Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
May-2014 Volume 33 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2014 Volume 33 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Intramuscular injection of adenoviral hepatocyte growth factor at a distal site ameliorates dextran sodium sulfate-induced colitis in mice

  • Authors:
    • Kentaro Yuge
    • Tomoyuki Takahashi
    • Ngin Cin Khai
    • Kazuko Goto
    • Takako Fujiwara
    • Hisayoshi Fujiwara
    • Ken-Ichiro Kosai
  • View Affiliations / Copyright

    Affiliations: Department of Gene Therapy and Regenerative Medicine, Graduate School of Medicine, Gifu University, Gifu 502-1194, Japan, Department of Food Science, Kyoto Women's University, Kyoto 605-8501, Japan
    Copyright: © Yuge et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1064-1074
    |
    Published online on: March 6, 2014
       https://doi.org/10.3892/ijmm.2014.1686
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Inflammatory bowel disease (IBD) severely affects the quality of life of patients. At present, there is no clinical solution for this condition; therefore, there is a need for innovative therapies for IBD. Hepatocyte growth factor (HGF) exerts various biological activities in various organs. However, a clinically applicable and effective HGF-based therapy for IBD has yet to be developed. In this study, we examined the therapeutic effect of injecting an adenoviral vector encoding the human HGF gene (Ad.HGF) into the hindlimbs of mice with dextran sodium sulfate (DSS)-induced colitis. Plasma levels of circulating human HGF (hHGF) were measured in injected mice. The results showed that weight loss and colon shortening were significantly lower in Ad.HGF-infected mice as compared to control (Ad.LacZ-infected) colitic mice. Additionally, inflammation and crypt scores were significantly reduced in the entire length of the colon, particularly in the distal section. This therapeutic effect was associated with increased cell proliferation and an antiapoptotic effect, as well as a reduction in the number of CD4+ cells and a decreased CD4/CD8 ratio. The levels of inflammatory, as well as Th1 and Th2 cytokines were higher in Ad.HGF-infected mice as compared to the control colitic mice. Thus, systemically circulating hHGF protein, produced by an adenovirally transduced hHGF gene introduced at distal sites in the limbs, significantly ameliorated DSS-induced colitis by promoting cell proliferation (i.e., regeneration), preventing apoptosis, and immunomodulation. Owing to its clinical feasibility and potent therapeutic effects, this method may be developed into a clinical therapy for treating IBD.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Hisamatsu T, Kanai T, Mikami Y, Yoneno K, Matsuoka K and Hibi T: Immune aspects of the pathogenesis of inflammatory bowel disease. Pharmacol Ther. 137:283–297. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Bernklev T, Jahnsen J, Aadland E, et al: Health-related quality of life in patients with inflammatory bowel disease five years after the initial diagnosis. Scand J Gastroenterol. 39:365–373. 2004.PubMed/NCBI

3 

Burger D and Travis S: Conventional medical management of inflammatory bowel disease. Gastroenterology. 140:1827–1837. e18222011. View Article : Google Scholar : PubMed/NCBI

4 

Nakamura T, Nawa K and Ichihara A: Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem Biophys Res Commun. 122:1450–1459. 1984. View Article : Google Scholar : PubMed/NCBI

5 

Russell WE, McGowan JA and Bucher NL: Partial characterization of a hepatocyte growth factor from rat platelets. J Cell Physiol. 119:183–192. 1984. View Article : Google Scholar : PubMed/NCBI

6 

Thaler FJ and Michalopoulos GK: Hepatopoietin A: partial characterization and trypsin activation of a hepatocyte growth factor. Cancer Res. 45:2545–2549. 1985.PubMed/NCBI

7 

Gohda E, Tsubouchi H, Nakayama H, et al: Human hepatocyte growth factor in plasma from patients with fulminant hepatic failure. Exp Cell Res. 166:139–150. 1986. View Article : Google Scholar : PubMed/NCBI

8 

Nakamura T, Nishizawa T, Hagiya M, et al: Molecular cloning and expression of human hepatocyte growth factor. Nature. 342:440–443. 1989. View Article : Google Scholar : PubMed/NCBI

9 

Miyazawa K, Tsubouchi H, Naka D, et al: Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor. Biochem Biophys Res Commun. 163:967–973. 1989. View Article : Google Scholar : PubMed/NCBI

