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Article

Apolipoprotein A-IV as a novel gene associated with polycystic ovary syndrome

  • Authors:
    • Yong-Soo Kim
    • Bon-Hee Gu
    • Bum-Chae Choi
    • Myung-Sun Kim
    • Sangjin Song
    • Ji-Hyun Yun
    • Mi Kyung Chung
    • Cheol-Hee Choi
    • Kwang-Hyun Baek
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science, Fertility Center, CHA University, CHA General Hospital, Seoul, Republic of Korea, Research Center for Resistant Cells, Department of Pharmacology, Chosun University Medical School, Gwangju, Republic of Korea, Department of Obstetrics and Gynecology, CL Women's Hospital, Gwangju, Republic of Korea
  • Pages: 707-716
    |
    Published online on: January 17, 2013
       https://doi.org/10.3892/ijmm.2013.1250
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Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disorder, affecting 6-10% of women of reproductive age. The etiology remains poorly understood. To investigate the differentially expressed proteins from PCOS patients versus healthy women, the protein expression in follicular fluid was analyzed using two-dimensional electrophoresis (2-DE). Since follicular fluid contains a number of secretory proteins required for oocyte fertilization and follicle maturation, it is possible that follicular fluid can be used as a provisional source for identifying pivotal proteins associated with PCOS. In this study, six overexpressed proteins [kininogen 1, cytokeratin 9, antithrombin, fibrinogen γ-chain, apolipoprotein A-IV (apoA-IV) precursor and α-1-B-glycoprotein (A1BG)] in follicular fluids from PCOS patients were identified with matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF-MS) and nano LC-MS/MS. Western blot analysis confirmed that the protein expression levels of apoA-IV precursor and A1BG were increased in follicular fluid from PCOS patients compared with those from normal controls. The analysis of protein expression for other proteins revealed individual variation. These results facilitate the understanding of the molecular mechanisms of PCOS and provide candidate biomarkers for the development of diagnostic and therapeutic tools.
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View References

1 

Goodarzi MO, Dumesic DA, Chazenbalk G and Azziz R: Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat Rew Endocrinol. 7:219–231. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Hart R, Hickey M and Franks S: Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol. 18:671–683. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Pasquali R, Stener-Victorin E, Yildiz BO, Duleba AJ, Hoeger K, Mason H, Homburg R, Hickey T, Franks S, Tapanainen JS, et al: PCOS Forum: research in polycystic ovary syndrome today and tomorrow. Clin Endocrinol (Oxf). 74:424–433. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Dumesic DA, Abbott DH and Padmanabhan V: Polycystic ovary syndrome and its developmental origins. Rev Endocr Metab Disord. 8:127–141. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Hourvitz A, Kuwahara A, Hennebold JD, Tavares AB, Negishi H, Lee TH, Erickson GF and Adashi EY: The regulated expression of the pregnancy-associated plasma protein-A in the rodent ovary: a proposed role in the development of dominant follicles and of corpora lutea. Endocrinology. 143:1833–1844. 2002. View Article : Google Scholar

6 

Teixeira Filho FL, Baracat EC, Lee TH, Suh CS, Matsui M, Chang RJ, Shimasaki S and Erickson GF: Aberrant expression of growth differentiation factor-9 in oocytes of women with polycystic ovary syndrome. J Clin Endocrinol Metab. 87:1337–1344. 2002.PubMed/NCBI

7 

Munir I, Yen HW, Baruth T, Tarkowki R, Azziz R, Magoffin DA and Jakimiuk AJ: Resistin stimulation of 17alpha-hydroxylase activity in ovarian theca cells in vitro: relevance to polycystic ovary syndrome. J Clin Endocrinol Metab. 90:4852–4857. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Wickenheisser JK, Nelson-Degrave VL and McAllister JM: Dysregulation of cytochrome P450 17alpha-hydroxylase messenger ribonucleic acid stability in theca cells isolated from women with polycystic ovary syndrome. J Clin Endocrinol Metab. 90:1720–1727. 2005. View Article : Google Scholar

