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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
January 2013 Volume 31 Issue 1

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Alzheimer's disease: An update of the roles of receptors, astrocytes and primary cilia (Review)

Ubaldo Armato, Balu Chakravarthy, Raffaella Pacchiana, James F. Whitfield
Pages: 3-10
Published online on: 24 October 2012

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Review

New strategies for the treatment of lysosomal storage diseases (Review)

Giancarlo Parenti, Claudio Pignata, Pietro Vajro, Mariacarolina Salerno
Pages: 11-20
Published online on: 19 November 2012

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Article Open Access

Epigenetics-related genes in prostate cancer: expression profile in prostate cancer tissues, androgen-sensitive and -insensitive cell lines

David Adler, Andreas Lindstrot, Jacqueline  Ochsenfahrt, Kerstin Fuchs, Nicolas Wernert
Pages: 21-25
Published online on: 06 November 2012

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Article Open Access

Pretreatment of therapeutic cells with poly(ADP-ribose) polymerase inhibitor enhances their efficacy in an in vitro model of cell-based therapy in myocardial infarct

Mónika Szepes, Zsófia Janicsek, Zsolt Benkő, Attila Cselenyák, Levente Kiss
Pages: 26-32
Published online on: 16 November 2012

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Article

Cationic liposome-mediated nitric oxide synthase gene therapy enhances the antitumor effects of cisplatin in lung cancer

Sujuan Ye, Weihan Yang, Yu Wang, Wenjing Ou, Qingping Ma, Chuanjiang Yu, Jiang Ren, Guoxing Zhong, Huashan Shi, Zhu Yuan, Xiaolan Su, Wen Zhu
Pages: 33-42
Published online on: 01 November 2012

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Article

A novel GATA5 loss-of-function mutation underlies lone atrial fibrillation

Xin-Hua Wang, Cong-Xin Huang, Qian Wang, Ruo-Gu Li, Ying-Jia Xu, Xu Liu, Wei-Yi Fang, Yi-Qing Yang
Pages: 43-50
Published online on: 20 November 2012

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Article

Somatic mutations in the GATA6 gene underlie sporadic tetralogy of Fallot

Ri-Tai Huang, Song Xue, Ying-Jia Xu, Yi-Qing Yang
Pages: 51-58
Published online on: 20 November 2012

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Article

Induction of differentiation-specific miRNAs in TPA-induced myeloid leukemia cells through MEK/ERK activation

Jing Wang, Lijun Liu, Lan Xie, Guangxin Xiang, Yuxiang Zhou
Pages: 59-66
Published online on: 21 November 2012

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Article

The mechanism of long-term low-dose asymmetric dimethylarginine inducing transforming growth factor-β expression in endothelial cells

Yiduo Feng, Dongliang Zhang, Yu Zhang, Qidong Zhang, Wenhu Liu
Pages: 67-74
Published online on: 20 November 2012

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Article

Electroacupuncture exerts anti-inflammatory effects in cerebral ischemia-reperfusion injured rats via suppression of the TLR4/NF-κB pathway

Lan Lan, Jing Tao, Azhen Chen, Guanli Xie, Jia Huang, Jiumao Lin, Jun Peng, Lidian Chen
Pages: 75-80
Published online on: 16 November 2012

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Article

Comparison of the pathologic and pathogenic features in six different regions of postmortem brains of three patients with fatal familial insomnia

Wu-Ling Xie, Qi Shi, Sheng-Li Xia, Bao-Yun Zhang, Han-Shi Gong, Shao-Bin Wang, Yin Xu, Yan Guo, Chan Tian, Jin Zhang, Bian-Li Xu, Yong Liu, Xiao-Ping Dong
Pages: 81-90
Published online on: 22 November 2012

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Article

Transplantation of bone marrow-derived endothelial progenitor cells attenuates cerebral ischemia and reperfusion injury by inhibiting neuronal apoptosis, oxidative stress and nuclear factor-κB expression

Jing Qiu, Wei Li, Shuhang Feng, Min Wang, Zhiyi He
Pages: 91-98
Published online on: 13 November 2012

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Article

Molecular cloning, characterization and differential expression of DRK1 in Sporothrix schenckii