10 

Matsumoto K and Nakamura T: Hepatocyte growth factor (HGF) as a tissue organizer for organogenesis and regeneration. Biochem Biophys Res Commun. 239:639–644. 1997. View Article : Google Scholar : PubMed/NCBI

11 

Matsuno M, Shiota G, Umeki K, Kawasaki H, Kojo H and Miura K: Clinical evaluation of hepatocyte growth factor in patients with gastrointestinal and pancreatic diseases with special reference to inflammatory bowel disease. Res Commun Mol Pathol Pharmacol. 97:25–37. 1997.PubMed/NCBI

12 

Kitamura S, Kondo S, Shinomura Y, et al: Expression of hepatocyte growth factor and c-met in ulcerative colitis. Inflamm Res. 49:320–324. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Srivastava M, Zurakowski D, Cheifetz P, Leichtner A and Bousvaros A: Elevated serum hepatocyte growth factor in children and young adults with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 33:548–553. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Ortega-Cava CF, Ishihara S, Kawashima K, et al: Hepatocyte growth factor expression in dextran sodium sulfate-induced colitis in rats. Dig Dis Sci. 47:2275–2285. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Dignass AU, Lynch-Devaney K and Podolsky DK: Hepatocyte growth factor/scatter factor modulates intestinal epithelial cell proliferation and migration. Biochem Biophys Res Commun. 202:701–709. 1994. View Article : Google Scholar : PubMed/NCBI

16 

Numata M, Ido A, Moriuchi A, et al: Hepatocyte growth factor facilitates the repair of large colonic ulcers in 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats. Inflamm Bowel Dis. 11:551–558. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Tahara Y, Ido A, Yamamoto S, et al: Hepatocyte growth factor facilitates colonic mucosal repair in experimental ulcerative colitis in rats. J Pharmacol Exp Ther. 307:146–151. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Ohda Y, Hori K, Tomita T, et al: Effects of hepatocyte growth factor on rat inflammatory bowel disease models. Dig Dis Sci. 50:914–921. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Setoyama H, Ido A, Numata M, et al: Repeated enemas with hepatocyte growth factor selectively stimulate epithelial cell proliferation of injured mucosa in rats with experimental colitis. Life Sci. 89:269–275. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Arthur LG, Schwartz MZ, Kuenzler KA and Birbe R: Hepatocyte growth factor treatment ameliorates diarrhea and bowel inflammation in a rat model of inflammatory bowel disease. J Pediatr Surg. 39:139–143. 2004. View Article : Google Scholar

21 

Mukoyama T, Kanbe T, Murai R, et al: Therapeutic effect of adenoviral-mediated hepatocyte growth factor gene administration on TNBS-induced colitis in mice. Biochem Biophys Res Commun. 329:1217–1224. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Hanawa T, Suzuki K, Kawauchi Y, et al: Attenuation of mouse acute colitis by naked hepatocyte growth factor gene transfer into the liver. J Gene Med. 8:623–635. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Kanbe T, Murai R, Mukoyama T, et al: Naked gene therapy of hepatocyte growth factor for dextran sulfate sodium-induced colitis in mice. Biochem Biophys Res Commun. 345:1517–1525. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Kanayama M, Takahara T, Yata Y, et al: Hepatocyte growth factor promotes colonic epithelial regeneration via Akt signaling. Am J Physiol Gastrointest Liver Physiol. 293:G230–G239. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Li Y, Takemura G, Kosai K, et al: Postinfarction treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice. Circulation. 107:2499–2506. 2003. View Article : Google Scholar

26 

Chen SH, Chen XH, Wang Y, et al: Combination gene therapy for liver metastasis of colon carcinoma in vivo. Proc Natl Acad Sci USA. 92:2577–2581. 1995. View Article : Google Scholar : PubMed/NCBI

27 

Takahashi T, Kawai T, Ushikoshi H, et al: Identification and isolation of embryonic stem cell-derived target cells by adenoviral conditional targeting. Mol Ther. 14:673–683. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Okabe Y, Kusaga A, Takahashi T, et al: Neural development of methyl-CpG-binding protein 2 null embryonic stem cells: a system for studying Rett syndrome. Brain Res. 1360:17–27. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Horikawa Y, Wang Y, Nagano S, et al: Assessment of an altered E1B promoter on the specificity and potency of triple-regulated conditionally replicating adenoviruses: implications for the generation of ideal m-CRAs. Cancer Gene Ther. 18:724–733. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y and Nakaya R: A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology. 98:694–702. 1990.PubMed/NCBI