9 

Goodarzi MO, Jones MR, Chen YD and Azziz R: First evidence of genetic association between AKT2 and polycystic ovary syndrome. Diabetes Care. 31:2284–2287. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Kim JJ, Choi YM, Hong MA, Hwang SS, Yoon SH, Chae SJ, Jee BC, Ku SY, Kim JG and Moon SY: Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome. Hum Reprod. 24:1184–1190. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Gu BH and Baek KH: Pro12Ala and His447His polymorphisms of PPAR-gamma are associated with polycystic ovary syndrome. Reprod Biomed Online. 18:644–650. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Choi SW, Gu BH, Ramakrishna S, Park JM and Baek KH: Association between a single nucleotide polymorphism in MTHFR gene and polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 145:85–88. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Fortune JE: Ovarian follicular growth and development in mammals. Biol Reprod. 50:225–232. 1994. View Article : Google Scholar : PubMed/NCBI

14 

Chiu PC, Koistinen R, Koistinen H, Seppala M, Lee KF and Yeung WS: Zona-binding inhibitory factor-1 from human follicular fluid is an isoform of glycodelin. Biol Reprod. 69:365–372. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Coy P, Gadea J, Romar R, Matas C and Garcia E: Effect of in vitro fertilization medium on the acrosome reaction, cortical reaction, zona pellucida hardening and in vitro development in pigs. Reproduction. 124:279–288. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Yao Y, Ho P and Yeung WS: Effects of human follicular fluid on the capacitation and motility of human spermatozoa. Fertil Steril. 73:680–686. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Wang TH, Chang CL, Wu HM, Chiu YM, Chen CK and Wang HS: Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo development. Fertil Steril. 86:1392–1401. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Wu YT, Tang L, Cai J, Lu XE, Xu J, Zhu XM, Luo Q and Huang HF: High bone morphogenetic protein-15 level in follicular fluid is associated with high quality oocyte and subsequent embryonic development. Hum Reprod. 22:1526–1531. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Rosen MP, Zamah AM, Shen S, Dobson AT, McCulloch CE, Rinaudo PF, Lamb JD and Cedars MI: The effect of follicular fluid hormones on oocyte recovery after ovarian stimulation: FSH level predicts oocyte recovery. Reprod Biol Endocrinol. 7:352009. View Article : Google Scholar : PubMed/NCBI

20 

Kim YS, Kim MS, Lee SH, Choi BC, Lim JM, Cha KY and Baek KH: Proteomic analysis of recurrent pregnancy loss: Identification of an inadequately expressed set of proteins in human follicular fluid. Proteomics. 6:3445–3454. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Kim MS, Gu BH, Song S, Choi BC, Cha DH and Baek KH: ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients. Mol Biosyst. 7:1430–1440. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Atiomo W, Khalid S, Parameshweran S, Houda M and Layfield R: Proteomic biomarkers for the diagnosis and risk stratification of polycystic ovary syndrome: a systematic review. BJOG. 116:137–143. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Jarkovska K, Martinkova J, Liskova L, Halada P, Moos J, Rezabek K, Gadher SJ and Kovarova H: Proteome mining of human follicular fluid reveals a crucial role of complement cascade and key biological pathways in women undergoing in vitro fertilization. J Proteome Res. 9:1289–1301. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Revised 2003 consensus on diagnostic criteria and long health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 19:41–47. 2004. View Article : Google Scholar

