Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
January 2013 Volume 31 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January 2013 Volume 31 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Inhibitory effects of Asterina pectinifera extracts on melanin biosynthesis through tyrosinase activity

  • Authors:
    • Min-Ho Jeong
    • Kwang-Mo Yang
    • Jung-Ki Kim
    • Byung-Hyouk Nam
    • Gi‑Yong Kim
    • Sang-Wha Lee
    • Su-Yeong Seo
    • Wol-Soon Jo
  • View Affiliations / Copyright

    Affiliations: Department of Microbiology, College of Medicine, Dong-A University, Busan, Republic of Korea, Research Center, Dongnam Institute of Radiological and Medical Sciences, Busan, Republic of Korea, Test and Certification Team, Marine Bio-Industry Development Center, Busan, Republic of Korea
  • Pages: 205-212
    |
    Published online on: November 14, 2012
       https://doi.org/10.3892/ijmm.2012.1181
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The control of melanogenesis is an important strategy in the treatment of abnormal skin pigmentation for cosmetic purposes. The aim of the present study was to investigate the anti-melanogenic effect of Asterina pectinifera (A. pectinifera) extracts by cell-free mushroom tyrosinase assay, cellular tyrosinase assay, melanin content assay and the analysis of related protein expression in melan-a cells. A. pectinifera was extracted with 80% methanol (80-MAP) and further fractionated with hexane (He-AP) and ethyl acetate (EA-AP). In addition, the enzyme extract (En-AP) of A. pectinifera, to which protease was added, was processed. EA-AP and En-AP among A. pectinifera extracts showed strong inhibitory activity against the cell-free mushroom tyrosinase activity. EA-AP and En-AP induced significant inhibition of melanin production and cellular tyrosinase activity. In the action of EA-AP and En-AP on melanogenesis, they reduced the expression of melanogenic genes and proteins including tyrosinase, tyrosinase-related protein-1 (TRP-1) and dopachrome tautomerase (Dct). These results showed that EA-AP and En-AP inhibited melanogenesis by reducing tyrosinase activity and melanin production via subsequent downregulation of tyrosinase-related proteins. The overall results suggest that EA-AP and En-AP among A. pectinifera extracts may be promising candidates for the treatment of hyperpigmentation disorder and useful for self-tanning cosmetic products.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Pawelek JM, Chakraborty AK, Osber MP and Bolognia JL: Ultraviolet light and pigmentation of the skin. Cosmetics & Toiletries Magazine. 107:61–68. 1992.

2 

Briganti S, Camera E and Picardo M: Chemical and instrumental approaches to treat hyperpigmentation. Pigment Cell Res. 16:101–110. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Kobayashi T, Urabe K, Winder A, et al: Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis. EMBO J. 13:5818–5825. 1994.PubMed/NCBI

4 

del Marmol V and Beermann F: Tyrosinase and related proteins in mammalian pigmentation. FEBS Lett. 381:165–168. 1996.PubMed/NCBI

5 

Lerner AB, Fitzpatrick TB, Calkins E and Summerson WH: Mammalian tyrosinase; preparation and properties. J Biol Chem. 178:185–195. 1949.PubMed/NCBI

6 

Slominski A, Tobin DJ, Shibahara S and Wortsman J: Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev. 84:1155–1228. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Jones K, Hughes J, Hong M, Jia Q and Orndorff S: Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase. Pigment Cell Res. 15:335–340. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Maeda K and Fukuda M: In vitro effectiveness of several whitening cosmetic components in human Melanocyte. J Soc Cosmet Chem. 4:361–368. 1991.

9 

Shiino M, Watanabe Y and Umezawa K: Synthesis of N-substituted N-nitrosohydroxylamines as inhibitors of mashroom tyrosinase. Bioorg Med Chem. 9:1233–1240. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Shimogaki H, Tanaka Y, Tamai H and Masuda M: In vitro and in vivo evaluation of ellagic acid on melanogenesis inhibition. Int J Cosmetic Sci. 22:291–303. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Kim DS, Kim SY, Chung JH, Kim KH, Eun HC and Park KC: Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes. Cell Signal. 14:779–785. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Shimizu K, Kondo R, Sakai K, Lee SH and Sato H: The inhibitory components from Artocarpus incisus on melanin biosynthesis. Planta Med. 64:408–412. 1998. View Article : Google Scholar

13 

Komthong P, Igura N and Shimoda M: Effect of ascorbic acid on the odours of cloudy apple juice. Food Chem. 100:1342–1349. 2007. View Article : Google Scholar

14 

Cha SH, Ko SC, Kim D and Jeon YJ: Screening of marine algae for potential tyrosinase inhibitor: those inhibitors reduced tyrosinase activity and melanin synthesis in zebrafish. J Dermatol. 38:354–363. 2010. View Article : Google Scholar

15 

Park MS and Kim BY: Feeding behaviour of the starfish, Asterias amurensis (LUTKEN). Bull Fish Res Dev Agency. 34:1–174. 1985.