31 

Tomoyose M, Mitsuyama K, Ishida H, Toyonaga A and Tanikawa K: Role of interleukin-10 in a murine model of dextran sulfate sodium-induced colitis. Scand J Gastroenterol. 33:435–440. 1998. View Article : Google Scholar : PubMed/NCBI

32 

Kanauchi O, Nakamura T, Agata K, Mitsuyama K and Iwanaga T: Effects of germinated barley foodstuff on dextran sulfate sodium-induced colitis in rats. J Gastroenterol. 33:179–188. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Yuge K, Takahashi T, Nagano S, et al: Adenoviral gene transduction of hepatocyte growth factor elicits inhibitory effects for hepatoma. Int J Oncol. 27:77–85. 2005.PubMed/NCBI

34 

Kamisasanuki T, Tokushige S, Terasaki H, et al: Targeting CD9 produces stimulus-independent antiangiogenic effects predominantly in activated endothelial cells during angiogenesis: a novel antiangiogenic therapy. Biochem Biophys Res Commun. 413:128–135. 2011. View Article : Google Scholar

35 

Murthy SN, Cooper HS, Shim H, Shah RS, Ibrahim SA and Sedergran DJ: Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin. Dig Dis Sci. 38:1722–1734. 1993. View Article : Google Scholar : PubMed/NCBI

36 

Li Y, Takemura G, Kosai K, et al: Critical roles for the Fas/Fas ligand system in postinfarction ventricular remodeling and heart failure. Circ Res. 95:627–636. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Iwamoto M, Koji T, Makiyama K, Kobayashi N and Nakane PK: Apoptosis of crypt epithelial cells in ulcerative colitis. J Pathol. 180:152–159. 1996. View Article : Google Scholar : PubMed/NCBI

38 

Sträter J, Wellisch I, Riedl S, et al: CD95 (APO-1/Fas)-mediated apoptosis in colon epithelial cells: a possible role in ulcerative colitis. Gastroenterology. 113:160–167. 1997.PubMed/NCBI

39 

Rogler G and Andus T: Cytokines in inflammatory bowel disease. World J Surg. 22:382–389. 1998. View Article : Google Scholar : PubMed/NCBI

40 

Egger B, Bajaj-Elliott M, MacDonald TT, Inglin R, Eysselein VE and Büchler MW: Characterisation of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency. Digestion. 62:240–248. 2000. View Article : Google Scholar : PubMed/NCBI

41 

Tomanin R and Scarpa M: Why do we need new gene therapy viral vectors? Characteristics, limitations and future perspectives of viral vector transduction. Curr Gene Ther. 4:357–372. 2004. View Article : Google Scholar : PubMed/NCBI

42 

Boulaiz H, Marchal JA, Prados J, Melguizo C and Aránega A: Non-viral and viral vectors for gene therapy. Cell Mol Biol (Noisy-le-grand). 51:3–22. 2005.

43 

Oh K, Iimuro Y, Takeuchi M, et al: Ameliorating effect of hepatocyte growth factor on inflammatory bowel disease in a murine model. Am J Physiol Gastrointest Liver Physiol. 288:G729–G735. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Shiota G, Kawasaki H, Nakamura T and Schmidt EV: Characterization of double transgenic mice expressing hepatocye growth factor and transforming growth factor alpha. Res Commun Mol Pathol Pharmacol. 90:17–24. 1995.PubMed/NCBI

45 

Sakata H, Takayama H, Sharp R, Rubin JS, Merlino G and LaRochelle WJ: Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers. Cell Growth Differ. 7:1513–1523. 1996.

