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International Journal of Molecular Medicine
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Article

Antiviral activity of ginseng extract against respiratory syncytial virus infection

  • Authors:
    • Jong Seok Lee
    • Eun-Ju Ko
    • Hye Suk Hwang
    • Yu-Na Lee
    • Young-Man Kwon
    • Min-Chul Kim
    • Sang-Moo Kang
  • View Affiliations / Copyright

    Affiliations: Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA
  • Pages: 183-190
    |
    Published online on: April 22, 2014
       https://doi.org/10.3892/ijmm.2014.1750
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Abstract

Panax ginseng has been known to have a number of immuno-modulatory effects. In this study, we investigated whether Panax Korean red ginseng extract (KRGE) has in vitro and in vivo antiviral effects on respiratory syncytial virus (RSV) infection. KRGE improved the survival of human lung epithelial cells against RSV infection and inhibited RSV replication. In addition, KRGE treatment suppressed the expression of RSV-induced inflammatory cytokine genes (IL-6 and IL-8) and the formation of reactive oxygen species in epithelial cell cultures. Oral administration of mice with KRGE resulted in lowering lung viral loads after RSV infection. Additionally, the in vivo effects of KRGE showed an enhanced level of interferon-γ (IFN-γ) producing dendritic cells subsequent to RSV infection. Taken together, these results suggested that KRGE has antiviral activity against RSV infection.
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1 

Murphy BR, Prince GA, Collins PL, Van Wyke Coelingh K, Olmsted RA, et al: Current approaches to the development of vaccines effective against parainfluenza and respiratory syncytial viruses. Virus Res. 11:1–15. 1988. View Article : Google Scholar : PubMed/NCBI

2 

Kim HW, Canchola JG, Brandt CD, Pyles G, Chanock RM, et al: Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol. 89:422–434. 1969.PubMed/NCBI

3 

Collins PL and Graham BS: Viral and host factors in human respiratory syncytial virus pathogenesis. J Virol. 82:2040–2055. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Chin J, Magoffin RL, Shearer LA, Schieble JH and Lennette EH: Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population. Am J Epidemiol. 89:449–463. 1969.PubMed/NCBI

5 

Fulginiti VA, Eller JJ, Sieber OF, Joyner JW, Minamitani M and Meiklejohn G: Respiratory virus immunization. I. A field trial of two inactivated respiratory virus vaccines; an aqueous trivalent parainfluenza virus vaccine and an alum-precipitated respiratory syncytial virus vaccine. Am J Epidemiol. 89:435–448. 1969.

6 

Garofalo RP, Kolli D and Casola A: Respiratory syncytial virus infection: mechanisms of redox control and novel therapeutic opportunities. Antioxid Redox Signal. 18:186–217. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Becker S, Soukup J and Yankaskas JR: Respiratory syncytial virus infection of human primary nasal and bronchial epithelial cell cultures and bronchoalveolar macrophages. Am J Respir Cell Mol Biol. 6:369–374. 1992. View Article : Google Scholar : PubMed/NCBI

8 

Hong CE and Lyu SY: Anti-inflammatory and anti-oxidative effects of Korean red ginseng extract in human keratinocytes. Immune Netw. 11:42–49. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Culley FJ, Pennycook AM, Tregoning JS, Hussell T and Openshaw PJ: Differential chemokine expression following respiratory virus infection reflects Th1- or Th2-biased immunopathology. J Virol. 80:4521–4527. 2006. View Article : Google Scholar

10 

Jiang Z, Kunimoto M and Patel JA: Autocrine regulation and experimental modulation of interleukin-6 expression by human pulmonary epithelial cells infected with respiratory syncytial virus. J Virol. 72:2496–2499. 1998.PubMed/NCBI

11 

Hammad H and Lambrecht BN: Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nat Rev Immunol. 8:193–204. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Kwok HH, Ng WY, Yang MS, Mak NK, Wong RN and Yue PY: The ginsenoside protopanaxatriol protects endothelial cells from hydrogen peroxide-induced cell injury and cell death by modulating intracellular redox status. Free Radic Biol Med. 48:437–445. 2010. View Article : Google Scholar

13 

Chan LY, Kwok HH, Chan RW, Peiris MJ, Mak NK, et al: Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis. J Ethnopharmacol. 137:1542–1546. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Moore ML, Chi MH, Luongo C, Lukacs NW, Polosukhin VV, et al: A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction. J Virol. 83:4185–4194. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Quan FS, Kim Y, Lee S, Yi H, Kang SM, et al: Viruslike particle vaccine induces protection against respiratory syncytial virus infection in mice. J Infect Dis. 204:987–995. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Panuska JR, Merolla R, Rebert NA, Hoffmann SP, Tsivitse P, et al: Respiratory syncytial virus induces interleukin-10 by human alveolar macrophages. Suppression of early cytokine production and implications for incomplete immunity. J Clin Invest. 96:2445–2453. 1995. View Article : Google Scholar

17 

Arnold R, König B, Galatti H, Werchau H and König W: Cytokine (IL-8, IL-6, TNF-alpha) and soluble TNF receptor-I release from human peripheral blood mononuclear cells after respiratory syncytial virus infection. Immunology. 85:364–372. 1995.

