Antiviral activity of ginseng extract against respiratory syncytial virus infection

Lee,Jong Seok; Ko,Eun-Ju; Hwang,Hye Suk; Lee,Yu-Na; Kwon,Young-Man; Kim,Min-Chul; Kang,Sang-Moo

doi:10.3892/ijmm.2014.1750

Antiviral activity of ginseng extract against respiratory syncytial virus infection

Authors:
- Jong Seok Lee
- Eun-Ju Ko
- Hye Suk Hwang
- Yu-Na Lee
- Young-Man Kwon
- Min-Chul Kim
- Sang-Moo Kang
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Affiliations: Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA
Published online on: April 22, 2014 https://doi.org/10.3892/ijmm.2014.1750
Pages: 183-190

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Abstract

Panax ginseng has been known to have a number of immuno-modulatory effects. In this study, we investigated whether Panax Korean red ginseng extract (KRGE) has in vitro and in vivo antiviral effects on respiratory syncytial virus (RSV) infection. KRGE improved the survival of human lung epithelial cells against RSV infection and inhibited RSV replication. In addition, KRGE treatment suppressed the expression of RSV-induced inflammatory cytokine genes (IL-6 and IL-8) and the formation of reactive oxygen species in epithelial cell cultures. Oral administration of mice with KRGE resulted in lowering lung viral loads after RSV infection. Additionally, the in vivo effects of KRGE showed an enhanced level of interferon-γ (IFN-γ) producing dendritic cells subsequent to RSV infection. Taken together, these results suggested that KRGE has antiviral activity against RSV infection.

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