Binbin Hou, Zhenying Zhang, Fangliang Zheng, Xiaoming Liu
Pages: 99-104
Published online on: 22 November 2012

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Article

Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP-1

Zeng-Feng Xin, Cheng-Chun Shen, Li-Jiang Tao, Shi-Gui Yan, Hao-Bo Wu
Pages: 105-112
Published online on: 21 November 2012

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Article

Vincristine induces cell cycle arrest and apoptosis in SH-SY5Y human neuroblastoma cells

Yue Tu, Shixiang Cheng, Sai Zhang, Hongtao Sun, Zhongwei Xu
Pages: 113-119
Published online on: 30 October 2012

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Article

HPV16/18 E5, a promising candidate for cervical cancer vaccines, affects SCPs, cell proliferation and cell cycle, and forms a potential network with E6 and E7

Shujie Liao, Dongrui Deng, Xiaoji Hu, Wei Wang, Li Li, Wei Li, Jianfeng  Zhou, Gang Xu, Li Meng, Shixuan Wang, Ding Ma
Pages: 120-128
Published online on: 30 October 2012

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Article

microRNA changes in the dorsal horn of the spinal cord of rats with chronic constriction injury: A TaqMan® Low Density Array study

Yuuki Genda, Masae Arai, Masashi Ishikawa, Shunsuke Tanaka, Tadashi Okabe, Atsuhiro Sakamoto
Pages: 129-137
Published online on: 24 October 2012

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Article

Characterization of atrial histopathological and electrophysiological changes in a mouse model of aging

Tao Luo, Cui-Xian Chang, Xin Zhou, Shi-Kui Gu, Tie-Ming Jiang, Yu-Ming Li
Pages: 138-146
Published online on: 06 November 2012

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Article

Vaccination with embryonic stem cells generates effective antitumor immunity against ovarian cancer

Zujuan Zhang, Xinhua Chen, Xiaohong Chang, Xue Ye, Yi Li, Heng Cui
Pages: 147-153
Published online on: 22 November 2012

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Article

Anti-inflammatory effects of egg white combined with chalcanthite in lipopolysaccharide-stimulated BV2 microglia through the inhibition of NF-κB, MAPK and PI3K/Akt signaling pathways

Eun A Choi, Hye Young Park, Hwa-Seung Yoo, Yung Hyun Choi
Pages: 154-162
Published online on: 01 November 2012

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Article

Targeted delivery of biodegradable nanoparticles with ultrasound-targeted microbubble destruction-mediated hVEGF-siRNA transfection in human PC-3 cells in vitro

Yun-Hua Li, Qiu-Sheng Shi, Jing Du, Li-Fang Jin, Lian-Fang Du, Pei-Feng Liu, You-Rong Duan
Pages: 163-171
Published online on: 08 November 2012

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Article

Activated microglia provide a neuroprotective role by balancing glial cell-line derived neurotrophic factor and tumor necrosis factor-α secretion after subacute cerebral ischemia

Jianping Wang, Zhitang Yang, Cong Liu, Yuanzheng Zhao, Yibing Chen
Pages: 172-178
Published online on: 13 November 2012

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Article

Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine

Ki-Mo Lee, Haeng-A Kang, Chang-Bo Ko, Eun-Ha Oh, Min Park, Hwa-Youn Lee, Ha‑Rim Choi, Chul-Ho Yun, Woon-Won Jung, Jae-Wook Oh, Hyung-Sik Kang
Pages: 179-187
Published online on: 15 November 2012

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Article

Attenuation of exogenous angiotensin II stress-induced damage and apoptosis in human vascular endothelial cells via microRNA-155 expression

Te Liu, Dingzhu Shen, Sanli Xing, Jiulin Chen, Zhihua Yu, Jian Wang, Beiling Wu, Huiying Chi, Hongbin Zhao, Zhenzhen Liang, Chuan Chen
Pages: 188-196
Published online on: 15 November 2012

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Article

Hepatitis B virus X protein modulates remodelling of minichromosomes related to hepatitis B virus replication in HepG2 cells

Li Luo, Shu Chen, Qian Gong, Na Luo, Yu Lei, Jinjun Guo, Song He
Pages: 197-204
Published online on: 26 October 2012

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Article

Inhibitory effects of Asterina pectinifera extracts on melanin biosynthesis through tyrosinase activity