25 

Gravett MG, Thomas A, Schneider KA, Reddy AP, Dasari S, Jacob T, Lu X, Rodland M, Pereira L, Sadowsky DW, et al: Proteomic analysis of cervical vaginal fluid: identification of novel biomarkers for detection of intra-amniotic infection. J Proteome Res. 6:89–96. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Park JS, Oh KJ, Norwitz ER, Han JS, Choi HJ, Seong HS, Kang YD, Park CW, Kim BJ, Jun JK, et al: Identification of proteomic biomarkers of preeclampsia in amniotic fluid using SELDI-TOF mass spectrometry. Reprod Sci. 15:457–468. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Sadeghi M, Roohafza H, Afshar H, Rajabi F, Ramzani M, Shemirani H and Sarafzadeghan N: Relationship between depression and apolipoproteins A and B: a case-control study. Clinics (Sao Paulo). 66:113–117. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Ferrer F, Nazih H, Zair Y, Krempf M and Bard JM: Postprandial changes in the distribution of apolipoprotein AIV between apolipoprotein B- and non apolipoprotein B-containing lipoproteins in obese women. Metabolism. 52:1537–1541. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Araki S, Okazaki M and Goto S: Impaired lipid metabolism in aged mice as revealed by fasting-induced expression of apolipoprotein mRNAs in the liver and changes in serum lipids. Gerontology. 50:206–215. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Qin X and Tso P: The role of apolipoprotein AIV on the control of food intake. Curr Drug Targets. 6:145–151. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Whited KL, Lu D, Tso P, Kent Lloyd KC and Raybould HE: Apolipoprotein A-IV is involved in detection of lipid in the rat intestine. J Physiol. 569:949–958. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Culnan DM, Cooney RN, Stanley B and Lynch CJ: Apolipoprotein A-IV, a putative satiety/antiatherogenic factor, rises after gastric bypass. Obesity. 17:46–52. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Ostos MA, Conconi M, Vergnes L, Baroukh N, Ribalta J, Girona J, Caillaud JM, Ochoa A and Zakin MM: Antioxidative and antiatherosclerotic effects of human apolipoprotein A-IV in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 21:1023–1028. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Broedl UC, Schachinger V, Lingenhel A, Lehrke M, Stark R, Seibold F, Göke B, Kronenberg F, Parhofer KG and Konrad-Zerna A: Apolipoprotein A-IV is an independent predictor of disease activity in patients with inflammatory bowel disease. Inflamm Bowel Dis. 13:391–397. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Remaley AT, Stonik JA, Demosky SJ, Neufeld EB, Bocharov AV, Vishnyakova TG, Eggerman TL, Patterson AP, Duverger NJ, Santamarina-Fojo S, et al: Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem Biophys Res Commun. 280:818–823. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Stylianou IM, Affourtit JP, Shockley KR, Wilpan RY, Abdi FA, Bhardwaj S, Rollins J, Churchill GA and Paigen B: Applying gene expression, proteomics and single-nucleotide polymorphism analysis for complex trait gene identification. Genetics. 178:1795–1805. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Jin EH, Shim SC, Kim HG, Chae SC and Chung HT: Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders. Exp Mol Med. 41:354–361. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Weinberg RB: Apolipoprotein A-IV polymorphisms and diet-gene interactions. Curr Opin Lipidol. 13:125–134. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Vincent S, Planells R, Defoort C, Bernard MC, Gerber M, Prudhomme J, Vague P and Lairon D: Genetic polymorphisms and lipoprotein responses to diets. Proc Nutr Soc. 61:427–434. 2002. View Article : Google Scholar : PubMed/NCBI

40 

Bai H, Liu R, Liu Y, Saku K and Liu BW: Distribution and effect of apo A-IV genotype on plasma lipid and apolipoprotein levels in a Chinese population. Acta Cardiol. 63:315–322. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Heilbronn LK, Noakes M, Morris AM, Kind KL and Clifton PM: 360His polymorphism of the apolipoproteinA-IV gene and plasma lipid response to envergy restricted diets in overweight subjects. Atherosclerosis. 150:187–192. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Kretowski A, Hokanson JE, McFann K, Kinney GL, Snell-Bergeon JK, Maahs DM, Wadwa RP, Eckel RH, Ogden LG and Garg SK: The apolipoprotein A-IV Gln360His polymorphism predicts progression of coronary artery calcification in patients with type 1 diabetes. Diabetologia. 49:1946–1954. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Antoine HJ, Pall M, Trader BC, Chen YD, Azziz R and Goodarzi MO: Genetic variants in peroxisome proliferator-activated receptor gamma influence insulin resistance and testosterone levels in normal women, but not those with polycystic ovary syndrome. Fertil Steril. 87:862–869. 2007. View Article : Google Scholar

