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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
January 2013 Volume 31 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Alzheimer's disease: An update of the roles of receptors, astrocytes and primary cilia (Review)

Ubaldo Armato, Balu Chakravarthy, Raffaella Pacchiana, James F. Whitfield
Pages: 3-10
Published online on: 24 October 2012

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Review

New strategies for the treatment of lysosomal storage diseases (Review)

Giancarlo Parenti, Claudio Pignata, Pietro Vajro, Mariacarolina Salerno
Pages: 11-20
Published online on: 19 November 2012

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Article Open Access

Epigenetics-related genes in prostate cancer: expression profile in prostate cancer tissues, androgen-sensitive and -insensitive cell lines

David Adler, Andreas Lindstrot, Jacqueline  Ochsenfahrt, Kerstin Fuchs, Nicolas Wernert
Pages: 21-25
Published online on: 06 November 2012

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Article Open Access

Pretreatment of therapeutic cells with poly(ADP-ribose) polymerase inhibitor enhances their efficacy in an in vitro model of cell-based therapy in myocardial infarct

Mónika Szepes, Zsófia Janicsek, Zsolt Benkő, Attila Cselenyák, Levente Kiss
Pages: 26-32
Published online on: 16 November 2012

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Article

Cationic liposome-mediated nitric oxide synthase gene therapy enhances the antitumor effects of cisplatin in lung cancer

Sujuan Ye, Weihan Yang, Yu Wang, Wenjing Ou, Qingping Ma, Chuanjiang Yu, Jiang Ren, Guoxing Zhong, Huashan Shi, Zhu Yuan, Xiaolan Su, Wen Zhu
Pages: 33-42
Published online on: 01 November 2012

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Article

A novel GATA5 loss-of-function mutation underlies lone atrial fibrillation

Xin-Hua Wang, Cong-Xin Huang, Qian Wang, Ruo-Gu Li, Ying-Jia Xu, Xu Liu, Wei-Yi Fang, Yi-Qing Yang
Pages: 43-50
Published online on: 20 November 2012

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Article

Somatic mutations in the GATA6 gene underlie sporadic tetralogy of Fallot

Ri-Tai Huang, Song Xue, Ying-Jia Xu, Yi-Qing Yang
Pages: 51-58
Published online on: 20 November 2012

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Article

Induction of differentiation-specific miRNAs in TPA-induced myeloid leukemia cells through MEK/ERK activation

Jing Wang, Lijun Liu, Lan Xie, Guangxin Xiang, Yuxiang Zhou
Pages: 59-66
Published online on: 21 November 2012

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Article

The mechanism of long-term low-dose asymmetric dimethylarginine inducing transforming growth factor-β expression in endothelial cells

Yiduo Feng, Dongliang Zhang, Yu Zhang, Qidong Zhang, Wenhu Liu
Pages: 67-74
Published online on: 20 November 2012

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Article

Electroacupuncture exerts anti-inflammatory effects in cerebral ischemia-reperfusion injured rats via suppression of the TLR4/NF-κB pathway

Lan Lan, Jing Tao, Azhen Chen, Guanli Xie, Jia Huang, Jiumao Lin, Jun Peng, Lidian Chen
Pages: 75-80
Published online on: 16 November 2012

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Article

Comparison of the pathologic and pathogenic features in six different regions of postmortem brains of three patients with fatal familial insomnia

Wu-Ling Xie, Qi Shi, Sheng-Li Xia, Bao-Yun Zhang, Han-Shi Gong, Shao-Bin Wang, Yin Xu, Yan Guo, Chan Tian, Jin Zhang, Bian-Li Xu, Yong Liu, Xiao-Ping Dong
Pages: 81-90
Published online on: 22 November 2012

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Article

Transplantation of bone marrow-derived endothelial progenitor cells attenuates cerebral ischemia and reperfusion injury by inhibiting neuronal apoptosis, oxidative stress and nuclear factor-κB expression