Min-Ho Jeong, Kwang-Mo Yang, Jung-Ki Kim, Byung-Hyouk Nam, Gi‑Yong Kim, Sang-Wha Lee, Su-Yeong Seo, Wol-Soon Jo
Pages: 205-212
Published online on: 14 November 2012

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Article

Involvement of the mitochondrial pathway and Bim/Bcl-2 balance in dihydroartemisinin-induced apoptosis in human breast cancer in vitro

Haiting Mao, Hongtao Gu, Xun Qu, Jintang Sun, Bingfeng Song, Wenjuan Gao, Jia Liu, Qianqian Shao
Pages: 213-218
Published online on: 08 November 2012

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Article

Growth inhibition and apoptosis-inducing effect on human cancer cells by RCE-4, a spirostanol saponin derivative from natural medicines

Guiping Wang, Wenfeng Huang, Haibo He, Xuejiao Fu, Junzhi Wang, Kun Zou, Jianfeng Chen
Pages: 219-224
Published online on: 09 November 2012

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Article

Electroacupuncture promotes neurological functional recovery via the retinoic acid signaling pathway in rats following cerebral ischemia-reperfusion injury

Jiangcong Hong, Guangwen Wu, Yulong Zou, Jing Tao, Lidian Chen
Pages: 225-231
Published online on: 26 October 2012

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Article

Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis

Enrica Bianchi, Fabio Scarinci, Guido Ripandelli, Janos Feher, Elena Pacella, Giuseppe Magliulo, Corrado Balacco Gabrieli, Rocco Plateroti, Pasquale Plateroti, Fiorenzo Mignini, Marco Artico
Pages: 232-242
Published online on: 26 October 2012

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Article

The flavonoid glabridin attenuates 2-deoxy-D-ribose-induced oxidative damage and cellular dysfunction in MC3T3-E1 osteoblastic cells

Hyun-Sook Kim, Kwang Sik Suh, Ara Ko, Donggeun Sul, Dalwoong  Choi, Seung Kwan Lee, Woon-Won Jung
Pages: 243-251
Published online on: 02 November 2012

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Article

Inhibition of HIV-1 replication by RNA with a microRNA-like function

Keijiro Kato, Takashi Senoki, Hiroshi Takaku
Pages: 252-258
Published online on: 01 November 2012

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Article

Involvement of Nrf2 activation in the upregulation of S100A9 by exposure to inorganic arsenite

Daigo Sumi, Yuri Shimizu, Seiichiro Himeno
Pages: 259-264
Published online on: 16 November 2012

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Article

Quercetin and quercitrin protect against cytokine‑induced injuries in RINm5F β-cells via the mitochondrial pathway and NF-κB signaling

Xiaoqian Dai, Ye Ding, Zhaofeng Zhang, Xiaxia Cai, Yong Li
Pages: 265-271
Published online on: 08 November 2012

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Journal Cover
October-2026 Volume 58 Issue 4

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Role of adipocytes and their derived extracellular vesicles in the progression, diagnosis and treatment of liver diseases (Review)

Kangrong Li, Muhammad Zubair, Yongmin Yan, Jiahao Xu
Article Number: 293
Published online on: 20 August 2026

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Correction Open Access

[Corrigendum] EBM84 attenuates airway inflammation and mucus hypersecretion in an ovalbumin‑induced murine model of asthma

In Sik Shin, Mee Young Lee, Woo Young Jeon, Na Ra Shin, Chang Seob Seo, Hyekyung Ha
Article Number: 292
Published online on: 20 August 2026

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Review Open Access

Decoding fibroblast activation: Transcriptional networks in hepatic stellate cells and across fibrotic organs (Review)

Denita Charoenthanakitkul, Chaiyaboot Ariyachet
Article Number: 291
Published online on: 20 August 2026

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Review Open Access

Inflammatory bowel disease treatment: Mechanisms to clinical translation (Review)

Siqi Tang, Guoyou Gou, Youjia Liu, Fang Wang, Feihong Shu, Ya Deng, Ting Zhang, Jingyu Xu, Rui Xie
Article Number: 290
Published online on: 18 August 2026

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Review Open Access

Redox biology in PCOS: Biomarkers, mechanistic networks, and targeted interventions (Review)

