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Article

Inhibitory effects of Diospyros kaki in a model of allergic inflammation: Role of cAMP, calcium and nuclear factor-κB

  • Authors:
    • Hui-Hun Kim
    • Duk-Sil Kim
    • Sung-Wan Kim
    • Se-Hyun Lim
    • Dae Keun Kim
    • Tae-Yong Shin
    • Sang-Hyun Kim
  • View Affiliations / Copyright

    Affiliations: Korea Traditional Medicine Agency, Korea Promotion Institute for Traditional Medicine Industry, Gyeongsan 712‑210, Republic of Korea, Department of Thoracic and Cardiovascular Surgery, CHA Gumi Medical Center, CHA University, Gumi 730-040, Republic of Korea, College of Pharmacy, Woosuk University, Jeonju 565-701, Republic of Korea, Cell and Matrix Research Institute, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea
  • Pages: 945-951
    |
    Published online on: August 7, 2013
       https://doi.org/10.3892/ijmm.2013.1465
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Abstract

Diospyros kaki (D. kaki) has been cultivated throughout Eastern Asia for hundreds of years. D. kaki contains various biological active compounds, such as amino acids, carotenoids, flavonoids, tannins, catechins and vitamin A. Previous studies have shown that D. kaki has beneficial effects on homeostasis, constipation, hypertension, atherosclerosis and allergic dermatitis and is a good source of antioxidants, polyphenols and dietary fiber. However, the anti‑allergic and anti-inflammatory effects of D. kaki have not yet been elucidated. This study aimed to investigate the protective effects of the aqueous extract of Diospyros kaki (AEDK) on mast cell-mediated allergic inflammation and to determine its possible mechanisms of action by using in vitro and in vivo mast cell-based models. The cAMP and intracellular calcium levels were measured to clarify the mechanisms by which AEDK inhibits the release of histamine from mast cells. AEDK inhibited the release of histamine and β-hexosaminidase from mast cells by modulating cAMP and intracellular calcium levels. We also measured the expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β. AEDK decreased gene expression and the secretion of the pro-inflammatory cytokines, TNF-α and IL-1β by inhibiting nuclear factor-κB. In addition, AEDK inhibited systemic and cutaneous allergic reaction. The inhibitory effects of AEDK on allergic reaction and the release of histamine were found to be similar to those of disodium cromoglycate, a known anti-allergic drug. To isolate the active component of AEDK, activity-guided fractionation was performed, based on the inhibitory effects on systemic anaphylaxis. Catechin was identified as an active compound. The present findings provide evidence that AEDK inhibits allergic inflammation and suggest the therapeutic application of AEDK in allergic inflammatory disorders.
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1 

Caughey GH: Mast cell proteases as protective and inflammatory mediators. Adv Exp Med Biol. 716:212–234. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Galli SJ, Tsai M and Piliponsky AM: The development of allergic inflammation. Nature. 454:445–454. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Galli SJ, Kalesnikoff J, Grimbaldeston MA, Piliponsky AM, Williams CM and Tsai M: Mast cells as ‘tunable’ effector and immunoregulatory cells: recent advances. Annu Rev Immunol. 23:749–786. 2005.

4 

Kim SH, Jun CD, Suk K, et al: Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells. Toxicol Sci. 91:123–131. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Amin K: The role of mast cells in allergic inflammation. Respir Med. 106:9–14. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Lee DH, Kim SH, Eun JS and Shin TY: Mosla dianthera inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production. Toxicol Appl Pharmacol. 216:479–484. 2006. View Article : Google Scholar

7 

Tagen M, Elorza A, Kempuraj D, et al: Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content. J Immunol. 183:6313–6319. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Gwack Y, Feske S, Srikanth S, Hogan PG and Rao A: Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium. 42:145–156. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Sismanopoulos N, Delivanis DA, Alysandratos KD, et al: Mast cells in allergic and inflammatory diseases. Curr Pharm Des. 18:2261–2277. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Mallavadhani UV, Panda AK and Rao YR: Pharmacology and chemotaxonomy of Diospyros. Phytochemistry. 49:901–951. 1998.PubMed/NCBI

11 

Duan J, Zheng Y, Dong Q and Fang J: Structural analysis of a pectic polysaccharide from the leaves of Diospyros kaki. Phytochemistry. 65:609–615. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Matsumoto N, Okushio K and Hara Y: Effect of black tea polyphenols on plasma lipids in cholesterol-fed rats. J Nutr Sci Vitaminol (Tokyo). 44:337–342. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Kotani M, Matsumoto M, Fujita A, et al: Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. J Allergy Clin Immunol. 106:159–166. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Kameda K, Takaku T, Okuda H, et al: Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity. J Nat Prod. 50:680–683. 1987. View Article : Google Scholar : PubMed/NCBI

15 

Funayama S and Hikino H: Hypotensive principles of Diospyros kaki leaves. Chem Pharm Bull (Tokyo). 27:2865–2868. 1979. View Article : Google Scholar

16 

Sun L, Zhang J, Lu X, Zhang L and Zhang Y: Evaluation to the antioxidant activity of total flavonoids extract from persimmon (Diospyros kaki L.) leaves. Food Chem Toxicol. 49:2689–2696. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Steinmetz KA and Potter JD: Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc. 96:1027–1039. 1996. View Article : Google Scholar : PubMed/NCBI

18 

Rattmann YD, Cipriani TR, Sassaki GL, et al: Nitric oxide-dependent vasorelaxation induced by extractive solutions and fractions of Maytenus ilicifolia Mart ex Reissek (Celastraceae) leaves. J Ethnopharmacol. 104:328–335. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Ali K, Maltese F, Toepfer R, Choi YH and Verpoorte R: Metabolic characterization of Palatinate German white wines according to sensory attributes, varieties, and vintages using NMR spectroscopy and multivariate data analyses. J Biomol NMR. 49:255–266. 2011. View Article : Google Scholar