Jing Qiu, Wei Li, Shuhang Feng, Min Wang, Zhiyi He
Pages: 91-98
Published online on: 13 November 2012

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Article

Molecular cloning, characterization and differential expression of DRK1 in Sporothrix schenckii

Binbin Hou, Zhenying Zhang, Fangliang Zheng, Xiaoming Liu
Pages: 99-104
Published online on: 22 November 2012

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Article

Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP-1

Zeng-Feng Xin, Cheng-Chun Shen, Li-Jiang Tao, Shi-Gui Yan, Hao-Bo Wu
Pages: 105-112
Published online on: 21 November 2012

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Article

Vincristine induces cell cycle arrest and apoptosis in SH-SY5Y human neuroblastoma cells

Yue Tu, Shixiang Cheng, Sai Zhang, Hongtao Sun, Zhongwei Xu
Pages: 113-119
Published online on: 30 October 2012

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Article

HPV16/18 E5, a promising candidate for cervical cancer vaccines, affects SCPs, cell proliferation and cell cycle, and forms a potential network with E6 and E7

Shujie Liao, Dongrui Deng, Xiaoji Hu, Wei Wang, Li Li, Wei Li, Jianfeng  Zhou, Gang Xu, Li Meng, Shixuan Wang, Ding Ma
Pages: 120-128
Published online on: 30 October 2012

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Article

microRNA changes in the dorsal horn of the spinal cord of rats with chronic constriction injury: A TaqMan® Low Density Array study

Yuuki Genda, Masae Arai, Masashi Ishikawa, Shunsuke Tanaka, Tadashi Okabe, Atsuhiro Sakamoto
Pages: 129-137
Published online on: 24 October 2012

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Article

Characterization of atrial histopathological and electrophysiological changes in a mouse model of aging

Tao Luo, Cui-Xian Chang, Xin Zhou, Shi-Kui Gu, Tie-Ming Jiang, Yu-Ming Li
Pages: 138-146
Published online on: 06 November 2012

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Article

Vaccination with embryonic stem cells generates effective antitumor immunity against ovarian cancer

Zujuan Zhang, Xinhua Chen, Xiaohong Chang, Xue Ye, Yi Li, Heng Cui
Pages: 147-153
Published online on: 22 November 2012

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Article

Anti-inflammatory effects of egg white combined with chalcanthite in lipopolysaccharide-stimulated BV2 microglia through the inhibition of NF-κB, MAPK and PI3K/Akt signaling pathways

Eun A Choi, Hye Young Park, Hwa-Seung Yoo, Yung Hyun Choi
Pages: 154-162
Published online on: 01 November 2012

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Article

Targeted delivery of biodegradable nanoparticles with ultrasound-targeted microbubble destruction-mediated hVEGF-siRNA transfection in human PC-3 cells in vitro

Yun-Hua Li, Qiu-Sheng Shi, Jing Du, Li-Fang Jin, Lian-Fang Du, Pei-Feng Liu, You-Rong Duan
Pages: 163-171
Published online on: 08 November 2012

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Article

Activated microglia provide a neuroprotective role by balancing glial cell-line derived neurotrophic factor and tumor necrosis factor-α secretion after subacute cerebral ischemia

Jianping Wang, Zhitang Yang, Cong Liu, Yuanzheng Zhao, Yibing Chen
Pages: 172-178
Published online on: 13 November 2012

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Article

Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine

Ki-Mo Lee, Haeng-A Kang, Chang-Bo Ko, Eun-Ha Oh, Min Park, Hwa-Youn Lee, Ha‑Rim Choi, Chul-Ho Yun, Woon-Won Jung, Jae-Wook Oh, Hyung-Sik Kang
Pages: 179-187
Published online on: 15 November 2012

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Article

Attenuation of exogenous angiotensin II stress-induced damage and apoptosis in human vascular endothelial cells via microRNA-155 expression

Te Liu, Dingzhu Shen, Sanli Xing, Jiulin Chen, Zhihua Yu, Jian Wang, Beiling Wu, Huiying Chi, Hongbin Zhao, Zhenzhen Liang, Chuan Chen
Pages: 188-196
Published online on: 15 November 2012

