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Article

Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine

  • Authors:
    • Ki-Mo Lee
    • Haeng-A Kang
    • Chang-Bo Ko
    • Eun-Ha Oh
    • Min Park
    • Hwa-Youn Lee
    • Ha‑Rim Choi
    • Chul-Ho Yun
    • Woon-Won Jung
    • Jae-Wook Oh
    • Hyung-Sik Kang
  • View Affiliations / Copyright

    Affiliations: School of Biological Sciences and Technology, Chonnam National University, Gwangju 500‑757, Republic of Korea, Department of Food and Nutrition, Nambu University, Gwangju 506-706, Republic of Korea, College of Health Sciences, Korea University, Seoul 136-70, Republic of Korea, Division of Animal Life Science, College of Animal Bioscience and Technology, Konkuk University, Seoul 143-701, Republic of Korea
  • Pages: 179-187
    |
    Published online on: November 15, 2012
       https://doi.org/10.3892/ijmm.2012.1183
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Abstract

Enalapril and nifedipine are used as antihypertensive drugs; however, the therapeutic target molecules regulated by enalapril and nifedipine have yet to be fully identified. The aim of this study was to identify novel target genes that are specifically regulated by enalapril and nifedipine in tissues from spontaneously hypertensive rats (SHR) using DNA microarray analysis. We found that administration of SHR with enalapril and nifedipine differentially regulated 33 genes involved in the pathogenesis of cardiovascular diseases. Furthermore, we identified 16 genes that have not previously been implicated in cardiovascular diseases, including interleukin-24 (IL-24). Among them, exogenous administration of IL-24 attenuated the expression of vascular inflammation and hypertension-related genes induced by H2O2 treatment in mouse vascular smooth muscle (MOVAS) cells. This study provides valuable information for the development of novel antihypertensive drugs. In addition, the genes identified may be of use as biomarkers and therapeutic targets for cardiovascular diseases, including hypertension.
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1 

Trippodo NC and Frohlic ED: Similarities of genetic (spontaneous) hypertension. Man and rat Circ Res. 48:309–319. 1981. View Article : Google Scholar : PubMed/NCBI

2 

Okamoto K and Aoki K: Development of a strain of spontaneously hypertensive rats. Jpn Circ J. 27:282–293. 1963. View Article : Google Scholar : PubMed/NCBI

3 

Klingbeil AU, Schneider M, Martus P, et al: A meta-analysis of the effects of treatment on left ventricular mass in essential hypertension. Am J Med. 115:41–46. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Ménard J, Campbell DJ, Azizi M and Gonzales MF: Synergistic effects of ACE inhibition and Ang II antagonism on blood pressure, cardiac weight, and renin in spontaneously hypertensive rats. Circulation. 96:3072–3078. 1997.PubMed/NCBI

5 

Hosomi N, Mizushige K and Ohyama H: Angiotensin-converting enzyme inhibition with enalapril slows progressive intima-media thickening of the common carotid artery in patients with non-insulin-dependent diabetes mellitus. Stroke. 32:1539–1545. 2001. View Article : Google Scholar

6 

Croom KF and Wellington K: A Review of the use of modified-release formulations in the treatment of hypertension and angina pectoris. Drugs. 66:497–528. 2006.PubMed/NCBI

7 

Ueng KC, Lin MC, Chan KC and Lin CS: Nifedipine gastrointestinal therapeutic system: an overview of its antiatherosclerotic effects. Expert Opin Drug Metab Toxicol. 3:769–780. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Tostes JM: Effects of hypertension on abdominal wall healing: experimental study in rats. Surg Today. 37:215–219. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Yono M, Yamamoto Y, Yoshida M, Ueda S, et al: Effects of doxazosin on blood flow and mRNA expression of nitric oxide synthase in the spontaneously hypertensive rat genitourinary tract. Life Sciences. 81:218–222. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Spijkers LJ, Janssen BJ, Nelissen J, et al: Antihypertensive treatment differentially affects vascular sphingolipid biology in spontaneously hypertensive rats. PLoS One. 6:e292222011. View Article : Google Scholar

11 

Sul D, Kim H, Oh E, Phark S, et al: Gene expression profiling in lung tissues from rats exposed to formaldehyde. Arch Toxicol. 81:589–597. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Touyz RM and Schiffrin EL: Reactive oxygen species in vascular biology: implications in hypertension. Histochem Cell Biol. 122:339–352. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Ruef J, Hu ZY, Yin LY, Wu Y, et al: Induction of vascular endothelial growth factor in balloon-injured baboon arteries. Circ Res. 81:24–33. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Chua CC, Hamdy RC and Chua BH: Upregulation of vascular endothelial growth factor by H2O2 in rat heart endothelial cells. Free Radic Biol Med. 25:891–897. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Cohuet G and Struijker-Boudier H: Mechanisms of target organ damage caused by hypertension: therapeutic potential. Pharmacol Ther. 111:81–98. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Mancia G, De Backer G, Dominiczak A, Cifkova R, et al: 2007 guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 28:1462–1536. 2007.

