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Article

Protective effects of osthole, a natural derivative of coumarin, against intestinal ischemia-reperfusion injury in mice

  • Authors:
    • Wenpeng Dong
    • Zhen Zhang
    • Zhengjun Liu
    • Hao Liu
    • Xianyue Wang
    • Shenghui Bi
    • Xiaowu Wang
    • Tao Ma
    • Weida Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Surgery, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Department of Vascular and Endocrine Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
  • Pages: 1367-1374
    |
    Published online on: April 15, 2013
       https://doi.org/10.3892/ijmm.2013.1347
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Abstract

Intestinal ischemia/reperfusion (I/R) injury is consi­dered to be associated with high morbidity and mortality rates. Osthole, a natural derivative of coumarin, has been shown to exert a variety of pharmacological and therapeutic effects under physiological and pathological conditions. In the present study, to investigate the protective effects of osthole against intestinal I/R injury, various doses of osthole (5, 10, 25 and 50 mg/kg) were pre-administered to mice subjected to intestinal I/R injury. A dose-dependent increase in the survival rate was observed in the osthole-treated mice. Pre-treatment with osthole (50 mg/kg) attenuated the destruction of epithelial cells within the villi induced by intestinal I/R injury, and suppressed oxidative stress, neutrophil infiltration and modulated nitric oxide (NO) levels. Moreover, the increased IκBα phosphorylation and nuclear factor (NF)-κB nuclear translocation induced by I/R injury were significantly decreased following pre-treatment with osthole. Taken together, our data demonstrate that osthole exerts protective effects against intestinal I/R injury in mice by suppressing oxidative stress, neutrophil infiltration and NO levels, partly through the inhibition of NF-κB nuclear translocation. Hence, the findings of the present study provide insight into the mechanisms through which osthole exerts its protective effects against intestinal I/R injury.
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Copy and paste a formatted citation
Spandidos Publications style
Dong W, Zhang Z, Liu Z, Liu H, Wang X, Bi S, Wang X, Ma T and Zhang W: Protective effects of osthole, a natural derivative of coumarin, against intestinal ischemia-reperfusion injury in mice. Int J Mol Med 31: 1367-1374, 2013.
APA
Dong, W., Zhang, Z., Liu, Z., Liu, H., Wang, X., Bi, S. ... Zhang, W. (2013). Protective effects of osthole, a natural derivative of coumarin, against intestinal ischemia-reperfusion injury in mice. International Journal of Molecular Medicine, 31, 1367-1374. https://doi.org/10.3892/ijmm.2013.1347
MLA
Dong, W., Zhang, Z., Liu, Z., Liu, H., Wang, X., Bi, S., Wang, X., Ma, T., Zhang, W."Protective effects of osthole, a natural derivative of coumarin, against intestinal ischemia-reperfusion injury in mice". International Journal of Molecular Medicine 31.6 (2013): 1367-1374.
Chicago
Dong, W., Zhang, Z., Liu, Z., Liu, H., Wang, X., Bi, S., Wang, X., Ma, T., Zhang, W."Protective effects of osthole, a natural derivative of coumarin, against intestinal ischemia-reperfusion injury in mice". International Journal of Molecular Medicine 31, no. 6 (2013): 1367-1374. https://doi.org/10.3892/ijmm.2013.1347
Copy and paste a formatted citation
x
Spandidos Publications style
Dong W, Zhang Z, Liu Z, Liu H, Wang X, Bi S, Wang X, Ma T and Zhang W: Protective effects of osthole, a natural derivative of coumarin, against intestinal ischemia-reperfusion injury in mice. Int J Mol Med 31: 1367-1374, 2013.
APA
Dong, W., Zhang, Z., Liu, Z., Liu, H., Wang, X., Bi, S. ... Zhang, W. (2013). Protective effects of osthole, a natural derivative of coumarin, against intestinal ischemia-reperfusion injury in mice. International Journal of Molecular Medicine, 31, 1367-1374. https://doi.org/10.3892/ijmm.2013.1347
MLA
Dong, W., Zhang, Z., Liu, Z., Liu, H., Wang, X., Bi, S., Wang, X., Ma, T., Zhang, W."Protective effects of osthole, a natural derivative of coumarin, against intestinal ischemia-reperfusion injury in mice". International Journal of Molecular Medicine 31.6 (2013): 1367-1374.
Chicago
Dong, W., Zhang, Z., Liu, Z., Liu, H., Wang, X., Bi, S., Wang, X., Ma, T., Zhang, W."Protective effects of osthole, a natural derivative of coumarin, against intestinal ischemia-reperfusion injury in mice". International Journal of Molecular Medicine 31, no. 6 (2013): 1367-1374. https://doi.org/10.3892/ijmm.2013.1347
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