Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
April 2012 Volume 29 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April 2012 Volume 29 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Pattern of cancer/testis antigen expression in lung cancer patients

  • Authors:
    • Yeong-Dae Kim
    • Hae-Rim Park
    • Myung-Ha Song
    • Dong-Hoon Shin
    • Chang-Hun Lee
    • Min-Ki Lee
    • Sang-Yull Lee
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Pusan National University Hospital, Seo-gu, Busan 602-739, Republic of Korea, Department of Biochemistry, School of Medicine, Pusan National University, Beomeo-ri, Mulgeum-eup, Yangsan 626-770, Republic of Korea
  • Pages: 656-662
    |
    Published online on: January 24, 2012
       https://doi.org/10.3892/ijmm.2012.896
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cancer/testis (CT) antigens represent promising targets for immunotherapy. We investigated the composite expression of 13 CT antigens by RT-PCR in 79 lung cancer tissues and by immunohistochemistry in 22 lung cancer tissues. In the 79 lung cancer tissues, MAGE-3 (42%) was expressed most frequently and followed by NY-SAR-35 (33%), NY-ESO-1 (30%), MAGE-1 (27%), CT-7 (20%), MAGE-4 (19%), LAGE-1 (16%), and MAGE-10 (14%). Twenty-one tissues did not express any of the CT antigens tested, 58 (73%) expressed at least one, 36 (46%) co-expressed two, 24 (30%) co-expressed three, 17 (22%) co-expressed four, 14 (18%) co-expressed five, 8 (10%) co-expressed six, 4 (6%) co-expressed seven and 2 tissues expressed 9 of the 13 examined CT antigens. Expression of CT antigens was significantly associated with age (P<0.001), smoking history (P=0.009), and gender (P=0.001) of patients, whereas no correlation was found between the expression of CT antigens and other clinical factors, such as pT status, pN status, tumor stage, and histology history. The present results show that CT antigens are potential candidates in lung cancer patients for polyvalent immunotherapy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

DM ParkinF BrayJ FerlayP PisaniGlobal cancer statistics, 2002CA Cancer J Clin5574108200510.3322/canjclin.55.2.74

2 

LJ OldCancer vaccines 2003: opening addressCancer Immun3Suppl 2S12003

3 

MJ ScanlanAJ SimpsonLJ OldThe cancer/testis genes: review, standardization, and commentaryCancer Immun41200414738373

4 

PG CoulieV BrichardA Van PelT WolfelJ SchneiderC TraversariS MatteiE De PlaenC LurquinJP SzikoraA new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomasJ Exp Med1803542199410.1084/jem.180.1.358006593

5 

S LabrecqueN NaorD ThomsonG MatlashewskiAnalysis of the anti-p53 antibody response in cancer patientsCancer Res533468347119938339249

6 

ML DisisE CalenoffG McLaughlinAE MurphyW ChenB GronerM JeschkeN LydonE McGlynnRB LivingstonExistent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancerCancer Res54162019947505195

7 

T BoonPG CoulieB Van den EyndeTumor antigens recognized by T cellsImmunol Today18267268199710.1016/S0167-5699(97)80020-59190110

8 

YT ChenAO GureS TsangE StockertE JagerA KnuthLJ OldIdentification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line libraryProc Natl Acad Sci USA9569196923199810.1073/pnas.95.12.69199618514

9 

AJ SimpsonOL CaballeroA JungbluthYT ChenLJ OldCancer/testis antigens, gametogenesis and cancerNat Rev Cancer5615625200510.1038/nrc166916034368

10 

RB ParmigianiF BettoniMD VibranovskiMH LopesWK MartinsIW CunhaFA SoaresAJ SimpsonSJ de SouzaAA CamargoCharacterization of a cancer/testis (CT) antigen gene family capable of eliciting humoral response in cancer patientsProc Natl Acad Sci USA1031806618071200610.1073/pnas.060885310317114284

11 

OL CaballeroYT ChenCancer/testis (CT) antigens: potential targets for immunotherapyCancer Sci10020142021200910.1111/j.1349-7006.2009.01303.x19719775