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Article

Hepatitis B virus X protein modulates remodelling of minichromosomes related to hepatitis B virus replication in HepG2 cells

Li Luo, Shu Chen, Qian Gong, Na Luo, Yu Lei, Jinjun Guo, Song He
Pages: 197-204
Published online on: 26 October 2012

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Article

Inhibitory effects of Asterina pectinifera extracts on melanin biosynthesis through tyrosinase activity

Min-Ho Jeong, Kwang-Mo Yang, Jung-Ki Kim, Byung-Hyouk Nam, Gi‑Yong Kim, Sang-Wha Lee, Su-Yeong Seo, Wol-Soon Jo
Pages: 205-212
Published online on: 14 November 2012

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Article

Involvement of the mitochondrial pathway and Bim/Bcl-2 balance in dihydroartemisinin-induced apoptosis in human breast cancer in vitro

Haiting Mao, Hongtao Gu, Xun Qu, Jintang Sun, Bingfeng Song, Wenjuan Gao, Jia Liu, Qianqian Shao
Pages: 213-218
Published online on: 08 November 2012

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Article

Growth inhibition and apoptosis-inducing effect on human cancer cells by RCE-4, a spirostanol saponin derivative from natural medicines

Guiping Wang, Wenfeng Huang, Haibo He, Xuejiao Fu, Junzhi Wang, Kun Zou, Jianfeng Chen
Pages: 219-224
Published online on: 09 November 2012

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Article

Electroacupuncture promotes neurological functional recovery via the retinoic acid signaling pathway in rats following cerebral ischemia-reperfusion injury

Jiangcong Hong, Guangwen Wu, Yulong Zou, Jing Tao, Lidian Chen
Pages: 225-231
Published online on: 26 October 2012

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Article

Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis

Enrica Bianchi, Fabio Scarinci, Guido Ripandelli, Janos Feher, Elena Pacella, Giuseppe Magliulo, Corrado Balacco Gabrieli, Rocco Plateroti, Pasquale Plateroti, Fiorenzo Mignini, Marco Artico
Pages: 232-242
Published online on: 26 October 2012

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Article

The flavonoid glabridin attenuates 2-deoxy-D-ribose-induced oxidative damage and cellular dysfunction in MC3T3-E1 osteoblastic cells

Hyun-Sook Kim, Kwang Sik Suh, Ara Ko, Donggeun Sul, Dalwoong  Choi, Seung Kwan Lee, Woon-Won Jung
Pages: 243-251
Published online on: 02 November 2012

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Article

Inhibition of HIV-1 replication by RNA with a microRNA-like function

Keijiro Kato, Takashi Senoki, Hiroshi Takaku
Pages: 252-258
Published online on: 01 November 2012

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Article

Involvement of Nrf2 activation in the upregulation of S100A9 by exposure to inorganic arsenite

Daigo Sumi, Yuri Shimizu, Seiichiro Himeno
Pages: 259-264
Published online on: 16 November 2012

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Article

Quercetin and quercitrin protect against cytokine‑induced injuries in RINm5F β-cells via the mitochondrial pathway and NF-κB signaling

Xiaoqian Dai, Ye Ding, Zhaofeng Zhang, Xiaxia Cai, Yong Li
Pages: 265-271
Published online on: 08 November 2012

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

miR‑205: A dual regulator of angiogenesis in health and disease (Review)

Maria Oltra, Miriam Martínez‑Santos, Maria Ybarra, Maria Pires, Chiara Ceresoni, Clara Gomis‑Coloma, Cristina Medina‑Trillo, Javier Sancho, Jorge Barcia
Article Number: 51
Published online on: 29 December 2025

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Review Open Access

Astragaloside IV: A multipotent phytochemical for treating fibrotic diseases (Review)