16 

Park SW, Kim TH and Oh HK: A study on the development of the extermination gear for starfish, Asterias amurensis and its efficiency. J Korean Soc Fish Technol. 33:166–172. 1997.

17 

Seo JK: Conformation and biological activity of Mastoparan B and its analogs: isolation and characterization of the biological substances from Inshore Hagfish (Eptatretus burgeri) skin and starfish (Asterina pectinifera). Thesis. Pukyong National University; 1997

18 

Cho SY, Kang HJ, Joo DS, Jeon JK, Oh MH and Kim JS: Seperation and identification of nature antimicrobial agent from starfish. In: 47th Conference of Korean Society; J Food Science Nutr. pp. 695–701. 2000

19 

Cho SY, You BJ, Chang MH, Lee SJ, Sung NJ and Lee EH: Screening for antimicrobial compounds in unused marine resources by the paper disk method. Korean J Food Sci Technol. 26:261–265. 1994.(In Korean).

20 

Jo WS, Choi YJ, Kim HJ, Nam BH, Lee GA, Seo SY, Lee SW and Jeong MH: Methanolic extract of Asterina pectinifera inhibits LPS-induced inflammatory mediators in murine macrophage. Toxicol Res. 6:1–82. 2010.

21 

Chang TS, Ding HY, Tai SSK and Wu CY: Mushroom tyrosinase inhibitory effects of isoflavones isolated from soygerm koji fermented with Aspergillus oryzae BCRC 32288. Food Chem. 105:1430–1438. 2007. View Article : Google Scholar

22 

Masamoto Y, Ando H, Murata Y, Shimoishi YTM and Takahata K: Mushroom tyrosinase inhibitory activity of esculetin isolated from seeds of Euphorbia lathyris L. Biosci Biotechnol Biochem. 67:631–634. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Hosoi J, Abe E, Suda T and Kuroki T: Regulation of melanin synthesis of B16 mouse melanoma cells by 1α, 25-dihydroxyvitamin D3 and retinoic acid. Cancer Res. 45:1474–1478. 1985.

24 

Pomerantz HS: Tyrosine hydroxylation catalyzed by mammalian tyrosinase: an improved method of assay. Biochem Biophys Res Commun. 16:188–194. 1964. View Article : Google Scholar : PubMed/NCBI

25 

Li EPH, Min HJ, Belk RW, Kimura J and Bahl S: Skin lightening and beauty in four Asian cultures. Adv Consum Res. 35:444–449. 2008.

26 

Oh EY, Jang JY, Choi YH, Choi YW and Choi BT: Inhibitory effects of 1-O-methyl-fructofuranose from Schisandra chinensis fruit on melanogenesis in B16F0 melanoma cells. J Ethnopharmacol. 132:219–224. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Virador VM, Kobayashi N, Matsunaga J and Hearing VJ: A standardized protocol for assessing regulators of pigmentation. Anal Biochem. 270:207–219. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Hearing VJ and Tsukamoto K: Enzymatic control of pigmentation in mammals. FASEB J. 5:2902–2909. 1991.PubMed/NCBI

29 

Busca R and Ballotti R: Cyclic AMP a key messenger in the regulation of skin pigmentation. Pigment Cell Res. 13:60–69. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Momtaz S, Mapunya BM, Houghton PJ, Edgerly C, Hussein A, Naidoo S and Lall N: Tyrosinase inhibition by extracts and constituents of Sideroxylon inerme L. stem bark, used in South Africa for skin lightening. J Ethnopharmacol. 119:507–517. 2008.PubMed/NCBI

31 

Dooley TP: Topical skin depigmenting agents: current products and discovery of novel inhibitors of melanogenesis. J Dermatol Treat. 7:188–200. 1997.

