Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine

Lee,Ki-Mo; Kang,Haeng-A; Ko,Chang-Bo; Oh,Eun-Ha; Park,Min; Lee,Hwa-Youn; Choi,Ha‑Rim; Yun,Chul-Ho; Jung,Woon-Won; Oh,Jae-Wook; Kang,Hyung-Sik

doi:10.3892/ijmm.2012.1183

Differential gene expression profiles in spontaneously hypertensive rats induced by administration of enalapril and nifedipine

Authors:
- Ki-Mo Lee
- Haeng-A Kang
- Chang-Bo Ko
- Eun-Ha Oh
- Min Park
- Hwa-Youn Lee
- Ha‑Rim Choi
- Chul-Ho Yun
- Woon-Won Jung
- Jae-Wook Oh
- Hyung-Sik Kang
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Affiliations: School of Biological Sciences and Technology, Chonnam National University, Gwangju 500‑757, Republic of Korea, Department of Food and Nutrition, Nambu University, Gwangju 506-706, Republic of Korea, College of Health Sciences, Korea University, Seoul 136-70, Republic of Korea, Division of Animal Life Science, College of Animal Bioscience and Technology, Konkuk University, Seoul 143-701, Republic of Korea
Published online on: November 15, 2012 https://doi.org/10.3892/ijmm.2012.1183
Pages: 179-187

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Abstract

Enalapril and nifedipine are used as antihypertensive drugs; however, the therapeutic target molecules regulated by enalapril and nifedipine have yet to be fully identified. The aim of this study was to identify novel target genes that are specifically regulated by enalapril and nifedipine in tissues from spontaneously hypertensive rats (SHR) using DNA microarray analysis. We found that administration of SHR with enalapril and nifedipine differentially regulated 33 genes involved in the pathogenesis of cardiovascular diseases. Furthermore, we identified 16 genes that have not previously been implicated in cardiovascular diseases, including interleukin-24 (IL-24). Among them, exogenous administration of IL-24 attenuated the expression of vascular inflammation and hypertension-related genes induced by H2O2 treatment in mouse vascular smooth muscle (MOVAS) cells. This study provides valuable information for the development of novel antihypertensive drugs. In addition, the genes identified may be of use as biomarkers and therapeutic targets for cardiovascular diseases, including hypertension.

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