18 

Zhang Y, Luxon BA, Casola A, Garofalo RP, Jamaluddin M and Brasier AR: Expression of respiratory syncytial virus-induced chemokine gene networks in lower airway epithelial cells revealed by cDNA microarrays. J Virol. 75:9044–9058. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Lee DC and Lau AS: Effects of Panax ginseng on tumor necrosis factor-α-mediated inflammation: a mini-review. Molecules. 16:2802–2816. 2011.

20 

Legg JP, Hussain IR, Warner JA, Johnston SL and Warner JO: Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis. Am J Respir Crit Care Med. 168:633–639. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Matsuse H, Hirose H, Tsuchida T, Fukahori S, Fukushima C, et al: Effects of respiratory syncytial virus infection on dendritic cells and cysteinyl leukotrienes in lung tissues of a murine model of asthma. Allergol Int. 56:165–169. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Song JM, Hossain J, Yoo DG, Lipatov AS, Davis CT, et al: Protective immunity against H5N1 influenza virus by a single dose vaccination with virus-like particles. Virology. 405:165–175. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Song JM, Van Rooijen N, Bozja J, Compans RW and Kang SM: Vaccination inducing broad and improved cross protection against multiple subtypes of influenza A virus. Proc Natl Acad Sci USA. 108:757–761. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Attele AS, Wu JA and Yuan CS: Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol. 58:1685–1693. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Jie YH, Cammisuli S and Baggiolini M: Immunomodulatory effects of Panax Ginseng C.A. Meyer in the mouse. Agents Actions. 15:386–391. 1984.

26 

Pulendran B: Modulating vaccine responses with dendritic cells and Toll-like receptors. Immunol Rev. 199:227–250. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Panuska JR, Midulla F, Cirino NM, Villani A, Gilbert IA, et al: Virus-induced alterations in macrophage production of tumor necrosis factor and prostaglandin E2. Am J Physiol. 259:L396–L402. 1990.PubMed/NCBI

28 

Zeng R, Li C, Li N, Wei L and Cui Y: The role of cytokines and chemokines in severe respiratory syncytial virus infection and subsequent asthma. Cytokine. 53:1–7. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Cormier SA, You D and Honnegowda S: The use of a neonatal mouse model to study respiratory syncytial virus infections. Expert Rev Anti Infect Ther. 8:1371–1380. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Mata M, Morcillo E, Gimeno C and Cortijo J: N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV). Biochem Pharmacol. 82:548–555. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Watanabe W, Shimizu T, Sawamura R, Hino A, Konno K, et al: Effects of tetrabromobisphenol A, a brominated flame retardant, on the immune response to respiratory syncytial virus infection in mice. Int Immunopharmacol. 10:393–397. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lee JS, Ko E, Hwang HS, Lee Y, Kwon Y, Kim M and Kang S: Antiviral activity of ginseng extract against respiratory syncytial virus infection. Int J Mol Med 34: 183-190, 2014.
APA
Lee, J.S., Ko, E., Hwang, H.S., Lee, Y., Kwon, Y., Kim, M., & Kang, S. (2014). Antiviral activity of ginseng extract against respiratory syncytial virus infection. International Journal of Molecular Medicine, 34, 183-190. https://doi.org/10.3892/ijmm.2014.1750
MLA
Lee, J. S., Ko, E., Hwang, H. S., Lee, Y., Kwon, Y., Kim, M., Kang, S."Antiviral activity of ginseng extract against respiratory syncytial virus infection". International Journal of Molecular Medicine 34.1 (2014): 183-190.
Chicago
Lee, J. S., Ko, E., Hwang, H. S., Lee, Y., Kwon, Y., Kim, M., Kang, S."Antiviral activity of ginseng extract against respiratory syncytial virus infection". International Journal of Molecular Medicine 34, no. 1 (2014): 183-190. https://doi.org/10.3892/ijmm.2014.1750
Copy and paste a formatted citation
x
Spandidos Publications style
Lee JS, Ko E, Hwang HS, Lee Y, Kwon Y, Kim M and Kang S: Antiviral activity of ginseng extract against respiratory syncytial virus infection. Int J Mol Med 34: 183-190, 2014.
APA
Lee, J.S., Ko, E., Hwang, H.S., Lee, Y., Kwon, Y., Kim, M., & Kang, S. (2014). Antiviral activity of ginseng extract against respiratory syncytial virus infection. International Journal of Molecular Medicine, 34, 183-190. https://doi.org/10.3892/ijmm.2014.1750
MLA
Lee, J. S., Ko, E., Hwang, H. S., Lee, Y., Kwon, Y., Kim, M., Kang, S."Antiviral activity of ginseng extract against respiratory syncytial virus infection". International Journal of Molecular Medicine 34.1 (2014): 183-190.
Chicago
Lee, J. S., Ko, E., Hwang, H. S., Lee, Y., Kwon, Y., Kim, M., Kang, S."Antiviral activity of ginseng extract against respiratory syncytial virus infection". International Journal of Molecular Medicine 34, no. 1 (2014): 183-190. https://doi.org/10.3892/ijmm.2014.1750
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