46 

Chen P, Kovesdi I and Bruder JT: Effective repeat administration with adenovirus vectors to the muscle. Gene Ther. 7:587–595. 2000. View Article : Google Scholar : PubMed/NCBI

47 

Jeschke MG, Bolder U, Finnerty CC, et al: The effect of hepatocyte growth factor on gut mucosal apoptosis and proliferation, and cellular mediators after severe trauma. Surgery. 138:482–489. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Futamatsu H, Suzuki J, Mizuno S, et al: Hepatocyte growth factor ameliorates the progression of experimental autoimmune myocarditis: a potential role for induction of T helper 2 cytokines. Circ Res. 96:823–830. 2005. View Article : Google Scholar : PubMed/NCBI

49 

Kuroiwa T, Iwasaki T, Imado T, Sekiguchi M, Fujimoto J and Sano H: Hepatocyte growth factor prevents lupus nephritis in a murine lupus model of chronic graft-versus-host disease. Arthritis Res Ther. 8:R1232006. View Article : Google Scholar : PubMed/NCBI

50 

Okunishi K, Dohi M, Nakagome K, et al: A novel role of hepatocyte growth factor as an immune regulator through suppressing dendritic cell function. J Immunol. 175:4745–4753. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Ito W, Takeda M, Tanabe M, et al: Anti-allergic inflammatory effects of hepatocyte growth factor. Int Arch Allergy Immunol. 146(Suppl 1): S82–S87. 2008. View Article : Google Scholar

52 

Okunishi K, Dohi M, Fujio K, et al: Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice. J Immunol. 179:5504–5513. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yuge K, Takahashi T, Khai NC, Goto K, Fujiwara T, Fujiwara H and Kosai K: Intramuscular injection of adenoviral hepatocyte growth factor at a distal site ameliorates dextran sodium sulfate-induced colitis in mice. Int J Mol Med 33: 1064-1074, 2014.
APA
Yuge, K., Takahashi, T., Khai, N.C., Goto, K., Fujiwara, T., Fujiwara, H., & Kosai, K. (2014). Intramuscular injection of adenoviral hepatocyte growth factor at a distal site ameliorates dextran sodium sulfate-induced colitis in mice. International Journal of Molecular Medicine, 33, 1064-1074. https://doi.org/10.3892/ijmm.2014.1686
MLA
Yuge, K., Takahashi, T., Khai, N. C., Goto, K., Fujiwara, T., Fujiwara, H., Kosai, K."Intramuscular injection of adenoviral hepatocyte growth factor at a distal site ameliorates dextran sodium sulfate-induced colitis in mice". International Journal of Molecular Medicine 33.5 (2014): 1064-1074.
Chicago
Yuge, K., Takahashi, T., Khai, N. C., Goto, K., Fujiwara, T., Fujiwara, H., Kosai, K."Intramuscular injection of adenoviral hepatocyte growth factor at a distal site ameliorates dextran sodium sulfate-induced colitis in mice". International Journal of Molecular Medicine 33, no. 5 (2014): 1064-1074. https://doi.org/10.3892/ijmm.2014.1686
Copy and paste a formatted citation
x
Spandidos Publications style
Yuge K, Takahashi T, Khai NC, Goto K, Fujiwara T, Fujiwara H and Kosai K: Intramuscular injection of adenoviral hepatocyte growth factor at a distal site ameliorates dextran sodium sulfate-induced colitis in mice. Int J Mol Med 33: 1064-1074, 2014.
APA
Yuge, K., Takahashi, T., Khai, N.C., Goto, K., Fujiwara, T., Fujiwara, H., & Kosai, K. (2014). Intramuscular injection of adenoviral hepatocyte growth factor at a distal site ameliorates dextran sodium sulfate-induced colitis in mice. International Journal of Molecular Medicine, 33, 1064-1074. https://doi.org/10.3892/ijmm.2014.1686
MLA
Yuge, K., Takahashi, T., Khai, N. C., Goto, K., Fujiwara, T., Fujiwara, H., Kosai, K."Intramuscular injection of adenoviral hepatocyte growth factor at a distal site ameliorates dextran sodium sulfate-induced colitis in mice". International Journal of Molecular Medicine 33.5 (2014): 1064-1074.
Chicago
Yuge, K., Takahashi, T., Khai, N. C., Goto, K., Fujiwara, T., Fujiwara, H., Kosai, K."Intramuscular injection of adenoviral hepatocyte growth factor at a distal site ameliorates dextran sodium sulfate-induced colitis in mice". International Journal of Molecular Medicine 33, no. 5 (2014): 1064-1074. https://doi.org/10.3892/ijmm.2014.1686
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team