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Review

GPR40: A therapeutic target for mediating insulin secretion (Review)

  • Authors:
    • Xiao-Tao Feng
    • Jing Leng
    • Zhen Xie
    • Shuang-Lei Li
    • Wei Zhao
    • Qian-Li Tang
  • View Affiliations / Copyright

    Affiliations: Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, P.R. China, Department of Pharmaceutical Analysis, Faculty of Pharmacy, Guangxi University of Chinese Medicine, Nanning, P.R. China, Department of Endocrinology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, P.R. China
  • Pages: 1261-1266
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    Published online on: September 26, 2012
       https://doi.org/10.3892/ijmm.2012.1142
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Abstract

G-protein-coupled receptor 40 (GPR40), known as free fatty acid receptor 1, is mainly expressed in pancreatic β-cells and activated by medium- and long-chain fatty acids. Increasing evidence indicates that the activation of GPR40 in cells causes insulin secretion, and GPR40 has become an attractive therapeutic target for type 2 diabetes. Recently, certain novel GPR40 agonists have been identified that regulate glucose-stimulated insulin secretion, leading to the development of new drugs for the treatment of type 2 diabetes. In this review, we focus on progress in the physiological role of GPR40 and potential drugs targeting GPR40 over the past decade.
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Copy and paste a formatted citation
Spandidos Publications style
Feng X, Leng J, Xie Z, Li S, Zhao W and Tang Q: GPR40: A therapeutic target for mediating insulin secretion (Review). Int J Mol Med 30: 1261-1266, 2012.
APA
Feng, X., Leng, J., Xie, Z., Li, S., Zhao, W., & Tang, Q. (2012). GPR40: A therapeutic target for mediating insulin secretion (Review). International Journal of Molecular Medicine, 30, 1261-1266. https://doi.org/10.3892/ijmm.2012.1142
MLA
Feng, X., Leng, J., Xie, Z., Li, S., Zhao, W., Tang, Q."GPR40: A therapeutic target for mediating insulin secretion (Review)". International Journal of Molecular Medicine 30.6 (2012): 1261-1266.
Chicago
Feng, X., Leng, J., Xie, Z., Li, S., Zhao, W., Tang, Q."GPR40: A therapeutic target for mediating insulin secretion (Review)". International Journal of Molecular Medicine 30, no. 6 (2012): 1261-1266. https://doi.org/10.3892/ijmm.2012.1142
Copy and paste a formatted citation
x
Spandidos Publications style
Feng X, Leng J, Xie Z, Li S, Zhao W and Tang Q: GPR40: A therapeutic target for mediating insulin secretion (Review). Int J Mol Med 30: 1261-1266, 2012.
APA
Feng, X., Leng, J., Xie, Z., Li, S., Zhao, W., & Tang, Q. (2012). GPR40: A therapeutic target for mediating insulin secretion (Review). International Journal of Molecular Medicine, 30, 1261-1266. https://doi.org/10.3892/ijmm.2012.1142
MLA
Feng, X., Leng, J., Xie, Z., Li, S., Zhao, W., Tang, Q."GPR40: A therapeutic target for mediating insulin secretion (Review)". International Journal of Molecular Medicine 30.6 (2012): 1261-1266.
Chicago
Feng, X., Leng, J., Xie, Z., Li, S., Zhao, W., Tang, Q."GPR40: A therapeutic target for mediating insulin secretion (Review)". International Journal of Molecular Medicine 30, no. 6 (2012): 1261-1266. https://doi.org/10.3892/ijmm.2012.1142
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