ChangYJ ChenYF LeeKD YangJT ChengCC HuangRT LiumiR-146b is highly expressed in adult papillary thyroid carcinomas with high risk features including extrathyroidal invasion and the BRAF mutationThyroid20489494201010.1089/thy.2009.002720406109

70. 

R VisoneL RussoP PallanteI De MartinoA FerraroV LeoneE BorboneF PetroccaH AlderCM CroceA FuscoMicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27 protein levels and cell cycleEndocr Relat Cancer14791798200710.1677/ERC-07-012917914108

71. 

KB AinAnaplastic thyroid carcinoma: behavior, biology, and therapeutic approachesThyroid8715722199810.1089/thy.1998.8.7159737368

72. 

L ViniC HarmerManagement of thyroid cancerLancet Oncol3407414200210.1016/S1470-2045(02)00787-812142170

73. 

S TakakuraN MitsutakeM NakashimaH NambaVA SaenkoTI RogounovitchY NakazawaT HayashiA OhtsuruS YamashitaOncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cellsCancer Sci9911471154200810.1111/j.1349-7006.2008.00800.x18429962

74. 

P BruniA BocciaG BaldassarreF TrapassoM SantoroG ChiappettaA FuscoG VigliettoPTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells is mediated by p27kip1Oncogene1931463155200010.1038/sj.onc.1203633

75. 

T FriskT FoukakisT DwightJ LundbergA HöögG WallinC EngJ ZedeniusC LarssonSilencing of the PTEN tumor-suppressor gene in anaplastic thyroid cancerGenes Chromosomes Cancer357480200210.1002/gcc.1009812203792

76. 

S MitomoC MaesawaS OgasawaraT IwayaM ShibazakiA Yashima-AboK KotaniH OikawaE SakuraiN IzutsuDownregulation of miR-138 is associated with overexpression of human telomerase reverse transcriptase protein in human anaplastic thyroid carcinoma cell linesCancer Science99280286200810.1111/j.1349-7006.2007.00666.x

77. 

Y ItoH YoshidaC TomodaT UrunoY TakamuraA MiyaK KobayashiF MatsuzukaK KumaA MiyauchiTelomerase activity in thyroid neoplasms evaluated by the expression of human telomerase reverse transcriptase (hTERT)Anticancer Res25509514200515816620

78. 

J BraunC Hoang-VuH DralleS HüttelmaierDownregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomasOncogene2942374244201010.1038/onc.2010.16920498632

79. 

SM ParkAB GaurE LengyelME PeterThe miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2Gen Dev22894907200810.1101/gad.164060818381893

80. 

R VisoneP PallanteA VecchioneR CirombellaM FerracinA FerraroS VoliniaS ColuzziV LeoneE BorboneSpecific microRNAs are downregulated in human thyroid anaplastic carcinomasOncogene2675907595200710.1038/sj.onc.121056417563749

81. 

F PacificoE CrescenziS MelloneA IannettiN PorrinoD LiguoroF MoscatoM GriecoS FormisanoA LeonardiNuclear factor-{kappa}B contributes to anaplastic thyroid carcinomas through upregulation of miR-146aJ Clin Endocrinol Metab95142114302010

82. 

D AbrahamN JacksonJS GundaraJ ZhaoAJ GillL DelbridgeBG RobinsonSB SidhuMicroRNA profiling of sporadic and hereditary medullary thyroid cancer identifies predictors of nodal metastasis, prognosis, and potential therapeutic targetsClin Cancer Res1747724781201110.1158/1078-0432.CCR-11-0242

83. 

V AmbrosThe functions of animal microRNAsNature431350355200410.1038/nature0287115372042

84. 

GA CalinM FerracinA CimminoG Di LevaM ShimizuSE WojcikMV IorioR VisoneNI SeverM FabbriA microRNA signature associated with prognosis and progression in chronic lymphocytic leukemiaN Engl J Med35317931801200510.1056/NEJMoa05099516251535

85. 

MZ MichaelSM O’ConnorNG Van Holst PellekaanGP YoungRJ JamesReduced accumulation of specific microRNAs in colorectal neoplasiaMol Cancer Res1882891200314573789

86. 

J TakamizawaH KonishiK YanagisawaS TomidaH OsadaH EndohT HaranoY YatabeM NaginoY NimuraReduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survivalCancer Res6437533756200410.1158/0008-5472.CAN-04-063715172979

87. 

M BoeriC VerriD ConteL RozP ModenaF FacchinettiE CalabròCM CroceU PastorinoG SozziMicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancerProc Natl Acad Sci USA10837133718201110.1073/pnas.110004810821300873

88. 

G PopoveniucJ JonklaasThyroid nodulesMed Clin North Am96329349201210.1016/j.mcna.2012.02.002

89. 

K ZenCY ZhangCirculating microRNAs: a novel class of biomarkers to diagnose and monitor human cancersMed Res Rev32326348201210.1002/med.2021522383180

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Copy and paste a formatted citation
Spandidos Publications style
Leonardi GC, Candido S, Carbone M, Colaianni V, Garozzo SF, Cinà D and Libra M: microRNAs and thyroid cancer: Biological and clinical significance (Review). Int J Mol Med 30: 991-999, 2012.
APA
Leonardi, G.C., Candido, S., Carbone, M., Colaianni, V., Garozzo, S.F., Cinà, D., & Libra, M. (2012). microRNAs and thyroid cancer: Biological and clinical significance (Review). International Journal of Molecular Medicine, 30, 991-999. https://doi.org/10.3892/ijmm.2012.1089
MLA
Leonardi, G. C., Candido, S., Carbone, M., Colaianni, V., Garozzo, S. F., Cinà, D., Libra, M."microRNAs and thyroid cancer: Biological and clinical significance (Review)". International Journal of Molecular Medicine 30.5 (2012): 991-999.
Chicago
Leonardi, G. C., Candido, S., Carbone, M., Colaianni, V., Garozzo, S. F., Cinà, D., Libra, M."microRNAs and thyroid cancer: Biological and clinical significance (Review)". International Journal of Molecular Medicine 30, no. 5 (2012): 991-999. https://doi.org/10.3892/ijmm.2012.1089
Copy and paste a formatted citation
x
Spandidos Publications style
Leonardi GC, Candido S, Carbone M, Colaianni V, Garozzo SF, Cinà D and Libra M: microRNAs and thyroid cancer: Biological and clinical significance (Review). Int J Mol Med 30: 991-999, 2012.
APA
Leonardi, G.C., Candido, S., Carbone, M., Colaianni, V., Garozzo, S.F., Cinà, D., & Libra, M. (2012). microRNAs and thyroid cancer: Biological and clinical significance (Review). International Journal of Molecular Medicine, 30, 991-999. https://doi.org/10.3892/ijmm.2012.1089
MLA
Leonardi, G. C., Candido, S., Carbone, M., Colaianni, V., Garozzo, S. F., Cinà, D., Libra, M."microRNAs and thyroid cancer: Biological and clinical significance (Review)". International Journal of Molecular Medicine 30.5 (2012): 991-999.
Chicago
Leonardi, G. C., Candido, S., Carbone, M., Colaianni, V., Garozzo, S. F., Cinà, D., Libra, M."microRNAs and thyroid cancer: Biological and clinical significance (Review)". International Journal of Molecular Medicine 30, no. 5 (2012): 991-999. https://doi.org/10.3892/ijmm.2012.1089
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