44 

Codner E and Cassorla F: Puberty and ovarian function in girls with type 1 diabetes mellitus. Horm Res. 71:12–21. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Tsanadis G, Vartholomatos G, Korkontzelos I, Avgoustatos F, Kakosimos G, Sotiriadis A, Tatsioni A, Eleftheriou A and Lolis D: Polycystic ovarian syndrome and thrombophilia. Hum Reprod. 17:314–319. 2002. View Article : Google Scholar : PubMed/NCBI

46 

Atiomo WU, Bates SA, Condon JE, Shaw S, West JH and Prentice AG: The plasminogen activator system in women with polycystic ovary syndrome. Fertil Steril. 69:236–241. 1998. View Article : Google Scholar : PubMed/NCBI

47 

Dahlgren E, Janson PO, Johansson S, Lapidus L, Lindstedt G and Tengborn L: Hemostatic and metabolic variables in women with polycystic ovary syndrome. Fertil Steril. 61:455–460. 1994.PubMed/NCBI

48 

Kelly CJ, Lyall H, Petrie JR, Gould GW, Connell JM, Rumley A, Lowe GD and Sattar N: A specific elevation in tissue plasminogen activator antigen in women with polycystic ovarian syndrome. J Clin Endocrinol Metab. 87:3287–3290. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim Y, Gu B, Choi B, Kim M, Song S, Yun J, Chung MK, Choi C and Baek K: Apolipoprotein A-IV as a novel gene associated with polycystic ovary syndrome. Int J Mol Med 31: 707-716, 2013.
APA
Kim, Y., Gu, B., Choi, B., Kim, M., Song, S., Yun, J. ... Baek, K. (2013). Apolipoprotein A-IV as a novel gene associated with polycystic ovary syndrome. International Journal of Molecular Medicine, 31, 707-716. https://doi.org/10.3892/ijmm.2013.1250
MLA
Kim, Y., Gu, B., Choi, B., Kim, M., Song, S., Yun, J., Chung, M. K., Choi, C., Baek, K."Apolipoprotein A-IV as a novel gene associated with polycystic ovary syndrome". International Journal of Molecular Medicine 31.3 (2013): 707-716.
Chicago
Kim, Y., Gu, B., Choi, B., Kim, M., Song, S., Yun, J., Chung, M. K., Choi, C., Baek, K."Apolipoprotein A-IV as a novel gene associated with polycystic ovary syndrome". International Journal of Molecular Medicine 31, no. 3 (2013): 707-716. https://doi.org/10.3892/ijmm.2013.1250
Copy and paste a formatted citation
x
Spandidos Publications style
Kim Y, Gu B, Choi B, Kim M, Song S, Yun J, Chung MK, Choi C and Baek K: Apolipoprotein A-IV as a novel gene associated with polycystic ovary syndrome. Int J Mol Med 31: 707-716, 2013.
APA
Kim, Y., Gu, B., Choi, B., Kim, M., Song, S., Yun, J. ... Baek, K. (2013). Apolipoprotein A-IV as a novel gene associated with polycystic ovary syndrome. International Journal of Molecular Medicine, 31, 707-716. https://doi.org/10.3892/ijmm.2013.1250
MLA
Kim, Y., Gu, B., Choi, B., Kim, M., Song, S., Yun, J., Chung, M. K., Choi, C., Baek, K."Apolipoprotein A-IV as a novel gene associated with polycystic ovary syndrome". International Journal of Molecular Medicine 31.3 (2013): 707-716.
Chicago
Kim, Y., Gu, B., Choi, B., Kim, M., Song, S., Yun, J., Chung, M. K., Choi, C., Baek, K."Apolipoprotein A-IV as a novel gene associated with polycystic ovary syndrome". International Journal of Molecular Medicine 31, no. 3 (2013): 707-716. https://doi.org/10.3892/ijmm.2013.1250
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