Yuena Qiu, Xiaojing Guo, Jie An
Article Number: 289
Published online on: 18 August 2026

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Review Open Access

Glucose metabolism in osteoporosis: A potential therapeutic target (Review)

Shengyao Peng, Zhuo Yao, Junzhe Guo, Chi Zhang, Keda Yang, Lin Tao
Article Number: 288
Published online on: 17 August 2026

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Retraction Open Access

[Retracted] Engulfment of platelets delays endothelial cell aging via girdin and its phosphorylation

Yong Lan, Yongjun Li, Dajun Li, Peng Li, Jiyang Wang, Yongpeng Diao, Guodong Ye, Yangfang Li
Article Number: 287
Published online on: 17 August 2026

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Article Open Access

α‑Cyperone targets the PAK1‑JNK/NF‑κB axis to modulate dendritic cells maturation and Th2/Th9 differentiation in an asthma model

Hang Hu, Xing Wang, Linlin Guo, Ziling Zeng, Hongmei Tang, Yun Zhang, Jiayao Duan, Kaijin Wang
Article Number: 286
Published online on: 14 August 2026

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Article Open Access

Early high‑frequency spinal cord stimulation modulates the ROS/p38 MAPK/NF‑κB and CXCL10/CXCR3 pathways to alleviate neuropathic pain and promote spinal cord injury repair

Sitong Su, Tao Liu, Honghui Lei, Yang Yu, Caizhi Ma, Xinglang Wang, Haoyuan Chen, Zebin Huang, Meiling Cheng, Tongtong Qian, Fangyong Wang
Article Number: 285
Published online on: 13 August 2026

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Review Open Access

Shared mechanisms of musculoskeletal dysfunction in type 2 diabetes mellitus: Insights into future therapeutic directions (Review)

Zhenhong He, Hanyu Li, Yuhan Luo, Yingying Yu, Siyu Li, Tao Zhang, Dingsu Bao
Article Number: 284
Published online on: 12 August 2026

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Expression of Concern Open Access

[Expression of Concern] Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway

Xinying Zhang, Li Zhang, Zhe Chen, Siwei Li, Bingbing Che, Ningning Wang, Junting Chen, Changqing Xu, Can Wei
Article Number: 283
Published online on: 12 August 2026

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Article Open Access

G protein‑coupled receptor kinase 4 governs early kidney development via STAT3 and Nhe3a

Linh Anna Trúc Vu, Julian Gerhards, Lars D. Maerz, Martin D. Burkhalter, Melanie Philipp
Article Number: 282
Published online on: 11 August 2026

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Retraction Open Access

[Retracted] Resistant starch prevents tumorigenesis of dimethylhydrazine‑induced colon tumors via regulation of an ER stress‑mediated mitochondrial apoptosis pathway  

Qiuyu Wang, Peng Wang, Zhigang Xiao
Article Number: 281
Published online on: 10 August 2026

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Review Open Access

XBP1 signaling from tumor metabolic stress to myeloid driven immunotherapy resistance (Review)

Ziwei Chen, Jiaqi Wu, Wenxi Liu, Jie Tan, Xiaochun Peng, Yanhua Zhang, Gai Liang
Article Number: 280
Published online on: 05 August 2026

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Review Open Access

Decoding miRNA‑146a: Mechanisms of action in cardiovascular diseases and endocrine metabolic disorders (Review)

Xiu Yang, Pengcheng Li, Hao Zhao
Article Number: 279
Published online on: 05 August 2026

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Review Open Access

Contribution of p38 MAPK in liver fibrosis: An overview of mechanisms, signaling pathways, and therapeutic targets (Review)

Xueqin Yang, Huarong Li, Hao Ye, Ting Wu, Fangyun Xu, Chao Hu, Chunlei Yu, Pian Ye
Article Number: 278
Published online on: 05 August 2026

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Correction Open Access

[Corrigendum] Peroxisome proliferator‑activated receptor α regulates acesulfame‑K‑induced NAFLD via hepatic PLCβ: Foe and friend

Peng-Yao Lin, Jia-Rong Xie, Tian-Chen Qian, Shi-Song Wang, Si-Yi Yu, Wen-Bo Shi, Ying Wang, Lu-Ze Cen, Qing-Jing Zhu, Yi-Yang Zheng, Hui Gao, Rong Fang, Zhao-Xia Xia, Ai-Ming Liu, Lei Xu
Article Number: 277
Published online on: 05 August 2026

