Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1

  • Authors:
    • Shuangsheng Huang
    • Ninggang Yang
    • Yuanyuan Liu
    • Jing Gao
    • Tao  Huang
    • Lamei Hu
    • Jin Zhao
    • Yongquan Li
    • Caili Li
    • Xiaosu Zhang
  • View Affiliations

  • Published online on: October 1, 2012     https://doi.org/10.3892/ijmm.2012.1147
  • Pages: 1410-1416
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Abstract

Tumor cells trigger angiogenesis through overexpression of various angiogenic factors including vascular endothelial growth factor (VEGF) and angiopoietin 1 (Ang1). Therefore, inhibition of the expression of both VEGF and Ang1, the initial step of tumor angiogenesis, is a promising strategy for cancer chemoprevention and therapy. Grape seed proanthocyanidins (GSPs) are widely consumed dietary supplements that have antitumor activity. Due to their polymeric structure, GSPs are poorly absorbed along the gastrointestinal tract and can reach the colon at high concentrations, allowing these chemicals to act as chemopreventive agents for colon cancer. In the present study, we found that GSPs inhibited colon tumor-induced angiogenesis and, thus, the growth of colon tumor xenografts on the chick chorioallantoic membranes. The mechanisms of their action were related to inhibiting the expression of both VEGF and Ang1 through scavenging reactive oxygen species. Previous studies have demonstrated that the chemopreventive effects of GSPs on colon cancer are associated with their growth inhibitory and apoptosis-inducing effects. Our results demonstrate another mechanism by which GSPs inhibit colon tumor growth, which will be helpful for developing GSPs as a pharmacologically safe angiopreventive agent against colorectal cancer.
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December 2012
Volume 30 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Huang S, Yang N, Liu Y, Gao J, Huang T, Hu L, Zhao J, Li Y, Li C, Zhang X, Zhang X, et al: Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1. Int J Mol Med 30: 1410-1416, 2012
APA
Huang, S., Yang, N., Liu, Y., Gao, J., Huang, T., Hu, L. ... Zhang, X. (2012). Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1. International Journal of Molecular Medicine, 30, 1410-1416. https://doi.org/10.3892/ijmm.2012.1147
MLA
Huang, S., Yang, N., Liu, Y., Gao, J., Huang, T., Hu, L., Zhao, J., Li, Y., Li, C., Zhang, X."Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1". International Journal of Molecular Medicine 30.6 (2012): 1410-1416.
Chicago
Huang, S., Yang, N., Liu, Y., Gao, J., Huang, T., Hu, L., Zhao, J., Li, Y., Li, C., Zhang, X."Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1". International Journal of Molecular Medicine 30, no. 6 (2012): 1410-1416. https://doi.org/10.3892/ijmm.2012.1147