Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1

Huang,Shuangsheng; Yang,Ninggang; Liu,Yuanyuan; Gao,Jing; Huang,Tao; Hu,Lamei; Zhao,Jin; Li,Yongquan; Li,Caili; Zhang,Xiaosu

doi:10.3892/ijmm.2012.1147

December 2012 Volume 30 Issue 6

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December 2012 Volume 30 Issue 6

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Article

Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1

Authors:
- Shuangsheng Huang
- Ninggang Yang
- Yuanyuan Liu
- Jing Gao
- Tao Huang
- Lamei Hu
- Jin Zhao
- Yongquan Li
- Caili Li
- Xiaosu Zhang
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Affiliations: Medical College of Northwest University for Nationalities, Lanzhou, Gansu, P.R. China, Department of Urology, Lanzhou First People's Hospital, Lanzhou, Gansu, P.R. China, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu, P.R. China, Institute of Pharmacology, School of Basic Medical Science, Lanzhou University, Lanzhou, Gansu, P.R. China
Pages: 1410-1416
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Published online on: October 1, 2012

https://doi.org/10.3892/ijmm.2012.1147
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Abstract

Tumor cells trigger angiogenesis through overexpression of various angiogenic factors including vascular endothelial growth factor (VEGF) and angiopoietin 1 (Ang1). Therefore, inhibition of the expression of both VEGF and Ang1, the initial step of tumor angiogenesis, is a promising strategy for cancer chemoprevention and therapy. Grape seed proanthocyanidins (GSPs) are widely consumed dietary supplements that have antitumor activity. Due to their polymeric structure, GSPs are poorly absorbed along the gastrointestinal tract and can reach the colon at high concentrations, allowing these chemicals to act as chemopreventive agents for colon cancer. In the present study, we found that GSPs inhibited colon tumor-induced angiogenesis and, thus, the growth of colon tumor xenografts on the chick chorioallantoic membranes. The mechanisms of their action were related to inhibiting the expression of both VEGF and Ang1 through scavenging reactive oxygen species. Previous studies have demonstrated that the chemopreventive effects of GSPs on colon cancer are associated with their growth inhibitory and apoptosis-inducing effects. Our results demonstrate another mechanism by which GSPs inhibit colon tumor growth, which will be helpful for developing GSPs as a pharmacologically safe angiopreventive agent against colorectal cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1

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Abstract

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