20 

Kim SH, Lee S, Kim IK, et al: Suppression of mast cell-mediated allergic reaction by Amomum xanthioides. Food Chem Toxicol. 45:2138–2144. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Kim HH, Yoo JS, Lee HS, Kwon TK, Shin TY and Kim SH: Elsholtzia ciliata inhibits mast cell-mediated allergic inflammation: role of calcium, p38 mitogen-activated protein kinase and nuclear factor-{kappa}B. Exp Biol Med (Maywood). 236:1070–1077. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Itoh T, Tsukane M, Koike M, et al: Inhibitory effects of whisky congeners on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. J Agric Food Chem. 58:7149–7157. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Bae Y, Lee S and Kim SH: Chrysin suppresses mast cell-mediated allergic inflammation: involvement of calcium, caspase-1 and nuclear factor-kappaB. Toxicol Appl Pharmacol. 254:56–64. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Lee S, Yun HS and Kim SH: The comparative effects of mesoporous silica nanoparticles and colloidal silica on inflammation and apoptosis. Biomaterials. 32:9434–9443. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Eisenhut M and Wallace H: Ion channels in inflammation. Pflugers Arch. 461:401–421. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Park HH, Lee S, Oh JM, et al: Anti-inflammatory activity of fisetin in human mast cells (HMC-1). Pharmacol Res. 55:31–37. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Boden SR and Wesley Burks A: Anaphylaxis: a history with emphasis on food allergy. Immunol Rev. 242:247–257. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Beaven MA, Rogers J, Moore JP, Hesketh TR, Smith GA and Metcalfe JC: The mechanism of the calcium signal and correlation with histamine release in 2H3 cells. J Biol Chem. 259:7129–7136. 1984.PubMed/NCBI

29 

Alfonso A, Cabado AG, Vieytes MR and Botana LM: Functional compartments in rat mast cells for cAMP and calcium on histamine release. Cell Signal. 12:343–350. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Makino H, Saijo T, Ashida Y, Kuriki H and Maki Y: Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase. Int Arch Allergy Appl Immunol. 82:66–71. 1987. View Article : Google Scholar

31 

Walsh LJ, Trinchieri G, Waldorf HA, Whitaker D and Murphy GF: Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1. Proc Natl Acad Sci USA. 88:4220–4224. 1991. View Article : Google Scholar

32 

Karin M: NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol. 1:a0001412009. View Article : Google Scholar : PubMed/NCBI

33 

Bani D, Giannini L, Ciampa A, et al: Epigallocatechin-3-gallate reduces allergen-induced asthma-like reaction in sensitized guinea pigs. J Pharmacol Exp Ther. 317:1002–1011. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim H, Kim D, Kim S, Lim S, Kim DK, Shin T and Kim S: Inhibitory effects of Diospyros kaki in a model of allergic inflammation: Role of cAMP, calcium and nuclear factor-κB. Int J Mol Med 32: 945-951, 2013.
APA
Kim, H., Kim, D., Kim, S., Lim, S., Kim, D.K., Shin, T., & Kim, S. (2013). Inhibitory effects of Diospyros kaki in a model of allergic inflammation: Role of cAMP, calcium and nuclear factor-κB. International Journal of Molecular Medicine, 32, 945-951. https://doi.org/10.3892/ijmm.2013.1465
MLA
Kim, H., Kim, D., Kim, S., Lim, S., Kim, D. K., Shin, T., Kim, S."Inhibitory effects of Diospyros kaki in a model of allergic inflammation: Role of cAMP, calcium and nuclear factor-κB". International Journal of Molecular Medicine 32.4 (2013): 945-951.
Chicago
Kim, H., Kim, D., Kim, S., Lim, S., Kim, D. K., Shin, T., Kim, S."Inhibitory effects of Diospyros kaki in a model of allergic inflammation: Role of cAMP, calcium and nuclear factor-κB". International Journal of Molecular Medicine 32, no. 4 (2013): 945-951. https://doi.org/10.3892/ijmm.2013.1465
Copy and paste a formatted citation
x
Spandidos Publications style
Kim H, Kim D, Kim S, Lim S, Kim DK, Shin T and Kim S: Inhibitory effects of Diospyros kaki in a model of allergic inflammation: Role of cAMP, calcium and nuclear factor-κB. Int J Mol Med 32: 945-951, 2013.
APA
Kim, H., Kim, D., Kim, S., Lim, S., Kim, D.K., Shin, T., & Kim, S. (2013). Inhibitory effects of Diospyros kaki in a model of allergic inflammation: Role of cAMP, calcium and nuclear factor-κB. International Journal of Molecular Medicine, 32, 945-951. https://doi.org/10.3892/ijmm.2013.1465
MLA
Kim, H., Kim, D., Kim, S., Lim, S., Kim, D. K., Shin, T., Kim, S."Inhibitory effects of Diospyros kaki in a model of allergic inflammation: Role of cAMP, calcium and nuclear factor-κB". International Journal of Molecular Medicine 32.4 (2013): 945-951.
Chicago
Kim, H., Kim, D., Kim, S., Lim, S., Kim, D. K., Shin, T., Kim, S."Inhibitory effects of Diospyros kaki in a model of allergic inflammation: Role of cAMP, calcium and nuclear factor-κB". International Journal of Molecular Medicine 32, no. 4 (2013): 945-951. https://doi.org/10.3892/ijmm.2013.1465
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