12 

P van der BruggenC TraversariP ChomezC LurquinE De PlaenB Van den EyndeA KnuthT BoonA gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanomaScience254164316471991

13 

P BoelC WildmannML SensiR BrasseurJC RenauldP CoulieT BoonP van der BruggenBAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytesImmunity2167175199510.1016/S1074-7613(95)80053-07895173

14 

B Van den EyndeO PeetersO De BackerB GauglerS LucasT BoonA new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanomaJ Exp Med1826896981995

15 

O TureciU SahinI SchobertM KoslowskiH ScmittHJ SchildF StennerG SeitzHG RammenseeM PfreundschuhThe SSX-2 gene, which is involved in the t(X;18) translocation of synovial sarcomas, codes for the human tumor antigen HOM-MEL-40Cancer Res564766477219968840996

16 

YT ChenMJ ScanlanU SahinO TureciAO GureS TsangB WilliamsonE StockertM PfreundschuhLJ OldA testicular antigen aberrantly expressed in human cancers detected by autologous antibody screeningProc Natl Acad Sci USA9419141918199710.1073/pnas.94.5.19149050879

17 

O TureciU SahinC ZwickM KoslowskiG SeitzM PfreundschuhIdentification of a meiosis-specific protein as a member of the class of cancer/testis antigensProc Natl Acad Sci USA9552115216199810.1073/pnas.95.9.52119560255

18 

SY LeeY ObataM YoshidaE StockertB WilliamsonAA JungbluthYT ChenLJ OldMJ ScanlanImmunomic analysis of human sarcomaProc Natl Acad Sci USA10026512656200310.1073/pnas.043797210012601173

19 

SY LeeB WilliamsonOL CaballeroYT ChenMJ ScanlanG RitterCV JongeneelAJ SimpsonLJ OldIdentification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancerCancer Immun413200415546177

20 

U SahinO TureciH SchmittB CochloviusT JohannesR SchmitsF StennerG LuoI SchobertM PfreundschuhHuman neoplasms elicit multiple specific immune responses in the autologous hostProc Natl Acad Sci USA921181011813199510.1073/pnas.92.25.118108524854

21 

K TajimaY ObataH TamakiM YoshidaYT ChenMJ ScanlanLJ OldH KuwanoT TakahashiT MitsudomiExpression of cancer/testis (CT) antigens in lung cancerLung Cancer422333200310.1016/S0169-5002(03)00244-714512184

22 

JR TsaiIW ChongYH ChenMJ YangCC SheuHC ChangJJ HwangJY HungSR LinDifferential expression profile of MAGE family in non-small-cell lung cancerLung Cancer56185192200710.1016/j.lungcan.2006.12.00417208331

23 

LH SobinP HermanekRV HutterTNM classification of malignant tumors. A comparison between the new (1987) and the old editionsCancer6123102314198810.1002/1097-0142(19880601)61:11%3C2310::AID-CNCR2820611127%3E3.0.CO;2-X3284634

24 

SH KimS LeeCH LeeMK LeeYD KimDH ShinKU ChoiJY KimY Park doMY SolExpression of cancer-testis antigens MAGE-A3/6 and NY-ESO-1 in non-small-cell lung carcinomas and their relationship with immune cell infiltrationLung187401411200910.1007/s00408-009-9181-319795170

25 

P WeynantsB LetheF BrasseurM MarchandT BoonExpression of mage genes by non-small-cell lung carcinomasInt J Cancer56826829199410.1002/ijc.29105606128119772

26 

S LucasC De SmetKC ArdenCS ViarsB LetheC LurquinT BoonIdentification of a new MAGE gene with tumor-specific expression by representational difference analysisCancer Res5874375219989485030

27 

C FischerF GudatP StulzC NoppenC SchaeferP ZajacM TrutmannT KocherM ZuberF HarderHigh expression of MAGE-3 protein in squamous-cell lung carcinomaInt J Cancer7111191121199710.1002/(SICI)1097-0215(19970611)71:6%3C1119::AID-IJC34%3E3.0.CO;2-59185722