Mingyu Wu, Ke Li, Jiabin Wu, Qiuyu Zhang, Xiaotong Ma, Wei Dai, Haoyang Gao, Xianyi Ding, Wenhong Wang, Weihua Xiao
Article Number: 50
Published online on: 24 December 2025

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Review Open Access

Activating transcription factors: Orchestrators of macrophage biology in pathological settings (Review)

Yue-Chen Liu, Jia-Wei Zhao, Xiong-Tao Yue, Qi-Jie Chen, Shan-Jie Rong, Shi-Wei Liu, Fei Sun, Chun-Liang Yang, Cong-Yi Wang
Article Number: 49
Published online on: 24 December 2025

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Review Open Access

Role of SIRT3 in digestive system diseases and therapeutic prospects (Review)

Jiajia Li, Qian Liu, Shun Yao, Xin Li, Li Zhang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 48
Published online on: 22 December 2025

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Article Open Access

Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling

Jin-Hwa Kim, Sang-Hyup Lee, Sang-Yoon Kim, Jeong-Won Kim, Ji-Soo Jeong, Eun-Hye Chung, Su-Ha Lee, Chang-Yeop Kim, Bong-Keun Choi, Je-Won Ko, Tae-Won Kim
Article Number: 47
Published online on: 22 December 2025

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Review Open Access

A comprehensive review on pain: Model, target, therapy, and prospect (Review)

Chenyu Chang, Xutao Wu, Kejia Liu, Lei Wang, Mozili Adu, Qingyuan Lin, Huilian Huang, Qinge Ma, Rongrui Wei, Xiaoyun Wang, Wenmin Liu
Article Number: 46
Published online on: 17 December 2025

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Retraction Open Access

[Retracted] Curculigoside attenuates myocardial ischemia‑reperfusion injury by inhibiting the opening of the mitochondrial permeability transition pore

Yanbing Zhao, Yuxuan Guo, Yuqiong Chen, Shuang Liu, Nan Wu, Dalin Jia
Article Number: 45
Published online on: 15 December 2025

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Review Open Access

Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review)

Quanquan Zhou, Ge‑Lin Zhang, Weitong Sun, Jiayi Cai, Li-Hua Yu
Article Number: 44
Published online on: 10 December 2025

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Article Open Access

Selective autophagic degradation of glycolytic activator PFKFB3 contributes to maintaining intestinal epithelial barrier in inflammatory bowel disease

Yiyang Pan, Feng Yang, Liucan Wang, Tianshu Yang, Guangsheng Du, Cong Xu, Hua Yang, Min Yu, Weidong Xiao
Article Number: 43
Published online on: 10 December 2025

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Review Open Access

Lactylation‑mediated ferroptosis: A novel mechanism and therapeutic prospects in human diseases (Review)

Zhengjun Lin, Yugang Zou, Songzhu Zou, Kunming Wen
Article Number: 42
Published online on: 08 December 2025

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Review Open Access

Dual role of lactate in ferroptosis: Mechanisms, pathophysiology and therapeutic opportunities (Review)

Qian Yu, Yu Kuang, Jie He, Li Yang, Xinjie Li, Hao Yu
Article Number: 41
Published online on: 08 December 2025

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Retraction Open Access

[Retracted] MicroRNA‑493‑5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targeting VAMP2

Guannan Wang, Xiaosan Fang, Meng Han, Xiaoming Wang, Qiang Huang
Article Number: 40
Published online on: 08 December 2025

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Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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Article Open Access

STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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Article Open Access

HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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Article Open Access

FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Review Open Access

Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Review Open Access

Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Review Open Access

Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)

Chang Gao, Guiqing Chen, Hongyan Jia, Hong Zhu, Yun Cai, Dakai Yang, Kai Zhao
Article Number: 62
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 61
Published online on: 14 January 2026

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Review Open Access

Harnessing MSC‑derived exosomes to modulate the pathophysiology of ASD: Recent advances and therapeutic implications (Review)

Zhaojian Sun, Nouman Amjad, Majid Muhammad, Zhiyuan Li
Article Number: 60
Published online on: 13 January 2026

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Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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