32 

Levy C, Khaled M and Fisher DE: MITF: master regulator of melanocyte development and melanoma oncogene. Trends Mol Med. 12:406–414. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Sturm RA, O’ Sullivan BJ, Box NF, et al: Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family. Genomics. 29:24–34. 1995. View Article : Google Scholar : PubMed/NCBI

34 

Kobayashi T, Imokawa G, Bennett DC and Hearing VJ: Tyrosinase stabilization by Tyrp1 (the brown locus protein). J Biol Chem. 273:31801–31805. 1998. View Article : Google Scholar : PubMed/NCBI

35 

Setaluri V: The melanosome: dark pigment granule shines bright light on vesicle biogenesis and more. J Invest Dermatol. 121:650–660. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Wu H and Park HY: Protein kinase C-beta-mediated complex formation between tyrosinase and TRP-1. Biochem Biophys Res Commun. 311:948–953. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Pawelek JM and Chakraborty AK: The enzymology of melanogenesis. The Pigmentary System: Physiology and Pathophysiology. Nordlund JJ, Boissy RE, Hearing VJ, King RA and Ortonne JP: Oxford University Press; New York: pp. 391–400. 1998

38 

Manga P, Sato K, Ye L, Beermann F, Amoreux ML and Orlow SJ: Mutational analysis of the modulation of tyrosinase by tyrosinase-related proteins 1 and 2 in vitro. Pigment Cell Res. 13:364–374. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Hamid MA, Sarmidi MR and Park CS: Mangosteen leaf extract increases melanogenesis in B16F1 melanoma cells by stimulating tyrosinase activity in vitro and by up-regulating tyrosinase gene expression. Int J Mol Med. 29:209–217. 2012.PubMed/NCBI

40 

Kim DS, Jeong YM, Park IK, et al: A new 2-imino-1,3-thiazoline derivative, KHG22394, inhibits melanin synthesis in mouse B16 melanoma cells. Biol Pharm Bull. 30:180–183. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jeong M, Yang K, Kim J, Nam B, Kim GY, Lee S, Seo S and Jo W: Inhibitory effects of Asterina pectinifera extracts on melanin biosynthesis through tyrosinase activity. Int J Mol Med 31: 205-212, 2013.
APA
Jeong, M., Yang, K., Kim, J., Nam, B., Kim, G., Lee, S. ... Jo, W. (2013). Inhibitory effects of Asterina pectinifera extracts on melanin biosynthesis through tyrosinase activity. International Journal of Molecular Medicine, 31, 205-212. https://doi.org/10.3892/ijmm.2012.1181
MLA
Jeong, M., Yang, K., Kim, J., Nam, B., Kim, G., Lee, S., Seo, S., Jo, W."Inhibitory effects of Asterina pectinifera extracts on melanin biosynthesis through tyrosinase activity". International Journal of Molecular Medicine 31.1 (2013): 205-212.
Chicago
Jeong, M., Yang, K., Kim, J., Nam, B., Kim, G., Lee, S., Seo, S., Jo, W."Inhibitory effects of Asterina pectinifera extracts on melanin biosynthesis through tyrosinase activity". International Journal of Molecular Medicine 31, no. 1 (2013): 205-212. https://doi.org/10.3892/ijmm.2012.1181
Copy and paste a formatted citation
x
Spandidos Publications style
Jeong M, Yang K, Kim J, Nam B, Kim GY, Lee S, Seo S and Jo W: Inhibitory effects of Asterina pectinifera extracts on melanin biosynthesis through tyrosinase activity. Int J Mol Med 31: 205-212, 2013.
APA
Jeong, M., Yang, K., Kim, J., Nam, B., Kim, G., Lee, S. ... Jo, W. (2013). Inhibitory effects of Asterina pectinifera extracts on melanin biosynthesis through tyrosinase activity. International Journal of Molecular Medicine, 31, 205-212. https://doi.org/10.3892/ijmm.2012.1181
MLA
Jeong, M., Yang, K., Kim, J., Nam, B., Kim, G., Lee, S., Seo, S., Jo, W."Inhibitory effects of Asterina pectinifera extracts on melanin biosynthesis through tyrosinase activity". International Journal of Molecular Medicine 31.1 (2013): 205-212.
Chicago
Jeong, M., Yang, K., Kim, J., Nam, B., Kim, G., Lee, S., Seo, S., Jo, W."Inhibitory effects of Asterina pectinifera extracts on melanin biosynthesis through tyrosinase activity". International Journal of Molecular Medicine 31, no. 1 (2013): 205-212. https://doi.org/10.3892/ijmm.2012.1181
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team