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Article

The effect of PS-341 on pulmonary vascular remodeling in high blood flow-induced pulmonary hypertension

  • Authors:
    • Xue Zhang
    • Zong-Shuai Wang
    • Yun Luan
    • Mei Lin
    • Xiao-Bo Zhu
    • Yu Ma
    • Zhao-Hua Zhang
    • Yi-Biao Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Central Research Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China
  • Pages: 105-110
    |
    Published online on: November 21, 2013
       https://doi.org/10.3892/ijmm.2013.1562
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Abstract

The aim of the present study was to investigate the effects of PS-341 on vascular remodeling in an experimental rat model of high blood flow-induced pulmonary arterial hypertension (PAH), as well as to elucidate its mechanisms of action. We established the PAH model by a surgical method that implanted a left-to-right shunt. Three days post-surgery, the animals were randomly assigned to 3 groups (n=15 in each group): sham-operated (control), shunt (model) and PS-341 (treated) groups. Eight weeks post-surgery, hemodynamic parameters were significantly improved in the PS-341 group compared with the shunt group (P<0.05). Immunohistochemical analysis indicated that the expression levels of ubiquitin and nuclear factor-κB (NF-κB) p65 were significantly higher in the shunt group compared with the sham-operated group (P<0.05). Semi-quantitative western blot analysis further confirmed that the levels of ubiquitin and NF-κB p65 were decreased, while those of IκB-α (an inhibitor of NF-κB) were significantly increased in the PS-341 group compared with the shunt group (P<0.05). In conclusion, PS-341 attenuates high blood flow-induced pulmonary artery remodeling in rats via inhibition of the NF-κB pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Wang Z, Luan Y, Lin M, Zhu X, Ma Y, Zhang Z and Wang Y: The effect of PS-341 on pulmonary vascular remodeling in high blood flow-induced pulmonary hypertension. Int J Mol Med 33: 105-110, 2014.
APA
Zhang, X., Wang, Z., Luan, Y., Lin, M., Zhu, X., Ma, Y. ... Wang, Y. (2014). The effect of PS-341 on pulmonary vascular remodeling in high blood flow-induced pulmonary hypertension. International Journal of Molecular Medicine, 33, 105-110. https://doi.org/10.3892/ijmm.2013.1562
MLA
Zhang, X., Wang, Z., Luan, Y., Lin, M., Zhu, X., Ma, Y., Zhang, Z., Wang, Y."The effect of PS-341 on pulmonary vascular remodeling in high blood flow-induced pulmonary hypertension". International Journal of Molecular Medicine 33.1 (2014): 105-110.
Chicago
Zhang, X., Wang, Z., Luan, Y., Lin, M., Zhu, X., Ma, Y., Zhang, Z., Wang, Y."The effect of PS-341 on pulmonary vascular remodeling in high blood flow-induced pulmonary hypertension". International Journal of Molecular Medicine 33, no. 1 (2014): 105-110. https://doi.org/10.3892/ijmm.2013.1562
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Wang Z, Luan Y, Lin M, Zhu X, Ma Y, Zhang Z and Wang Y: The effect of PS-341 on pulmonary vascular remodeling in high blood flow-induced pulmonary hypertension. Int J Mol Med 33: 105-110, 2014.
APA
Zhang, X., Wang, Z., Luan, Y., Lin, M., Zhu, X., Ma, Y. ... Wang, Y. (2014). The effect of PS-341 on pulmonary vascular remodeling in high blood flow-induced pulmonary hypertension. International Journal of Molecular Medicine, 33, 105-110. https://doi.org/10.3892/ijmm.2013.1562
MLA
Zhang, X., Wang, Z., Luan, Y., Lin, M., Zhu, X., Ma, Y., Zhang, Z., Wang, Y."The effect of PS-341 on pulmonary vascular remodeling in high blood flow-induced pulmonary hypertension". International Journal of Molecular Medicine 33.1 (2014): 105-110.
Chicago
Zhang, X., Wang, Z., Luan, Y., Lin, M., Zhu, X., Ma, Y., Zhang, Z., Wang, Y."The effect of PS-341 on pulmonary vascular remodeling in high blood flow-induced pulmonary hypertension". International Journal of Molecular Medicine 33, no. 1 (2014): 105-110. https://doi.org/10.3892/ijmm.2013.1562
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