28 

MJ ScanlanNK AltorkiAO GureB WilliamsonA JungbluthYT ChenLJ OldExpression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9Cancer Lett150155164200010.1016/S0304-3835(99)00385-710704737

29 

D RimoldiV Rubio-GodoyV DutoitD LienardS SalviP GuillaumeD SpeiserE StockertG SpagnoliC ServisEfficient simultaneous presentation of NY-ESO-1/LAGE-1 primary and nonprimary open reading frame-derived CTL epitopes in melanomaJ Immunol16572537261200010.4049/jimmunol.165.12.725311120859

30 

F van RheeSM SzmaniaF ZhanSK GuptaM PomtreeP LinRB BatchuA MorenoG SpagnoliJ ShaughnessyNY-ESO-1 is highly expressed in poor-prognosis multiple myeloma and induces spontaneous humoral and cellular immune responsesBlood10539393944200515671442

31 

B LetheS LucasL MichauxC De SmetD GodelaineA SerranoE De PlaenT BoonLAGE-1, a new gene with tumor specificityInt J Cancer76903908199810.1002/(SICI)1097-0215(19980610)76:6%3C903::AID-IJC22%3E3.0.CO;2-19626360

32 

JH ParkMH SongCH LeeMK LeeYM ParkL OldSY LeeExpression of the human cancer/testis antigen NY-SAR-35 is activated by CpG island hypomethylationBiotechnol Lett3310851091201110.1007/s10529-011-0559-y21318630

33 

A MischoB KubuschokK ErtanKD PreussB RomeikeE RegitzC SchormannD de BruijnA WadleF NeumannProspective study on the expression of cancer testis genes and antibody responses in 100 consecutive patients with primary breast cancerInt J Cancer118696703200610.1002/ijc.2135216094643

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kim Y, Park H, Song M, Shin D, Lee C, Lee M and Lee S: Pattern of cancer/testis antigen expression in lung cancer patients . Int J Mol Med 29: 656-662, 2012.
APA
Kim, Y., Park, H., Song, M., Shin, D., Lee, C., Lee, M., & Lee, S. (2012). Pattern of cancer/testis antigen expression in lung cancer patients . International Journal of Molecular Medicine, 29, 656-662. https://doi.org/10.3892/ijmm.2012.896
MLA
Kim, Y., Park, H., Song, M., Shin, D., Lee, C., Lee, M., Lee, S."Pattern of cancer/testis antigen expression in lung cancer patients ". International Journal of Molecular Medicine 29.4 (2012): 656-662.
Chicago
Kim, Y., Park, H., Song, M., Shin, D., Lee, C., Lee, M., Lee, S."Pattern of cancer/testis antigen expression in lung cancer patients ". International Journal of Molecular Medicine 29, no. 4 (2012): 656-662. https://doi.org/10.3892/ijmm.2012.896
Copy and paste a formatted citation
x
Spandidos Publications style
Kim Y, Park H, Song M, Shin D, Lee C, Lee M and Lee S: Pattern of cancer/testis antigen expression in lung cancer patients . Int J Mol Med 29: 656-662, 2012.
APA
Kim, Y., Park, H., Song, M., Shin, D., Lee, C., Lee, M., & Lee, S. (2012). Pattern of cancer/testis antigen expression in lung cancer patients . International Journal of Molecular Medicine, 29, 656-662. https://doi.org/10.3892/ijmm.2012.896
MLA
Kim, Y., Park, H., Song, M., Shin, D., Lee, C., Lee, M., Lee, S."Pattern of cancer/testis antigen expression in lung cancer patients ". International Journal of Molecular Medicine 29.4 (2012): 656-662.
Chicago
Kim, Y., Park, H., Song, M., Shin, D., Lee, C., Lee, M., Lee, S."Pattern of cancer/testis antigen expression in lung cancer patients ". International Journal of Molecular Medicine 29, no. 4 (2012): 656-662. https://doi.org/10.3892/ijmm.2012.896
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team