17 

Lugo-Baruqui A, Muñoz-Valle JF, Arévalo-Gallegos S, et al: Role of angiotensin II in liver fibrosis-induced portal hypertension and therapeutic implications. Hepatol Res. 40:95–104. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Okuda T, Sumiya T, Mizutani K, et al: Analyses of differential gene expression in genetic hypertensive rats by microarray. Hypertens Res. 25:249–255. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Yono M, Yoshida M, Yamamoto Y, et al: Identification of potential therapeutic targets in hypertension-associated bladder dysfunction. BJU Int. 105:877–883. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Liu J, Sukhova GK, Sun JS, Xu WH, et al: Lysosomal cysteine proteases in atherosclerosis. Arterioscler Thromb Vasc Biol. 24:1359–1366. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Sevenich L, Schurigt U, Sachse K, Gajda M, et al: Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc Natl Acad Sci USA. 107:2497–2502. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Chapman HA, Riese RJ and Shi GP: Emerging roles for cysteine proteases in human biology. Annu Rev Physiol. 59:63–88. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Nägler DK, Storer AC, Portaro FC, Carmona E, et al: Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts. Biochemistry. 36:12608–12615. 1997.PubMed/NCBI

24 

Krueger S, Kalinski T, Hundertmark T, Wex T, et al: Upregulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer. J Pathol. 207:32–42. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Wang J, Chen L, Li Y and Guan XY: Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. PLoS One. 6:e249672001. View Article : Google Scholar : PubMed/NCBI

26 

Castle A and Castle D: Ubiquitously expressed secretory carrier membrane proteins (SCAMPs) 1–4 mark different pathways and exhibit limited constitutive trafficking to and from the cell surface. J Cell Sci. 118:3769–3780. 2005.

27 

Fernández-Chacón R and Südhof TC: Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions. J Neurosci. 20:7941–7950. 2000.PubMed/NCBI

28 

Fernández-Chacón R, Achiriloaie M, Janz R, et al: SCAMP1 function in endocytosis. J Biol Chem. 275:12752–12756. 2000.

29 

Guo Z, Liu L, Cafiso D and Castle D: Perturbation of a very late step of regulated exocytosis by a secretory carrier membrane protein (SCAMP2)-derived peptide. J Biol Chem. 277:35357–35363. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Liao H, Ellena J, Liu L, Szabo G, et al: Secretory carrier membrane protein SCAMP2 and phosphatidylinositol 4,5-bisphosphate interactions in the regulation of dense core vesicle exocytosis. Biochemistry. 46:10909–10920. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Müller HK, Wiborg O and Haase J: Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2. J Biol Chem. 281:28901–28909. 2006.PubMed/NCBI

32 

MacLean MR, Deuchar GA, Hicks MN, et al: Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension. Circulation. 109:2150–2155. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Sainz-Perez A, Gary-Gouy H, Gaudin F, et al: IL-24 induces apoptosis of chronic lymphocytic leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression. J Immunol. 181:6051–6060. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Lebedeva IV, Emdad L, Su ZZ, Gupta P, et al: mda-7/IL-24, novel anticancer cytokine: Focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review). Int J Oncol. 31:985–1007. 2007.

35 

Chen J, Chada S, Mhashilkar A and Miano JM: Tumor suppressor MDA-7/IL-24 selectively inhibits vascular smooth muscle cell growth and migration. Mol Ther. 8:220–229. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Ross JS, Stagliano NE, Donovan MJ, Breitbart RE, et al: Atherosclerosis: a cancer of the blood vessels? Am J Clin Pathol. 116(Suppl): S97–S107. 2001.PubMed/NCBI

37 

Rao GN and Berk BC: Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression. Circ Res. 70:593–599. 1992. View Article : Google Scholar : PubMed/NCBI

38 

Li WG, Miller FJ Jr, Zhang HJ, Spitz DR, et al: Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression. J Biol Chem. 276:29251–29256. 2001.

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Copy and paste a formatted citation
Spandidos Publications style
Lee K, Kang H, Ko C, Oh E, Park M, Lee H, Choi HR, Yun C, Jung W, Oh J, Oh J, et al: Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine. Int J Mol Med 31: 179-187, 2013.
APA
Lee, K., Kang, H., Ko, C., Oh, E., Park, M., Lee, H. ... Kang, H. (2013). Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine. International Journal of Molecular Medicine, 31, 179-187. https://doi.org/10.3892/ijmm.2012.1183
MLA
Lee, K., Kang, H., Ko, C., Oh, E., Park, M., Lee, H., Choi, H., Yun, C., Jung, W., Oh, J., Kang, H."Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine". International Journal of Molecular Medicine 31.1 (2013): 179-187.
Chicago
Lee, K., Kang, H., Ko, C., Oh, E., Park, M., Lee, H., Choi, H., Yun, C., Jung, W., Oh, J., Kang, H."Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine". International Journal of Molecular Medicine 31, no. 1 (2013): 179-187. https://doi.org/10.3892/ijmm.2012.1183
Copy and paste a formatted citation
x
Spandidos Publications style
Lee K, Kang H, Ko C, Oh E, Park M, Lee H, Choi HR, Yun C, Jung W, Oh J, Oh J, et al: Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine. Int J Mol Med 31: 179-187, 2013.
APA
Lee, K., Kang, H., Ko, C., Oh, E., Park, M., Lee, H. ... Kang, H. (2013). Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine. International Journal of Molecular Medicine, 31, 179-187. https://doi.org/10.3892/ijmm.2012.1183
MLA
Lee, K., Kang, H., Ko, C., Oh, E., Park, M., Lee, H., Choi, H., Yun, C., Jung, W., Oh, J., Kang, H."Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine". International Journal of Molecular Medicine 31.1 (2013): 179-187.
Chicago
Lee, K., Kang, H., Ko, C., Oh, E., Park, M., Lee, H., Choi, H., Yun, C., Jung, W., Oh, J., Kang, H."Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine". International Journal of Molecular Medicine 31, no. 1 (2013): 179-187. https://doi.org/10.3892/ijmm.2012.1183
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