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Review Open Access

Multi‑omics insights into uveitis: From mechanisms to precision medicine (Review)

Chengzhi Liu, Qiong Wu, Mingzhen Yuan, Mingyue Liu, Xinyu Wang, Jiaqi Shen, Xusheng Cao
Article Number: 276
Published online on: 03 August 2026

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Retraction Open Access

[Retracted] Effects of miRNA‑455 on cardiac hypertrophy induced by pressure overload

Chuntao Wu, Shimin Dong, Yongjun Li
Article Number: 275
Published online on: 03 August 2026

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Article Open Access

Energy stress activates AMPK to suppress ferroptosis in neurodegenerative proteinopathies

Yuanyuan Yong, Yuxin Hu, Qian Feng, Xiaogang Zhou, Lu Yu, Dalian Qin, Jianing Mi, Jianming Wu, Jianxin Liu, Anguo Wu
Article Number: 274
Published online on: 31 July 2026

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Article Open Access

Brazilin attenuates methylglyoxal‑induced endothelial injury by enhancing eIF5A hypusination and inhibiting the AMPK/mTOR‑mediated autophagy/apoptosis axis in vitro and in vivo

Yu Liang, Jinxiang Chen, Haiyang Li, Junjing Xiong, Jingcan You, Liqun Wang, Jianbo Wu, Youkun Zheng, Mao Luo
Article Number: 273
Published online on: 30 July 2026

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Review Open Access

Post‑translational modifications in atherosclerosis: Roles, mechanisms and therapeutic potential (Review)

Xiaoxiang Xu, Fei Ma, Wei Yu
Article Number: 272
Published online on: 30 July 2026

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Review Open Access

Role of extracellular matrix in liver fibrosis regression and regeneration (Review)

Yuanzhi Zhou, Zeyuan Qiang, Yang Duan, Jiwei Huang, Haichuan Wang
Article Number: 271
Published online on: 29 July 2026

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Correction Open Access

[Corrigendum] Circulating microRNA profiles and the identification of miR‑593 and miR‑511 which directly target the PROP1 gene in children with combined pituitary hormone deficiency

Yanyan Hu, Qian Wang, Zengmin Wang, Fengxue Wang, Xiaobo Guo, Guimei Li
Article Number: 270
Published online on: 29 July 2026

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Review Open Access

Unveiling the role of spatial transcriptomics in the analysis of the tumor immune microenvironment (Review)

Jialin Jiang, Xinyu Tu, Yi Cao, Qun Yan, Buqing Sai, Jian Ma
Article Number: 269
Published online on: 28 July 2026

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Expression of Concern Open Access

[Expression of Concern] Luteolin protects mice from severe acute pancreatitis by exerting HO‑1‑mediated anti‑inflammatory and antioxidant effects

Jie Xiong, Kezhou Wang, Chunxiao Yuan, Rong Xing, Jianbo Ni, Guoyong Hu, Fengling Chen, Xingpeng Wang
Article Number: 268
Published online on: 27 July 2026

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Article Open Access

circRNA_013145‑miR‑185‑5p‑RhoA axis: A novel mechanism in the pathophysiology of diabetes‑induced erectile dysfunction

Wenhan Huang, Xin Lv, Jiahua Qian, Yihao Chen, Yuhe Si, Jingwei Wang, Jianxiong Ma
Article Number: 267
Published online on: 24 July 2026

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Review Open Access

Gut‑liver‑kidney axis: A systems biology framework for understanding and treating chronic kidney disease (Review)

Jinyi Hou, Yaotan Li, Shijia Lin, Qingqing Liu, Huijuan Zheng, Weijing Liu, Yaoxian Wang, Liang Peng, Zhen Wang
Article Number: 266
Published online on: 23 July 2026

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Review Open Access

Effects of cuproptosis and its application in inflammatory bowel disease (Review)

Li Chen, Francis Atim Akanyibah, Jing Guan, Bing Pei, Bo Wang, Fei Mao
Article Number: 265
Published online on: 23 July 2026

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November-2026 Volume 58 Issue 5

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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